Search Results - "Zhong, Xiuying"

cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions by Sun, Linchong, Song, Libing, Wan, Qianfen, Wu, Gongwei, Li, Xinghua, Wang, Yinghui, Wang, Jin, Liu, Zhaoji, Zhong, Xiuying, He, Xiaoping, Shen, Shengqi, Pan, Xin, Li, Ailing, Wang, Yulan, Gao, Ping, Tang, Huiru, Zhang, Huafeng

“…Cancer cells are known to undergo metabolic reprogramming to sustain survival and rapid proliferation, however, it remains to be fully elucidated how oncogenic…”
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Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission by Wang, Lihua, Zhang, Tong, Wang, Lin, Cai, Yongping, Zhong, Xiuying, He, Xiaoping, Hu, Lan, Tian, Shengya, Wu, Mian, Hui, Lijian, Zhang, Huafeng, Gao, Ping

“…Pluripotent stem cells are known to display distinct metabolic phenotypes than their somatic counterparts. While accumulating studies are focused on the roles…”
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Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells by Zhong, Xiuying, Cui, Peng, Cai, Yongping, Wang, Lihua, He, Xiaoping, Long, Peipei, Lu, Kangyang, Yan, Ronghui, Zhang, Ying, Pan, Xin, Zhao, Xiaoyang, Li, Wei, Zhang, Huafeng, Zhou, Qi, Gao, Ping

“…While the pluripotency of stem cells is known to determine the fate of embryonic development, the mechanisms underlying the acquisition and maintenance of full…”
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HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation Is Critical for Cancer Progression by Huang, De, Li, Tingting, Li, Xinghua, Zhang, Long, Sun, Linchong, He, Xiaoping, Zhong, Xiuying, Jia, Dongya, Song, Libing, Semenza, Gregg L., Gao, Ping, Zhang, Huafeng

“…Hypoxia-inducible factor 1 (HIF-1) mediates a metabolic switch that blocks the conversion of pyruvate to acetyl-CoA in cancer cells. Here, we report that…”
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Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1 by Ma, Xiaoyu, Li, Chenchen, Sun, Linchong, Huang, De, Li, Tingting, He, Xiaoping, Wu, Gongwei, Yang, Zheng, Zhong, Xiuying, Song, Libing, Gao, Ping, Zhang, Huafeng

“…Aberrant expression of Lin28 and let-7 has been observed in many human malignancies. However, its functions and underlying mechanisms remain largely elusive…”
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Secreted protease PRSS35 suppresses hepatocellular carcinoma by disabling CXCL2-mediated neutrophil extracellular traps by Wang, Ting, Zhou, Yingli, Zhou, Zilong, Zhang, Pinggen, Yan, Ronghui, Sun, Linchong, Ma, Wenhao, Zhang, Tong, Shen, Shengqi, Liu, Haiying, Lu, Hui, Ye, Ling, Feng, Junru, Chen, Zhaolin, Zhong, Xiuying, Wu, Gao, Cai, Yongping, Jia, Weidong, Gao, Ping, Zhang, Huafeng

“…Hepatocytes function largely through the secretion of proteins that regulate cell proliferation, metabolism, and intercellular communications. During the…”
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Metformin sensitises hepatocarcinoma cells to methotrexate by targeting dihydrofolate reductase by Wang, Yinghui, Lu, Hui, Sun, Linchong, Chen, Xin, Wei, Haoran, Suo, Caixia, Feng, Junru, Yuan, Mengqiu, Shen, Shengqi, Jia, Weidong, Wang, Ying, Zhang, Huafeng, Li, Zijun, Zhong, Xiuying, Gao, Ping

“…Metformin, the first-line drug for type II diabetes, has recently been considered an anticancer agent. However, the molecular target and underlying mechanism…”
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HKDC1 promotes tumor immune evasion in hepatocellular carcinoma by coupling cytoskeleton to STAT1 activation and PD-L1 expression by Zhang, Yi, Wang, Mingjie, Ye, Ling, Shen, Shengqi, Zhang, Yuxi, Qian, Xiaoyu, Zhang, Tong, Yuan, Mengqiu, Ye, Zijian, Cai, Jin, Meng, Xiang, Qiu, Shiqiao, Liu, Shengzhi, Liu, Rui, Jia, Weidong, Yang, Xianzhu, Zhang, Huafeng, Zhong, Xiuying, Gao, Ping

“…Immune checkpoint blockade (ICB) has shown considerable promise for treating various malignancies, but only a subset of cancer patients benefit from immune…”
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Chronic nicotine exposure impairs uncertainty modulation on reinforcement learning in anterior cingulate cortex and serotonin system by Wei, Zhengde, Han, Long, Zhong, Xiuying, Liu, Ying, Zha, Rujing, Wang, Ying, Yang, Li-Zhuang, Bu, Junjie, Song, Hongwen, Wang, Wenjuan, Zhou, Yifeng, Gao, Ping, Zhang, Xiaochu

“…Deficits in the computational processes of reinforcement learning have been suggested to underlie addiction. Additionally, environmental uncertainty, which is…”
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KDELR2 promotes breast cancer proliferation via HDAC3‐mediated cell cycle progression by Wei, Haoran, Ma, Wenhao, Lu, Xiaofei, Liu, Haiying, Lin, Kashuai, Wang, Yinghui, Ye, Zijian, Sun, Linchong, Huang, Zhitong, Pan, Tingting, Zhou, Zilong, Cheng, Eric Y., Zhang, Huafeng, Gao, Ping, Zhong, Xiuying

“…Background Histone deacetylases (HDACs) engage in the regulation of various cellular processes by controlling global gene expression. The dysregulation of…”
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Human fibroblast reprogramming to pluripotent stem cells regulated by the miR19a/b-PTEN axis by He, Xiaoping, Cao, Yang, Wang, Lihua, Han, Yingli, Zhong, Xiuying, Zhou, Guixiang, Cai, Yongping, Zhang, Huafeng, Gao, Ping

“…Induction of pluripotent stem cells (iPSC) by defined transcription factors is the recognized canonical means for somatic reprogramming, however, it remains…”
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Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications by Tian, Shengya, Feng, Junru, Cao, Yang, Shen, Shengqi, Cai, Yongping, Yang, Dongdong, Yan, Ronghui, Wang, Lihua, Zhang, Huafeng, Zhong, Xiuying, Gao, Ping

“…Metabolic remodelling has emerged as critical for stem cell pluripotency; however, the underlying mechanisms have yet to be fully elucidated. Here, we found…”
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Mitochondria-localized cGAS suppresses ferroptosis to promote cancer progression by Qiu, Shiqiao, Zhong, Xiuying, Meng, Xiang, Li, Shiting, Qian, Xiaoyu, Lu, Hui, Cai, Jin, Zhang, Yi, Wang, Mingjie, Ye, Zijian, Zhang, Huafeng, Gao, Ping

“…A well-established role of cyclic GMP-AMP synthase (cGAS) is the recognition of cytosolic DNA, which is linked to the activation of host defense programs…”
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Methylparaben suppresses the citrus postharvest pathogen Penicillium digitatum by undermining the cell wall and membrane and inducing the antioxidant system by Yang, Fan, Zhong, Xiuying, Wang, Yuqing, Zhao, Juan, Lu, Yongqing, Long, Chao-an

“…•Methylparaben (MP) efficiently inhibits the growth of P. digitatum in vitro.•MP undermines the cell wall and plasma membrane of P. digitatum.•MP destroys the…”
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GAR-transferase contributes to purine synthesis and mitochondrion function to maintain fungal development and full virulence of Penicillium digitatum by Yang, Fan, Lu, Yongqing, Du, Yulin, Liu, Shuqi, Zhong, Xiuying, Du, Yujie, Tian, Zhonghuan, Long, Chao-an

“…Penicillium digitatum is one of the most critical phytopathogens during the citrus postharvest period. However, the molecular mechanism of pathogenesis remains…”
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EPDR1 promotes PD-L1 expression and tumor immune evasion by inhibiting TRIM21-dependent ubiquitylation of IkappaB kinase-β by Qian, Xiaoyu, Cai, Jin, Zhang, Yi, Shen, Shengqi, Wang, Mingjie, Liu, Shengzhi, Meng, Xiang, Zhang, Junjiao, Ye, Zijian, Qiu, Shiqiao, Zhong, Xiuying, Gao, Ping

“…While immune checkpoint blockade (ICB) has shown promise for clinical cancer therapy, its efficacy has only been observed in a limited subset of patients and…”
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Branched-chain amino acid catabolism breaks glutamine addiction to sustain hepatocellular carcinoma progression by Yang, Dongdong, Liu, Haiying, Cai, Yongping, Lu, Kangyang, Zhong, Xiuying, Xing, Songge, Song, Wei, Zhang, Yaping, Ye, Ling, Zhu, Xia, Wang, Ting, Zhang, Pinggen, Li, Shi-Ting, Feng, Jiaqian, Jia, Weidong, Zhang, Huafeng, Gao, Ping

“…Branched-chain amino acid (BCAA) catabolism is related to tumorigenesis. However, the underlying mechanism and specific contexts in which BCAAs affect tumor…”
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DIS3L2 Promotes Progression of Hepatocellular Carcinoma via hnRNP U-Mediated Alternative Splicing by Xing, Songge, Li, Zhaoyong, Ma, Wenhao, He, Xiaoping, Shen, Shengqi, Wei, Haoran, Li, Shi-Ting, Shu, Ying, Sun, Linchong, Zhong, Xiuying, Huangfu, Yuhao, Su, Lanhong, Feng, Junru, Zhang, Xiaozhang, Gao, Ping, Jia, Wei-Dong, Zhang, Huafeng

“…DIS3-like 3'-5' exoribonuclease 2 (DIS3L2) degrades aberrant RNAs, however, its function in tumorigenesis remains largely unexplored. Here, aberrant DIS3L2…”
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Carnosine regulation of intracellular pH homeostasis promotes lysosome-dependent tumor immunoevasion by Yan, Ronghui, Zhang, Pinggen, Shen, Shengqi, Zeng, Yu, Wang, Ting, Chen, Zhaolin, Ma, Wenhao, Feng, Junru, Suo, Caixia, Zhang, Tong, Wei, Haoran, Jiang, Zetan, Chen, Rui, Li, Shi-ting, Zhong, Xiuying, Jia, Weidong, Sun, Linchong, Cang, Chunlei, Zhang, Huafeng, Gao, Ping

“…Tumor cells and surrounding immune cells undergo metabolic reprogramming, leading to an acidic tumor microenvironment. However, it is unclear how tumor cells…”
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Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP‐1 by Zhang, Yang, Li, Chenchen, Hu, Chuanzhen, Wu, Qian, Cai, Yongping, Xing, Songge, Lu, Hui, Wang, Lin, Huang, De, Sun, Linchong, Li, Tingting, He, Xiaoping, Zhong, Xiuying, Wang, Junfeng, Gao, Ping, Smith, Zachary J, Jia, Weidong, Zhang, Huafeng

“…Lin28 plays an important role in promoting tumor development, whereas its exact functions and underlying mechanisms are largely unknown. Here, we show that…”
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