miR-363-5p as potential prognostic marker for hepatocellular carcinoma indicated by weighted co-expression network analysis of miRNAs and mRNA

This study aimed to investigate potential miRNAs and genes associated with the prognosis of hepatocellular carcinoma (HCC). Weighted co-expression network analysis was utilized to analyze the mRNA and miRNA sequencing data of HCC from TCGA (The Cancer Genome Atlas) database. Significant network modu...

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Bibliographic Details
Published in:	BMC gastroenterology Vol. 17; no. 1; p. 81
Main Authors:	Zhang, Jun, Fan, Jia, Zhou, Chongming, Qi, Yanyu
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 20-06-2017 BioMed Central BMC
Subjects:	Alcohol Analysis Bioinformatics Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Databases, Genetic Fatty liver Female Gastroenterology Gene Expression Gene Regulatory Networks - genetics Genes Genetic aspects Genomes Hepatitis Hepatocellular carcinoma Humans Kaplan-Meier Estimate Liver cancer Liver diseases Liver Neoplasms - genetics Liver Neoplasms - pathology Male Medical prognosis MicroRNA MicroRNAs MicroRNAs - analysis miRNA mRNA Neoplasm Staging Non-alcoholic Fatty Liver Disease - genetics Pathogenesis Prognosis RNA, Messenger - analysis Studies Weighted co-expression network analysis Hepatocellular carcinoma microRNA Weighted co-expression network analysis Prognosis
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Summary:	This study aimed to investigate potential miRNAs and genes associated with the prognosis of hepatocellular carcinoma (HCC). Weighted co-expression network analysis was utilized to analyze the mRNA and miRNA sequencing data of HCC from TCGA (The Cancer Genome Atlas) database. Significant network modules were identified, and then functions of genes in the gene network modules and target genes of miRNAs in the miRNA network modules were explored. Additionally, correlations between network modules and prognostic factors of HCC were analyzed. In total, 10 mRNA network modules were identified, three of which were significantly related to tumor stage, NAFLD (non-alcoholic fatty liver disease) and patient age. Four miRNA network modules were identified, of which one was associated with tumor stage. Targets of hsa-miR-363-5p were found distributed in the gene network modules, such as RGPD5, RGPD6, ZNF445 and ZNF780B. Kaplan-Meier test revealed that low expression of hsa-miR-363-5p was associated with better overall survival of HCC patients. hsa-miR-363-5p may be a potential prognostic marker for HCC.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1471-230X 1471-230X
DOI:	10.1186/s12876-017-0637-2