Search Results - "Zhau, H E"

Stromal fibroblast-derived miR-409 promotes epithelial-to-mesenchymal transition and prostate tumorigenesis by Josson, S, Gururajan, M, Sung, S Y, Hu, P, Shao, C, Zhau, H E, Liu, C, Lichterman, J, Duan, P, Li, Q, Rogatko, A, Posadas, E M, Haga, C L, Chung, L W K

“…Tumor–stromal interaction is a dynamic process that promotes tumor growth and metastasis via cell–cell interaction and extracellular vesicles. Recent studies…”
Get full text

EPLIN downregulation promotes epithelial-mesenchymal transition in prostate cancer cells and correlates with clinical lymph node metastasis by Zhang, S, Wang, X, Osunkoya, A O, Iqbal, S, Wang, Y, Chen, Z, Müller, S, Chen, Z, Josson, S, Coleman, I M, Nelson, P S, Wang, Y A, Wang, R, Shin, D M, Marshall, F F, Kucuk, O, Chung, L W K, Zhau, H E, Wu, D

“…Epithelial–mesenchymal transition (EMT) is a crucial mechanism for the acquisition of migratory and invasive capabilities by epithelial cancer cells. By…”
Get full text

cAMP-responsive element-binding protein regulates vascular endothelial growth factor expression: implication in human prostate cancer bone metastasis by WU, D, ZHAU, H. E, HUANG, W.-C, IQBAL, S, HABIB, F. K, SARTOR, O, CVITANOVIC, L, MARSHALL, F. F, XU, Z, CHUNG, L. W. K

“…Aberrant expression of vascular endothelial growth factor (VEGF) is associated with human prostate cancer (PCa) metastasis and poor clinical outcome. We found…”
Get full text

Quantum dots-based multiplexed immunohistochemistry of protein expression in human prostate cancer cells by Shi, C, Zhou, G, Zhu, Y, Su, Y, Cheng, T, Zhau, H E, Chung, L W K

“…Semiconductor quantum dots (QDs) are bright fluorescent nanoparticles that have been successfully used for the detection of biomarker expression in cells. The…”
Get full text

Establishing human prostate cancer cell xenografts in bone: Induction of osteoblastic reaction by prostate‐specific antigen‐producing tumors in athymic and SCID/bg mice using LNCaP and lineage‐derived metastatic sublines by Wu, Tony T., Sikes, Robert A., Cui, Quanjun, Thalmann, George N., Kao, Chinghai, Murphy, Cheryl F., Yang, Hua, Zhau, Haiyen E., Balian, Gary, Chung, Leland W. K.

“…LNCaP lineage‐derived human prostate cancer cell lines C4‐2 and C4‐2B4 acquire androgen independence and osseous metastatic potential in vivo. Using C4‐2 and…”
Get full text

Androgen-independent cancer progression and bone metastasis in the LNCaP model for human prostate cancer by THALMANN, G. N, ANEZINIS, P. E, SHI-MING CHANG, ZHAU, H. E, KIM, E. E, HOPWOOD, V. L, PATHAK, S, VON ESCHENBACH, A. C, CHUNG, L. W. K

“…Our laboratory has previously reported on the derivation of LNCaP cell sublines from LNCaP tumors maintained in castrated and intact athymic male mice. These…”
Get full text

Establishment of human prostate carcinoma skeletal metastasis models by Zhau, Haiyen E., Li, Chang‐Ling, Chung, Leland W. K.

“…BACKGROUND Prostate carcinoma progression from an androgen dependent (AD) state to an androgen independent (AI) state occurs clinically in patients who undergo…”
Get full text

Fibroblast-Mediated Acceleration of Human Epithelial Tumor Growth In vivo by Camps, Joseph L., Chang, Shi-Ming, Hsu, T. C., Freeman, Michael R., Hong, Sung-Joon, Zhau, Haiyen E., von Eschenbach, Andrew C., Leland W. K. Chung

“…Transformed fibroblasts coinoculated with epithelial cells accelerated the growth and shortened the latency period of human epithelial tumors in athymic mice…”
Get full text

Genetic changes associated with the acquisition of androgen-independent growth, tumorigenicity and metastatic potential in a prostate cancer model by HYYTINEN, E.-R, THALMANN, G. N, ZHAU, H. E, KARHU, R, KALLIONIEMI, O.-P, CHUNG, L. W. K, VISAKORPI, T

“…Genetic changes underlying the progression of human prostate cancer are incompletely understood. Recently, an experimental model system that resembles human…”
Get full text

c-met proto-oncogene expression in benign and malignant human prostate tissues by Pisters, L L, Troncoso, P, Zhau, H E, Li, W, von Eschenbach, A C, Chung, L W

“…Previously, we demonstrated that hepatocyte growth factor/scatter factor (HGF/SF) is expressed by human bone stromal cells and is a powerful mitogen to…”
Get more information

A conditional replication-competent adenoviral vector, Ad-OC-E1a, to cotarget prostate cancer and bone stroma in an experimental model of androgen-independent prostate cancer bone metastasis by MATSUBARA, Shigeji, WADA, Yoshitaka, CHUNG, Leland W. K, GARDNER, Thomas A, EGAWA, Masayuki, PARK, Moon-Soo, HSIEH, Chia-Ling, ZHAU, Haiyen E, KAO, Chinghai, KAMIDONO, Sadao, GILLENWATER, Jay Y

“…Prostate cancer has a high propensity to metastasize to bone, which often resists hormone, radiation, and chemotherapies. Because of the reciprocal nature of…”
Get full text

Regulation of basal and luminal cell-specific cytokeratin expression in rat accessory sex organs. Evidence for a new class of androgen-repressed genes and insight into their pairwise control by Hsieh, J T, Zhau, H E, Wang, X H, Liew, C C, Chung, L W

“…Co-expression of cytokeratin (CK) pairs has been found to be associated with specific epithelial cell types whose expressions are developmentally regulated. In…”
Get full text

Co-inoculation of tumorigenic rat prostate mesenchymal cells with non-tumorigenic epithelial cells results in the development of carcinosarcoma in syngeneic and athymic animals by Chung, L W, Chang, S M, Bell, C, Zhau, H E, Ro, J Y, von Eschenbach, A C

“…Co-inoculation of NbF-I and NbE-I s.c. into either adult male syngeneic rats or athymic nude mice induced the development of tumors that resembled…”
Get more information

Epidermal growth factor receptor-mediated autocrine and paracrine stimulation of human transitional cell carcinoma by GLEAVE, M. E, JER-TSONG HSIEH, HSI-CHIN WU, SUNG-JOON HONG, ZHAU, H. E, GUTHRIE, P. D, CHUNG, L. W. K

“…Stromal-epithelial interactions may play a key role in tumor growth and metastasis. We have established a model to study the cellular and molecular basis of…”
Get full text

Biomarkers associated with prostate cancer progression by Zhau, H E, Pisters, L L, Hall, M C, Zhao, L S, Troncoso, P, Pollack, A, Chung, L W

“…In search of biomarkers that predict of human prostate cancer progression, we hypothesized that these markers must be expressed in prostatic epithelial cells…”
Get more information

A fetal rat urogenital sinus mesenchymal cell line (rUGM): accelerated growth and conferral of androgen-induced growth responsiveness upon a human bladder cancer epithelial cell line in vivo by Zhau, H E, Hong, S J, Chung, L W

“…A cell-cell interaction model was developed to examine the intercellular communication between mesenchymal and epithelial cells in vivo, and to define the role…”
Get more information

Androgen receptor mediates the reduced tumor growth, enhanced androgen responsiveness, and selected target gene transactivation in a human prostate cancer cell line by CINAR, Bekir, KOENEMAN, Kenneth S, EDLUND, Magnus, PRINS, Gail S, ZHAU, Haiyen E, CHUNG, Leland W. K

“…The growth and development of the prostate gland are regulated by the androgen and the androgen receptor (AR). Despite our molecular understanding of the roles…”
Get full text

Osteocalcin-directed gene therapy for prostate-cancer bone metastasis by Koeneman, K S, Kao, C, Ko, S C, Yang, L, Wada, Y, Kallmes, D F, Gillenwater, J Y, Zhau, H E, Chung, L W, Gardner, T A

“…Osteocalcin (OC) is a major noncollagenous bone protein whose expression is limited almost exclusively to osteotropic tumors and mature calcified tissue…”
Get full text

Reciprocal mesenchymal-epithelial interaction affecting prostate tumour growth and hormonal responsiveness by Chung, L W, Gleave, M E, Hsieh, J T, Hong, S J, Zhau, H E

“…A novel cell-cell recombination model was established to test the reciprocal mesenchymal (fibroblast)-epithelial interaction in the prostate gland. Both growth…”
Get more information

Molecular therapy with recombinant p53 adenovirus in an androgen-independent, metastatic human prostate cancer model by Ko, S C, Gotoh, A, Thalmann, G N, Zhau, H E, Johnston, D A, Zhang, W W, Kao, C, Chung, L W

“…The lethal phenotypes of advanced prostate cancer are androgen independent (AI) and metastatic to the axial skeleton. Our laboratory has developed an AI mouse…”
Get more information