Search Results - "Zheng, Yingfeng"

Glutathione depletion induces ferroptosis, autophagy, and premature cell senescence in retinal pigment epithelial cells by Sun, Yun, Zheng, Yingfeng, Wang, Chunxiao, Liu, Yizhi

“…Glutathione (GSH) protects against oxidative damage in many tissues, including retinal pigment epithelium (RPE). Oxidative stress-mediated senescence and death…”
Get full text

The worldwide epidemic of diabetic retinopathy by Zheng, Yingfeng, He, Mingguang, Congdon, Nathan

“…Diabetic retinopathy (DR), a major microvascular complication of diabetes, has a significant impact on the world's health systems. Globally, the number of…”
Get full text

Necroptosis in microglia contributes to neuroinflammation and retinal degeneration through TLR4 activation by Huang, Zijing, Zhou, Tian, Sun, Xiaowei, Zheng, Yingfeng, Cheng, Bing, Li, Mei, Liu, Xialin, He, Chang

“…Inflammation has emerged to be a critical mechanism responsible for neural damage and neurodegenerative diseases. Microglia, the resident innate immune cells…”
Get full text

Effects of sex and aging on the immune cell landscape as assessed by single-cell transcriptomic analysis by Huang, Zhaohao, Chen, Binyao, Liu, Xiuxing, Li, He, Xie, Lihui, Gao, Yuehan, Duan, Runping, Li, Zhaohuai, Zhang, Jian, Zheng, Yingfeng, Su, Wenru

“…Sex and aging influence the human immune system, resulting in disparate responses to infection, autoimmunity, and cancer. However, the impact of sex and aging…”
Get full text

Nature restoration shifts the abundance and structure of soil nematode communities in subtropical forests by Wang, Jianqing, Zheng, Yingfeng, Shi, Xiuzhen, Lam, Shu Kee, Lucas-Borja, Manuel Esteban, Huang, Zhiqun

“…Aims Soil nematode community is an important component of the soil food web, which has been widely recognized as a key bio-indicator for assessing the…”
Get full text

Single-Cell RNA Sequencing Maps Endothelial Metabolic Plasticity in Pathological Angiogenesis by Rohlenova, Katerina, Goveia, Jermaine, García-Caballero, Melissa, Subramanian, Abhishek, Kalucka, Joanna, Treps, Lucas, Falkenberg, Kim D., de Rooij, Laura P.M.H., Zheng, Yingfeng, Lin, Lin, Sokol, Liliana, Teuwen, Laure-Anne, Geldhof, Vincent, Taverna, Federico, Pircher, Andreas, Conradi, Lena-Christin, Khan, Shawez, Stegen, Steve, Panovska, Dena, De Smet, Frederik, Staal, Frank J.T., Mclaughlin, Rene J., Vinckier, Stefan, Van Bergen, Tine, Ectors, Nadine, De Haes, Patrik, Wang, Jian, Bolund, Lars, Schoonjans, Luc, Karakach, Tobias K., Yang, Huanming, Carmeliet, Geert, Liu, Yizhi, Thienpont, Bernard, Dewerchin, Mieke, Eelen, Guy, Li, Xuri, Luo, Yonglun, Carmeliet, Peter

“…Endothelial cell (EC) metabolism is an emerging target for anti-angiogenic therapy in tumor angiogenesis and choroidal neovascularization (CNV), but little is…”
Get full text

A human circulating immune cell landscape in aging and COVID-19 by Zheng, Yingfeng, Liu, Xiuxing, Le, Wenqing, Xie, Lihui, Li, He, Wen, Wen, Wang, Si, Ma, Shuai, Huang, Zhaohao, Ye, Jinguo, Shi, Wen, Ye, Yanxia, Liu, Zunpeng, Song, Moshi, Zhang, Weiqi, Han, Jing-Dong J., Izpisua Belmonte, Juan Carlos, Xiao, Chuanle, Qu, Jing, Wang, Hongyang, Liu, Guang-Hui, Su, Wenru

“…Age-associated changes in immune cells have been linked to an increased risk for infection. However, a global and detailed characterization of the changes that…”
Get full text

PMFFRC: a large-scale genomic short reads compression optimizer via memory modeling and redundant clustering by Sun, Hui, Zheng, Yingfeng, Xie, Haonan, Ma, Huidong, Liu, Xiaoguang, Wang, Gang

“…Abstract Background Genomic sequencing reads compressors are essential for balancing high-throughput sequencing short reads generation speed, large-scale…”
Get full text

Retinal Vascular Tortuosity, Blood Pressure, and Cardiovascular Risk Factors by Cheung, Carol Yim-lui, PhD, Zheng, Yingfeng, MD, Hsu, Wynne, PhD, Lee, Mong Li, PhD, Lau, Qiangfeng Peter, BComp, Mitchell, Paul, MD, PhD, Wang, Jie Jin, MMed, PhD, Klein, Ronald, MD, MPH, Wong, Tien Yin, MD, PhD

“…Objective To examine the relationship of retinal vascular tortuosity to age, blood pressure, and other cardiovascular risk factors. Design Population-based,…”
Get full text

Prevalence, Racial Variations, and Risk Factors of Age-Related Macular Degeneration in Singaporean Chinese, Indians, and Malays by Cheung, Chui Ming Gemmy, MBBS, FRCOphth, Li, Xiang, BSc, Cheng, Ching-Yu, MD, PhD, Zheng, Yingfeng, MD, Mitchell, Paul, MD, PhD, Wang, Jie Jin, PhD, Wong, Tien Yin, MD, PhD

“…Objective To describe the prevalence and risk factors for age-related macular degeneration (AMD) in a multiethnic Asian cohort of Chinese, Malay, and Indian…”
Get full text

Prevalence of myopia in urban and rural children in mainland China by He, Mingguang, Zheng, Yingfeng, Xiang, Fan

“…It has been well recognized that myopia more likely affects East Asians, particularly the Japanese and Chinese population. Although some studies have reported…”
Get full text

Prediction of myopia development among Chinese school-aged children using refraction data from electronic medical records: A retrospective, multicentre machine learning study by Lin, Haotian, Long, Erping, Ding, Xiaohu, Diao, Hongxing, Chen, Zicong, Liu, Runzhong, Huang, Jialing, Cai, Jingheng, Xu, Shuangjuan, Zhang, Xiayin, Wang, Dongni, Chen, Kexin, Yu, Tongyong, Wu, Dongxuan, Zhao, Xutu, Liu, Zhenzhen, Wu, Xiaohang, Jiang, Yuzhen, Yang, Xiao, Cui, Dongmei, Liu, Wenyan, Zheng, Yingfeng, Luo, Lixia, Wang, Haibo, Chan, Chi-Chao, Morgan, Ian G, He, Mingguang, Liu, Yizhi

“…Electronic medical records provide large-scale real-world clinical data for use in developing clinical decision systems. However, sophisticated methodology and…”
Get full text

Refractive Error and Visual Impairment in School Children in Rural Southern China by He, Mingguang, MD, MPH, Huang, Wenyong, MD, MPH, Zheng, Yingfeng, MD, Huang, Li, MD, Ellwein, Leon B., PhD

“…Purpose To assess the prevalence of refractive error and visual impairment in school children in a rural area of southern China. Design Prospective…”
Get full text

The noncoding and coding transcriptional landscape of the peripheral immune response in patients with COVID‐19 by Tang, Hao, Gao, Yuehan, Li, Zhaohuai, Miao, Yushan, Huang, Zhaohao, Liu, Xiuxing, Xie, Lihui, Li, He, Wen, Wen, Zheng, Yingfeng, Su, Wenru

“…Background COVID‐19 is currently a global pandemic, but the response of human immune system to severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)…”
Get full text

Multicellular immune dynamics implicate PIM1 as a potential therapeutic target for uveitis by Li, He, Xie, Lihui, Zhu, Lei, Li, Zhaohuai, Wang, Rong, Liu, Xiuxing, Huang, Zhaohao, Chen, Binyao, Gao, Yuehan, Wei, Lai, He, Chang, Ju, Rong, Liu, Yizhi, Liu, Xialin, Zheng, Yingfeng, Su, Wenru

“…Uveitis is a severe autoimmune disease, and a common cause of blindness; however, its individual cellular dynamics and pathogenic mechanism remain poorly…”
Get full text

A Peer-to-Peer Live-Streaming Intervention for Children During COVID-19 Homeschooling to Promote Physical Activity and Reduce Anxiety and Eye Strain: Cluster Randomized Controlled Trial by Zheng, Yingfeng, Wang, Wei, Zhong, Yuxin, Wu, Fengchun, Zhu, Zhuoting, Tham, Yih-Chung, Lamoureux, Ecosse, Xiao, Liang, Zhu, Erta, Liu, Haoning, Jin, Ling, Liang, Linyi, Luo, Lixia, He, Mingguang, Morgan, Ian, Congdon, Nathan, Liu, Yizhi

“…The COVID-19 pandemic has led to worldwide school closures, with millions of children confined to online learning at home. As a result, children may be…”
Get full text

Effects of poor sleep on the immune cell landscape as assessed by single-cell analysis by Liu, Xiuxing, Chen, Binyao, Huang, Zhaohao, Duan, Runping, Li, He, Xie, Lihui, Wang, Rong, Li, Zhaohuai, Gao, Yuehan, Zheng, Yingfeng, Su, Wenru

“…Poor sleep has become an important public health issue. With loss of sleep durations, poor sleep has been linked to the increased risks for diseases. Here we…”
Get full text

Enhancement of the Performance of Large Language Models in Diabetes Education through Retrieval-Augmented Generation: Comparative Study by Wang, Dingqiao, Liang, Jiangbo, Ye, Jinguo, Li, Jingni, Li, Jingpeng, Zhang, Qikai, Hu, Qiuling, Pan, Caineng, Wang, Dongliang, Liu, Zhong, Shi, Wen, Shi, Danli, Li, Fei, Qu, Bo, Zheng, Yingfeng

“…Background Large language models (LLMs) demonstrated advanced performance in processing clinical information. However, commercially available LLMs lack…”
Get full text

Prevalence and Causes of Visual Impairment and Blindness in an Urban Indian Population: The Singapore Indian Eye Study by Zheng, Yingfeng, MD, Lavanya, Raghavan, MD, Wu, Renyi, MD, PhD, Wong, Wan-Ling, BSc, Wang, Jie Jin, MMed, PhD, Mitchell, Paul, MD, PhD, Cheung, Ning, MD, Cajucom-Uy, Howard, MD, Lamoureux, Ecosse, PhD, Aung, Tin, MD, PhD, Saw, Seang-Mei, MBBS, MPH, PhD, Wong, Tien Y., MD, PhD

“…Purpose To describe the prevalence and causes of visual impairment and blindness in an urban Indian population. Design Population-based study. Participants…”
Get full text

Immune Cell Landscape of Patients With Diabetic Macular Edema by Single-Cell RNA Analysis by Ma, Pengjuan, Zhang, Ping, Chen, Shuxia, Shi, Wen, Ye, Jinguo, Chen, Shida, Ju, Rong, Liu, Bingqian, Zheng, Yingfeng, Liu, Yizhi

“…Purpose: We performed single-cell RNA sequencing (scRNA-seq), an unbiased and high-throughput single cell technology, to determine phenotype and function of…”
Get full text