Search Results - "Zheng, James Q"

Growth Cone Travel in Space and Time: the Cellular Ensemble of Cytoskeleton, Adhesion, and Membrane by Vitriol, Eric A., Zheng, James Q.

“…Growth cones, found at the tip of axonal projections, are the sensory and motile organelles of developing neurons that enable axon pathfinding and target…”
Get full text

Actin-based growth cone motility and guidance by Omotade, Omotola F., Pollitt, Stephanie L., Zheng, James Q.

“…Nerve growth cones, the dilated tip of developing axons, are equipped with exquisite abilities to sense environmental cues and to move rapidly through complex…”
Get full text

Calcium signaling in neuronal motility by Zheng, James Q, Poo, Mu-Ming

“…Neuronal motility is a fundamental feature that underlies the development, regeneration, and plasticity of the nervous system. Two major developmental…”
Get full text

ADF/cofilin-mediated actin dynamics regulate AMPA receptor trafficking during synaptic plasticity by Zheng, James Q, Gu, Jiaping, Lee, Chi Wai, Fan, Yanjie, Komlos, Daniel, Tang, Xin, Sun, Chicheng, Yu, Kuai, Hartzell, H Criss, Chen, Gong, Bamburg, James R

“…Segregating glutamate receptor trafficking function from the changes in synaptic spine morphology, this study finds that actin depolymerizing factor (ADF)- and…”
Get full text

Dynamic Localization of G-Actin during Membrane Protrusion in Neuronal Motility by Lee, Chi Wai, Vitriol, Eric A., Shim, Sangwoo, Wise, Ariel L., Velayutham, Radhi P., Zheng, James Q.

“…Actin-based cell motility is fundamental for development, function, and malignant events in eukaryotic organisms. During neural development, axonal growth…”
Get full text

Microtubules in Dendritic Spine Development by Gu, Jiaping, Firestein, Bonnie L, Zheng, James Q

“…It is generally believed that only the actin cytoskeleton resides in dendritic spines and controls spine morphology and plasticity. Here, we report that…”
Get full text

Repetitive mild head trauma induces activity mediated lifelong brain deficits in a novel Drosophila model by Behnke, Joseph A., Ye, Changtian, Setty, Aayush, Moberg, Kenneth H., Zheng, James Q.

“…Mild head trauma, including concussion, can lead to chronic brain dysfunction and degeneration but the underlying mechanisms remain poorly understood. Here, we…”
Get full text

The molecular basis for calcium-dependent axon pathfinding by Gomez, Timothy M, Zheng, James Q

“…Ca(2+) signals have profound and varied effects on growth cone motility and guidance. Modulation of Ca(2+) influx and release from stores by guidance cues…”
Get full text

Effective testing of personal protective equipment in blast loading conditions in shock tube: Comparison of three different testing locations by Skotak, Maciej, Alay, Eren, Zheng, James Q, Halls, Virginia, Chandra, Namas

“…We exposed a headform instrumented with 10 pressure sensors mounted flush with the surface to a shock wave with three nominal intensities: 70, 140 and 210 kPa…”
Get full text

Two functionally distinct sources of actin monomers supply the leading edge of lamellipodia by Vitriol, Eric A, McMillen, Laura M, Kapustina, Maryna, Gomez, Shawn M, Vavylonis, Dimitrios, Zheng, James Q

“…Lamellipodia, the sheet-like protrusions of motile cells, consist of networks of actin filaments (F-actin) regulated by the ordered assembly from and…”
Get full text

Drosophila melanogaster as a model to study age and sex differences in brain injury and neurodegeneration after mild head trauma by Ye, Changtian, Behnke, Joseph A, Hardin, Katherine R, Zheng, James Q

“…Repetitive physical insults to the head, including those that elicit mild traumatic brain injury (mTBI), are a known risk factor for a variety of…”
Get full text

animal-to-human scaling law for blast-induced traumatic brain injury risk assessment by Jean, Aurélie, Nyein, Michelle K., Zheng, James Q., Moore, David F., Joannopoulos, John D., Radovitzky, Raúl

“…Significance A physics-based animal-to-human scaling law for the effects of a blast wave on brain tissue is proposed. This scaling law, or transfer function,…”
Get full text

Tropomodulin Isoform-Specific Regulation of Dendrite Development and Synapse Formation by Omotade, Omotola F, Rui, Yanfang, Lei, Wenliang, Yu, Kuai, Hartzell, H Criss, Fowler, Velia M, Zheng, James Q

“…Neurons of the CNS elaborate highly branched dendritic arbors that host numerous dendritic spines, which serve as the postsynaptic platform for most excitatory…”
Get full text

Phosphoinositide-dependent enrichment of actin monomers in dendritic spines regulates synapse development and plasticity by Lei, Wenliang, Myers, Kenneth R, Rui, Yanfang, Hladyshau, Siarhei, Tsygankov, Denis, Zheng, James Q

“…Dendritic spines are small postsynaptic compartments of excitatory synapses in the vertebrate brain that are modified during learning, aging, and neurological…”
Get full text

Effects of gage length, loading rates, and damage on the strength of PPTA fibers by Lim, Jaeyoung, Zheng, James Q., Masters, Karl, Chen, Weinong W.

“…Axial tension and transverse compression experiments on single fibers were performed to investigate the mechanical behavior of three high-performance fibers…”
Get full text

BMP gradients steer nerve growth cones by a balancing act of LIM kinase and Slingshot phosphatase on ADF/cofilin by Wen, Zhexing, Han, Liang, Bamburg, James R, Shim, Sangwoo, Ming, Guo-li, Zheng, James Q

“…Bone morphogenic proteins (BMPs) are involved in axon pathfinding, but how they guide growth cones remains elusive. In this study, we report that a BMP7…”
Get full text

p39 Is Responsible for Increasing Cdk5 Activity during Postnatal Neuron Differentiation and Governs Neuronal Network Formation and Epileptic Responses by Li, Wenqi, Allen, Megan E, Rui, Yanfang, Ku, Li, Liu, Guanglu, Bankston, Andrew N, Zheng, James Q, Feng, Yue

“…Two distinct protein cofactors, p35 and p39, independently activate Cyclin-dependent kinase 5 (Cdk5), which plays diverse roles in normal brain function and…”
Get full text

Actin capping protein regulates postsynaptic spine development through CPI-motif interactions by Myers, Kenneth R., Fan, Yanjie, McConnell, Patrick, Cooper, John A., Zheng, James Q.

“…Dendritic spines are small actin-rich protrusions essential for the formation of functional circuits in the mammalian brain. During development, spines begin…”
Get full text

Super-Resolution Microscopy Reveals a Nanoscale Organization of Acetylcholine Receptors for Trans-Synaptic Alignment at Neuromuscular Synapses by York, Amanda L, Zheng, James Q

“…The neuromuscular junction (NMJ) is a chemical synapse formed between motoneurons and skeletal muscle fibers. The vertebrate NMJ uses acetylcholine (ACh) as…”
Get full text

Instantaneous inactivation of cofilin reveals its function of F-actin disassembly in lamellipodia by Vitriol, Eric A, Wise, Ariel L, Berginski, Mathew E, Bamburg, James R, Zheng, James Q

“…Cofilin is a key regulator of the actin cytoskeleton. It can sever actin filaments, accelerate filament disassembly, act as a nucleation factor, recruit or…”
Get full text