Search Results - "Zheng, Ding Ming"

Cotinine: Pharmacologically Active Metabolite of Nicotine and Neural Mechanisms for Its Actions by Tan, Xiaoying, Vrana, Kent, Ding, Zheng-Ming

“…Tobacco use disorder continues to be a leading public health issue and cause of premature death in the United States. Nicotine is considered as the major…”
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Gene Expression Changes in Glutamate and GABA-A Receptors, Neuropeptides, Ion Channels, and Cholesterol Synthesis in the Periaqueductal Gray Following Binge-Like Alcohol Drinking by Adolescent Alcohol-Preferring (P) Rats by McClintick, Jeanette N., McBride, William J., Bell, Richard L., Ding, Zheng-Ming, Liu, Yunlong, Xuei, Xiaoling, Edenberg, Howard J.

“…Background Binge drinking of alcohol during adolescence is a serious public health concern with long‐term consequences, including increased pain, fear, and…”
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Ethanol Increases Glutamate Neurotransmission in the Posterior Ventral Tegmental Area of Female Wistar Rats by Ding, Zheng-Ming, Engleman, Eric A., Rodd, Zachary A., McBride, William J.

“…Background:  The posterior ventral tegmental area (pVTA) mediates the reinforcing and stimulating effects of ethanol (EtOH). Electrophysiological studies…”
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Sensitization of Ventral Tegmental Area Dopamine Neurons to the Stimulating Effects of Ethanol by Ding, Zheng-Ming, Rodd, Zachary A., Engleman, Eric A., McBride, William J.

“…Background:  Previous studies indicated that chronic alcohol drinking increased the sensitivity of the posterior ventral tegmental area (p‐VTA) to the…”
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Gene expression changes in the ventral hippocampus and medial prefrontal cortex of adolescent alcohol-preferring (P) rats following binge-like alcohol drinking by McClintick, Jeanette N., McBride, William J., Bell, Richard L., Ding, Zheng-Ming, Liu, Yunlong, Xuei, Xiaoling, Edenberg, Howard J.

“…Binge drinking of alcohol during adolescence is a serious public health concern with long-term consequences, including decreased hippocampal and prefrontal…”
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Reduced Levels of mGlu2 Receptors within the Prelimbic Cortex Are Not Associated with Elevated Glutamate Transmission or High Alcohol Drinking by Ding, Zheng‐Ming, Ingraham, Cynthia M., Hauser, Sheketha R., Lasek, Amy W., Bell, Richard L., McBride, William J.

“…Background A Grm2 cys407* stop codon mutation, which results in a loss of the metabotropic glutamate 2 (mGlu2) receptor protein, was identified as being…”
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Microinjections of Acetaldehyde or Salsolinol into the Posterior Ventral Tegmental Area Increase Dopamine Release in the Nucleus Accumbens Shell by Deehan Jr, Gerald A., Engleman, Eric A., Ding, Zheng-Ming, McBride, William J., Rodd, Zachary A.

“…Background Published findings indicate that acetaldehyde (ACD; the first metabolite of ethanol [EtOH]) and salsolinol (SAL; formed through the nonenzymatic…”
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Alcohol drinking and deprivation alter basal extracellular glutamate concentrations and clearance in the mesolimbic system of alcohol-preferring (P) rats by Ding, Zheng-Ming, Rodd, Zachary A., Engleman, Eric A., Bailey, Jason A., Lahiri, Debomoy K., McBride, William J.

“…The present study determined the effects of voluntary ethanol drinking and deprivation on basal extracellular glutamate concentrations and clearance in the…”
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Modeling Aversion Resistant Alcohol Intake in Indiana Alcohol-Preferring (P) Rats by Katner, Simon N, Sentir, Alena M, Steagall, Kevin B, Ding, Zheng-Ming, Wetherill, Leah, Hopf, Frederic W, Engleman, Eric A

“…With the substantial social and medical burden of addiction, there is considerable interest in understanding risk factors that increase the development of…”
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Identification of genes involved in regulating MnSOD2 production and root colonization in Bacillus cereus 905 by GAO, Tan-tan, DING, Ming-zheng, LI, Yan, ZENG, Qing-chao, WANG, Qi

“…sodA2-encoding manganese-containing superoxide dismutase (MnSOD2) in Bacillus cereus 905 plays an essential role in antioxidative stress, nutrition…”
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The reinforcing effects of ethanol within the posterior ventral tegmental area depend on dopamine neurotransmission to forebrain cortico-limbic systems by Ding, Zheng-Ming, Ingraham, Cynthia M., Rodd, Zachary A., McBride, William J.

“…Ethanol can be self‐infused directly into the posterior ventral tegmental area (pVTA) and these effects involve activation of local dopamine neurons. However,…”
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Nicotine Modulates Alcohol-Seeking and Relapse by Alcohol-Preferring (P) Rats in a Time-Dependent Manner by Hauser, Sheketha R., Getachew, Bruk, Oster, Scott M., Dhaher, Ronnie, Ding, Zheng-Ming, Bell, Richard L., McBride, William J., Rodd, Zachary A.

“…Background:  Alcohol is frequently co‐abused with smoking. In humans, nicotine use can increase alcohol craving and consumption. The objectives of the current…”
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Ethanol Is Self-Administered Into the Nucleus Accumbens Shell, But Not the Core: Evidence of Genetic Sensitivity by Engleman, Eric A., Ding, Zheng-Ming, Oster, Scott M., Toalston, Jamie E., Bell, Richard L., Murphy, James M., McBride, William J., Rodd, Zachary A.

“…Background:  A previous study indicated that selectively bred alcohol‐preferring (P) rats self‐administered ethanol (EtOH) directly into the posterior ventral…”
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Development of an Oral Operant Nicotine/Ethanol Co-Use Model in Alcohol-Preferring (P) Rats by Hauser, Sheketha R., Katner, Simon N., Deehan Jr, Gerald A., Ding, Zheng-Ming, Toalston, Jamie E., Scott, Briana J., Bell, Richard L., McBride, William J., Rodd, Zachary A.

“…Background Alcohol abuse is frequently associated with nicotine (Nic) use. The current experiments were conducted to establish an oral operant ethanol + Nic…”
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Selective breeding for high alcohol preference increases the sensitivity of the posterior VTA to the reinforcing effects of nicotine by Hauser, Sheketha R., Bracken, Amy L., Deehan Jr, Gerald A., Toalston, Jamie E., Ding, Zheng-Ming, Truitt, William A., Bell, Richard L., McBride, William J., Rodd, Zachary A.

“…The rate of codependency for alcohol and nicotine is extremely high. Numerous studies have indicated that there is a common genetic association for alcoholism…”
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The Reinforcing Properties of Salsolinol in the Ventral Tegmental Area: Evidence for Regional Heterogeneity and the Involvement of Serotonin and Dopamine by Rodd, Zachary A., Oster, Scott M., Ding, Zheng-Ming, Toalston, Jamie E., Deehan, Gerald, Bell, Richard L., Li, Ting-Kai, McBride, William J.

“…Background:  Salsolinol (SAL), the condensation product of acetaldehyde and dopamine, may be a factor contributing to alcohol abuse. Previous research…”
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Relapse to cotinine seeking in rats: differential effects of sex by Tan, Xiaoying, Neslund, Elizabeth, Ding, Zheng-Ming

“…Relapse is a defining feature of smoking and a significant challenge in cessation management. Elucidation of novel factors underlying relapse may inform future…”
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Fluorocitrate inhibition of astrocytes reduces nicotine self-administration and alters extracellular levels of glutamate and dopamine within the nucleus accumbens in male wistar rats by Tan, Xiaoying, Neslund, Elizabeth M., Fentis, Khawla, Ding, Zheng-Ming

“…Emerging evidence suggests an important role of astrocytes in mediating behavioral and molecular effects of commonly misused drugs. Passive exposure to…”
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Self-Administration of Cotinine in Wistar Rats: Comparisons to Nicotine by Ding, Zheng-Ming, Gao, Yong, Sentir, Alena M, Tan, Xiaoying

“…Nicotine is the major addictive component in tobacco. Cotinine is the major metabolite of nicotine and a weak agonist for nicotinic acetylcholine receptors…”
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The involvement of dopamine and D2 receptor-mediated transmission in effects of cotinine in male rats by Tan, Xiaoying, Neslund, Elizabeth M., Ding, Zheng-Ming

“…Previous studies indicated that cotinine, the major metabolite of nicotine, supported intravenous self-administration and exhibited relapse-like drug-seeking…”
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