Search Results - "Zheng, Yichao"

Recent Advances of m6A Demethylases Inhibitors and Their Biological Functions in Human Diseases by You, Yazhen, Fu, Yundong, Huang, Mingjie, Shen, Dandan, Zhao, Bing, Liu, Hongmin, Zheng, Yichao, Huang, Lihua

“…N6-methyladenosine (m6A) is a post-transcriptional RNA modification and one of the most abundant types of RNA chemical modifications. m6A functions as a…”
Get full text

USP7: Novel Drug Target in Cancer Therapy by Wang, Zhiru, Kang, Wenting, You, Yinghua, Pang, Jingru, Ren, Hongmei, Suo, Zhenhe, Liu, Hongmin, Zheng, Yichao

“…Ubiquitin specific protease 7 (USP7) is one of the deubiquitinating enzymes (DUB) that erases ubiquitin and protects substrate protein from degradation. Full…”
Get full text

Vulnerability Analysis Method Based on Network and Copula Entropy by Chen, Mengyuan, Liu, Jilan, Zhang, Ning, Zheng, Yichao

“…With the deepening of the diversification and openness of financial systems, financial vulnerability, as an endogenous attribute of financial systems, becomes…”
Get full text

Myofibroblast Deficiency of LSD1 Alleviates TAC-Induced Heart Failure by Huo, Jin-Ling, Jiao, Lemin, An, Qi, Chen, Xiuying, Qi, Yuruo, Wei, Bingfei, Zheng, Yichao, Shi, Xiaojing, Gao, Erhe, Liu, Hong-Min, Chen, Dong, Wang, Cong, Zhao, Wen

“…[Figure: see text]…”
Get full text

Research progress of PD-1/PD-L1 immunotherapy in gastrointestinal tumors by Sun, Jiangang, Zheng, Yichao, Mamun, MAA, Li, Xiaojing, Chen, Xiaoping, Gao, Yongshun

“…Gastrointestinal tumor (GIT) is a common malignant tumor of the digestive system, which seriously threatens people's health and life. With the deepening of the…”
Get full text

High-fat diet promotes tumor growth in the patient-derived orthotopic xenograft (PDOX) mouse model of ER positive endometrial cancer by Shen, Ke, Shen, Dandan, Jin, Dongdong, Zheng, Yichao, Zhu, Yuanhang, Zhao, Xinyue, Zhang, Zhenan, Wang, Nannan, Chen, Huanhuan, Yang, Li

“…Endometrial cancer, one of the common gynecological malignancies, is affected by several influencing factors. This study established a unique patient-derived…”
Get full text

Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing by Wang, Zhiru, Kang, Wenting, Li, Ouwen, Qi, Fengyu, Wang, Junwei, You, Yinghua, He, Pengxing, Suo, Zhenhe, Zheng, Yichao, Liu, Hong-Min

“…Targeting immune checkpoints such as programmed cell death protein 1 (PD-1) and programmed death ligand-1 (PD-L1) have been approved for treating melanoma,…”
Get full text

New insights into the non-enzymatic function of HDAC6 by Zhu, Yuanzai, Feng, Mengkai, Wang, Bo, Zheng, Yichao, Jiang, Dandan, Zhao, Lijuan, Mamun, M.A.A., Kang, Huiqin, Nie, Haiqian, Zhang, Xiya, Guo, Ningjie, Qin, Shangshang, Wang, Ning, Liu, Hongmin, Gao, Ya

“…Histone deacetylase 6 (HDAC6) is a class IIb histone deacetylase that contains two catalytic domains and a zinc-finger ubiquitin binding domain (ZnF-UBP)…”
Get full text

Development of the triazole-fused pyrimidine derivatives as highly potent and reversible inhibitors of histone lysine specific demethylase 1 (LSD1/KDM1A) by Li, Zhonghua, Ding, Lina, Li, Zhongrui, Wang, Zhizheng, Suo, Fengzhi, Shen, Dandan, Zhao, Taoqian, Sun, Xudong, Wang, Junwei, Liu, Ying, Ma, Liying, Zhao, Bing, Geng, Pengfei, Yu, Bin, Zheng, Yichao, Liu, Hongmin

“…Histone lysine specific demethylase 1 (LSD1) has been recognized as an important modulator in post-translational process in epigenetics. Dysregulation of LSD1…”
Get full text

MAIT cells in chronic HBV infection‐related liver fibrosis: Friends or foes? by Han, Fei, Zheng, Yichao, Leeansyah, Edwin

“…[...]MAIT-like cells within the T7 cluster may act as antiviral immune mediators through upregulated IFNγ production as well as Th17 effector responses,…”
Get full text

Potent and specific MTH1 inhibitors targeting gastric cancer by Zhou, Wenjuan, Ma, Liying, Yang, Jing, Qiao, Hui, Li, Lingyu, Guo, Qian, Ma, Jinlian, Zhao, Lijuan, Wang, Junwei, Jiang, Guozhong, Wan, Xiangbin, Adam Goscinski, Mariusz, Ding, Lina, Zheng, Yichao, Li, Wencai, Liu, Hongmin, Suo, Zhenhe, Zhao, Wen

“…Human mutT homolog 1(MTH1), the oxidized dNTP pool sanitizer enzyme, has been reported to be highly expressed in various malignant tumors. However, the…”
Get full text

Exploration of 5-cyano-6-phenylpyrimidin derivatives containing an 1,2,3-triazole moiety as potent FAD-based LSD1 inhibitors by Ma, Liying, Wang, Haojie, You, Yinghua, Ma, Chaoya, Liu, Yuejiao, Yang, Feifei, Zheng, Yichao, Liu, Hongmin

“…Histone lysine specific demethylase 1 (LSD1) has become a potential therapeutic target for the treatment of cancer. Discovery and develop novel and potent LSD1…”
Get full text

Discovery of [1,2,4]triazolo[1,5-a]pyrimidine derivatives as new bromodomain-containing protein 4 (BRD4) inhibitors by Wang, Shuai, Shen, Dandan, Zhao, Lijie, Yuan, Xiaohan, Cheng, Jialing, Yu, Bin, Zheng, Yichao, Liu, Hongmin

“…[Display omitted] New [1,2,4]triazolo[1,5-a]pyrimidine derivatives inhibit BRD4 and show potential for AML treatment. [Display omitted] Targeting…”
Get full text

High-fidelity optical fiber microphone based on graphene oxide and Au nanocoating by Hou, Liangtao, Li, Yan, Sun, Libin, Liu, Chao, Zheng, Yichao, Liu, Yi, Qu, Shiliang

“…A high-fidelity optical fiber microphone (HF-OFM) with hybrid frequency and fast response is theoretically and experimentally demonstrated by the…”
Get full text

Design, synthesis, biological evaluation, and molecular docking of 1,7-dibenzyl-substituted theophylline derivatives as novel BRD4-BD1-selective inhibitors by Chang, Yingjie, Zhang, Jinge, Yang, Shuangshuang, Lu, Wanying, Ding, Lina, Zheng, Yichao, Li, Wen

“…Bromodomain-containing protein 4 (BRD4), an epigenetic reader, is recognized as a potential therapeutic target for several types of cancer and cardiovascular…”
Get full text

Exploring the Role of Innate Lymphocytes in the Immune System of Bats and Virus-Host Interactions by Sia, Wan Rong, Zheng, Yichao, Han, Fei, Chen, Shiwei, Ma, Shaohua, Wang, Lin-Fa, Leeansyah, Edwin

“…Bats are reservoirs of a large number of viruses of global public health significance, including the ancestral virus for severe acute respiratory syndrome…”
Get full text

IL7RA single nucleotide polymorphisms are associated with the size and function of the MAIT cell population in treated HIV-1 infection by Han, Fei, Gulam, Muhammad Yaaseen, Zheng, Yichao, Zulhaimi, Nurul Syuhada, Sia, Wan Rong, He, Dan, Ho, Amanda, Hadadi, Leila, Liu, Zhenyu, Qin, Peiwu, Lobie, Peter E, Kamarulzaman, Adeeba, Wang, Lin-Fa, Sandberg, Johan K, Lewin, Sharon R, Rajasuriar, Reena, Leeansyah, Edwin

“…MAIT cells are persistently depleted and functionally exhausted in HIV-1-infected patients despite long-term combination antiretroviral therapy (cART). IL-7…”
Get full text

A Learning-Based Model to Evaluate Hospitalization Priority in COVID-19 Pandemics by Zheng, Yichao, Zhu, Yinheng, Ji, Mengqi, Wang, Rongpin, Liu, Xinfeng, Zhang, Mudan, Liu, Jun, Zhang, Xiaochun, Qin, Choo Hui, Fang, Lu, Ma, Shaohua

“…The emergence of the novel coronavirus disease 2019 (COVID-19) is placing an increasing burden on healthcare systems. Although the majority of infected…”
Get full text

One‐Pot Reversible Complexation‐Mediated Polymerization (RCMP) from Benzylic Alcohols for Facile Access to Polymer‐Grafted Lignin by Jiang, Bo, Zheng, Yichao, Goto, Atsushi

“…One‐pot synthesis of methacrylic and acrylic polymers from benzylic alcohols (R−OH) used as initiating moieties was developed. R−OH was converted to alkyl…”
Get full text

Novel Torsion Sensor Based on the Interaction Between Modal Interference and Polarization Interference by Zheng, Yichao, Li, Jinjian, Liu, Yi, Li, Yan, Qu, Shiliang

“…A novel torsion sensor based on modal interference and the Lyot filter by utilizing the exciting mode in the single eccentric hole-assisted dual-core fiber…”
Get full text