Search Results - "Zhendong Song"
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1
Tyrosine phosphatase SHP2 inhibitors in tumor-targeted therapies
Published in Acta pharmaceutica Sinica. B (01-01-2021)“…Src homology containing protein tyrosine phosphatase 2 (SHP2) represents a noteworthy target for various diseases, serving as a well-known oncogenic…”
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2
Improving automatic segmentation of liver tumor images using a deep learning model
Published in Heliyon (15-04-2024)“…Liver tumors are one of the most aggressive malignancies in the human body. Computer-aided technology and liver interventional surgery are effective in the…”
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3
Hybrid Dilated and Recursive Recurrent Convolution Network for Time-Domain Speech Enhancement
Published in Applied sciences (01-04-2022)“…In this paper, we propose a fully convolutional neural network based on recursive recurrent convolution for monaural speech enhancement in the time domain. The…”
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4
Surface Electromyography-Based Recognition of Electronic Taste Sensations
Published in Biosensors (Basel) (01-08-2024)“…Taste sensation recognition is a core for taste-related queries. Most prior research has been devoted to recognizing the basic taste sensations using the…”
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5
Dynamic analysis and design of a multipurpose lower limb exoskeleton for rehabilitation
Published in International journal of advanced robotic systems (01-11-2022)“…To solve some defects of exoskeleton robot at present, this article establishes the dynamic model of human lower limb. The torque curves for hip joint and knee…”
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6
Novel Selective and Potent EGFR Inhibitor that Overcomes T790M-Mediated Resistance in Non-Small Cell Lung Cancer
Published in Molecules (Basel, Switzerland) (01-11-2016)“…Treating patients suffering from EGFR mutant non-small cell lung cancer (NSCLC) with first-generation EGFR tyrosine kinase inhibitors (EGFR TKI) provides…”
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7
New fusional framework combining sparse selection and clustering for key frame extraction
Published in IET computer vision (01-06-2016)“…Key frame extraction can facilitate rapid browsing and efficient video indexing in many applications. However, to be effective, key frames must preserve…”
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Discovery of small molecule Gαq/11 protein inhibitors against uveal melanoma
Published in Acta pharmaceutica Sinica. B (01-08-2022)“…Constitutively activated G proteins caused by specific mutations mediate the development of multiple malignancies. The mutated Gαq/11 are perceived as…”
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9
Adenine: an important drug scaffold for the design of antiviral agents
Published in Acta pharmaceutica Sinica. B (01-09-2015)“…Adenine derivatives, in particular the scaffold bearing the acyclic nucleoside phosphonates(ANPS), possess signi fi cant antiviral and cytostatic activity…”
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10
Study of Nanometer-Sized Precipitation and Properties of Fire Resistant Hot-Rolled Steel
Published in Metals (Basel ) (01-11-2019)“…Nanometer-sized precipitated carbides in a low carbon Ti-V-Mo bearing steel were obtained through hot rolling and air cooling and were investigated by…”
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11
Development of a Candidate 11C‑Labeled Selective Phosphodiesterase 1 Radioligand for Positron Emission Tomography
Published in ACS omega (05-11-2024)“…Phosphodiesterases (PDEs) constitute a superfamily of phosphohydrolytic enzymes that regulate intracellular second messenger signaling by hydrolyzing cyclic…”
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12
Deep learning-driven MIMO: Data encoding and processing mechanism
Published in Physical communication (01-04-2023)“…Large-scale Multiple-Input Multiple Output (MIMO) is the key technology of 5G communication. However, dealing with physical channels is a complex process…”
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13
Can a new national system policy for science and technology promote industrial restructuring in China’s national innovation center cities?
Published in Soft computing (Berlin, Germany) (25-01-2024)“…We establish two types of difference-in-difference (DID) models to study the effects of the policy shocks of the new national system of science and technology…”
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14
Comparative investigation on the chemical pre-desulfurization process of a high sulfur coal through orthogonal experiments: a case study
Published in International journal of coal preparation and utilization (01-09-2024)“…The effect of different chemical pre-desulfurization processes were compared to achieve the utilization of high sulfur coal efficiently and economically and…”
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15
Challenges and Perspectives on the Development of Small-Molecule EGFR Inhibitors against T790M-Mediated Resistance in Non-Small-Cell Lung Cancer
Published in Journal of medicinal chemistry (28-07-2016)“…Because of the development of drug-resistance mutations, particularly the "gatekeeper" threonine(790)-to-methionine(790) (T790M) mutation in the ATP-binding…”
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16
Targeting mutated GTPase KRAS in tumor therapies
Published in European journal of medicinal chemistry (15-12-2021)“…Kirsten rat sarcoma virus oncogene (KRAS) mutation accounts for approximately 85% of RAS-driven cancers, and participates in multiple signaling pathways and…”
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17
Numerical simulation study of the injection characteristics affecting trans-/supercritical sprays based on orthogonal experiment design
Published in Energy (Oxford) (15-04-2024)“…A mixture of numerical models and orthogonal experiments was used to better understand the mixing behavior and heat/mass transfer in jets operating under…”
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Challenges and Perspectives on the Development of Small-Molecule EGFR Inhibitors against T790M-Mediated Resistance in Non-Small-Cell Lung Cancer: Miniperspective
Published in Journal of medicinal chemistry (28-07-2016)“…Because of the development of drug-resistance mutations, particularly the “gatekeeper” threonine790-to-methionine790 (T790M) mutation in the ATP-binding pocket…”
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Insights into the Dispersion Mechanism of Microfine Coal Particles Modified with Naphthalene Sulfonate Formaldehyde Based on EDLVO Theory
Published in Energy & fuels (01-06-2023)“…Coal water slurry (CWS) fuel prepared using microfine coal particles with a size distribution of 1–10 μm is a promising way to cleanly utilize solid resources…”
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20
Cloud-Edge Collaborative Computing for Consumer Electronics via Deep Reinforcement Learning
Published in IEEE transactions on consumer electronics (07-08-2024)“…With the explosive growth of consumer electronic devices, edge computing has emerged as a promising paradigm to process large-scale data in real-time and…”
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