Search Results - "Zheng, X F"

Superoxide dismutase 1 acts as a nuclear transcription factor to regulate oxidative stress resistance by Tsang, Chi Kwan, Liu, Yuan, Thomas, Janice, Zhang, Yanjie, Zheng, X. F. S.

“…Superoxide dismutase 1 (Sod1) has been known for nearly half a century for catalysis of superoxide to hydrogen peroxide. Here we report a new Sod1 function in…”
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SOD1 regulates ribosome biogenesis in KRAS mutant non-small cell lung cancer by Wang, Xiaowen, Zhang, Hong, Sapio, Russell, Yang, Jun, Wong, Justin, Zhang, Xin, Guo, Jessie Y., Pine, Sharon, Van Remmen, Holly, Li, Hong, White, Eileen, Liu, Chen, Kiledjian, Megerditch, Pestov, Dimitri G., Steven Zheng, X. F.

“…SOD1 is known as the major cytoplasmic superoxide dismutase and an anticancer target. However, the role of SOD1 in cancer is not fully understood. Herein we…”
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Toward rapamycin analog (rapalog)-based precision cancer therapy by Meng, Ling-hua, Zheng, XF Steven

“…Rapamycin and its analogs (rapalogs) are the first generation of mTOR inhibitors, which have the same molecular scaffold, but different physiochemical…”
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A review of thermoelectrics research – Recent developments and potentials for sustainable and renewable energy applications by Zheng, X.F., Liu, C.X., Yan, Y.Y., Wang, Q.

“…In recent years, thermoelectric (TE) devices have emerged as promising alternative environmental friendly applications for heat pumps and power generators…”
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Emerging Role of MicroRNAs in mTOR Signaling by Zhang, Yanjie, Huang, Bo, Wang, Hui-Yun, Chang, Augustus, Zheng, X. F. Steven

“…Mechanistic target of rapamycin (mTOR) is a conserved serine/threonine kinase that plays a critical role in the control of cellular growth and metabolism…”
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mTOR regulates aerobic glycolysis through NEAT1 and nuclear paraspeckle-mediated mechanism in hepatocellular carcinoma by Zhang, Hong, Su, Xiaoyang, Burley, Stephen K, Zheng, X F Steven

“…Hepatocellular Carcinoma (HCC) is a major form of liver cancer and a leading cause of cancer-related death worldwide. New insights into HCC pathobiology and…”
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Targeting the mTOR kinase domain: the second generation of mTOR inhibitors by Zhang, Yan-Jie, Duan, Yanwen, Zheng, X.F. Steven

“…The mTOR signaling pathway is dysregulated in ∼50% of all human malignancies and is a major cancer drug target. Although rapamycin analogs (rapalogs) have…”
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MAF1 suppresses AKT‐mTOR signaling and liver cancer through activation of PTEN transcription by Li, Yue, Tsang, Chi Kwan, Wang, Suihai, Li, Xiao‐Xing, Yang, Yang, Fu, Liwu, Huang, Wenlin, Li, Ming, Wang, Hui‐Yun, Zheng, X.F. Steven

“…The phosphatidylinositol 3‐kinase/phosphatidylinositol 3,4,5‐trisphosphate 3‐phosphatase/protein kinase B/mammalian target of rapamycin (PI3K‐PTEN‐AKT‐mTOR)…”
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A potential candidate for the sustainable and reliable domestic energy generation–Thermoelectric cogeneration system by Zheng, X.F., Yan, Y.Y., Simpson, K.

“…Due to being solid-state, noiseless and maintenance free, thermoelectric devices have found wide applications in different areas since they were discovered…”
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Rab1 in cell signaling, cancer and other diseases by Yang, X-Z, Li, X-X, Zhang, Y-J, Rodriguez-Rodriguez, L, Xiang, M-Q, Wang, H-Y, Zheng, X F S

“…The endoplasmic reticulum (ER) and Golgi membrane system have major roles in cell signaling and regulation of the biosynthesis/transport of proteins and lipids…”
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Rab1A Is an mTORC1 Activator and a Colorectal Oncogene by Thomas, Janice D., Zhang, Yan-Jie, Wei, Yue-Hua, Cho, Jun-Hung, Morris, Laura E., Wang, Hui-Yun, Zheng, X.F. Steven

“…Amino acid (AA) is a potent mitogen that controls growth and metabolism. Here we describe the identification of Rab1 as a conserved regulator of AA signaling…”
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SOX9 is targeted for proteasomal degradation by the E3 ligase FBW7 in response to DNA damage by Hong, Xuehui, Liu, Wenyu, Song, Ruipeng, Shah, Jamie J, Feng, Xing, Tsang, Chi Kwan, Morgan, Katherine M, Bunting, Samuel F, Inuzuka, Hiroyuki, Zheng, X F Steven, Shen, Zhiyuan, Sabaawy, Hatem E, Liu, LianXin, Pine, Sharon R

“…SOX9 encodes a transcription factor that governs cell fate specification throughout development and tissue homeostasis. Elevated SOX9 is implicated in the…”
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Significance and mechanism of androgen receptor overexpression and androgen receptor/mechanistic target of rapamycin cross‐talk in hepatocellular carcinoma by Zhang, Hong, Li, Xiao‐Xing, Yang, Yang, Zhang, Yanjie, Wang, Hui‐Yun, Zheng, X.F. Steven

“…Hepatocellular carcinoma (HCC) is a male‐dominant cancer, and androgen receptor (AR) has been linked to the pathogenesis of HCC. However, AR expression and its…”
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Beyond regulation of pol III: Role of MAF1 in growth, metabolism, aging and cancer by Zhang, Shanshan, Li, Xiaoxing, Wang, Hui-Yun, Steven Zheng, X.F.

“…MAF1 was discovered as a master repressor of Pol III-dependent transcription in response to diverse extracellular signals, including growth factor, nutrient…”
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Overexpressed HDAC4 is associated with poor survival and promotes tumor progression in esophageal carcinoma by Zeng, Li-Si, Yang, Xian-Zi, Wen, Yue-Feng, Mail, Shi-Juan, Wang, Meng-He, Zhang, Mei-Yin, Zheng, X F Steven, Wang, Hui-Yun

“…Histone deacetylases (HDACs) mediate histone deacetylation, leading to transcriptional repression, which is involved in many diseases, including age-related…”
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Sorafenib and Carfilzomib Synergistically Inhibit the Proliferation, Survival, and Metastasis of Hepatocellular Carcinoma by Jiang, Chao, Xu, Rui, Li, Xiao-Xing, Zhou, Yu-Feng, Xu, Xiao-Yi, Yang, Yang, Wang, Hui-Yun, Zheng, X F Steven

“…Hepatocellular carcinoma (HCC) is one of the most common and deadly human cancers. The 5-year survival rate is very low. Unfortunately, there are few…”
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Clinical Significance and Prognostic Value of microRNA Expression Signatures in Hepatocellular Carcinoma by RONGRONG WEI, HUANG, Guo-Liang, STEVEN ZHENG, X. F, YUAN, Yun-Fei, WANG, Hui-Yun, ZHANG, Mei-Yin, LI, Bin-Kui, ZHANG, Hui-Zhong, MING SHI, CHEN, Xiao-Qian, LONG HUANG, ZHOU, Qing-Ming, JIA, Wei-Hua

“…MicroRNAs (miRNAs) play important roles in the development and progression of cancer. The aim of this study is to identify miRNA expression signatures in…”
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Mechanisms of regulation of RNA polymerase III-dependent transcription by TORC1 by Wei, Yuehua, Tsang, Chi Kwan, Zheng, X F Steven

“…We have found earlier that Tor1 binds to 5S rDNA chromatin but the functional significance has not been established. Here, we show that association with 5S…”
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Experimental study of a domestic thermoelectric cogeneration system by Zheng, X.F., Liu, C.X., Boukhanouf, R., Yan, Y.Y., Li, W.Z.

“…Thermoelectric application for power generation does not appear to be appealing due to the low conversion efficiency given by the current commercially…”
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Maf1 is an intrinsic suppressor against spontaneous neural repair and functional recovery after ischemic stroke by Tsang, Chi Kwan, Mi, Qiongjie, Su, Guangpu, Hwa Lee, Gum, Xie, Xuemin, D'Arcangelo, Gabriella, Huang, Li'an, Steven Zheng, X.F.

“…[Display omitted] •MAF1 is a novel intrinsic inhibitor of spontaneous recovery after ischemic stroke.•MAF1 is upregulated and activated in neurons of…”
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