Preconception paternal bisphenol A exposure induces sex-specific anxiety and depression behaviors in adult rats

Bisphenol A (BPA), an environmental endocrine-disrupting compound, has drawn a great attention for its adverse effect on behavioral development. Maternal exposure to this compound has been reported to induce anxiety and depression in offspring, but the effect of its paternal exposure is rarely discu...

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Published in:	PloS one Vol. 13; no. 2; p. e0192434
Main Authors:	Fan, Ying, Tian, Chong, Liu, Qilin, Zhen, Xianyue, Zhang, Hui, Zhou, Liangneng, Li, Taibiao, Zhang, Yun, Ding, Shibin, He, Dongliang, Jin, Xin, Liu, Jian, Zhang, Beibei, Wu, Nannan, Manyande, Anne, Zhu, Maoshu
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 08-02-2018 Public Library of Science (PLoS)
Subjects:	Anxiety BASIC BIOLOGICAL SCIENCES behavior biological locomotion Biology and Life Sciences Bisphenol-A cognitive impairment Complications and side effects Depression (Mood disorder) diet emotions Medicine and Health Sciences Psychological aspects rats Research and Analysis Methods Risk factors Social Sciences swimming China
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Summary:	Bisphenol A (BPA), an environmental endocrine-disrupting compound, has drawn a great attention for its adverse effect on behavioral development. Maternal exposure to this compound has been reported to induce anxiety and depression in offspring, but the effect of its paternal exposure is rarely discussed. This study investigated whether preconception paternal BPA exposure can affect the emotions of male rats and their offspring. Eighteen adult male rats (F0) received either a vehicle or 50 μg/kg/day BPA diet for 21 weeks and were then mated with non-exposed females to produce offspring (F1). The affective behaviors of F0 and F1 rats were evaluated in the open-field test, the elevated-plus maze and the forced swimming test, and their serum corticosterone were then examined. BPA exposure induced increased anxiety behaviors along with increased serum corticosterone in F0 rats. This paternal exposure also led to increased anxiety behaviors in F1 females and aggravated depression behaviors in both sexes of F1 rats. Furthermore, only F1 females exhibited increased serum corticosterone. Overall, these data indicate that preconception paternal exposure to a low dose of BPA may induce transgenerational sex-specific impairments in the affection of adult rats.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Fundamental Research Funds for the Central Univ. National Natural Science Foundation of China (NSFC) Provincial Natural Science Foundation of Fujian 2016D020; 2018D0022; 2015QN096; 81373007 Competing Interests: The authors have declared that no competing interests exist.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0192434