Search Results - "Zhongyu Zhu"

Eradication of Tumors through Simultaneous Ablation of CD276/B7-H3-Positive Tumor Cells and Tumor Vasculature by Seaman, Steven, Zhu, Zhongyu, Saha, Saurabh, Zhang, Xiaoyan M., Yang, Mi Young, Hilton, Mary Beth, Morris, Karen, Szot, Christopher, Morris, Holly, Swing, Deborah A., Tessarollo, Lino, Smith, Sean W., Degrado, Sylvia, Borkin, Dmitry, Jain, Nareshkumar, Scheiermann, Julia, Feng, Yang, Wang, Yanping, Li, Jinyu, Welsch, Dean, DeCrescenzo, Gary, Chaudhary, Amit, Zudaire, Enrique, Klarmann, Kimberly D., Keller, Jonathan R., Dimitrov, Dimiter S., St. Croix, Brad

“…Targeting the tumor vasculature with antibody-drug conjugates (ADCs) is a promising anti-cancer strategy that in order to be realized must overcome several…”
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Age shock index and age-modified shock index are valuable bedside prognostic tools for postdischarge mortality in ST-elevation myocardial infarction patients by Wang, Shan, Zhang, You, Qi, Datun, Wang, Xianpei, Zhu, Zhongyu, Yang, Wei, Li, Muwei, Hu, Dayi, Gao, Chuanyu

“…The incidence of mortality is considerable after ST-elevation myocardial infarction (STEMI) hospitalization; risk assessment is needed to guide postdischarge…”
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Tumor stroma-targeted antibody-drug conjugate triggers localized anticancer drug release by Szot, Christopher, Saha, Saurabh, Zhang, Xiaoyan M, Zhu, Zhongyu, Hilton, Mary Beth, Morris, Karen, Seaman, Steven, Dunleavey, James M, Hsu, Kuo-Sheng, Yu, Guo-Jun, Morris, Holly, Swing, Deborah A, Haines, Diana C, Wang, Yanping, Hwang, Jennifer, Feng, Yang, Welsch, Dean, DeCrescenzo, Gary, Chaudhary, Amit, Zudaire, Enrique, Dimitrov, Dimiter S, St Croix, Brad

“…Although nonmalignant stromal cells facilitate tumor growth and can occupy up to 90% of a solid tumor mass, better strategies to exploit these cells for…”
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Changes in process and outcome for ST elevation myocardial infarction in central China from 2011 to 2018 by Zhang, You, Wang, Shan, Qi, Datun, Wang, Xianpei, Li, Muwei, Zhu, Zhongyu, Cheng, Qianqian, Hu, Dayi, Gao, Chuanyu

“…Limited data are available on the changes in the quality of care for ST elevation myocardial infarction (STEMI) during China's health system reform from 2009…”
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Germline-like predecessors of broadly neutralizing antibodies lack measurable binding to HIV-1 envelope glycoproteins: Implications for evasion of immune responses and design of vaccine immunogens by Xiao, Xiaodong, Chen, Weizao, Feng, Yang, Zhu, Zhongyu, Prabakaran, Ponraj, Wang, Yanping, Zhang, Mei-Yun, Longo, Nancy S., Dimitrov, Dimiter S.

“…Several human monoclonal antibodies (hmAbs) including b12, 2G12, and 2F5 exhibit relatively potent and broad HIV-1-neutralizing activity. However, their…”
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Cancer cell survival depends on collagen uptake into tumor-associated stroma by Hsu, Kuo-Sheng, Dunleavey, James M., Szot, Christopher, Yang, Liping, Hilton, Mary Beth, Morris, Karen, Seaman, Steven, Feng, Yang, Lutz, Emily M., Koogle, Robert, Tomassoni-Ardori, Francesco, Saha, Saurabh, Zhang, Xiaoyan M., Zudaire, Enrique, Bajgain, Pradip, Rose, Joshua, Zhu, Zhongyu, Dimitrov, Dimiter S., Cuttitta, Frank, Emenaker, Nancy J., Tessarollo, Lino, St. Croix, Brad

“…Collagen I, the most abundant protein in humans, is ubiquitous in solid tumors where it provides a rich source of exploitable metabolic fuel for cancer cells…”
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Identification of a putative Crimean-Congo hemorrhagic fever virus entry factor by Xiao, Xiaodong, Feng, Yang, Zhu, Zhongyu, Dimitrov, Dimiter S.

“…► Identified putative receptor for the Crimean-Congo hemorrhagic fever virus which allows new exploration of virus entry and development of inhibitors. ►…”
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Armored BCMA CAR T Cells Eliminate Multiple Myeloma and Are Resistant to the Suppressive Effects of TGF-β by Alabanza, Leah M, Xiong, Ying, Vu, Bang, Webster, Brian, Wu, Darong, Hu, Peirong, Zhu, Zhongyu, Dropulic, Boro, Dash, Pradyot, Schneider, Dina

“…CAR T-cell therapies targeting the B-cell maturation antigen eliminate tumors in relapsed/refractory multiple myeloma patients, however durable remissions…”
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A treatment for and vaccine against the deadly Hendra and Nipah viruses by Broder, Christopher C., Xu, Kai, Nikolov, Dimitar B., Zhu, Zhongyu, Dimitrov, Dimiter S., Middleton, Deborah, Pallister, Jackie, Geisbert, Thomas W., Bossart, Katharine N., Wang, Lin-Fa

“…•Advanced antivirals against Nipah and Hendra are a Hendra-sG subunit vaccine and a human monoclonal antibody, m102.4.•The Hendra-sG vaccine was launched in…”
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Small-molecule inhibition of the METTL3/METTL14 complex suppresses neuroblastoma tumor growth and promotes differentiation by Pomaville, Monica, Chennakesavalu, Mohansrinivas, Wang, Pingluan, Jiang, Zhiwei, Sun, Hui-Lung, Ren, Peizhe, Borchert, Ryan, Gupta, Varsha, Ye, Chang, Ge, Ruiqi, Zhu, Zhongyu, Brodnik, Mallory, Zhong, Yuhao, Moore, Kelley, Salwen, Helen, George, Rani E., Krajewska, Malgorzata, Chlenski, Alexandre, Applebaum, Mark A., He, Chuan, Cohn, Susan L.

“…The N6-methyladenosine (m6A) RNA modification is an important regulator of gene expression. m6A is deposited by a methyltransferase complex that includes…”
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A broadly neutralizing germline-like human monoclonal antibody against dengue virus envelope domain III by Hu, Dan, Zhu, Zhongyu, Li, Shun, Deng, Yongqiang, Wu, Yanling, Zhang, Nana, Puri, Vinita, Wang, Chunyu, Zou, Peng, Lei, Cheng, Tian, Xiaolong, Wang, Yulu, Zhao, Qi, Li, Wei, Prabakaran, Ponraj, Feng, Yang, Cardosa, Jane, Qin, Chengfeng, Zhou, Xiaohui, Dimitrov, Dimiter S, Ying, Tianlei

“…Dengue is the most widespread vector-borne viral disease caused by dengue virus (DENV) for which there are no safe, effective drugs approved for clinical use…”
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Structure of Severe Acute Respiratory Syndrome Coronavirus Receptor-binding Domain Complexed with Neutralizing Antibody by Prabakaran, Ponraj, Gan, Jianhua, Feng, Yang, Zhu, Zhongyu, Choudhry, Vidita, Xiao, Xiaodong, Ji, Xinhua, Dimitrov, Dimiter S.

“…The severe acute respiratory syndrome coronavirus (SARS-CoV, or SCV), which caused a world-wide epidemic in 2002 and 2003, binds to a receptor,…”
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Antibody Aggregation: Insights from Sequence and Structure by Li, Wei, Prabakaran, Ponraj, Chen, Weizao, Zhu, Zhongyu, Feng, Yang, Dimitrov, Dimiter

“…Monoclonal antibodies (mAbs) are the fastest-growing biological therapeutics with important applications ranging from cancers, autoimmunity diseases and…”
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A neutralizing human monoclonal antibody protects against lethal disease in a new ferret model of acute nipah virus infection by Bossart, Katharine N, Zhu, Zhongyu, Middleton, Deborah, Klippel, Jessica, Crameri, Gary, Bingham, John, McEachern, Jennifer A, Green, Diane, Hancock, Timothy J, Chan, Yee-Peng, Hickey, Andrew C, Dimitrov, Dimiter S, Wang, Lin-Fa, Broder, Christopher C

“…Nipah virus is a broadly tropic and highly pathogenic zoonotic paramyxovirus in the genus Henipavirus whose natural reservoirs are several species of Pteropus…”
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Human domain antibodies to conserved sterically restricted regions on gp120 as exceptionally potent cross-reactive HIV-1 neutralizers by Chen, Weizao, Zhu, Zhongyu, Feng, Yang, Dimitrov, Dimiter S

“…The antibody access to some conserved structures on the HIV-1 envelope glycoprotein (Env) is sterically restricted. We have hypothesized that the smallest…”
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Renal Interstitial Fibrosis Is Reduced in High-Fat Diet-Induced Obese Pigs following Renal Denervation from the Intima and Adventitia of the Renal Artery by Zhu, Binbin, Liu, Yahui, Qi, Datun, Zhao, Linwei, Yang, Xiaohang, Su, Enyong, Zhu, Zhongyu, Zhang, You, Gao, Chuanyu

“…Background: This study aims to compare whether 2 different routes of renal denervation (RDN) from the intima and adventitia of the renal artery can reduce…”
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Engineering CD276/B7-H3-targeted antibody-drug conjugates with enhanced cancer-eradicating capability by Feng, Yang, Lee, Jaewon, Yang, Liping, Hilton, Mary Beth, Morris, Karen, Seaman, Steven, Edupuganti, Veera V. Shivaji R., Hsu, Kuo-Sheng, Dower, Christopher, Yu, Guojun, So, Daeho, Bajgain, Pradip, Zhu, Zhongyu, Dimitrov, Dimiter S., Patel, Nimit L., Robinson, Christina M., Difilippantonio, Simone, Dyba, Marzena, Corbel, Amanda, Basuli, Falguni, Swenson, Rolf E., Kalen, Joseph D., Suthe, Sreedhar Reddy, Hussain, Myer, Italia, James S., Souders, Colby A., Gao, Ling, Schnermann, Martin J., St. Croix, Brad

“…CD276/B7-H3 represents a promising target for cancer therapy based on widespread overexpression in both cancer cells and tumor-associated stroma. In previous…”
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A Unique Human Immunoglobulin Heavy Chain Variable Domain-Only CD33 CAR for the Treatment of Acute Myeloid Leukemia by Schneider, Dina, Xiong, Ying, Hu, Peirong, Wu, Darong, Chen, Weizao, Ying, Tianlei, Zhu, Zhongyu, Dimitrov, Dimiter S, Dropulic, Boro, Orentas, Rimas J

“…Acute myeloid leukemia (AML) remains a challenging pediatric and adult disease. Given the elevated expression of the CD33 antigen on leukemic blasts,…”
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Exceptionally Potent and Broadly Cross-Reactive, Bispecific Multivalent HIV-1 Inhibitors Based on Single Human CD4 and Antibody Domains by Chen, Weizao, Feng, Yang, Prabakaran, Ponraj, Ying, Tianlei, Wang, Yanping, Sun, Jianping, Macedo, Camila D S, Zhu, Zhongyu, He, Yuxian, Polonis, Victoria R, Dimitrov, Dimiter S

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Age and gender mediated the association between anemia and 30-day outcomes in patients with ST-segment elevated myocardial infarction by Wang, Shan, Zhang, You, Qi, Datun, Wang, Xianpei, Zhu, Zhongyu, Yang, Wei, Li, Muwei, Hu, Dayi, Gao, Chuanyu

“…The higher prevalence of anemia in females and elderly may be attributed to its association with worsened outcomes in ST-elevation myocardial infarction…”
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