Search Results - "Zheng, Qiantao"

One-step base editing in multiple genes by direct embryo injection for pig trait improvement by Song, Ruigao, Wang, Yu, Zheng, Qiantao, Yao, Jing, Cao, Chunwei, Wang, Yanfang, Zhao, Jianguo

“…The precise and simultaneous acquisition of multiple beneficial alleles in the genome is in great demand for the development of elite pig breeders. Cytidine…”
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One-step generation of triple gene-targeted pigs using CRISPR/Cas9 system by Wang, Xianlong, Cao, Chunwei, Huang, Jiaojiao, Yao, Jing, Hai, Tang, Zheng, Qiantao, Wang, Xiao, Zhang, Hongyong, Qin, Guosong, Cheng, Jinbo, Wang, Yanfang, Yuan, Zengqiang, Zhou, Qi, Wang, Hongmei, Zhao, Jianguo

“…Pig shows multiple superior characteristics in anatomy, physiology, and genome that have made this species to be more suitable models for human diseases,…”
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BIX-01294 increases pig cloning efficiency by improving epigenetic reprogramming of somatic cell nuclei by Huang, Jiaojiao, Zhang, Hongyong, Yao, Jing, Qin, Guosong, Wang, Feng, Wang, Xianlong, Luo, Ailing, Zheng, Qiantao, Cao, Chunwei, Zhao, Jianguo

“…Accumulating evidence suggests that faulty epigenetic reprogramming leads to the abnormal development of cloned embryos and results in the low success rates…”
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LepRb+ cell-specific deletion of Slug mitigates obesity and nonalcoholic fatty liver disease in mice by Kim, Min-Hyun, Li, Yuan, Zheng, Qiantao, Jiang, Lin, Myers, Jr, Martin G, Wu, Wen-Shu, Rui, Liangyou

“…Leptin exerts its biological actions by activating the long-form leptin receptor (LepRb). LepRb signaling impairment and leptin resistance are believed to…”
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Cold adaptation in pigs depends on UCP3 in beige adipocytes by Lin, Jun, Cao, Chunwei, Tao, Cong, Ye, Rongcai, Dong, Meng, Zheng, Qiantao, Wang, Chao, Jiang, Xiaoxiao, Qin, Guosong, Yan, Changguo, Li, Kui, Speakman, John R, Wang, Yanfang, Jin, Wanzhu, Zhao, Jianguo

“…Pigs lack functional uncoupling protein 1 （UCP1） making them susceptible to cold. Nevertheless, several pig breeds are known to be cold resistant. The…”
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Efficient CRISPR/Cas9-mediated biallelic gene disruption and site-specific knockin after rapid selection of highly active sgRNAs in pigs by Wang, Xianlong, Zhou, Jinwei, Cao, Chunwei, Huang, Jiaojiao, Hai, Tang, Wang, Yanfang, Zheng, Qiantao, Zhang, Hongyong, Qin, Guosong, Miao, Xiangnan, Wang, Hongmei, Cao, Suizhong, Zhou, Qi, Zhao, Jianguo

“…Genetic engineering in livestock was greatly enhanced by the emergence of clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated…”
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Cytosine Base Editor (hA3A-BE3-NG)-Mediated Multiple Gene Editing for Pyramid Breeding in Pigs by Wang, Yu, Bi, Dengfeng, Qin, Guosong, Song, Ruigao, Yao, Jing, Cao, Chunwei, Zheng, Qiantao, Hou, Naipeng, Wang, Yanfang, Zhao, Jianguo

“…Pig is an important agricultural economic animal, providing large amount of meat products. With the development of functional genomics and bioinformatics, lots…”
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Creation of miniature pig model of human Waardenburg syndrome type 2A by ENU mutagenesis by Hai, Tang, Guo, Weiwei, Yao, Jing, Cao, Chunwei, Luo, Ailing, Qi, Meng, Wang, Xianlong, Wang, Xiao, Huang, Jiaojiao, Zhang, Ying, Zhang, Hongyong, Wang, Dayu, Shang, Haitao, Hong, Qianlong, Zhang, Rui, Jia, Qitao, Zheng, Qiantao, Qin, Guosong, Li, Yongshun, Zhang, Tao, Jin, Weiwu, Chen, Zheng-Yi, Wang, Hongmei, Zhou, Qi, Meng, Anming, Wei, Hong, Yang, Shiming, Zhao, Jianguo

“…Human Waardenburg syndrome 2A (WS2A) is a dominant hearing loss (HL) syndrome caused by mutations in the microphthalmia-associated transcription factor ( MITF…”
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Rescuing ocular development in an anophthalmic pig by blastocyst complementation by Zhang, Hongyong, Huang, Jiaojiao, Li, Zechen, Qin, Guosong, Zhang, Nan, Hai, Tang, Hong, Qianlong, Zheng, Qiantao, Zhang, Ying, Song, Ruigao, Yao, Jing, Cao, Chunwei, Zhao, Jianguo, Zhou, Qi

“…Porcine‐derived xenogeneic sources for transplantation are a promising alternative strategy for providing organs for treatment of end‐stage organ failure in…”
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Fecal Microbiota Was Reshaped in UCP1 Knock-In Pigs via the Adipose-Liver-Gut Axis and Contributed to Less Fat Deposition by Pan, Jianfei, Chui, Linya, Liu, Tianxia, Zheng, Qiantao, Liu, Xuexue, Liu, Lulu, Zhao, Ying, Zhang, Lilan, Song, Min, Han, Jianlin, Huang, Jiaojiao, Tang, Chaohua, Tao, Cong, Zhao, Jianguo, Wang, Yanfang

“…The relationship between the host gut microbiota and obesity has been well documented in humans and mice; however, few studies reported the association between…”
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Pilot study of large-scale production of mutant pigs by ENU mutagenesis by Hai, Tang, Cao, Chunwei, Shang, Haitao, Guo, Weiwei, Mu, Yanshuang, Yang, Shulin, Zhang, Ying, Zheng, Qiantao, Zhang, Tao, Wang, Xianlong, Liu, Yu, Kong, Qingran, Li, Kui, Wang, Dayu, Qi, Meng, Hong, Qianlong, Zhang, Rui, Wang, Xiupeng, Jia, Qitao, Wang, Xiao, Qin, Guosong, Li, Yongshun, Luo, Ailing, Jin, Weiwu, Yao, Jing, Huang, Jiaojiao, Zhang, Hongyong, Li, Menghua, Xie, Xiangmo, Zheng, Xuejuan, Guo, Kenan, Wang, Qinghua, Zhang, Shibin, Li, Liang, Xie, Fei, Zhang, Yu, Weng, Xiaogang, Yin, Zhi, Hu, Kui, Cong, Yimei, Zheng, Peng, Zou, Hailong, Xin, Leilei, Xia, Jihan, Ruan, Jinxue, Li, Hegang, Zhao, Weiming, Yuan, Jing, Liu, Zizhan, Gu, Weiwang, Li, Ming, Wang, Yong, Wang, Hongmei, Yang, Shiming, Liu, Zhonghua, Wei, Hong, Zhao, Jianguo, Zhou, Qi, Meng, Anming

“…N-ethyl-N-nitrosourea (ENU) mutagenesis is a powerful tool to generate mutants on a large scale efficiently, and to discover genes with novel functions at the…”
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An exonic splicing enhancer mutation in DUOX2 causes aberrant alternative splicing and severe congenital hypothyroidism in Bama pigs by Cao, Chunwei, Zhang, Ying, Jia, Qitao, Wang, Xiao, Zheng, Qiantao, Zhang, Hongyong, Song, Ruigao, Li, Yongshun, Luo, Ailing, Hong, Qianlong, Qin, Guosong, Yao, Jing, Zhang, Nan, Wang, Yanfang, Wang, Hongmei, Zhou, Qi, Zhao, Jianguo

“…Pigs share many similarities with humans in terms of anatomy, physiology and genetics, and have long been recognized as important experimental animals in…”
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2065-LB: Slug Regulates Adipogenesis and Adipose Tissue Growth by Ju, Liping, Kang, Qianqian, Zhou, Ruoyu, Zheng, Qiantao, Rui, Liangyou

“…Adipose stem cell commitment, proliferation, and differentiation critically regulate adipose tissue development and homeostasis. Transcription factor Slug,…”
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216-LB: Hepatocyte N6-Methyladenosine mRNA Modification in Hepatic Gluconeogenesis and Diabetes by ZHENG, QIANTAO, ZHONG, XIAO, REN, DECHENG, RUI, LIANGYOU

“…The liver produces endogenous glucose to support life during fasting. Counterregulatory hormones, including glucagon, catecholamines, and glucocorticoids,…”
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Reconstitution of UCP1 using CRISPR/Cas9 in the white adipose tissue of pigs decreases fat deposition and improves thermogenic capacity by Zheng, Qiantao, Lin, Jun, Huang, Jiaojiao, Zhang, Hongyong, Zhang, Rui, Zhang, Xueying, Cao, Chunwei, Hambly, Catherine, Qin, Guosong, Yao, Jing, Song, Ruigao, Jia, Qitao, Wang, Xiao, Li, Yongshun, Zhang, Nan, Piao, Zhengyu, Ye, Rongcai, Speakman, John R., Wang, Hongmei, Zhou, Qi, Wang, Yanfang, Jin, Wanzhu, Zhao, Jianguo

“…Uncoupling protein 1 (UCP1) is localized on the inner mitochondrial membrane and generates heat by uncoupling ATP synthesis from proton transit across the…”
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cell-specific deletion of Slug mitigates obesity and nonalcoholic fatty liver disease in mice by Kim, Min-Hyun, Li, Yuan, Zheng, Qiantao, Jiang, Lin, Myers, Martin G. Jr, Wu, Wen-Shu, Rui, Liangyou

“…Leptin exerts its biological actions by activating the long-form leptin receptor (LepRb). LepRb signaling impairment and leptin resistance are believed to…”
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Adipose lipidomics and RNA-Seq analysis revealed the enhanced mitochondrial function in UCP1 knock-in pigs by Pan, Jianfei, Tao, Cong, Cao, Chunwei, Zheng, Qiantao, Lam, Sin Man, Shui, Guanghou, Liu, Xuexue, Li, Kui, Zhao, Jianguo, Wang, Yanfang

“…Uncoupling protein 1 (UCP1) plays a key role in nonshivering thermogenesis and is involved in the pathogenesis of obesity. In a previous study, we generated…”
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Thyroid hormone regulates hematopoiesis via the TR-KLF9 axis by Zhang, Ying, Xue, Yuanyuan, Cao, Chunwei, Huang, Jiaojiao, Hong, Qianlong, Hai, Tang, Jia, Qitao, Wang, Xianlong, Qin, Guosong, Yao, Jing, Wang, Xiao, Zheng, Qiantao, Zhang, Rui, Li, Yongshun, Luo, Ailing, Zhang, Nan, Shi, Guizhi, Wang, Yanfang, Ying, Hao, Liu, Zhonghua, Wang, Hongmei, Meng, Anming, Zhou, Qi, Wei, Hong, Liu, Feng, Zhao, Jianguo

“…Congenital hypothyroidism (CH) is one of the most prevalent endocrine diseases, for which the underlying mechanisms remain unknown; it is often accompanied by…”
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Mitochondrial uncoupling protein 1 antagonizes atherosclerosis by blocking NLRP3 inflammasome-dependent interleukin-1β production by Gu, Ping, Hui, Xiaoyan, Zheng, Qiantao, Gao, Yuan, Jin, Leigang, Jiang, Weimin, Zhou, Changsheng, Liu, Tianxia, Huang, Yu, Liu, Qing, Nie, Tao, Wang, Yanfang, Wang, Yu, Zhao, Jianguo, Xu, Aimin

“…Mitochondrial uncoupling protein 1 (UCP1) is the hallmark of brown adipocytes responsible for cold- and diet-induced thermogenesis. Here, we report a…”
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A pig model carrying heterozygous point mutation of NCSTN simulates familial acne inversa and reveals dysregulated cholesterol biosynthesis via the Notch-pAMPK-HMGCR pathway by Song, Ruigao, Liu, Keqiang, Wang, Yu, Qin, Guosong, Xiao, Meng, Liu, Yaping, Yang, Jun, Zong, Ruojun, Yan, Xinghui, Zheng, Qiantao, Zhang, Hongyong, Hou, Naipeng, Yao, Jing, Wang, Xiao, Wang, Yanfang, Zhao, Jianguo, Zhang, Xue

“…Model of the Role of the NCSTN mutation in impaired skin barrier in acne inversa. Notch and AMPK signaling are required for cholesterol biosynthesis in the…”
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