HLA DRB1 ASSOCIATION WITH REPRODUCTIVE DISORDERS IN WOMEN

HLA DRB1 ASSOCIATION WITH REPRODUCTIVE DISORDERS IN WOMEN

HLA DRB1* gene associations with idiopathic fetal losses and infertility were studied in women. It was shown that idiopathic fetal losses are associated with HLA DRB1*04 specificity, whereas infertility correlated with HLA DRB1*04/07 genotype. The associations revealed may indicate to a special role...

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Bibliographic Details
Published in:Medit͡s︡inskai͡a︡ immunologii͡a Vol. 9; no. 6; pp. 643 - 648
Main Authors: Gordeeva, L. A., Shabaldin, A. V., Glushkov, A. N., Glushkova, O. A., Makarchenko, O. S., Simonova, T. A., Vetrova, I. V., Sherina, E. A., Zhilinskaya, N. K., Minina, V. I.
Format: Journal Article
Language:English
Published: St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 18-07-2014
Subjects:
autoimmunity
hla
reproductive disorders
Online Access:Get full text
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Summary:HLA DRB1* gene associations with idiopathic fetal losses and infertility were studied in women. It was shown that idiopathic fetal losses are associated with HLA DRB1*04 specificity, whereas infertility correlated with HLA DRB1*04/07 genotype. The associations revealed may indicate to a special role of autoimmune events in women during pregnancy. The authors suggest a hypothesis on existence of several immune modes of reproductive losses. HLA genotyping may be applied as a basic technique for their determination.
ISSN:1563-0625
2313-741X
DOI:10.15789/1563-0625-2007-6-643-648