Search Results - "Zhen, James"
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1
Structures and comparison of endogenous 2-oxoglutarate and pyruvate dehydrogenase complexes from bovine kidney
Published in Cell discovery (22-11-2022)“…The α-keto acid dehydrogenase complex family catalyzes the essential oxidative decarboxylation of α-keto acids to yield acyl-CoA and NADH. Despite performing…”
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Journal Article -
2
Segmental structural dynamics in Aβ42 globulomers
Published in Biochemical and biophysical research communications (19-03-2021)“…Aβ42 aggregation plays a central role in the pathogenesis of Alzheimer’s disease. In addition to the insoluble fibrils that comprise the amyloid plaques, Aβ42…”
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Journal Article -
3
Screening Tests for Lasso Problems
Published in IEEE transactions on pattern analysis and machine intelligence (01-05-2017)“…This paper is a survey of dictionary screening for the lasso problem. The lasso problem seeks a sparse linear combination of the columns of a dictionary to…”
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Journal Article -
4
Static and dynamic disorder in Aβ40 fibrils
Published in Biochemical and biophysical research communications (25-06-2022)“…Deposition of Aβ aggregates in the form of amyloid fibrils is a pathological hallmark of Alzheimer's disease. Understanding the structure and dynamics of Aβ…”
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Journal Article -
5
Structures From Cells and Viruses Through Endogenous CryoEm Methods
Published 01-01-2024“…As we seek to elucidate the functions and mechanisms of biological constructs, there is a growing need to learn about their structures in their native contexts…”
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Dissertation -
6
Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP
Published in Molecular cell (05-05-2022)“…7SK non-coding RNA (7SK) negatively regulates RNA polymerase II (RNA Pol II) elongation by inhibiting positive transcription elongation factor b (P-TEFb), and…”
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Journal Article -
7
Structural basis of RNA conformational switching in the transcriptional regulator 7SK RNP
Published in Biophysical journal (10-02-2023)Get full text
Journal Article -
8
Immunization of Mice with Virus-Like Vesicles of Kaposi Sarcoma-Associated Herpesvirus Reveals a Role for Antibodies Targeting ORF4 in Activating Complement-Mediated Neutralization
Published in Journal of virology (28-02-2023)“…Infection by Kaposi sarcoma-associated herpesvirus (KSHV) can cause severe consequences, such as cancers and lymphoproliferative diseases. Whole inactivated…”
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Journal Article -
9
Fast lasso screening tests based on correlations
Published in 2012 IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP) (01-03-2012)“…Representing a vector as a sparse linear combination of codewords, e.g. by solving a lasso problem, lies at the heart of many machine learning and statistics…”
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Conference Proceeding -
10
Edge-Preserving Image Regularization Based on Morphological Wavelets and Dyadic Trees
Published in IEEE transactions on image processing (01-04-2012)“…Despite the tremendous success of wavelet-based image regularization, we still lack a comprehensive understanding of the exact factor that controls edge…”
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Journal Article -
11
Lasso screening with a small regularization parameter
Published in 2013 IEEE International Conference on Acoustics, Speech and Signal Processing (01-05-2013)“…Screening for lasso problems is a means of quickly reducing the size of the dictionary needed to solve a given instance without impacting the optimality of the…”
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Conference Proceeding -
12
Tradeoffs in improved screening of lasso problems
Published in 2013 IEEE International Conference on Acoustics, Speech and Signal Processing (01-05-2013)“…Recently, methods of screening the lasso problem have been developed that use the target vector x to quickly identify a subset of columns of the dictionary…”
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Conference Proceeding -
13
Morphological wavelets and the complexity of dyadic trees
Published in 2010 IEEE International Conference on Acoustics, Speech and Signal Processing (01-03-2010)“…In this paper we reveal a connection between the coefficients of the morphological wavelet transform and complexity measures of dyadic tree representations of…”
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Conference Proceeding -
14
Combining structural knowledge with sparsity in machine learning and signal processing
Published 01-01-2012“…With the advancement of technology, we are able to collect, store, and transmit an ever-increasing volume of data. However, our ability to extract useful…”
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Dissertation -
15
Sparse boosting
Published in 2009 IEEE International Conference on Acoustics, Speech and Signal Processing (01-04-2009)“…We propose a boosting algorithm that seeks to minimize the AdaBoost exponential loss of a composite classifier using only a sparse set of base classifiers. The…”
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Conference Proceeding -
16
Learning a wavelet tree for multichannel image denoising
Published in 2011 18th IEEE International Conference on Image Processing (01-09-2011)“…We propose a new multichannel image denoising algorithm. To exploit important inter-channel dependencies, we first use dynamic programming to learn an explicit…”
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Conference Proceeding -
17
Morphological wavelet transform with adaptive dyadic structures
Published in 2010 IEEE International Conference on Image Processing (01-09-2010)“…We propose a two component method for denoising multidimensional signals, e.g. images. The first component uses a dynamic programing algorithm of complexity O…”
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Conference Proceeding -
18
Screening Tests for Lasso Problems
Published 21-08-2016“…This paper is a survey of dictionary screening for the lasso problem. The lasso problem seeks a sparse linear combination of the columns of a dictionary to…”
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Journal Article -
19
Combining structural knowledge with sparsity in machine learning and signal processing
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Dissertation -
20
Genetic algorithms in machine learning and optimization
Published 01-01-1992“…This dissertation focuses on the development of the theory of genetic algorithms and its applications in machine learning and optimization. A genetic-based…”
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Dissertation