Search Results - "Zhdanov, Dmitry D."

Engineering and Expression Strategies for Optimization of L-Asparaginase Development and Production by Shishparenok, Anastasiya N, Gladilina, Yulia A, Zhdanov, Dmitry D

“…Genetic engineering for heterologous expression has advanced in recent years. Model systems such as , and are often used as host microorganisms for the…”
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Many Faces of Regulatory T Cells: Heterogeneity or Plasticity? by Blinova, Varvara G, Zhdanov, Dmitry D

“…Regulatory T cells (Tregs) are essential for maintaining the immune balance in normal and pathological conditions. In autoimmune diseases and transplantation,…”
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L-Asparaginase Conjugates from the Hyperthermophilic Archaea Thermococcus sibiricus with Improved Biocatalytic Properties by Dobryakova, Natalia V, Dumina, Maria V, Zhgun, Alexander A, Pokrovskaya, Marina V, Aleksandrova, Svetlana S, Zhdanov, Dmitry D, Kudryashova, Elena V

“…This study investigated the effect of polycationic and uncharged polymers (and oligomers) on the catalytic parameters and thermostability of L-asparaginase…”
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Protein Immobilization on Bacterial Cellulose for Biomedical Application by Shishparenok, Anastasia N, Furman, Vitalina V, Dobryakova, Natalia V, Zhdanov, Dmitry D

“…New carriers for protein immobilization are objects of interest in various fields of biomedicine. Immobilization is a technique used to stabilize and provide…”
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L-Lysine α-Oxidase: Enzyme with Anticancer Properties by Lukasheva, Elena V., Babayeva, Gulalek, Karshieva, Saida Sh, Zhdanov, Dmitry D., Pokrovsky, Vadim S.

“…L-lysine α-oxidase (LO), one of L-amino acid oxidases, deaminates L-lysine with the yield of H2O2, ammonia, and α-keto-ε-aminocaproate. Multiple in vitro and…”
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DNA-Based Nanomaterials as Drug Delivery Platforms for Increasing the Effect of Drugs in Tumors by Shishparenok, Anastasiya N, Furman, Vitalina V, Zhdanov, Dmitry D

“…DNA nanotechnology has significantly advanced and might be used in biomedical applications, drug delivery, and cancer treatment during the past few decades…”
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Alternative Splicing of Human Telomerase Reverse Transcriptase (hTERT) and Its Implications in Physiological and Pathological Processes by Plyasova, Anna A., Zhdanov, Dmitry D.

“…Alternative splicing (AS) of human telomerase catalytic subunit (hTERT, human telomerase reverse transcriptase) pre-mRNA strongly regulates telomerase…”
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Cytoprotective Activity of Polyamines Is Associated with the Alternative Splicing of RAD51A Pre-mRNA in Normal Human CD4 + T Lymphocytes by Gladilina, Yulia A, Bey, Lylia, Hilal, Abdullah, Neborak, Ekaterina V, Blinova, Varvara G, Zhdanov, Dmitry D

“…Physiological polyamines are ubiquitous polycations with pleiotropic biochemical activities, including regulation of gene expression and cell proliferation as…”
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Molecular Analysis of L-Asparaginases for Clarification of the Mechanism of Action and Optimization of Pharmacological Functions by Pokrovskaya, Marina V, Pokrovsky, Vadim S, Aleksandrova, Svetlana S, Sokolov, Nikolay N, Zhdanov, Dmitry D

“…L-asparaginases (EC 3.5.1.1) are a family of enzymes that catalyze the hydrolysis of L-asparagine to L-aspartic acid and ammonia. These proteins with different…”
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The Role of Regulatory T Cells in the Onset and Progression of Primary Sjögren's Syndrome by Blinova, Varvara G, Vasilyev, Vladimir I, Rodionova, Ekaterina B, Zhdanov, Dmitry D

“…Regulatory T cells (Tregs) play a key role in maintaining immune balance and regulating the loss of self-tolerance mechanisms in various autoimmune diseases,…”
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DNase I Induces Other Endonucleases in Kidney Tubular Epithelial Cells by Its DNA-Degrading Activity by Fahmi, Tariq, Wang, Xiaoying, Zhdanov, Dmitry D, Islam, Intisar, Apostolov, Eugene O, Savenka, Alena V, Basnakian, Alexei G

“…Endonuclease-mediated DNA fragmentation is both an immediate cause and a result of apoptosis and of all other types of irreversible cell death after injury. It…”
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New Genetic Bomb Trigger: Design, Synthesis, Molecular Dynamics Simulation, and Biological Evaluation of Novel BIBR1532-Related Analogs Targeting Telomerase against Non-Small Cell Lung Cancer by Tawfik, Haytham O, El-Hamaky, Anwar A, El-Bastawissy, Eman A, Shcherbakov, Kirill A, Veselovsky, Alexander V, Gladilina, Yulia A, Zhdanov, Dmitry D, El-Hamamsy, Mervat H

“…Telomeres serve a critical function in cell replication and proliferation at every stage of the cell cycle. Telomerase is a ribonucleoprotein, responsible for…”
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Anticancer Cytotoxic Activity of Bispidine Derivatives Associated with the Increasing Catabolism of Polyamines by Neborak, Ekaterina V., Kaldybayeva, Altynay B., Bey, Lylia, Malmakova, Aigul Y., Tveritinova, Anna S., Hilal, Abdullah, Yu, Valentina K., Ploskonos, Maria V., Komarova, Marina V., Agostinelli, Enzo, Zhdanov, Dmitry D.

“…Polyamine (PA) catabolism is often reduced in cancer cells. The activation of this metabolic pathway produces cytotoxic substances that might cause apoptosis…”
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Improvement of Biocatalytic Properties and Cytotoxic Activity of L-Asparaginase from Rhodospirillum rubrum by Conjugation with Chitosan-Based Cationic Polyelectrolytes by Dobryakova, Natalia V, Zhdanov, Dmitry D, Sokolov, Nikolay N, Aleksandrova, Svetlana S, Pokrovskaya, Marina V, Kudryashova, Elena V

“…L-asparaginases (L-ASNases, EC 3.5.1.1) are a family of enzymes that are widely used for the treatment of lymphoblastic leukemias. L-ASNase from (RrA) has a…”
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Correction: Plyasova et al. Penetration into Cancer Cells via Clathrin-Dependent Mechanism Allows L-Asparaginase from Rhodospirillum rubrum to Inhibit Telomerase. Pharmaceuticals 2020, 13 , 286 by Plyasova, Anna A, Pokrovskaya, Marina V, Lisitsyna, Olga M, Pokrovsky, Vadim S, Alexandrova, Svetlana S, Hilal, Abdullah, Sokolov, Nikolay N, Zhdanov, Dmitry D

“…In the original publication [...]…”
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Modulation of Suppressive Activity and Proliferation of Human Regulatory T Cells by Splice-Switching Oligonucleotides Targeting FoxP3 Pre-mRNA by Blinova, Varvara G, Gladilina, Yulia A, Abramova, Anna A, Eliseeva, Daria D, Vtorushina, Valentina V, Shishparenok, Anastasia N, Zhdanov, Dmitry D

“…The maturation, development, and function of regulatory T cells (Tregs) are under the control of the crucial transcription factor Forkhead Box Protein 3…”
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Rhodospirillum rubrum L-Asparaginase Conjugates with Polyamines of Improved Biocatalytic Properties as a New Promising Drug for the Treatment of Leukemia by Dobryakova, Natalia V., Zhdanov, Dmitry D., Sokolov, Nikolay N., Aleksandrova, Svetlana S., Pokrovskaya, Marina V., Kudryashova, Elena V.

“…L-asparaginase Rhodospirillum rubrum (RrA) is an enzyme (amidohydrolases; EC 3.5.1.1) that catalyzes the L-asparagine hydrolysis reaction to form L-aspartic…”
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Association of Telomere Length in T Lymphocytes, B Lymphocytes, NK Cells and Monocytes with Different Forms of Age-Related Macular Degeneration by Khalatyan, Anait S, Shishparenok, Anastasiya N, Avetisov, Konstantin S, Gladilina, Yulia A, Blinova, Varvara G, Zhdanov, Dmitry D

“…Age plays a primary role in the development of age-related macular degeneration (AMD). Telomere length (TL) is one of the most relevant biomarkers of aging. In…”
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Penetration into Cancer Cells via Clathrin-Dependent Mechanism Allows L-Asparaginase from Rhodospirillum rubrum to Inhibit Telomerase by Plyasova, Anna A, Pokrovskaya, Marina V, Lisitsyna, Olga M, Pokrovsky, Vadim S, Alexandrova, Svetlana S, Hilal, Abdullah, Sokolov, Nikolay N, Zhdanov, Dmitry D

“…The anticancer effect of L-asparaginases (L-ASNases) is attributable to their ability to hydrolyze L-asparagine in the bloodstream and cancer cell…”
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Induction of FoxP3 Pre-mRNA Alternative Splicing to Enhance the Suppressive Activity of Regulatory T Cells from Amyotrophic Lateral Sclerosis Patients by Zhdanov, Dmitry D, Gladilina, Yulia A, Blinova, Varvara G, Abramova, Anna A, Shishparenok, Anastasia N, Eliseeva, Daria D

“…Forkhead box protein 3 (FoxP3) is a key transcription factor responsible for the development, maturation, and function of regulatory T cells (Tregs). The FoxP3…”
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