Search Results - "Zhau, Haiyen"

MAOA-Dependent Activation of Shh-IL6-RANKL Signaling Network Promotes Prostate Cancer Metastasis by Engaging Tumor-Stromal Cell Interactions by Wu, Jason Boyang, Yin, Lijuan, Shi, Changhong, Li, Qinlong, Duan, Peng, Huang, Jen-Ming, Liu, Chunyan, Wang, Fubo, Lewis, Michael, Wang, Yang, Lin, Tzu-Ping, Pan, Chin-Chen, Posadas, Edwin M., Zhau, Haiyen E., Chung, Leland W.K.

“…Metastasis is a predominant cause of death for prostate cancer (PCa) patients; however, the underlying mechanisms are poorly understood. We report that…”
Get full text

Near-infrared fluorescence heptamethine carbocyanine dyes mediate imaging and targeted drug delivery for human brain tumor by Wu, Jason Boyang, Shi, Changhong, Chu, Gina Chia-Yi, Xu, Qijin, Zhang, Yi, Li, Qinlong, Yu, John S, Zhau, Haiyen E, Chung, Leland W.K

“…Abstract Brain tumors and brain metastases are among the deadliest malignancies of all human cancers, largely due to the cellular blood–brain and blood–tumor…”
Get full text

β2-Microglobulin-mediated signaling as a target for cancer therapy by Nomura, Takeo, Huang, Wen-Chin, Zhau, Haiyen E, Josson, Sajni, Mimata, Hiromitsu, Chung, Leland W K

“…β2-microglobulin (β2-m) has become the focus of intense scrutiny since the discovery of its undesirable roles promoting osteomimicry and cancer progression…”
Get more information

Monoamine oxidase A mediates prostate tumorigenesis and cancer metastasis by Wu, Jason Boyang, Shao, Chen, Li, Xiangyan, Li, Qinlong, Hu, Peizhen, Shi, Changhong, Li, Yang, Chen, Yi-Ting, Yin, Fei, Liao, Chun-Peng, Stiles, Bangyan L, Zhau, Haiyen E, Shih, Jean C, Chung, Leland W K

“…Tumors from patients with high-grade aggressive prostate cancer (PCa) exhibit increased expression of monoamine oxidase A (MAOA), a mitochondrial enzyme that…”
Get full text

Near IR Heptamethine Cyanine Dye-Mediated Cancer Imaging by XIAOJIAN YANG, CHUNMENG SHI, HENARY, Maged, STREKOWSKI, Lucjan, CHUNK, Leland W. K, RONG TONG, WEIPING QIAN, ZHAU, Haiyen E, RUOXIANG WANG, GUODONG ZHU, JIANJUN CHENG, YANG, Vincent W, TIANMIN CHENG

“…Near-IR fluorescence imaging has great potential for noninvasive in vivo imaging of tumors. In this study, we show the preferential uptake and retention of two…”
Get full text

LIV-1 promotes prostate cancer epithelial-to-mesenchymal transition and metastasis through HB-EGF shedding and EGFR-mediated ERK signaling by Lue, Hui-Wen, Yang, Xiaojian, Wang, Ruoxiang, Qian, Weiping, Xu, Roy Z H, Lyles, Robert, Osunkoya, Adeboye O, Zhou, Binhua P, Vessella, Robert L, Zayzafoon, Majd, Liu, Zhi-Ren, Zhau, Haiyen E, Chung, Leland W K

“…LIV-1, a zinc transporter, is an effector molecule downstream from soluble growth factors. This protein has been shown to promote epithelial-to-mesenchymal…”
Get full text

miR-409-3p/-5p Promotes Tumorigenesis, Epithelial-to-Mesenchymal Transition, and Bone Metastasis of Human Prostate Cancer by JOSSON, Sajni, GURURAJAN, Murali, LICHTERMAN, Jake, NANDANA, Srinivas, QUANLIN LI, ROGATKO, Andre, BEREL, Dror, POSADAS, Edwin M, FAZLI, Ladan, SAREEN, Dhruv, CHUNG, Leland W. K, PEIZHEN HU, CHEN SHAO, CHU, Ginachia-Yi, ZHAU, Haiyen E, CHUNYAN LIU, KAIQIN LAO, LU, Chia-Lun, LU, Yi-Tsung

“…miR-409-3p/-5p is a miRNA expressed by embryonic stem cells, and its role in cancer biology and metastasis is unknown. Our pilot studies demonstrated elevated…”
Get full text

KRT13 promotes stemness and drives metastasis in breast cancer through a plakoglobin/c-Myc signaling pathway by Yin, Lijuan, Li, Qinlong, Mrdenovic, Stefan, Chu, Gina Chia-Yi, Wu, Boyang Jason, Bu, Hong, Duan, Peng, Kim, Jayoung, You, Sungyong, Lewis, Michael S, Liang, Gangning, Wang, Ruoxiang, Zhau, Haiyen E, Chung, Leland W K

“…Keratins (KRTs) are intermediate filament proteins that interact with multiple regulatory proteins to initiate signaling cascades. Keratin 13 (KRT13) plays an…”
Get full text

Monoamine Oxidase A Inhibitor–Near-Infrared Dye Conjugate Reduces Prostate Tumor Growth by Wu, Jason Boyang, Lin, Tzu-Ping, Gallagher, John D, Kushal, Swati, Chung, Leland W. K, Zhau, Haiyen E, Olenyuk, Bogdan Z, Shih, Jean C

“…Development of anti-cancer agents with high tumor-targeting specificity and efficacy is critical for modern multidisciplinary cancer research. Monoamine…”
Get full text

Insulin-like growth factor-I-dependent up-regulation of ZEB1 drives epithelial-to-mesenchymal transition in human prostate cancer cells by Graham, Tisheeka R, Zhau, Haiyen E, Odero-Marah, Valerie A, Osunkoya, Adeboye O, Kimbro, K Sean, Tighiouart, Mourad, Liu, Tongrui, Simons, Jonathan W, O'Regan, Ruth M

“…The epithelial-to-mesenchymal transition (EMT) is crucial for the migration and invasion of many epithelial tumors, including prostate cancer. Although it is…”
Get full text

Spontaneous cancer-stromal cell fusion as a mechanism of prostate cancer androgen-independent progression by Wang, Ruoxiang, Sun, Xiaojuan, Wang, Christopher Y, Hu, Peizhen, Chu, Chia-Yi, Liu, Shurong, Zhau, Haiyen E, Chung, Leland W K

“…We have previously shown that human prostate cancer cells are capable of acquiring malignant attributes through interaction with stromal cells in the tumor…”
Get full text

Vascular endothelial growth factor regulates myeloid cell leukemia-1 expression through neuropilin-1-dependent activation of c-MET signaling in human prostate cancer cells by Zhang, Shumin, Zhau, Haiyen E, Osunkoya, Adeboye O, Iqbal, Shareen, Yang, Xiaojian, Fan, Songqing, Chen, Zhengjia, Wang, Ruoxiang, Marshall, Fray F, Chung, Leland W K, Wu, Daqing

“…Myeloid cell leukemia-1 (Mcl-1) is a member of the Bcl-2 family, which inhibits cell apoptosis by sequestering pro-apoptotic proteins Bim and Bid. Mcl-1…”
Get full text

miR-154 and miR-379 in the DLK1-DIO3 microRNA mega-cluster regulate epithelial to mesenchymal transition and bone metastasis of prostate cancer by Gururajan, Murali, Josson, Sajni, Chu, Gina Chia-Yi, Lu, Chia-Lun, Lu, Yi-Tsung, Haga, Christopher L, Zhau, Haiyen E, Liu, Chunyan, Lichterman, Jake, Duan, Peng, Posadas, Edwin M, Chung, Leland W K

“…MicroRNAs in the delta-like 1 homolog-deiodinase, iodothyronine 3 (DLK1-DIO3) cluster have been shown to be critical for embryonic development and epithelial…”
Get full text

Near-infrared fluorescence imaging of cancer mediated by tumor hypoxia and HIF1α/OATPs signaling axis by Wu, Jason Boyang, Shao, Chen, Li, Xiangyan, Shi, Changhong, Li, Qinlong, Hu, Peizhen, Chen, Yi-Ting, Dou, Xiaoliang, Sahu, Divya, Li, Wei, Harada, Hiroshi, Zhang, Yi, Wang, Ruoxiang, Zhau, Haiyen E, Chung, Leland W.K

“…Abstract Near-infrared fluorescence (NIRF) imaging agents are promising tools for noninvasive cancer imaging. Here, we explored the mechanistic properties of a…”
Get full text

Novel Mitochondria-Based Targeting Restores Responsiveness in Therapeutically Resistant Human Lung Cancer Cells by Yin, Liyuan, Zhang, Yi, Yin, Lijuan, Ou, Yan, Lewis, Michael S, Wang, Ruoxiang, Zhau, Haiyen E, Zhou, Qinghua, Chung, Leland W K

“…Cisplatin and tyrosine kinase inhibitors (TKI) are recommended to treat non-small cell lung cancer (NSCLC). However, ubiquitously acquired drug resistance in…”
Get full text

Bioconjugated quantum dots for multiplexed and quantitative immunohistochemistry by Wang, May D, Nie, Shuming, Xing, Yun, Chaudry, Qaiser, Shen, Christopher, Kong, Koon Yin, Zhau, Haiyen E, Chung, Leland W, Petros, John A, O'Regan, Ruth M, Yezhelyev, Maksym V, Simons, Jonathan W

“…Bioconjugated quantum dots (QDs) provide a new class of biological labels for evaluating biomolecular signatures (biomarkers) on intact cells and tissue…”
Get full text

Combined cell surface carbonic anhydrase 9 and CD147 antigens enable high-efficiency capture of circulating tumor cells in clear cell renal cell carcinoma patients by Liu, Shijie, Tian, Zuhong, Zhang, Lei, Hou, Shuang, Hu, Sijun, Wu, Junshen, Jing, Yuming, Sun, Huimin, Yu, Fei, Zhao, Libo, Wang, Ruoxiang, Tseng, Hsian-Rong, Zhau, Haiyen E, Chung, Leland W K, Wu, Kaichun, Wang, Hao, Wu, Jason Boyang, Nie, Yongzhan, Shao, Chen

“…Circulating tumor cells (CTCs) have emerged as promising tools for noninvasive cancer detection and prognosis. Most conventional approaches for capturing CTCs…”
Get full text

Insulin-like Growth Factor-l-Dependent Up-regulation of ZEB1 Drives Epithelial-to-Mesenchymal Transition in Human Prostate Cancer Cells by GRAHAM, Tisheeka R, ZHAU, Haiyen E, ODERO-MARAH, Valerie A, OSUNKOYA, Adeboye O, KIMBRO, K. Sean, TIGHIOUART, Mourad, TONGRUI LIU, SIMONS, Jonathan W, O'REGAN, Ruth M

Get full text

β2-Microglobulin Induces Epithelial to Mesenchymal Transition and Confers Cancer Lethality and Bone Metastasis in Human Cancer Cells by JOSSON, Sajni, NOMURA, Takeo, LIN, Jen-Tai, HUANG, Wen-Chin, DAQING WU, ZHAU, Haiyen E, ZAYZAFOON, Majd, WEIZMANN, M. Neale, GURURAJAN, Murali, CHUNG, Leland W. K

“…Bone metastasis is one of the predominant causes of cancer lethality. This study demonstrates for the first time how β2-microglobulin (β2-M) supports lethal…”
Get full text

Multiplexed quantum dot labeling of activated c-Met signaling in castration-resistant human prostate cancer by Hu, Peizhen, Chu, Gina C-Y, Zhu, Guodong, Yang, Hua, Luthringer, Daniel, Prins, Gail, Habib, Fouad, Wang, Yuzhuo, Wang, Ruoxiang, Chung, Leland W K, Zhau, Haiyen E

“…The potential application of multiplexed quantum dot labeling (MQDL) for cancer detection and prognosis and monitoring therapeutic responses has attracted the…”
Get full text