Search Results - "Zhou, Daohong"

Hematopoietic stem cell injury induced by ionizing radiation by Shao, Lijian, Luo, Yi, Zhou, Daohong

“…Exposure to ionizing radiation (IR) as the result of nuclear accidents or terrorist attacks is a significant threat and a major medical concern. Hematopoietic…”
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Ionizing Radiation-Induced Endothelial Cell Senescence and Cardiovascular Diseases by Wang, Yingying, Boerma, Marjan, Zhou, Daohong

“…Exposure to ionizing radiation induces not only apoptosis but also senescence. While the role of endothelial cell apoptosis in mediating radiation-induced…”
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PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics by Khan, Sajid, He, Yonghan, Zhang, Xuan, Yuan, Yaxia, Pu, Shaoyan, Kong, Qingpeng, Zheng, Guangrong, Zhou, Daohong

“…Using PROteolysis TArgeting Chimeras (PROTACs) to degrade proteins that are important for tumorigenesis has emerged as a potential therapeutic strategy for…”
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Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse by Demaria, Marco, O'Leary, Monique N, Chang, Jianhui, Shao, Lijian, Liu, Su, Alimirah, Fatouma, Koenig, Kristin, Le, Catherine, Mitin, Natalia, Deal, Allison M, Alston, Shani, Academia, Emmeline C, Kilmarx, Sumner, Valdovinos, Alexis, Wang, Boshi, de Bruin, Alain, Kennedy, Brian K, Melov, Simon, Zhou, Daohong, Sharpless, Norman E, Muss, Hyman, Campisi, Judith

“…Cellular senescence suppresses cancer by irreversibly arresting cell proliferation. Senescent cells acquire a proinflammatory senescence-associated secretory…”
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Targeting KRAS in pancreatic cancer: Emerging therapeutic strategies by Khan, Sajid, Budamagunta, Vivekananda, Zhou, Daohong

“…KRAS, a predominant member of the RAS family, is the most frequently mutated oncogene in human pancreatic cancer (∼95% of cases). Mutations in KRAS lead to its…”
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Therapy-Induced Senescence: Opportunities to Improve Anticancer Therapy by Prasanna, Pataje G, Citrin, Deborah E, Hildesheim, Jeffrey, Ahmed, Mansoor M, Venkatachalam, Sundar, Riscuta, Gabriela, Xi, Dan, Zheng, Guangrong, Deursen, Jan van, Goronzy, Jorg, Kron, Stephen J, Anscher, Mitchell S, Sharpless, Norman E, Campisi, Judith, Brown, Stephen L, Niedernhofer, Laura J, O’Loghlen, Ana, Georgakilas, Alexandros G, Paris, Francois, Gius, David, Gewirtz, David A, Schmitt, Clemens A, Abazeed, Mohamed E, Kirkland, James L, Richmond, Ann, Romesser, Paul B, Lowe, Scott W, Gil, Jesus, Mendonca, Marc S, Burma, Sandeep, Zhou, Daohong, Coleman, C Norman

“…Abstract Cellular senescence is an essential tumor suppressive mechanism that prevents the propagation of oncogenically activated, genetically unstable, and/or…”
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Discovery of piperlongumine as a potential novel lead for the development of senolytic agents by Wang, Yingying, Chang, Jianhui, Liu, Xingui, Zhang, Xuan, Zhang, Suping, Zhang, Xin, Zhou, Daohong, Zheng, Guangrong

“…Accumulating evidence indicates that senescent cells play an important role in many age-associated diseases. The pharmacological depletion of senescent cells…”
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IL-17 and immunologically induced senescence regulate response to injury in osteoarthritis by Faust, Heather J, Zhang, Hong, Han, Jin, Wolf, Matthew T, Jeon, Ok Hee, Sadtler, Kaitlyn, Peña, Alexis N, Chung, Liam, Maestas, Jr, David R, Tam, Ada J, Pardoll, Drew M, Campisi, Judith, Housseau, Franck, Zhou, Daohong, Bingham, 3rd, Clifton O, Elisseeff, Jennifer H

“…Senescent cells (SnCs) are implicated in the pathogenesis of age-related diseases including osteoarthritis (OA), in part via expression of a…”
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Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity by He, Yonghan, Zhang, Xuan, Chang, Jianhui, Kim, Ha-Neui, Zhang, Peiyi, Wang, Yingying, Khan, Sajid, Liu, Xingui, Zhang, Xin, Lv, Dongwen, Song, Lin, Li, Wen, Thummuri, Dinesh, Yuan, Yaxia, Wiegand, Janet S., Ortiz, Yuma T., Budamagunta, Vivekananda, Elisseeff, Jennifer H., Campisi, Judith, Almeida, Maria, Zheng, Guangrong, Zhou, Daohong

“…Small molecules that selectively kill senescent cells (SCs), termed senolytics, have the potential to prevent and treat various age-related diseases and extend…”
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Inhibition of Bcl-2/xl with ABT-263 selectively kills senescent Type II pneumocytes and reverses persistent pulmonary fibrosis induced by ionizing radiation in mice by Pan, Jin, PhD, Li, Deguan, PhD, Xu, Yanfeng, PhD, Zhang, Junling, PhD, Wang, Yueying, BS, Chen, Mengyi, MS, Lin, Shuai, MS, Huang, Lan, BS, Chung, Eun Joo, PhD, Citrin, Deborah E., MD, Wang, Yingying, PhD, Hauer-Jensen, Martin, MD & PhD, Zhou, Daohong, MD, Meng, Aimin, MD

“…Abstract Purpose Ionizing radiation (IR)-induced pulmonary fibrosis (PF) is an irreversible and severe late effect of thoracic radiotherapy. The goal of this…”
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Inhibition of USP7 activity selectively eliminates senescent cells in part via restoration of p53 activity by He, Yonghan, Li, Wen, Lv, Dongwen, Zhang, Xin, Zhang, Xuan, Ortiz, Yuma T., Budamagunta, Vivekananda, Campisi, Judith, Zheng, Guangrong, Zhou, Daohong

“…The accumulation of senescent cells (SnCs) is a causal factor of various age‐related diseases as well as some of the side effects of chemotherapy…”
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MicroRNA Regulation of Ionizing Radiation-Induced Premature Senescence by Wang, Yong, M.D., Ph.D, Scheiber, Melissa N., B.S, Neumann, Carola, Ph.D, Calin, George A., Ph.D, Zhou, Daohong, M.D

“…Purpose MicroRNAs (miRNAs) have emerged as critical regulators of many cellular pathways. Ionizing radiation (IR) exposure causes DNA damage and induces…”
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Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity by Lv, Dongwen, Pal, Pratik, Liu, Xingui, Jia, Yannan, Thummuri, Dinesh, Zhang, Peiyi, Hu, Wanyi, Pei, Jing, Zhang, Qi, Zhou, Shuo, Khan, Sajid, Zhang, Xuan, Hua, Nan, Yang, Qingping, Arango, Sebastian, Zhang, Weizhou, Nayak, Digant, Olsen, Shaun K., Weintraub, Susan T., Hromas, Robert, Konopleva, Marina, Yuan, Yaxia, Zheng, Guangrong, Zhou, Daohong

“…PROteolysis-TArgeting Chimeras (PROTACs) have emerged as an innovative drug development platform. However, most PROTACs have been generated empirically because…”
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Oxidation resistance 1 is a novel senolytic target by Zhang, Xin, Zhang, Suping, Liu, Xingui, Wang, Yingying, Chang, Jianhui, Zhang, Xuan, Mackintosh, Samuel G., Tackett, Alan J., He, Yonghan, Lv, Dongwen, Laberge, Remi‐Martin, Campisi, Judith, Wang, Jianrong, Zheng, Guangrong, Zhou, Daohong

“…Summary The selective depletion of senescent cells (SCs) by small molecules, termed senolytic agents, is a promising therapeutic approach for treating…”
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Metformin ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice by Xu, Guoshun, Wu, Hongying, Zhang, Junling, Li, Deguan, Wang, Yueying, Wang, Yingying, Zhang, Heng, Lu, Lu, Li, Chengcheng, Huang, Song, Xing, Yonghua, Zhou, Daohong, Meng, Aimin

“…Exposure to ionizing radiation (IR) increases the production of reactive oxygen species (ROS) not only by the radiolysis of water but also through IR-induced…”
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Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies by He, Yonghan, Khan, Sajid, Huo, Zhiguang, Lv, Dongwen, Zhang, Xuan, Liu, Xingui, Yuan, Yaxia, Hromas, Robert, Xu, Mingjiang, Zheng, Guangrong, Zhou, Daohong

“…Proteolysis targeting chimeras (PROTACs) are heterobifunctional small molecules that utilize the ubiquitin proteasome system (UPS) to degrade proteins of…”
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Total body irradiation causes residual bone marrow injury by induction of persistent oxidative stress in murine hematopoietic stem cells by Wang, Yong, Liu, Lingbo, Pazhanisamy, Senthil K., Li, Hongliang, Meng, Aimin, Zhou, Daohong

“…Ionizing radiation (IR) and/or chemotherapy causes not only acute tissue damage but also late effects including long-term (or residual) bone marrow (BM)…”
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Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner by Shao, Lijian, Feng, Wei, Li, Hongliang, Gardner, David, Luo, Yi, Wang, Yong, Liu, Lingbo, Meng, Aimin, Sharpless, Norman E., Zhou, Daohong

“…Exposure to total body irradiation (TBI) induces not only acute hematopoietic radiation syndrome but also long-term or residual bone marrow (BM) injury. This…”
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Inter-Strain Differences in LINE-1 DNA Methylation in the Mouse Hematopoietic System in Response to Exposure to Ionizing Radiation by Miousse, Isabelle R, Chang, Jianhui, Shao, Lijian, Pathak, Rupak, Nzabarushimana, Étienne, Kutanzi, Kristy R, Landes, Reid D, Tackett, Alan J, Hauer-Jensen, Martin, Zhou, Daohong, Koturbash, Igor

“…Long Interspersed Nuclear Element 1 (LINE-1) retrotransposons are the major repetitive elements in mammalian genomes. LINE-1s are well-accepted as driving…”
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CD177 modulates the function and homeostasis of tumor-infiltrating regulatory T cells by Kim, Myung-Chul, Borcherding, Nicholas, Ahmed, Kawther K., Voigt, Andrew P., Vishwakarma, Ajaykumar, Kolb, Ryan, Kluz, Paige N., Pandey, Gaurav, De, Umasankar, Drashansky, Theodore, Helm, Eric Y., Zhang, Xin, Gibson-Corley, Katherine N., Klesney-Tait, Julia, Zhu, Yuwen, Lu, Jinglu, Lu, Jinsong, Huang, Xian, Xiang, Hongrui, Cheng, Jinke, Wang, Dongyang, Wang, Zheng, Tang, Jian, Hu, Jiajia, Wang, Zhengting, Liu, Hua, Li, Mingjia, Zhuang, Haoyang, Avram, Dorina, Zhou, Daohong, Bacher, Rhonda, Zheng, Song Guo, Wu, Xuefeng, Zakharia, Yousef, Zhang, Weizhou

“…Regulatory T (Treg) cells are one of the major immunosuppressive cell types in cancer and a potential target for immunotherapy, but targeting…”
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