Search Results - "Zheng, Ruixiang Blake"

Cryo-EM structure of arabinosyltransferase EmbB from Mycobacterium smegmatis by Tan, Yong Zi, Rodrigues, José, Keener, James E., Zheng, Ruixiang Blake, Brunton, Richard, Kloss, Brian, Giacometti, Sabrina I., Rosário, Ana L., Zhang, Lei, Niederweis, Michael, Clarke, Oliver B., Lowary, Todd L., Marty, Michael T., Archer, Margarida, Potter, Clinton S., Carragher, Bridget, Mancia, Filippo

“…Arabinosyltransferase B (EmbB) belongs to a family of membrane-bound glycosyltransferases that build the lipidated polysaccharides of the mycobacterial cell…”
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The LPG1x family from Leishmania major is constituted of rare eukaryotic galactofuranosyltransferases with unprecedented catalytic properties by Ati, Jihen, Colas, Cyril, Lafite, Pierre, Sweeney, Ryan P., Zheng, Ruixiang Blake, Lowary, Todd L., Daniellou, Richard

“…Galactofuranosyltransferases are poorly described enzymes despite their crucial role in the virulence and the pathogenicity of numerous microorganisms. These…”
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Characterization of the Antigenic Heterogeneity of Lipoarabinomannan, the Major Surface Glycolipid of Mycobacterium tuberculosis , and Complexity of Antibody Specificities toward This Antigen by Choudhary, Alok, Patel, Deendayal, Honnen, William, Lai, Zhong, Prattipati, Raja Sekhar, Zheng, Ruixiang Blake, Hsueh, Ying-Chao, Gennaro, Maria Laura, Lardizabal, Alfred, Restrepo, Blanca I, Garcia-Viveros, Moncerrato, Joe, Maju, Bai, Yu, Shen, Ke, Sahloul, Kamar, Spencer, John S, Chatterjee, Delphi, Broger, Tobias, Lowary, Todd L, Pinter, Abraham

“…Lipoarabinomannan (LAM), the major antigenic glycolipid of , is an important immunodiagnostic target for detecting tuberculosis (TB) infection in…”
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Synthetic polyprenol-pyrophosphate linked oligosaccharides are efficient substrates for mycobacterial galactan biosynthetic enzymes by Xue, Xiaochao, Zheng, Ruixiang Blake, Koizumi, Akihiko, Han, Ling, Klassen, John S, Lowary, Todd L

“…Mycobacteria, including the human pathogen Mycobacterium tuberculosis, produce a complex cell wall that is critical for their survival. The largest structural…”
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Tetrameric Structure of the GlfT2 Galactofuranosyltransferase Reveals a Scaffold for the Assembly of Mycobacterial Arabinogalactan by Wheatley, Robert W., Zheng, Ruixiang Blake, Richards, Michele R., Lowary, Todd L., Ng, Kenneth K.S.

“…Biosynthesis of the mycobacterial cell wall relies on the activities of many enzymes, including several glycosyltransferases (GTs). The polymerizing…”
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Inhibitor selectivity of a new class of oseltamivir analogs against viral neuraminidase over human neuraminidase enzymes by Albohy, Amgad, Mohan, Sankar, Zheng, Ruixiang Blake, Pinto, B. Mario, Cairo, Christopher W.

“…The viral neuraminidase enzyme is an established target for anti-influenza pharmaceuticals. However, viral neuraminidase inhibitors could have off-target…”
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Genetically encoded multivalent liquid glycan array displayed on M13 bacteriophage by Sojitra, Mirat, Sarkar, Susmita, Maghera, Jasmine, Rodrigues, Emily, Carpenter, Eric J., Seth, Shaurya, Ferrer Vinals, Daniel, Bennett, Nicholas J., Reddy, Revathi, Khalil, Amira, Xue, Xiaochao, Bell, Michael R., Zheng, Ruixiang Blake, Zhang, Ping, Nycholat, Corwin, Bailey, Justin J., Ling, Chang-Chun, Lowary, Todd L., Paulson, James C., Macauley, Matthew S., Derda, Ratmir

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ABO(H) Blood Group A and B Glycosyltransferases Recognize Substrate via Specific Conformational Changes by Alfaro, Javier A., Zheng, Ruixiang Blake, Persson, Mattias, Letts, James A., Polakowski, Robert, Bai, Yu, Borisova, Svetlana N., Seto, Nina O.L., Lowary, Todd L., Palcic, Monica M., Evans, Stephen V.

“…The final step in the enzymatic synthesis of the ABO(H) blood group A and B antigens is catalyzed by two closely related glycosyltransferases, an…”
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Kinetic Stability of the Streptavidin–Biotin Interaction Enhanced in the Gas Phase by Deng, Lu, Broom, Aron, Kitova, Elena N, Richards, Michele R, Zheng, Ruixiang Blake, Shoemaker, Glen K, Meiering, Elizabeth M, Klassen, John S

“…Results of the first detailed study of the structure and kinetic stability of the model high-affinity protein–ligand interaction between biotin (B) and the…”
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Development of a coupled spectrophotometric assay for GlfT2, a bifunctional mycobacterial galactofuranosyltransferase by Rose, Natisha L., Zheng, Ruixiang Blake, Pearcey, Jean, Zhou, Ruokun, Completo, Gladys C., Lowary, Todd L.

“…As a key constituent of their protective cell wall all mycobacteria produce a large structural component, the mycolyl-arabinogalactan (mAG) complex, which has…”
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Studies on the substrate specificity of a GDP-mannose pyrophosphorylase from Salmonella enterica by Zou, Lu, Zheng, Ruixiang Blake, Lowary, Todd L

“…A series of methoxy and deoxy derivatives of mannopyranose-1-phosphate (Manp-1P) were chemically synthesized, and their ability to be converted into the…”
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Probing a sialyltransferase's recognition domain to prepare alpha(2,8)-linked oligosialosides and analogs by Zhang, Ping, Zuccolo, Amir J, Li, Wenling, Zheng, Ruixiang Blake, Ling, Chang-Chun

“…We report the first observation that a monosialyl residue is the essential structural element recognized by the enzyme CST-II; this has resulted in an…”
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A Novel Sensitive Immunoassay Targeting the 5-Methylthio-d-Xylofuranose-Lipoarabinomannan Epitope Meets the WHO's Performance Target for Tuberculosis Diagnosis by Sigal, George B, Pinter, Abraham, Lowary, Todd L, Kawasaki, Masanori, Li, Andra, Mathew, Anu, Tsionsky, Michael, Zheng, Ruixiang Blake, Plisova, Tatiana, Shen, Ke, Katsuragi, Kiyonori, Choudhary, Alok, Honnen, William J, Nahid, Payam, Denkinger, Claudia M, Broger, Tobias

“…The only currently commercialized point-of-care assay for tuberculosis (TB) that measures lipoarabinomannan (LAM) in urine (Alere LF-LAM) has insufficient…”
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Structural Basis for the Inactivity of Human Blood Group O2 Glycosyltransferase by Lee, Ho Jun, Barry, Christopher H., Borisova, Svetlana N., Seto, Nina O.L., Zheng, Ruixiang Blake, Blancher, Antoine, Evans, Stephen V., Palcic, Monica M.

“…The human ABO(H) blood group antigens are carbohydrate structures generated by glycosyltransferase enzymes. Glycosyltransferase A (GTA) uses UDP-GalNAc as a…”
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Genetically encoded multivalent liquid glycan array displayed on M13 bacteriophage by Sojitra, Mirat, Sarkar, Susmita, Maghera, Jasmine, Rodrigues, Emily, Carpenter, Eric J., Seth, Shaurya, Ferrer Vinals, Daniel, Bennett, Nicholas J., Reddy, Revathi, Khalil, Amira, Xue, Xiaochao, Bell, Michael R., Zheng, Ruixiang Blake, Zhang, Ping, Nycholat, Corwin, Bailey, Justin J., Ling, Chang-Chun, Lowary, Todd L., Paulson, James C., Macauley, Matthew S., Derda, Ratmir

“…The central dogma of biology does not allow for the study of glycans using DNA sequencing. We report a liquid glycan array (LiGA) platform comprising a library…”
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Cryo-EM Structures and Regulation of Arabinofuranosyltransferase AftD from Mycobacteria by Tan, Yong Zi, Zhang, Lei, Rodrigues, José, Zheng, Ruixiang Blake, Giacometti, Sabrina I., Rosário, Ana L., Kloss, Brian, Dandey, Venkata P., Wei, Hui, Brunton, Richard, Raczkowski, Ashleigh M., Athayde, Diogo, Catalão, Maria João, Pimentel, Madalena, Clarke, Oliver B., Lowary, Todd L., Archer, Margarida, Niederweis, Michael, Potter, Clinton S., Carragher, Bridget, Mancia, Filippo

“…Mycobacterium tuberculosis causes tuberculosis, a disease that kills over 1 million people each year. Its cell envelope is a common antibiotic target and has a…”
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Insights into Interactions of Mycobacteria with the Host Innate Immune System from a Novel Array of Synthetic Mycobacterial Glycans by Zheng, Ruixiang Blake, Jégouzo, Sabine A. F, Joe, Maju, Bai, Yu, Tran, Huu-Anh, Shen, Ke, Saupe, Jörn, Xia, Li, Ahmed, Md. Faiaz, Liu, Yu-Hsuan, Patil, Pratap Subhashrao, Tripathi, Ashish, Hung, Shang-Cheng, Taylor, Maureen E, Lowary, Todd L, Drickamer, Kurt

“…An array of homogeneous glycans representing all the major carbohydrate structures present in the cell wall of the human pathogen Mycobacterium tuberculosis…”
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Neoglycolipids as Glycosphingolipid Surrogates for Protein Binding Studies Using Nanodiscs and Native Mass Spectrometry by Han, Ling, Xue, Xiaochao, Roy, Rashmi, Kitova, Elena N, Zheng, Ruixiang Blake, St-Pierre, Yves, Lowary, Todd L, Klassen, John S

“…Interactions between glycan-binding proteins (GBPs) and glycosphingolipids (GSLs) in the membranes of cells are implicated in a wide variety of normal and…”
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Genetically Encoded, Multivalent Liquid Glycan Array (LiGA) by Sojitra, Mirat, Sarkar, Susmita, Maghera, Jasmine, Rodrigues, Emily, Carpenter, Eric, Seth, Shaurya, Vinals, Daniel Ferrer, Bennett, Nicholas, Reddy, Revathi, Khalil, Amira, Xue, Xiaochao, Bell, Michael, Zheng, Ruixiang Blake, Zhang, Ping, Nycholat, Corwin, Bailey, Justin J., Ling, Chang-Chun, Lowary, Todd L., Paulson, James C., Macauley, Matthew S., Derda, Ratmir

“…The Central Dogma of Biology does not allow for the study of glycans using DNA sequencing. We report a “Liquid Glycan Array” (LiGA) platform comprising a…”
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Insight into substrate recognition and catalysis by the human neuraminidase 3 (NEU3) through molecular modeling and site-directed mutagenesis by Albohy, Amgad, Li, Matthew D, Zheng, Ruixiang Blake, Zou, Chunxia, Cairo, Christopher W

“…The mammalian neuraminidase (NEU) enzymes are found in diverse cellular compartments. Members of the family, such as NEU2 and NEU1, are cytosolic or lysosomal,…”
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