Search Results - "Zheng, Xirong"

Development of a quantitative relationship between CAR-affinity, antigen abundance, tumor cell depletion and CAR-T cell expansion using a multiscale systems PK-PD model by Singh, Aman P, Zheng, Xirong, Lin-Schmidt, Xiefan, Chen, Wenbo, Carpenter, Thomas J, Zong, Alice, Wang, Weirong, Heald, Donald L

“…The development of mechanism-based, multiscale pharmacokinetic-pharmacodynamic (PK-PD) models for chimeric antigen receptor (CAR)-T cells is needed to enable…”
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Bench‐to‐bedside translation of chimeric antigen receptor (CAR) T cells using a multiscale systems pharmacokinetic‐pharmacodynamic model: A case study with anti‐BCMA CAR‐T by Singh, Aman P., Chen, Wenbo, Zheng, Xirong, Mody, Hardik, Carpenter, Thomas J., Zong, Alice, Heald, Donald L.

“…Despite tremendous success of chimeric antigen receptor (CAR) T cell therapy in clinical oncology, the dose‐exposure‐response relationship of CAR‐T cells in…”
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Effects of alcohol on metabolism and toxicity of cocaine in rats by Shang, Linyue, Zheng, Xirong, Zhang, Ting, Deng, Jing, Zhan, Chang-Guo, Zheng, Fang

“…As most cocaine users drink alcohol, it is interesting to understand how a non-lethal dose of alcohol affects the metabolism and toxicity of cocaine. In this…”
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P871: IDECABTAGENE VICLEUCEL (IDE‐CEL) IN PATIENTS WITH AN INADEQUATE RESPONSE TO FRONTLINE AUTOLOGOUS STEM CELL TRANSPLANTATION (ASCT): RESULTS FROM KARMMA‐2 COHORT 2C by Alsina, Melissa, Dhodapkar, Madhav, Berdeja, Jesus, Patel, Krina, Richard, Shambavi, Vij, Ravi, Leleu, Xavier, Egan, Daniel, Leif Bergsagel, P., Ran, Reshef, Usmani, Saad Z, Truppel‐Hartmann, Anna, Basudhar, Debashree, Thompson, Ethan, Zheng, Xirong, Zhong, Xiaobo, Greggio, Chiara, Popa Mckiver, Mihaela, Carrasco Alfonso, Marlene, Siegel, David

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Model‐Based Cellular Kinetic Analysis of Chimeric Antigen Receptor‐T Cells in Humans by Liu, Can, Ayyar, Vivaswath S., Zheng, Xirong, Chen, Wenbo, Zheng, Songmao, Mody, Hardik, Wang, Weirong, Heald, Donald, Singh, Aman P., Cao, Yanguang

“…Chimeric antigen receptor (CAR)‐T cell therapy has achieved considerable success in treating B‐cell hematologic malignancies. However, the challenges of…”
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In vivo characterization of toxicity of norcocaethylene and norcocaine identified as the most toxic cocaine metabolites in male mice by Zheng, Xirong, Shang, Linyue, Zhan, Chang-Guo, Zheng, Fang

“…•Norcocaethylene and norcocaine are the most toxic metabolites of cocaine.•Therapeutic treatment of cocaine toxicity must account for these toxic…”
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A quantitative LC–MS/MS method for simultaneous determination of cocaine and its metabolites in whole blood by Chen, Xiabin, Zheng, Xirong, Ding, Kai, Zhou, Ziyuan, Zhan, Chang-Guo, Zheng, Fang

“…•A LC–MS/MS method to simultaneously detect cocaine and 9 metabolites is developed.•The method is highly sensitive and reliable for all of the 10 compounds…”
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Bioanalytical Methods for Characterization of CAR‐T Cellular Kinetics: Comparison of PCR Assays and Matrices by Masilamani, Madhan, Jawa, Vibha, Dai, Yanshan, Das, Romita, Park, Alice, Lamba, Manisha, Wu, Fan, Zheng, Xirong, Lu, Edwin, Gleason, Carol, Mack, Tim, Mora, Johanna, Surapaneni, Sekhar

“…Recently, multiple chimeric antigen receptor T‐cell (CAR‐T)‐based therapies have been approved for treating hematological malignancies, targeting CD19 and…”
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Development of a Highly Efficient Long-Acting Cocaine Hydrolase Entity to Accelerate Cocaine Metabolism by Zheng, Fang, Jin, Zhenyu, Deng, Jing, Chen, Xiabin, Zheng, Xirong, Wang, Guojun, Kim, Kyungbo, Shang, Linyue, Zhou, Ziyuan, Zhan, Chang-Guo

“…It is particularly challenging to develop a truly effective pharmacotherapy for cocaine use disorder (CUD) treatment. Accelerating cocaine metabolism via…”
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Catalytic activities of cocaine hydrolases against the most toxic cocaine metabolite norcocaethylene by Zheng, Xirong, Chen, Xiabin, Zhang, Ting, Zhan, Max, Zhan, Chang-Guo, Zheng, Fang

“…A majority of cocaine users also consume alcohol. The concurrent use of cocaine and alcohol produces the pharmacologically active metabolites cocaethylene and…”
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Gender differences in cocaine‐induced hyperactivity and dopamine transporter trafficking to the plasma membrane by Deng, Jing, Zheng, Xirong, Shang, Linyue, Zhan, Chang‐Guo, Zheng, Fang

“…As well known, cocaine induces stimulant effects and dopamine transporter (DAT) trafficking to the plasma membrane of dopaminergic neurons. In the present…”
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Development of a long-acting Fc-fused cocaine hydrolase with improved yield of protein expression by Chen, Xiabin, Deng, Jing, Zheng, Xirong, Zhang, Jinling, Zhou, Ziyuan, Wei, Huimei, Zhan, Chang-Guo, Zheng, Fang

“…Human butyrylcholinesterase (BChE) is known as a safe and effective protein for detoxification of organophosphorus (OP) nerve agents. Its rationally designed…”
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Structure-based discovery of mPGES-1 inhibitors suitable for preclinical testing in wild-type mice as a new generation of anti-inflammatory drugs by Ding, Kai, Zhou, Ziyuan, Hou, Shurong, Yuan, Yaxia, Zhou, Shuo, Zheng, Xirong, Chen, Jianzhong, Loftin, Charles, Zheng, Fang, Zhan, Chang-Guo

“…Human mPGES-1 is recognized as a promising target for next generation of anti-inflammatory drugs without the side effects of currently available…”
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Efficacy and Safety of Golcadomide, a Novel Cereblon E3 Ligase Modulator (CELMoD) Agent, Combined with Rituximab in a Phase 1/2 Open-Label Study of Patients with Relapsed/Refractory Non-Hodgkin Lymphoma by Chavez, Julio C., Nastoupil, Loretta J., Morschhauser, Franck, Cartron, Guillaume, Joergensen, Judit Mészáros, Bachy, Emmanuel, Bories, Pierre, Campbell, Victoria, Fontanet, Bijou, Patah, Poliana P., de Moucheron, Bérengère, Carrancio, Soraya, Zheng, Xirong, Mei, Chaoqun, Pourdehnad, Michael, Michot, Jean-Marie

“…Introduction: Golcadomide is a novel, oral, small-molecule CELMoD ® agent that co-opts cereblon to induce targeted degradation of the transcription factors…”
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Metabolic Enzymes of Cocaine Metabolite Benzoylecgonine by Chen, Xiabin, Zheng, Xirong, Zhan, Max, Zhou, Ziyuan, Zhan, Chang-Guo, Zheng, Fang

“…Cocaine is one of the most addictive drugs without a U.S. Food and Drug Administration (FDA)-approved medication. Enzyme therapy using an efficient…”
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Cocaine hydrolase blocks cocaine‐induced dopamine transporter trafficking to the plasma membrane by Deng, Jing, Kim, Kyungbo, Zheng, Xirong, Shang, Linyue, Zhan, Chang‐Guo, Zheng, Fang

“…Cocaine blocks dopamine uptake via dopamine transporter (DAT) on plasma membrane of neuron cells and, as a result, produces the high and induces DAT…”
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KarMMa-2 Cohort 2c: Efficacy and Safety of Idecabtagene Vicleucel in Patients with Clinical High-Risk Multiple Myeloma Due to Inadequate Response to Frontline Autologous Stem Cell Transplantation by Dhodapkar, Madhav, Alsina, Melissa, Berdeja, Jesus, Patel, Krina, Vij, Ravi, Leleu, Xavier, Truppel-Hartmann, Anna, Basudhar, Debashree, Thompson, Ethan, Zheng, Xirong, Ananthakrishnan, Revathi, Favre-Kontula, Linda, Greggio, Chiara, Sternas, Lars, Siegel, David

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KarMMa-2 Cohort 2a: Efficacy and Safety of Idecabtagene Vicleucel in Clinical High-Risk Multiple Myeloma Patients with Early Relapse after Frontline Autologous Stem Cell Transplantation by Usmani, Saad, Patel, Krina, Hari, Parameswaran, Berdeja, Jesus, Alsina, Melissa, Vij, Ravi, Raje, Noopur, Leleu, Xavier, Dhodapkar, Madhav, Reshef, Ran, Truppel-Hartmann, Anna, Basudhar, Debashree, Thompson, Ethan, Zheng, Xirong, Ananthakrishnan, Revathi, Greggio, Chiara, Favre-Kontula, Linda, Sternas, Lars, San-Miguel, Jesús

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Kinetic characterization of human butyrylcholinesterase mutants for the hydrolysis of cocaethylene by Hou, Shurong, Zhan, Max, Zheng, Xirong, Zhan, Chang-Guo, Zheng, Fang

“…It is known that the majority of cocaine users also consume alcohol. Alcohol can react with cocaine to produce a significantly more cytotoxic compound,…”
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Recovery of dopaminergic system after cocaine exposure and impact of a long‐acting cocaine hydrolase by Deng, Jing, Zhang, Ting, Zheng, Xirong, Shang, Linyue, Zhan, Chang‐Guo, Zheng, Fang

“…Dysregulation of dopamine transporters (DAT) within the dopaminergic system is an important biomarker of cocaine exposure. Depending on cocaine amount…”
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