Search Results - "Zhong, MingKang"

The bacterial multidrug resistance regulator BmrR distorts promoter DNA to activate transcription by Fang, Chengli, Li, Linyu, Zhao, Yihan, Wu, Xiaoxian, Philips, Steven J., You, Linlin, Zhong, Mingkang, Shi, Xiaojin, O’Halloran, Thomas V., Li, Qunyi, Zhang, Yu

“…The MerR-family proteins represent a unique family of bacteria transcription factors (TFs), which activate transcription in a manner distinct from canonical…”
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Factors Affecting Time-Varying Clearance of Cyclosporine in Adult Renal Transplant Recipients: A Population Pharmacokinetic Perspective by Mao, Junjun, Qiu, Xiaoyan, Qin, Weiwei, Xu, Luyang, Zhang, Ming, Zhong, Mingkang

“…Aim The pharmacokinetic (PK) properties of cyclosporine (CsA) in renal transplant recipients are patient- and time-dependent. Knowledge of this time-related…”
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Treatment access and satisfaction on disease-modifying therapies of neuromyelitis optica spectrum disorder patients in China: a cross-sectional survey by Yu, Yue, Zhong, Mingkang, Quan, Chao, Ma, Chunlai

“…Neuromyelitis optica spectrum disorder (NMOSD) is a rare and debilitating disease that has become more widely recognized in China. Legislative measures have…”
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Long way to go: Progress of orphan drug accessibility in China from 2017 to 2022 by Liu, Jia, Yu, Yue, Zhong, Mingkang, Ma, Chunlai, Shao, Rong

“…Over 400 million patients worldwide suffer from rare diseases. Access to orphan drugs is, therefore, crucial for this population. China has been actively…”
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In vitro mechanistic study on mycophenolate mofetil drug interactions: effect of prednisone, cyclosporine, and others by Mao, Junjun, Yu, Feifei, Qin, Weiwei, She, Guixian, Rong, Yi, Hu, Zhuohan, Zhong, Mingkang

“…The metabolism- and transporter-based drug-drug interactions (DDIs) between mycophenolate mofetil (MMF) and co-administered medications may be key factors for…”
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ESRRG-PKM2 axis reprograms metabolism to suppress esophageal squamous carcinoma progression and enhance anti-PD-1 therapy efficacy by Wang, Tianxiao, Zhu, Yongjun, Chen, Lu, Zhang, WenXin, Qi, Huijie, Shi, Xiaojin, Zhong, Mingkang, Chen, Haifei, Li, Qunyi

“…Background Glycolysis under normoxic conditions, known as the Warburg effect, confers a selective advantage for the survival and proliferation of many tumors…”
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SNPs and blood inflammatory marker featured machine learning for predicting the efficacy of fluorouracil-based chemotherapy in colorectal cancer by Li, Jiyifan, Zhang, Wenxin, Chen, Lu, Mao, Xiang, Wang, Xinhai, Liu, Jiafeng, Huang, Yuxin, Qi, Huijie, Chen, Li, Shi, Huanying, Chen, Bicui, Zhong, Mingkang, Li, Qunyi, Wang, Tianxiao

“…Fluorouracil-based chemotherapy responses in colorectal cancer (CRC) patients vary widely, highlighting the role of pharmacogenomics in developing better…”
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Azithromycin ameliorated cigarette smoke-induced airway epithelial barrier dysfunction by activating Nrf2/GCL/GSH signaling pathway by Song, Yun, Fu, Wenhuan, Zhang, Youzhi, Huang, Doudou, Wu, Jian, Tong, Shuangmei, Zhong, Mingkang, Cao, Huifang, Wang, Bin

“…Airway epithelium is the first barrier against environmental insults, and epithelial barrier dysfunction caused by cigarette smoke (CS) is particularly…”
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CDK12 inhibition upregulates ATG7 triggering autophagy via AKT/FOXO3 pathway and enhances anti-PD-1 efficacy in colorectal cancer by Wu, Zimei, Zhang, Wenxin, Chen, Lu, Wang, Tianxiao, Wang, Xinhai, Shi, Huanying, Zhang, Liudi, Zhong, Mingkang, Shi, Xiaojin, Mao, Xiang, Chen, Haifei, Li, Qunyi

“…As the world’s fourth most deadly cancer, colorectal cancer (CRC) still needed the novel therapeutic drugs and target urgently. Although cyclin-dependent…”
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Evaluation and Application of Population Pharmacokinetic Models for Identifying Delayed Methotrexate Elimination in Patients With Primary Central Nervous System Lymphoma by Mao, Junjun, Li, Qing, Li, Pei, Qin, Weiwei, Chen, Bobin, Zhong, Mingkang

“…Several population pharmacokinetic (popPK) models have been developed to determine the sources of methotrexate (MTX) PK variability. It remains unknown if…”
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Effects of FGFR gene polymorphisms on response and toxicity of cyclophosphamide-epirubicin-docetaxel-based chemotherapy in breast cancer patients by Chen, Lu, Qi, Huijie, Zhang, Liudi, Li, Haixia, Shao, Jie, Chen, Haifei, Zhong, Mingkang, Shi, Xiaojin, Ye, Ting, Li, Qunyi

“…The chemotherapy resistance and toxicity of chemotherapy are major problems in breast cancer treatment. However, candidate biomarkers for predicting clinical…”
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Inhibition of autophagy-related protein 7 enhances anti-tumor immune response and improves efficacy of immune checkpoint blockade in microsatellite instability colorectal cancer by Zhang, Wenxin, Chen, Lu, Liu, Jiafeng, Chen, Bicui, Shi, Huanying, Chen, Haifei, Qi, Huijie, Wu, Zimei, Mao, Xiang, Wang, Xinhai, Huang, Yuxin, Li, Jiyifan, Yu, Zheng, Zhong, Mingkang, Wang, Tianxiao, Li, Qunyi

“…The efficacy of anti-PD-1 therapy is primarily hindered by the limited T-cell immune response rate and immune evasion capacity of tumor cells…”
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Central Nervous System Inflammation Induced by Lipopolysaccharide Up-Regulates Hepatic Hepcidin Expression by Activating the IL-6/JAK2/STAT3 Pathway in Mice by Zhang, Fali, Zhao, Peng, Qian, Zhongming, Zhong, Mingkang

“…It is known that lipopolysaccharide (LPS) triggers inflammatory response after intracerebroventricular (ICV) injection and elevates the expression of hepcidin…”
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Applying machine learning to the pharmacokinetic modeling of cyclosporine in adult renal transplant recipients: a multi-method comparison by Mao, Junjun, Chen, Yuhao, Xu, Luyang, Chen, Weihuang, Chen, Biwen, Fang, Zhuo, Qin, Weiwei, Zhong, Mingkang

“…Objective: The aim of this study was to identify the important factors affecting cyclosporine (CsA) blood concentration and estimate CsA concentration using…”
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Reduced emergency room visits and improved medication adherence of an integrated oncology pharmaceutical care practice in China by Qi, Huijie, Zhu, Lili, Chen, Lu, Zhang, Wenxin, Wang, Tianxiao, Chen, Haifei, Wu, Qian, Zhan, Qiong, Le, Tianji, Zhang, Liudi, Zhong, Mingkang, Shi, Xiaojin, Li, Qunyi

“…Objective We described our initial experience of a new integrated oncology phamaceutical care practice to enhance the quality of pharmacy service and patient…”
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Determination of berberine, palmatine and jatrorrhizine in rabbit plasma by liquid chromatography–electrospray ionization-mass spectrometry by Liu, Fengqing, Li, Zhongdong, Shi, Xiaojin, Zhong, Mingkang

“…Incurred rabbit plasmas samples were utilized for method quality assessment in this study, where an optimized protein precipitation method for the preparation…”
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Effects of lipid vehicle and P-glycoprotein inhibition on the mesenteric lymphatic transport of paclitaxel in unconscious, lymph duct-cannulated rats by Cai, Qingqing, Deng, Xinxian, Li, Zhongdong, An, Dianyun, Shen, Teng, Zhong, Mingkang

“…The present study examined the effects of lipid vehicle and intestinally based efflux processes on intestinal lymphatic transport of paclitaxel (PTX) in the…”
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Incorporating nonlinear kinetics to improve predictive performance of population pharmacokinetic models for ciclosporin in adult renal transplant recipients: A comparison of modelling strategies by Mao, Junjun, Jiao, Zheng, Qiu, Xiaoyan, Zhang, Ming, Zhong, Mingkang

“…•Four population pharmacokinetic models constructed to examine model predictability.•Potential effects of nonlinearity and functional forms of covariates were…”
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A joint population pharmacokinetic model to assess the high variability of whole-blood and intracellular tacrolimus in early adult renal transplant recipients by Mao, Junjun, Zeng, Fang, Qin, Weiwei, Hu, Min, Xu, Luyang, Cheng, Fang, Zhong, Mingkang, Zhang, Yu

“…•The PK variability of TAC is relatively high during the early post-transplant period.•Correlations between blood concentration, intracellular levels, and…”
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Donor and recipient polymorphisms of MAPK signaling pathway genes influence post-transplant liver function in Chinese liver transplant patients taking tacrolimus by Niu, Wanjie, Zheng, Xinyi, Li, Ziran, Wu, Zhuo, Zhong, Mingkang, Qiu, Xiaoyan

“…•Investigated the impact of polymorphisms of MAPK kinase kinase (MAP3K) genes on clinical events in Han Chinese liver transplantation recipients taking…”
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