Search Results - "Zheng, Zhibing"

Beneficial Effects of Theaflavins on Metabolic Syndrome: From Molecular Evidence to Gut Microbiome by Shi, Meng, Lu, Yuting, Wu, Junling, Zheng, Zhibing, Lv, Chenghao, Ye, Jianhui, Qin, Si, Zeng, Chaoxi

“…In recent years, many natural foods and herbs rich in phytochemicals have been proposed as health supplements for patients with metabolic syndrome (MetS)…”
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Novel Scaffold Agonists of the α2A Adrenergic Receptor Identified via Ensemble-Based Strategy by Sun, Shiyang, Li, Pengyun, Wang, Jiaqi, Zhao, Dongsheng, Yang, Tingting, Zhou, Peilan, Su, Ruibin, Zheng, Zhibing, Li, Song

“…The α2A adrenergic receptor (α2A-AR) serves as a critical molecular target for sedatives and analgesics. However, α2A-AR ligands with an imidazole ring also…”
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Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism by Li, Pengyun, Lin, Qiaohong, Sun, Shiyang, Yang, Ning, Xia, Yu, Cao, Shengjie, Zhang, Wenjuan, Li, Qian, Guo, Haoxin, Zhu, Maoxiang, Wang, Yilong, Zheng, Zhibing, Li, Song

“…Triple-negative breast cancer (TNBC) is a heterogeneous subtype of breast cancer that displays highly aggressive with poor prognosis. Owing to the limited…”
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Dihydromyricetin Acts as a Potential Redox Balance Mediator in Cancer Chemoprevention by Chen, Liang, Shi, Meng, Lv, Chenghao, Song, Ying, Wu, Yuanjie, Liu, Suifei, Zheng, Zhibing, Lu, Xiangyang, Qin, Si

“…Dihydromyricetin (DHM) is a flavonoid extracted from the leaves and stems of the edible plant Ampelopsis grossedentata that has been used for Chinese…”
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Discovery of Novel Non-Oxime Reactivators Showing In Vivo Antidotal Efficiency for Sarin Poisoned Mice by Wei, Zhao, Zhang, Xinlei, Nie, Huifang, Yao, Lin, Liu, Yanqin, Zheng, Zhibing, Ouyang, Qin

“…A family of novel efficient non-oxime compounds exhibited promising reactivation efficacy for VX and sarin inhibited human acetylcholinesterase was discovered…”
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Novel potent molecular glue degraders against broad range of hematological cancer cell lines via multiple neosubstrates degradation by Li, Pengyun, Hu, Xiaotong, Fan, Zhiya, Sun, Shiyang, Ran, Qijie, Wei, Ting, Wei, Pengli, Jiang, Qiyu, Yan, Jian, Yang, Ning, Jia, Changkai, Yang, Tingting, Mao, Yaqiu, Cai, Xu, Xu, Tingting, Zhao, Zhiyuan, Qian, Xiaohong, Qin, Weijie, Zhuang, Xiaomei, Fan, Feng, Xiao, Junhai, Zheng, Zhibing, Li, Song

“…Targeted protein degradation of neosubstrates plays a crucial role in hematological cancer treatment involving immunomodulatory imide drugs (IMiDs) therapy…”
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Gene Expression Profiling and Biofunction Analysis of HepG2 Cells Targeted by Crocetin by Wen, Yi-Ling, Li, Yong, Zhu, Guangcheng, Zheng, Zhibing, Shi, Meng, Qin, Si

“…Crocetin is a carotenoid extracted from Gardenia jasminoides, one of the most popular traditional Chinese medicines, which has been used in the prevention and…”
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A novel chemical inhibitor suppresses breast cancer cell growth and metastasis through inhibiting HPIP oncoprotein by Li, Pengyun, Cao, Shengjie, Huang, Yubing, Zhang, Yanan, Liu, Jie, Cai, Xu, Zhou, Lulu, Li, Jianbin, Jiang, Zefei, Ding, Lihua, Zheng, Zhibing, Li, Song, Ye, Qinong

“…Increasing evidence suggests the pivotal role of hematopoietic pre-B-cell leukemia transcription factor (PBX)-interacting protein (HPIP/PBXIP1) in cancer…”
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Discovery of novel exceptionally potent and orally active c-MET PROTACs for the treatment of tumors with MET alterations by Li, Pengyun, Jia, Changkai, Fan, Zhiya, Hu, Xiaotong, Zhang, Wenjuan, Liu, Ke, Sun, Shiyang, Guo, Haoxin, Yang, Ning, Zhu, Maoxiang, Zhuang, Xiaomei, Xiao, Junhai, Zheng, Zhibing, Li, Song

“…Various c-mesenchymal-to-epithelial transition (c-MET) inhibitors are effective in the treatment of non-small cell lung cancer; however, the inevitable drug…”
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Novel Peripherally Restricted Cannabinoid 1 Receptor Selective Antagonist TXX-522 with Prominent Weight-Loss Efficacy in Diet Induced Obese Mice by Chen, Wei, Shui, Fengchun, Liu, Cheng, Zhou, Xinbo, Li, Wei, Zheng, Zhibing, Fu, Wei, Wang, Lili

“…The clinical development of the first generation of globally active cannabinoid 1 receptor (CB1R) antagonists was suspended because of their adverse…”
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A Biocompatible Liquid Pillar[n]arene-Based Drug Reservoir for Topical Drug Delivery by Zhang, Yahan, Ma, Mengke, Chen, Longming, Du, Xinbei, Meng, Zhao, Zhang, Han, Zheng, Zhibing, Chen, Junyi, Meng, Qingbin

“…Advanced external preparations that possess a sustained-release effect and integrate few irritant elements are urgently needed to satisfy the special…”
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Instant Dark Tea Alleviates Hyperlipidaemia in High-Fat Diet-Fed Rat: From Molecular Evidence to Redox Balance and Beyond by Qin, Si, He, Zhilan, Wu, Yuanjie, Zeng, Chaoxi, Zheng, Zhibing, Zhang, Haowei, Lv, Chenghao, Yuan, Yong, Wu, Haoren, Ye, Jianhui, Liu, Zhonghua, Shi, Meng

“…Instant dark tea (IDT) is a new product gaining increasing attention because it is convenient and can endow significant health benefit to consumers, which is…”
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Selective Fluorescent Sensing for Iron in Aqueous Solution by A Novel Functionalized Pillar[5]arene by Zhang, Yahan, Chen, Longming, Du, Xinbei, Yu, Xiang, Zhang, Han, Meng, Zhao, Zheng, Zhibing, Chen, Junyi, Meng, Qingbin

“…Abstract Iron ion is one of the most physiologically important elements in metabolic processes, indispensable for all living systems. Since its excess can lead…”
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Design, Synthesis, and Biological Evaluation of Novel PARP-1 Inhibitors Based on a 1H-Thieno[3,4-d] Imidazole-4-Carboxamide Scaffold by Wang, Lingxiao, Liu, Feng, Jiang, Ning, Zhou, Wenxia, Zhou, Xinbo, Zheng, Zhibing

“…A series of poly(ADP-ribose)polymerase (PARP)-1 inhibitors containing a novel scaffold, the 1H-thieno[3,4-d]imidazole-4-carboxamide moiety, was designed and…”
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Extraction, identification, and antioxidant property evaluation of limonin from pummelo seeds by Qin, Si, Lv, Chenghao, Wang, Qingshan, Zheng, Zhibing, Sun, Xi, Tang, Minyi, Deng, Fangming

“…Limonin, the main bioactive phytochemical constituent of limonoids with multi-functions, is enriched in citrus fruits and often found at a high concentration…”
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2,4-Diaryl-4,6,7,8-tetrahydroquinazolin-5(1 H)-one derivatives as anti-HBV agents targeting at capsid assembly by Zhu, Xuejun, Zhao, Guoming, Zhou, Xiaoping, Xu, Xiaoqian, Xia, Guangqiang, Zheng, Zhibing, Wang, Lili, Yang, Xiaohong, Li, Song

“…A series of novel 2,4-diaryl-4,6,7,8-tetrahydroquinazolin-5(1 H)-one derivatives were designed and synthesized as potent inhibitors of HBV capsid assembly…”
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Beclin 1-independent autophagy induced by a Bcl-XL/Bcl-2 targeting compound, Z18 by Tian, Songhai, Lin, Jian, Zhou, Jun, Wang, Xiaolong, Li, Yanjun, Ren, Xiaobai, Yu, Wenyu, Zhong, Wu, Xiao, Junhai, Sheng, Fugeng, Chen, Yingyu, Jin, Changwen, Li, Song, Zheng, Zhibing, Xia, Bin

“…Inhibitors of Bcl-X L /Bcl-2 can induce autophagy by releasing the autophagic protein Beclin 1 from its complexes with these proteins. Here we report a novel…”
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Selective Tissue Distribution Mediates Tissue-Dependent PPARγ Activation and Insulin Sensitization by INT131, a Selective PPARγ Modulator by Xie, Xinni, Chen, Wei, Zhang, Ning, Yuan, Mei, Xu, Cheng, Zheng, Zhibing, Li, Hua, Wang, Lili

“…The mechanisms underlying the enhancement of insulin sensitivity by selective peroxisome proliferator-activated receptor γ modulators (sPPARγMs) are still not…”
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Synthesis and biological evaluation of Chromenylurea and Chromanylurea derivatives as anti-TNF-α agents that target the p38 MAPK pathway by Li, Xingzhou, Zhou, Xinming, Zhang, Jing, Wang, Lili, Long, Long, Zheng, Zhibing, Li, Song, Zhong, Wu

“…A series of 1-aryl-3-(2H-chromen-5-yl)urea and 1-aryl-3-(chroman-5-yl)urea derivatives were designed, synthesized and evaluated for their inhibitory activities…”
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Corrigendum: Novel Peripherally Restricted Cannabinoid 1 Receptor Selective Antagonist TXX-522 with Prominent Weight-Loss Efficacy in Diet Induced Obese Mice by Chen, Wei, Shui, Fengchun, Liu, Cheng, Zhou, Xinbo, Li, Wei, Zheng, Zhibing, Fu, Wei, Wang, Lili

“…[This corrects the article on p. 707 in vol. 8, PMID: 29051736.]…”
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