Search Results - "Zheleva, D I"

Highly potent p21(WAF1)-derived peptide inhibitors of CDK-mediated pRb phosphorylation: delineation and structural insight into their interactions with cyclin A by Zheleva, D I, McInnes, C, Gavine, A-L, Zhelev, N Z, Fischer, P M, Lane, D P

“…The tumour suppressor protein p21(WAF1) plays a central role in regulating eukaryotic cell-cycle progression. Through its association with G1- and S-phase CDK…”
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A Quantitative Study of the in Vitro Binding of the C-Terminal Domain of p21 to PCNA:  Affinity, Stoichiometry, and Thermodynamics by Zheleva, Daniella I, Zhelev, Nikolai Z, Fischer, Peter M, Duff, Susan V, Warbrick, Emma, Blake, David G, Lane, David P

“…Proliferating cell nuclear antigen (PCNA) plays an essential role in DNA replication, repair, and control of cell proliferation, and its activity can be…”
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Use of Peptides from p21 (Waf1/Cip1) to Investigate PCNA Function in Xenopus Egg Extracts by Mattock, Heidi, Jares, Pedro, Zheleva, Daniella I., Lane, David P., Warbrick, Emma, Blow, J.Julian

“…Cell-free systems derived from unfertilized Xenopus eggs have been particularly informative in the study of the regulation and biochemistry of DNA replication…”
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Liquid-phase peptide synthesis on polyethylene glycol (PEG) supports using strategies based on the 9-fluorenylmethoxycarbonyl amino protecting group: application of PEGylated peptides in biochemical assays by Fischer, Peter M., Zheleva, Daniella I.

“…Stepwise synthetic assembly of polypeptide chains reversibly linked to polyethylene glycol represents a hybrid between traditional solution and solid‐phase…”
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Structural and Biochemical Studies of Human Proliferating Cell Nuclear Antigen Complexes Provide a Rationale for Cyclin Association and Inhibitor Design by Kontopidis, George, Wu, Su-Ying, Zheleva, Daniella I., Taylor, Paul, McInnes, Campbell, Lane, David P., Fischer, Peter M., Walkinshaw, Malcolm D., Fersht, Alan

“…The interactions between the tumor suppressor protein p21WAF1and the cyclin-dependent kinase (CDK) complexes and with proliferating cell nuclear antigen (PCNA)…”
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Discovery of a Novel Family of CDK Inhibitors with the Program LIDAEUS: Structural Basis for Ligand-Induced Disordering of the Activation Loop by Wu, Su Ying, McNae, Iain, Kontopidis, George, McClue, Steven J, McInnes, Campbell, Stewart, Kevin J, Wang, Shudong, Zheleva, Daniella I, Marriage, Howard, Lane, David P, Taylor, Paul, Fischer, Peter M, Walkinshaw, Malcolm D

“…A family of 4-heteroaryl-2-amino-pyrimidine CDK2 inhibitor lead compounds was discovered with the new database-mining program LIDAEUS through in silico…”
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Insights into Cyclin Groove Recognition: Complex Crystal Structures and Inhibitor Design through Ligand Exchange by Kontopidis, George, Andrews, Martin J.I., McInnes, Campbell, Cowan, Angela, Powers, Helen, Innes, Lorraine, Plater, Andy, Griffiths, Gary, Paterson, Dougie, Zheleva, Daniella I., Lane, David P., Green, Stephen, Walkinshaw, Malcolm D., Fischer, Peter M.

“…Inhibition of CDK2/CA (cyclin-dependent kinase 2/cyclin A complex) activity through blocking of the substrate recognition site in the cyclin A subunit has been…”
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Peptide inhibitors of CDK2-cyclin A that target the cyclin recruitment-Site: structural variants of the C-Terminal Phe by Atkinson, Gail E, Cowan, Angela, McInnes, Campbell, Zheleva, Daniella I, Fischer, Peter M, Chan, Weng C

“…A focused series of octapeptides based on the lead compound H-His-Ala-Lys-Arg-Arg-Leu-Ile-Phe-NH 2 1, in which the C-terminal phenylalanine residue was…”
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Discovery and Characterization of 2-Anilino-4- (Thiazol-5-yl)Pyrimidine Transcriptional CDK Inhibitors as Anticancer Agents by Wang, Shudong, Griffiths, Gary, Midgley, Carol A., Barnett, Anna L., Cooper, Michael, Grabarek, Joanna, Ingram, Laura, Jackson, Wayne, Kontopidis, George, McClue, Steven J., McInnes, Campbell, McLachlan, Janice, Meades, Christopher, Mezna, Mokdad, Stuart, Iain, Thomas, Mark P., Zheleva, Daniella I., Lane, David P., Jackson, Robert C., Glover, David M., Blake, David G., Fischer, Peter M.

“…The main difficulty in the development of ATP antagonist kinase inhibitors is target specificity, since the ATP-binding motif is present in many proteins. We…”
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