Search Results - "Zheng, Guanqun"

Efficient and quantitative high-throughput tRNA sequencing by Zheng, Guanqun, Qin, Yidan, Clark, Wesley C, Dai, Qing, Yi, Chengqi, He, Chuan, Lambowitz, Alan M, Pan, Tao

“…The combination of an engineered demthylase and a highly processive reverse transcriptase during tRNA library preparation for high-throughput sequencing allows…”
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Nucleic Acid Oxidation in DNA Damage Repair and Epigenetics by Zheng, Guanqun, Fu, Ye, He, Chuan

“…Zheng et al investigate nucleic acid oxidation in DNA damage repair and epigenetics. Methylation occurs in the acids and proteins and contributes to cytotoxic…”
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N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO by Jia, Guifang, Fu, Ye, Zhao, Xu, Dai, Qing, Zheng, Guanqun, Yang, Ying, Yi, Chengqi, Lindahl, Tomas, Pan, Tao, Yang, Yun-Gui, He, Chuan

“…N 6-Methyladenosine is an abundant nucleoside in cellular mRNA that undergoes demethylation under physiological conditions by fat mass and obesity-associated…”
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Determination of tRNA aminoacylation levels by high-throughput sequencing by Evans, Molly E, Clark, Wesley C, Zheng, Guanqun, Pan, Tao

“…Transfer RNA (tRNA) decodes mRNA codons when aminoacylated (charged) with an amino acid at its 3' end. Charged tRNAs turn over rapidly in cells, and variations…”
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tRNA base methylation identification and quantification via high-throughput sequencing by Clark, Wesley C, Evans, Molly E, Dominissini, Dan, Zheng, Guanqun, Pan, Tao

“…Eukaryotic transfer RNAs contain on average 14 modifications. Investigations of their biological functions require the determination of the modification sites…”
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Kinetic gating mechanism of DNA damage recognition by Rad4/XPC by Chen, Xuejing, Velmurugu, Yogambigai, Zheng, Guanqun, Park, Beomseok, Shim, Yoonjung, Kim, Youngchang, Liu, Lili, Van Houten, Bennett, He, Chuan, Ansari, Anjum, Min, Jung-Hyun

“…The xeroderma pigmentosum C (XPC) complex initiates nucleotide excision repair by recognizing DNA lesions before recruiting downstream factors. How XPC detects…”
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Influence of Gut Microbiota and Trimethylamine N-Oxide in Patients with Coronary Heart Disease by Liu, Yanqi, Zheng, Guanqun, Jin, Xiaoqi, Fan, Tao, Chen, Zhixian, Sheng, Xiaodong

“…In the current study, the gut microbiota of patients with and without coronary heart disease was compared and the relationship between gut microbiota…”
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Dynamics of spontaneous flipping of a mismatched base in DNA duplex by Yin, Yandong, Yang, Lijiang, Zheng, Guanqun, Gu, Chan, Yi, Chengqi, He, Chuan, Gao, Yi Qin, Zhao, Xin Sheng

“…DNA base flipping is a fundamental theme in DNA biophysics. The dynamics for a B-DNA base to spontaneously flip out of the double helix has significant…”
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Iron-catalysed oxidation intermediates captured in a DNA repair dioxygenase by Dai, Qing, Jian, Xing, Hou, Guanhua, He, Chuan, Yi, Chengqi, Cui, Qiang, Jia, Guifang, Zheng, Guanqun, Yang, Cai-Guang, Zhang, Wen

“…Mononuclear iron-containing oxygenases conduct a diverse variety of oxidation functions in biology, including the oxidative demethylation of methylated nucleic…”
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Selective Enzymatic Demethylation of N2,N2‐Dimethylguanosine in RNA and Its Application in High‐Throughput tRNA Sequencing by Dai, Qing, Zheng, Guanqun, Schwartz, Michael H., Clark, Wesley C., Pan, Tao

“…The abundant Watson–Crick face methylations in biological RNAs such as N1‐methyladenosine (m1A), N1‐methylguanosine (m1G), N3‐methylcytosine (m3C), and…”
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Extraction Method of Coronary Artery Blood Vessel Centerline in CT Coronary Angiography by Sheng, Xiaodong, Fan, Tao, Jin, Xiaoqi, Jin, Jing, Chen, Zhixian, Zheng, Guanqun, Lu, Min, Zhu, Zongcheng

“…Aiming at the problem that the traditional coronary artery centerline extraction method is computationally intensive and requires a large number of manual…”
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Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA by Liu, Nian, Parisien, Marc, Dai, Qing, Zheng, Guanqun, He, Chuan, Pan, Tao

“…N(6)-methyladenosine (m(6)A) is the most abundant modification in mammalian mRNA and long noncoding RNA (lncRNA). Recent discoveries of two m(6)A demethylases…”
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N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions by Liu, Nian, Dai, Qing, Zheng, Guanqun, He, Chuan, Parisien, Marc, Pan, Tao

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N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactions by Liu, Nian, Dai, Qing, Zheng, Guanqun, He, Chuan, Parisien, Marc, Pan, Tao

“…RNA-binding proteins control many aspects of cellular biology through binding single-stranded RNA binding motifs (RBMs). However, RBMs can be buried within…”
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The Bioinformatical Identification of Potential Biomarkers in Heart Failure Diagnosis and Treatment by Sheng, Xiaodong, Jin, Xiaoqi, Liu, Yanqi, Fan, Tao, Zhu, Zongcheng, Jin, Jing, Zheng, Guanqun, Chen, Zhixian, Lu, Min, Wang, Zhiqiang

“…Background. Heart failure (HF) is defined as the inability of the heart’s systolic and diastolic function to properly discharge blood flow from the veins to…”
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Probing N 6 -methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNA by Liu, Nian, Parisien, Marc, Dai, Qing, Zheng, Guanqun, He, Chuan, Pan, Tao

“…N 6 -methyladenosine (m 6 A) is the most abundant modification in mammalian mRNA and long noncoding RNA (lncRNA). Recent discoveries of two m 6 A demethylases…”
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ALKBH1-Mediated tRNA Demethylation Regulates Translation by Liu, Fange, Clark, Wesley, Luo, Guanzheng, Wang, Xiaoyun, Fu, Ye, Wei, Jiangbo, Wang, Xiao, Hao, Ziyang, Dai, Qing, Zheng, Guanqun, Ma, Honghui, Han, Dali, Evans, Molly, Klungland, Arne, Pan, Tao, He, Chuan

“…tRNA is a central component of protein synthesis and the cell signaling network. One salient feature of tRNA is its heavily modified status, which can…”
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The dynamic N(1)-methyladenosine methylome in eukaryotic messenger RNA by Dominissini, Dan, Nachtergaele, Sigrid, Moshitch-Moshkovitz, Sharon, Peer, Eyal, Kol, Nitzan, Ben-Haim, Moshe Shay, Dai, Qing, Di Segni, Ayelet, Salmon-Divon, Mali, Clark, Wesley C, Zheng, Guanqun, Pan, Tao, Solomon, Oz, Eyal, Eran, Hershkovitz, Vera, Han, Dali, Doré, Louis C, Amariglio, Ninette, Rechavi, Gideon, He, Chuan

“…Gene expression can be regulated post-transcriptionally through dynamic and reversible RNA modifications. A recent noteworthy example is N(6)-methyladenosine…”
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Liver kinase B1 suppresses growth of lung cancer cells through sonic hedgehog signaling pathway by Song, Kuiyuan, Zheng, Guanqun, Zhao, Yue

“…Lung cancer is one of life‐threatening cancers in the worldwide. Liver kinase B1 (LKB1) has been reported to be closely related to cancers; however, the…”
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ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility by Zheng, Guanqun, Dahl, John Arne, Niu, Yamei, Fedorcsak, Peter, Huang, Chun-Min, Li, Charles J., Vågbø, Cathrine B., Shi, Yue, Wang, Wen-Ling, Song, Shu-Hui, Lu, Zhike, Bosmans, Ralph P.G., Dai, Qing, Hao, Ya-Juan, Yang, Xin, Zhao, Wen-Ming, Tong, Wei-Min, Wang, Xiu-Jie, Bogdan, Florian, Furu, Kari, Fu, Ye, Jia, Guifang, Zhao, Xu, Liu, Jun, Krokan, Hans E., Klungland, Arne, Yang, Yun-Gui, He, Chuan

“…N6-methyladenosine (m6A) is the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes. Here we report ALKBH5 as another mammalian…”
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