Search Results - "Zhao, Yuguang"

Krϋppel-like factors (KLFs) in renal physiology and disease by Rane, Madhavi J., Zhao, Yuguang, Cai, Lu

“…Dysregulated Krϋppel-like factor (KLF) gene expression appears in many disease-associated pathologies. In this review, we discuss physiological functions of…”
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Target Identification and Mode of Action of Four Chemically Divergent Drugs against Ebolavirus Infection by Ren, Jingshan, Zhao, Yuguang, Fry, Elizabeth E, Stuart, David I

“…Here, we show that four chemically divergent approved drugs reported to inhibit Ebolavirus infection, benztropine, bepridil, paroxetine and sertraline,…”
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Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike by Huo, Jiandong, Zhao, Yuguang, Ren, Jingshan, Zhou, Daming, Duyvesteyn, Helen M.E., Ginn, Helen M., Carrique, Loic, Malinauskas, Tomas, Ruza, Reinis R., Shah, Pranav N.M., Tan, Tiong Kit, Rijal, Pramila, Coombes, Naomi, Bewley, Kevin R., Tree, Julia A., Radecke, Julika, Paterson, Neil G., Supasa, Piyada, Mongkolsapaya, Juthathip, Screaton, Gavin R., Carroll, Miles, Townsend, Alain, Fry, Elizabeth E., Owens, Raymond J., Stuart, David I.

“…There are as yet no licensed therapeutics for the COVID-19 pandemic. The causal coronavirus (SARS-CoV-2) binds host cells via a trimeric spike whose receptor…”
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Resveratrol attenuates testicular apoptosis in type 1 diabetic mice: Role of Akt-mediated Nrf2 activation and p62-dependent Keap1 degradation by Zhao, Yuguang, Song, Wenjing, Wang, Zhenyu, Wang, Zongqiang, Jin, Xing, Xu, Jiancheng, Bai, Ling, Li, Yuying, Cui, Jiuwei, Cai, Lu

“…Infertility is a common complication in diabetic men, mainly due to the loss of germ cells by apoptotic cell death. However, effective and safe approaches to…”
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Rapid grain refinement of 2024 Al alloy through recrystallization induced by electropulsing by Xu, Xiaofeng, Zhao, Yuguang, Ma, Bingdong, Zhang, Jiatao, Zhang, Ming

“…The hot rolled 2024 Al alloy subjected to electropulsing was investigated in this study. The results show that the electropulsing treated sample with optimized…”
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In Situ Observation of the Degradation Behavior and the Systematic Investigation of Corrosion Mechanism in AZ31 Alloy by Yan, Xudong, Chen, Lanyue, Xu, Xiaofeng, Zhao, Yuguang, Zhao, Mingchun

“…The degradation behaviors of as‐received and as‐solutionized AZ31 alloys in Hanks’ solution are in situ studied by a 3D digital optical microscope. The…”
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Hormetic Response to Low-Dose Radiation: Focus on the Immune System and Its Clinical Implications by Cui, Jiuwei, Yang, Guozi, Pan, Zhenyu, Zhao, Yuguang, Liang, Xinyue, Li, Wei, Cai, Lu

“…The interrelationship between ionizing radiation and the immune system is complex, multifactorial, and dependent on radiation dose/quality and immune cell…”
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Neutralization potency of monoclonal antibodies recognizing dominant and subdominant epitopes on SARS-CoV-2 Spike is impacted by the B.1.1.7 variant by Graham, Carl, Seow, Jeffrey, Huettner, Isabella, Khan, Hataf, Kouphou, Neophytos, Acors, Sam, Winstone, Helena, Pickering, Suzanne, Galao, Rui Pedro, Dupont, Liane, Lista, Maria Jose, Jimenez-Guardeño, Jose M., Laing, Adam G., Wu, Yin, Joseph, Magdalene, Muir, Luke, van Gils, Marit J., Ng, Weng M., Duyvesteyn, Helen M.E., Zhao, Yuguang, Bowden, Thomas A., Shankar-Hari, Manu, Rosa, Annachiara, Cherepanov, Peter, McCoy, Laura E., Hayday, Adrian C., Neil, Stuart J.D., Malim, Michael H., Doores, Katie J.

“…Interaction of the SARS-CoV-2 Spike receptor binding domain (RBD) with the receptor ACE2 on host cells is essential for viral entry. RBD is the dominant target…”
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Atomic-resolution monitoring of protein maturation in live human cells by NMR by Banci, Lucia, Barbieri, Letizia, Bertini, Ivano, Luchinat, Enrico, Secci, Erica, Zhao, Yuguang, Aricescu, A Radu

“…Analysis of proteins within their native environment can confirm and extend in vitro –derived conclusions. NMR analysis of superoxide dismutase 1 in live human…”
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Firing up “cold” tumors: Ferroptosis causes immune activation by improving T cell infiltration by Li, Xinru, Li, Yawen, Tuerxun, Halahati, Zhao, Yixin, Liu, Xingyu, Zhao, Yuguang

“…Immune checkpoint blocking (ICB), a tumor treatment based on the mechanism of T-cell activation, has shown high efficacy in clinical trials, but not all…”
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A novel strengthening and toughening strategy for T250 maraging steel: Cluster-orientation governed higher strength-ductility combination induced by electropulsing by Pan, Dong, Zhao, Yuguang, Xu, Xiaofeng, Wang, Yitong, Jiang, Wenqiang, Chong, Xueying

“…T250 steel is promising maraging steel for the development of ultrahigh strength structural materials due to the reduced cost of losing Co element. Whereas,…”
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2-D Terahertz Metallic Photonic Crystals in Parallel-Plate Waveguides by Yuguang Zhao, Grischkowsky, D.R.

“…2-D metallic photonic crystals without defects, with point defects, and with a Fabry-Perot (F-P) defect are characterized by terahertz time-domain…”
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Strengthening and Toughening of ZG25SiMn2CrB Steel without Tempering Brittleness via Electropulsing Treatment by Zhao, Yang, Cui, Xinwei, Zhao, Yuguang, Zhang, Zhihui, Shi, Lijun, Zhang, Baoyu, Ren, Luquan

“…High-strength low-alloy steels are widely used, but their traditional heat-treatment process is complex, energy-intensive, and makes it difficult to fully…”
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Rapid precipitation of T-phase in the 2024 aluminum alloy via cyclic electropulsing treatment by Xu, Xiaofeng, Zhao, Yuguang, Ma, Bingdong, Zhang, Ming

“…The effect of cyclic electropulsing treatment on the microstructure, conductivity and mechanical properties of 2024 Al alloy was investigated in this study…”
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The antibody response to SARS-CoV-2 Beta underscores the antigenic distance to other variants by Liu, Chang, Zhou, Daming, Nutalai, Rungtiwa, Duyvesteyn, Helen M.E., Tuekprakhon, Aekkachai, Ginn, Helen M., Dejnirattisai, Wanwisa, Supasa, Piyada, Mentzer, Alexander J., Wang, Beibei, Case, James Brett, Zhao, Yuguang, Skelly, Donal T., Chen, Rita E., Johnson, Sile Ann, Ritter, Thomas G., Mason, Chris, Malik, Tariq, Temperton, Nigel, Paterson, Neil G., Williams, Mark A., Hall, David R., Clare, Daniel K., Howe, Andrew, Goulder, Philip J.R., Fry, Elizabeth E., Diamond, Michael S., Mongkolsapaya, Juthathip, Ren, Jingshan, Stuart, David I., Screaton, Gavin R.

“…Alpha-B.1.1.7, Beta-B.1.351, Gamma-P.1, and Delta-B.1.617.2 variants of SARS-CoV-2 express multiple mutations in the spike protein (S). These may alter the…”
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Circ0007042 alleviates intervertebral disc degeneration by adsorbing miR-369 to upregulate BMP2 and activate the PI3K/AKt pathway by Wang, Zhenyu, Zhao, Yuguang, Liu, Yi, Qu, Zhigang, Zhuang, Xinming, Song, Qingxu, Li, Haoyu, Leng, Jiali

“…Abstract Background To identify regulatory ncRNA molecules that can cause differential expression of CDH2 in intervertebral disc degeneration (IDD) and explore…”
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Structure-Based in Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library by Shaikh, Faraz, Zhao, Yuguang, Alvarez, Luis, Iliopoulou, Maria, Lohans, Christopher, Schofield, Christopher J, Padilla-Parra, Sergi, Siu, Shirley W. I, Fry, Elizabeth E, Ren, Jingshan, Stuart, David I

“…Potent Ebolavirus (EBOV) inhibitors will help to curtail outbreaks such as that which occurred in 2014–16 in West Africa. EBOV has on its surface a single…”
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Hand-foot-and-mouth disease virus receptor KREMEN1 binds the canyon of Coxsackie Virus A10 by Zhao, Yuguang, Zhou, Daming, Ni, Tao, Karia, Dimple, Kotecha, Abhay, Wang, Xiangxi, Rao, Zihe, Jones, E. Yvonne, Fry, Elizabeth E., Ren, Jingshan, Stuart, David I.

“…Coxsackievirus A10 (CV-A10) is responsible for an escalating number of severe infections in children, but no prophylactics or therapeutics are currently…”
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Picornavirus uncoating intermediate captured in atomic detail by Ren, Jingshan, Wang, Xiangxi, Hu, Zhongyu, Gao, Qiang, Sun, Yao, Li, Xuemei, Porta, Claudine, Walter, Thomas S., Gilbert, Robert J., Zhao, Yuguang, Axford, Danny, Williams, Mark, McAuley, Katherine, Rowlands, David J., Yin, Weidong, Wang, Junzhi, Stuart, David I., Rao, Zihe, Fry, Elizabeth E.

“…It remains largely mysterious how the genomes of non-enveloped eukaryotic viruses are transferred across a membrane into the host cell. Picornaviruses are…”
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Exacerbation of diabetes-induced testicular apoptosis by zinc deficiency is most likely associated with oxidative stress, p38 MAPK activation, and p53 activation in mice by Zhao, Yuguang, Tan, Yi, Dai, Junying, Li, Bing, Guo, Luping, Cui, Jiuwei, Wang, Guanjun, Shi, Xue, Zhang, Xiang, Mellen, Nicholas, Li, Wei, Cai, Lu

“…Since diabetes induces testicular oxidative damage and cell death, and zinc (Zn) plays an important role in the spermatogenesis, the objective of the present…”
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