Search Results - "Zheng, Hongjin"

Substrate binding plasticity revealed by Cryo-EM structures of SLC26A2 by Hu, Wenxin, Song, Alex, Zheng, Hongjin

“…SLC26A2 is a vital solute carrier responsible for transporting essential nutritional ions, including sulfate, within the human body. Pathogenic mutations…”
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Crystal structure of a nitrate/nitrite exchanger by Zheng, Hongjin, Wisedchaisri, Goragot, Gonen, Tamir

“…Cellular nitrite is rapidly removed from the cell to prevent formation of the cytotoxic nitric oxide; here the X-ray crystal structure of NarK, a bacterial…”
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Cryo-EM reveals unique structural features of the FhuCDB Escherichia coli ferrichrome importer by Hu, Wenxin, Zheng, Hongjin

“…As one of the most elegant biological processes developed in bacteria, the siderophore-mediated iron uptake demands the action of specific ATP-binding cassette…”
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Structural and functional diversity calls for a new classification of ABC transporters by Thomas, Christoph, Aller, Stephen G., Beis, Konstantinos, Carpenter, Elisabeth P., Chang, Geoffrey, Chen, Lei, Dassa, Elie, Dean, Michael, Duong Van Hoa, Franck, Ekiert, Damian, Ford, Robert, Gaudet, Rachelle, Gong, Xin, Holland, I. Barry, Huang, Yihua, Kahne, Daniel K., Kato, Hiroaki, Koronakis, Vassilis, Koth, Christopher M., Lee, Youngsook, Lewinson, Oded, Lill, Roland, Martinoia, Enrico, Murakami, Satoshi, Pinkett, Heather W., Poolman, Bert, Rosenbaum, Daniel, Sarkadi, Balazs, Schmitt, Lutz, Schneider, Erwin, Shi, Yigong, Shyng, Show‐Ling, Slotboom, Dirk J., Tajkhorshid, Emad, Tieleman, D. Peter, Ueda, Kazumitsu, Váradi, András, Wen, Po‐Chao, Yan, Nieng, Zhang, Peng, Zheng, Hongjin, Zimmer, Jochen, Tampé, Robert

“…Members of the ATP‐binding cassette (ABC) transporter superfamily translocate a broad spectrum of chemically diverse substrates. While their eponymous…”
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Author Correction: Cryo-EM reveals unique structural features of the FhuCDB Escherichia coli ferrichrome importer by Hu, Wenxin, Zheng, Hongjin

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Mechanism and inhibition of Streptococcus pneumoniae IgA1 protease by Wang, Zhiming, Rahkola, Jeremy, Redzic, Jasmina S., Chi, Ying-Chih, Tran, Norman, Holyoak, Todd, Zheng, Hongjin, Janoff, Edward, Eisenmesser, Elan

“…Opportunistic pathogens such as Streptococcus pneumoniae secrete a giant metalloprotease virulence factor responsible for cleaving host IgA1, yet the molecular…”
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Proton-coupled sugar transport in the prototypical major facilitator superfamily protein XylE by Wisedchaisri, Goragot, Park, Min-Sun, Iadanza, Matthew G., Zheng, Hongjin, Gonen, Tamir

“…The major facilitator superfamily (MFS) is the largest collection of structurally related membrane proteins that transport a wide array of substrates. The…”
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Mechanistic Insights Revealed by YbtPQ in the Occluded State by Hu, Wenxin, Parkinson, Chance, Zheng, Hongjin

“…Recently, several ATP-binding cassette (ABC) importers have been found to adopt the typical fold of type IV ABC exporters. Presumably, these importers would…”
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Mechanosensitive channel YnaI has lipid-bound extended sensor paddles by Hu, Wenxin, Wang, Zhiming, Zheng, Hongjin

“…The general mechanism of bacterial mechanosensitive channels (MS) has been characterized by extensive studies on a small conductance channel MscS from…”
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A Type VI Secretion-Related Pathway in Bacteroidetes Mediates Interbacterial Antagonism by Russell, Alistair B., Wexler, Aaron G., Harding, Brittany N., Whitney, John C., Bohn, Alan J., Goo, Young Ah, Tran, Bao Q., Barry, Natasha A., Zheng, Hongjin, Peterson, S. Brook, Chou, Seemay, Gonen, Tamir, Goodlett, David R., Goodman, Andrew L., Mougous, Joseph D.

“…Bacteroidetes are a phylum of Gram-negative bacteria abundant in mammalian-associated polymicrobial communities, where they impact digestion, immunity, and…”
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Pathogenic siderophore ABC importer YbtPQ adopts a surprising fold of exporter by Wang, Zhiming, Hu, Wenxin, Zheng, Hongjin

“…To fight for essential metal ions, human pathogens secrete virulence-associated siderophores and retake the metal-chelated siderophores through a subfamily of…”
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Geometry-Aware Cell Detection with Deep Learning by Jiang, Hao, Li, Sen, Liu, Weihuang, Zheng, Hongjin, Liu, Jinghao, Zhang, Yang

“…Analyzing cells and tissues under a microscope is a cornerstone of biological research and clinical practice. However, the challenge faced by conventional…”
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An engineered Cas12i nuclease that is an efficient genome editing tool in animals and plants by Duan, Zhiqiang, Liang, Yafeng, Sun, Jialei, Zheng, Hongjin, Lin, Tong, Luo, Pengyu, Wang, Mengge, Liu, Ruiheng, Chen, Ying, Guo, Shuhua, Jia, Nannan, Xie, Hongtao, Zhou, Meili, Xia, Minghui, Zhao, Kaijun, Wang, Shuhui, Liu, Na, Jia, Yongling, Si, Wei, Chen, Qitong, Hong, Yechun, Tian, Ruilin, Zhu, Jian-Kang

“…The type V-I CRISPR-Cas system is becoming increasingly more attractive for genome editing. However, natural nucleases of this system often exhibit low…”
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A substrate-induced gating mechanism is conserved among Gram-positive IgA1 metalloproteases by Redzic, Jasmina S., Rahkola, Jeremy, Tran, Norman, Holyoak, Todd, Lee, Eunjeong, Martín-Galiano, Antonio Javier, Meyer, Nancy, Zheng, Hongjin, Eisenmesser, Elan

“…The mucosal adaptive immune response is dependent on the production of IgA antibodies and particularly IgA1, yet opportunistic bacteria have evolved mechanisms…”
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Voltage sensor ring in a native structure of a membrane-embedded potassium channel by Shi, Liang, Zheng, Hongjin, Zheng, Hui, Borkowski, Brian A., Shi, Dan, Gonen, Tamir, Jiang, Qiu-Xing

“…Voltage-gated ion channels support electrochemical activity in cells and are largely responsible for information flow throughout the nervous systems. The…”
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Interactions of the transmembrane polymeric rings of the Salmonella enterica serovar Typhimurium type III secretion system by Sanowar, Sarah, Singh, Pragya, Pfuetzner, Richard A, André, Ingemar, Zheng, Hongjin, Spreter, Thomas, Strynadka, Natalie C J, Gonen, Tamir, Baker, David, Goodlett, David R, Miller, Samuel I

“…The type III secretion system (T3SS) is an interspecies protein transport machine that plays a major role in interactions of Gram-negative bacteria with…”
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Mitochondrial accumulation of amyloid β (Aβ) peptides requires TOMM22 as a main Aβ receptor in yeast by Hu, Wenxin, Wang, Zhiming, Zheng, Hongjin

“…Mitochondrial accumulation of intracellular β-amyloid (Aβ) peptides is present in the brains of individuals with Alzheimer's disease (AD) as well as in related…”
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Determination and occurrence of sulfonamide transformation products in surface waters by Cui, Hongyang, Chang, Hong, Zheng, Hongjin, Wan, Yi

“…The transformation products of sulfonamides (SAs) have raised increasing environmental and health concerns in recent years, but information on their analysis…”
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Anion Pathways in the NarK Nitrate/Nitrite Exchanger by Chon, Nara Lee, Schultz, Natalie Jean, Zheng, Hongjin, Lin, Hai

“…NarK nitrate/nitrite antiporter imports nitrate (a mineral form of the essential element nitrogen) into the cell and exports nitrite (a metabolite that can be…”
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Pathogenic Siderophore ABC Importer YbtPQ Adopts a Surprising Fold of Exporter by Wang, Zhiming, Hu, Wenxin, Zheng, Hongjin

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