Search Results - "Zheng, Haihui"
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Modulation of Gut Microbiome Composition and Function in Experimental Colitis Treated with Sulfasalazine
Published in Frontiers in microbiology (07-09-2017)“…Inflammatory bowel disease (IBD) results from alterations in intestinal flora and the immune system. Sulfasalazine (SASP) is a sulfa antimicrobial used to…”
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Compound polysaccharides ameliorate experimental colitis by modulating gut microbiota composition and function
Published in Journal of gastroenterology and hepatology (01-09-2019)“…Background and Aim Inflammatory bowel disease results from a dysregulated immune response to intestinal microbial flora in individuals with genetic…”
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Metabolomics insights into the modulatory effects of long-term compound polysaccharide intake in high-fat diet-induced obese rats
Published in Nutrition & metabolism (23-01-2018)“…Polysaccharides can alleviate obesity in mammals; however, studies on mechanism of this alleviation are limited. A few studies have indicated that…”
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Beneficial changes of gut microbiota and metabolism in weaned rats with Lactobacillus acidophilus NCFM and Bifidobacterium lactis Bi-07 supplementation
Published in Journal of functional foods (01-09-2018)“…[Display omitted] •Supplementation of L-NCFM and B-LBi07 regulate host metabolism and gut microbiota metabolism.•Supplementation of L-NCFM and B-LBi07 increase…”
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5
An investigation of long-term outcome of rabbit anti-thymocyte globulin and cyclosporine therapy for pediatric severe aplastic anemia
Published in Blood science (01-07-2023)“…Children with severe aplastic anemia (SAA) face heterogeneous prognoses after immunosuppressive therapy (IST). There are few models that can predict the…”
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SGLT-1 Transport and Deglycosylation inside Intestinal Cells Are Key Steps in the Absorption and Disposition of Calycosin-7-O-β-d-Glucoside in Rats
Published in Drug metabolism and disposition (01-03-2016)“…Hydrolysis by lactase-phloridzin hydrolase (LPH) is the first and critical step in the absorption of isoflavonoid glucosides. However, the absorption…”
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Metabonomic strategy for the detection of metabolic effects of probiotics combined with prebiotic supplementation in weaned rats
Published in RSC advances (01-01-2018)“…The purpose of this study is to investigate the effects of probiotics combined with prebiotics (PP) supplementation on weaned rat metabolism. A metabonomic…”
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Study on alterations of physiological functions in aged constipation rats with fluid-deficiency based on metabonomic and microbiology analysis
Published in RSC advances (2017)“…Constipation, a common and complex clinical symptom, is a predisposing factor for many serious diseases, such as gastrointestinal diseases, cardiovascular…”
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Breast Cancer Resistance Protein and Multidrug Resistance Protein 2 Regulate the Disposition of Acacetin Glucuronides
Published in Pharmaceutical research (01-07-2017)“…Purpose To determine the mechanism responsible for acacetin glucuronide transport and the bioavailability of acacetin. Methods Area under the curve (AUC),…”
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Sulfotransferases and Breast Cancer Resistance Protein Determine the Disposition of Calycosin in Vitro and in Vivo
Published in Molecular pharmaceutics (05-09-2017)“…Sulfation is a key process of drug disposition that generally regulates drug effectiveness and toxicity. Calycosin derived from the dry root extract of Radix…”
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High-Throughput and Reliable Isotope Label-free Approach for Profiling 24 Metabolic Enzymes in FVB Mice and Sex Differences
Published in Drug metabolism and disposition (01-06-2017)“…FVB mice are extensively used in transgenic and pharmacokinetic research. In this study, a validated isotope label-free method was constructed using…”
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Profiles and Gender-Specifics of UDP-Glucuronosyltransferases and Sulfotransferases Expressions in the Major Metabolic Organs of Wild-Type and Efflux Transporter Knockout FVB Mice
Published in Molecular pharmaceutics (05-09-2017)“…Hepatic and extrahepatic tissues participate in xenobiotic detoxication, carcinogen activation, prodrug processing, and estrogen regulation through…”
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Age‐related changes in hepatic expression and activity of drug metabolizing enzymes in male wild‐type and breast cancer resistance protein knockout mice
Published in Biopharmaceutics & drug disposition (01-07-2018)“…This study aimed to reveal age‐related changes in the expression and activity of seven hepatic drug metabolizing enzymes (DMEs) in male wild‐type and breast…”
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Simultaneous qualitative and quantitative determination of compounds in Aloe arborescens Mill using liquid chromatography with ion trap time‐of‐flight mass spectrometry and diode array detectors
Published in Separation science plus (01-10-2018)“…An effective and comprehensive method was developed for the simultaneous analysis of compounds in the powder of Aloe arborescens Mill by liquid chromatography…”
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Disposition of Flavonoids for Personal Intake
Published in Current pharmacology reports (01-08-2017)“…Flavonoids represent a group of polyphenolic phytochemicals. Diverse biological activities of flavonoids are becoming increasingly popular in scientific and…”
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Metabonomic strategy for the detection of metabolic effects of probiotics combined with prebiotic supplementation in weaned ratsElectronic supplementary information (ESI) available. See DOI: 10.1039/c7ra12067b
Published 30-01-2018“…The purpose of this study is to investigate the effects of probiotics combined with prebiotics (PP) supplementation on weaned rat metabolism. A metabonomic…”
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In Vitro Study of UGT Metabolism and Permeability of Orientin and Isoorientin, Two Active flavonoid C-glycosides
Published in Drug metabolism letters (2016)“…C-glycosides are important flavonoids with significant pharmacological activities implicated in anticancer and antioxidative effects. However, their…”
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Study on alterations of physiological functions in aged constipation rats with fluid-deficiency based on metabonomic and microbiology analysisElectronic supplementary information (ESI) available. See DOI: 10.1039/c7ra07651g
Published 12-10-2017“…Constipation, a common and complex clinical symptom, is a predisposing factor for many serious diseases, such as gastrointestinal diseases, cardiovascular…”
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