Search Results - "Zharikova, D"

KRGP: Knowledge-Based Response Generation with Persona by Kosenko, D., Zharikova, D.

“…To create a personalized response, a generative model must take into account personal information about the user, question asked, and domain knowledge…”
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Accessible Russian Large Language Models: Open-Source Models and Instructive Datasets for Commercial Applications by Kosenko, D. P., Kuratov, Yu. M., Zharikova, D. R.

“…This paper presents an approach to developing and fine-tuning large language models for Russian language that are capable of following instructions across…”
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Quinol-Based Cyclic Antioxidant Mechanism in Estrogen Neuroprotection by Prokai, Laszlo, Prokai-Tatrai, Katalin, Perjesi, Pal, Zharikova, Alevtina D., Perez, Evelyn J., Liu, Ran, Simpkins, James W.

“…Substantial evidence now exists that intrinsic free-radical scavenging contributes to the receptor-independent neuroprotective effects of estrogens. This…”
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Plasmids encoding the mucosal chemokines CCL27 and CCL28 are effective adjuvants in eliciting antigen-specific immunity in vivo by Kutzler, M A, Kraynyak, K A, Nagle, S J, Parkinson, R M, Zharikova, D, Chattergoon, M, Maguire, H, Muthumani, K, Ugen, K, Weiner, D B

“…A hurdle facing DNA vaccine development is the ability to generate strong immune responses systemically and at local immune sites. We report a novel…”
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Cardiovascular effects of neuropeptide FF antagonists by Prokai, Laszlo, Zharikova, Alevtina D., Juhasz, Attila, Prokai-Tatrai, Katalin

“…The neuropeptide FF (NPFF) antagonist desaminotyrosyl-Phe-Leu-Phe-Gln-Pro-Gln-Arg-NH 2 dose-dependently reversed NPFF-induced elevation of blood pressure in…”
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Effect of chronic morphine exposure on the synaptic plasma-membrane subproteome of rats: a quantitative protein profiling study based on isotope-coded affinity tags and liquid chromatography/mass spectrometry by Prokai, Laszlo, Zharikova, Alevtina D., Stevens Jr, Stanley M.

“…The effect of chronic morphine exposure on the synaptic plasma‐membrane subproteome in rats was studied by the isotope‐coded affinity tag (ICAT) method coupled…”
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QUINOL-BASED METABOLIC CYCLE FOR ESTROGENS IN RAT LIVER MICROSOMES by PROKAI, Laszlo, PROKAI-TATRAI, Katalin, PERJESI, Pal, ZHARIKOVA, Alevtina D, SIMPKINS, James W

“…According to a recently reported metabolic pathway, phenolic A-ring estrogens are metabolized in rat liver microsomes partially to the corresponding quinols by…”
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Centrally Acting and Metabolically Stable Thyrotropin-Releasing Hormone Analogues by Replacement of Histidine with Substituted Pyridinium by Prokai, Laszlo, Prokai-Tatrai, Katalin, Zharikova, Alevtina D, Nguyen, Vien, Perjesi, Pal, Stevens, Stanley M

“…Metabolically stable and centrally acting thyrotropin-releasing hormone (TRH) analogues were designed by replacing the central histidine with substituted…”
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Neuropharmacodynamic evaluation of the centrally active thyrotropin-releasing hormone analogue [Leu 2]TRH and its chemical brain-targeting system by Prokai, Laszlo, Zharikova, Alevtina D

“…The centrally active thyrotropin-releasing hormone (TRH) analogue pGlu–Leu–Pro–NH 2 ([Leu 2]TRH) showed a significant increase in the extracellular…”
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Design, synthesis, and biological evaluation of novel, centrally-Acting thyrotropin-Releasing hormone analogues by Prokai-Tatrai, Katalin, Perjési, Pál, Zharikova, Alevtina D, Li, Xiaoxu, Prokai, Laszlo

“…Novel, metabolically stable and centrally acting TRH analogues with substituted pyridinium moieties replacing the [His 2] residue of the endogenous peptide…”
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A pyridinium-substituted analog of the TRH-like tripeptide pGlu-Glu-Pro-NH2 and its prodrugs as central nervous system agents by Prokai-Tatrai, K, Teixido, M, Nguyen, V, Zharikova, A D, Prokai, L

“…A metabolically stable and centrally acting analog of pGlu-Glu-Pro-NH2 ([Glu2]TRH, a tripeptide structurally related to TRH (thyrotropin-releasing hormone))…”
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Proteomic analysis of the synaptic plasma membrane fraction isolated from rat forebrain by Stevens, Stanley M, Zharikova, Alevtina D, Prokai, Laszlo

“…Mass spectrometry (MS) in conjunction with liquid chromatography and gel separation techniques has been utilized to identify synaptic plasma membrane (SPM)…”
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Prodrugs to enhance central nervous system effects of the TRH-like peptide pGlu-Glu-Pro-NH2 by PROKAI-TATRAI, Katalin, NGUYEN, Vien, ZHARIKOVA, Alevtina D, BRADDY, April C, STEVENS, Stanley M, PROKAI, Laszlo

“…Potential prodrugs for the TRH-like tripeptide pGlu-Glu-Pro-NH(2) were synthesized either by esterifying the Glu side-chain of the parent peptide in solution…”
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[Glu2 ]TRH dose-dependently attenuates TRH-evoked analeptic effect in mice by Nguyen, Vien, Zharikova, Alevtina D, Prokai-Tatrai, Katalin, Prokai, Laszlo

“…Abstract Thyrotropin-releasing hormone (TRH, pGlu-His-Pro-NH2 ) and the structurally related [Glu2 ]TRH (pGlu-Glu-Pro-NH2 ) are endogenous peptides with a…”
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Evidence for interplay between thyrotropin-releasing hormone (TRH) and its structural analogue pGlu-Glu-Pro-NH2 ([Glu2]TRH) in the brain : An in vivo microdialysis study by NGUYEN, Vien, ZHARIKOVA, Alevtina D, PROKAI, Laszlo

“…Local perfusion of pGlu-Glu-Pro-NH2, an endogenous peptide structurally related to thyrotropine-releasing hormone (TRH), via in vivo microdialysis into the rat…”
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Determination of clodronate content in liposomal formulation by capillary zone electrophoresis by Perjési, Pál, Kim, Taewook, Zharikova, Alevtina D., Li, Xiaoxu, Ramesh, Tennore, Ramasubbu, Jeyanthi, Prokai, Laszlo

“…Liposome-mediated intracellular delivery of clodronate is reported to selectively deplete mononuclear phagocytic cells such as macrophages that are important…”
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Membrane lipids and morphology of brain cortex synaptosomes isolated from hibernating Yakutian ground squirrel by Kolomiytseva, Iskra K., Perepelkina, Natalia I., Zharikova, Alevtina D., Popov, Victor I.

“…Synaptosomes were isolated from Yakutian ground squirrel brain cortex of summer and winter hibernating animals in active and torpor states. Synaptosomal…”
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Prospects for universal influenza virus vaccine by Gerhard, Walter, Mozdzanowska, Krystyna, Zharikova, Darya

“…The current vaccination strategy against influenza A and B viruses is vulnerable to the unanticipated emergence of epidemic strains that are poorly matched by…”
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Exploratory pharmacokinetics and brain distribution study of a neuropeptide FF antagonist by liquid chromatography/atmospheric pressure ionization tandem mass spectrometry by Prokai, Laszlo, Zharikova, Alevtina D., Janáky§, Tamás, Prokai-Tatrai, Katalin

“…Dansyl‐Pro‐Gln‐Arg‐NH2, an N‐terminally modified tripeptide amide and a putative neuropeptide FF antagonist, was amenable to both positive‐ion ESI and APCI…”
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Protein phosphorylation of synaptic membranes isolated from the brain of ground squirrels during hibernation by Shchipakina, T G, Zharikova, A D, Arkhipov, V I

“…In vitro protein phosphorylation of synaptic membranes isolated from neocortex and hippocampus of ground squirrels was studied. Three functional states of…”
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