Search Results - "Zheng, Ya Ying"

DNA Functionality with Photoswitchable Hydrazone Cytidine by Mao, Song, Chang, Zhihua, Ying Zheng, Ya, Shekhtman, Alexander, Sheng, Jia

“…A new family of hydrazone modified cytidine phosphoramidite building block was synthesized and incorporated into oligodeoxynucleotides to construct…”
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Bioorthogonal labeling and profiling of N6-isopentenyladenosine (i6A) modified RNA by Li, Yuanyuan, Zhou, Hongling, Chen, Shasha, Li, Yinan, Guo, Yuyang, Chen, Xiaoqian, Wang, Sheng, Wang, Li, Gan, Youfang, Zhang, Shusheng, Zheng, Ya Ying, Sheng, Jia, Zhou, Zhipeng, Wang, Rui

“…Abstract Chemical modifications in RNAs play crucial roles in diversifying their structures and regulating numerous biochemical processes. Since the 1990s,…”
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Sulfur modification in natural RNA and therapeutic oligonucleotides by Zheng, Ya Ying, Wu, Ying, Begley, Thomas J, Sheng, Jia

“…Sulfur modifications have been discovered on both DNA and RNA. Sulfur substitution of oxygen atoms at nucleobase or backbone locations in the nucleic acid…”
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Fluorescence-Based Binding Characterization of Small Molecule Ligands Targeting CUG RNA Repeats by Chang, Zhihua, Zheng, Ya Ying, Mathivanan, Johnsi, Valsangkar, Vibhav A, Du, Jinxi, Abou-Elkhair, Reham A I, Hassan, Abdalla E A, Sheng, Jia

“…Pathogenic CUG and CCUG RNA repeats have been associated with myotonic dystrophy type 1 and 2 (DM1 and DM2), respectively. Identifying small molecules that can…”
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Structural effects of inosine substitution in telomeric DNA quadruplex by Zheng, Ya Ying, Dartawan, Ricky, Wu, Yuhan, Wu, Chengze, Zhang, Hope, Lu, Jeanne, Hu, Ashley, Vangaveti, Sweta, Sheng, Jia

“…The telomeric DNA, a distal region of eukaryotic chromosome containing guanine-rich repetitive sequence of (TTAGGG)n, has been shown to adopt higher-order…”
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Structural Insights Into the 5′UG/3′GU Wobble Tandem in Complex With Ba2+ Cation by Ruszkowska, Agnieszka, Zheng, Ya Ying, Mao, Song, Ruszkowski, Milosz, Sheng, Jia

“…G•U wobble base pair frequently occurs in RNA structures. The unique chemical, thermodynamic, and structural properties of the G•U pair are widely exploited in…”
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Synthesis of Novel MicroRNA-30c Analogs to Reduce Apolipoprotein B Secretion in Human Hepatoma Cells by Zheng, Ya Ying, Haruehanroengra, Phensinee, Yadav, Pradeep Kumar, Irani, Sarah, Mao, Song, Wang, Ting, Hussain, Mahmood M, Sheng, Jia

“…Atherosclerosis, a condition characterized by thickening of the arteries due to lipid deposition, is the major contributor to and hallmark of cardiovascular…”
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Infrared and Raman spectra, conformational stability and vibrational assignment of 1-chloro-1-silacyclopentane by Durig, James R., Panikar, Savitha S., Glenn, Keith A., Zheng, Ya Ying, Guirgis, Gamil A.

“…Infrared and Raman spectra (3500–60cm−1) of gas and/or liquid and solid 1-chloro-1-silacyclopentane (c-C4H8SiClH) have been recorded and the vibrational data…”
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RNA modifications and cancer by Haruehanroengra, Phensinee, Zheng, Ya Ying, Zhou, Yubin, Huang, Yun, Sheng, Jia

“…RNA plays essential roles in not only translating nucleic acids into proteins, but also in gene regulation, environmental interactions and many human diseases…”
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The origin of translation by Zheng, Ya Ying, Sheng, Jia

“…The origin and evolution of translational machinery — which produces a specific peptide from an RNA sequence — is a major unsolved puzzle in prebiotic…”
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Inosine-Induced Base Pairing Diversity during Reverse Transcription by Zheng, Ya Ying, Reddy, Kaalak, Vangaveti, Sweta, Sheng, Jia

“…A-to-I editing catalyzed by adenosine deaminase acting on RNAs impacts numerous physiological and biochemical processes that are essential for cellular…”
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RNA Phosphorothioate Modification in Prokaryotes and Eukaryotes by Wu, Ying, Tang, Yaning, Dong, Xiaolong, Zheng, Ya Ying, Haruehanroengra, Phensinee, Mao, Song, Lin, Qishan, Sheng, Jia

“…RNA modifications play important roles in RNA structures and regulation of gene expression and translation. We report the first RNA modification on the…”
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Bio-Orthogonal Chemistry Conjugation Strategy Facilitates Investigation of N-methyladenosine and Thiouridine Guide RNA Modifications on CRISPR Activity by Hoy, Alyssa, Zheng, Ya Ying, Sheng, Jia, Royzen, Maksim

“…The CRISPR-Cas9 system is an important genome editing tool that holds enormous potential toward the treatment of human genetic diseases. Clinical success of…”
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Bioorthogonal labeling and profiling of N 6-isopentenyladenosine (i6A) modified RNA by Li, Yuanyuan, Zhou, Hongling, Chen, Shasha, Li, Yinan, Guo, Yuyang, Chen, Xiaoqian, Wang, Sheng, Wang, Li, Gan, Youfang, Zhang, Shusheng, Zheng, Ya Ying, Sheng, Jia, Zhou, Zhipeng, Wang, Rui

“…Abstract Chemical modifications in RNAs play crucial roles in diversifying their structures and regulating numerous biochemical processes. Since the 1990s,…”
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Chemical Biology Approach to Study RNA Modifications by Zheng, Ya Ying

“…Nucleic acid modifications have gained compelling interest for their pivotal roles in cellular and biological processes. These modifications introduced a new…”
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Dietary Agents in Cancer Prevention: An Immunological Perspective by Zheng, Ya Ying, Viswanathan, Bharathi, Kesarwani, Pravin, Mehrotra, Shikhar

“…Skin cancer is the most common form of cancer diagnosed in the United States. Exposure to solar ultraviolet (UV) radiations is believed to be the primary cause…”
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Probing the Substrate Requirements of the In Vitro Geranylation Activity of Selenouridine Synthase (SelU) by Haruehanroengra, Phensinee, Zheng, Ya Ying, Ma, Guolin, Lan, Tien‐Hung, Hassan, Abdalla E. A., Zhou, Yubin, Sheng, Jia

“…Natural RNA modifications diversify the structures and functions of existing nucleic acid building blocks. Geranyl is one of the most hydrophobic groups…”
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Detection and Quantification of RNA Phosphorothioate Modifications Using Mass Spectrometry by Wu, Ying, Zheng, Ya Ying, Lin, Qishan, Sheng, Jia

“…This article describes a protocol for detecting and quantifying RNA phosphorothioate modifications in cellular RNA samples. Starting from solid-phase synthesis…”
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Strontium fructose 1,6-diphosphate prevents bone loss in a rat model of postmenopausal osteoporosis via the OPG/RANKL/RANK pathway by Ma, Bo, Zhang, Qi, Wu, Di, Wang, Yong-lu, Hu, Ying-ying, Cheng, Yan-ping, Yang, Zhen-dong, Zheng, Ya-ya, Ying, Han-Jie

“…Aim： To evaluate the protective effects of strontium fructose 1,6-diphosphate （FDP-Sr）, a novel strontium salt that combined fructose 1,6-diphosphate （FDP）…”
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Structural Insights Into the 5'UG/3'GU Wobble Tandem in Complex With Ba 2+ Cation by Ruszkowska, Agnieszka, Zheng, Ya Ying, Mao, Song, Ruszkowski, Milosz, Sheng, Jia

“…G•U wobble base pair frequently occurs in RNA structures. The unique chemical, thermodynamic, and structural properties of the G•U pair are widely exploited in…”
Get full text