Search Results - "Zhao, Yan G."

Phase Separation in Membrane Biology: The Interplay between Membrane-Bound Organelles and Membraneless Condensates by Zhao, Yan G., Zhang, Hong

“…In eukaryotic cells, various membrane-bound organelles compartmentalize diverse cellular activities in a spatially and temporally controlled manner. Numerous…”
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Machinery, regulation and pathophysiological implications of autophagosome maturation by Zhao, Yan G., Codogno, Patrice, Zhang, Hong

“…Autophagy is a versatile degradation system for maintaining cellular homeostasis whereby cytosolic materials are sequestered in a double-membrane autophagosome…”
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Autophagosome maturation: An epic journey from the ER to lysosomes by Zhao, Yan G, Zhang, Hong

“…Macroautophagy involves the sequestration of cytoplasmic contents in a double-membrane autophagosome and their delivery to lysosomes for degradation. In…”
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Formation and maturation of autophagosomes in higher eukaryotes: a social network by Zhao, Yan G, Zhang, Hong

“…Autophagy, a self-eating process conserved from yeast to mammals, is critical for maintaining cell homeostasis. It involves the formation of a double-membrane…”
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Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice by Liu, Pengpeng, Liang, Shun-Qing, Zheng, Chunwei, Mintzer, Esther, Zhao, Yan G., Ponnienselvan, Karthikeyan, Mir, Aamir, Sontheimer, Erik J., Gao, Guangping, Flotte, Terence R., Wolfe, Scot A., Xue, Wen

“…Prime editors (PEs) mediate genome modification without utilizing double-stranded DNA breaks or exogenous donor DNA as a template. PEs facilitate nucleotide…”
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The ER-Localized Transmembrane Protein EPG-3/VMP1 Regulates SERCA Activity to Control ER-Isolation Membrane Contacts for Autophagosome Formation by Zhao, Yan G., Chen, Yong, Miao, Guangyan, Zhao, Hongyu, Qu, Wenyan, Li, Dongfang, Wang, Zheng, Liu, Nan, Li, Lin, Chen, She, Liu, Pingsheng, Feng, Du, Zhang, Hong

“…During autophagosome formation in mammalian cells, isolation membranes (IMs; autophagosome precursors) dynamically contact the ER. Here, we demonstrated that…”
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Role of Wdr45b in maintaining neural autophagy and cognitive function by Ji, Cuicui, Zhao, Hongyu, Li, Dongfang, Sun, Huayu, Hao, Junfeng, Chen, Ruiguo, Wang, Xiaoqun, Zhang, Hong, Zhao, Yan G

“…Macroautophagy/autophagy functions as a quality control mechanism by degrading misfolded proteins and damaged organelles and plays an essential role in…”
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The ER-Localized Protein DFCP1 Modulates ER-Lipid Droplet Contact Formation by Li, Dongfang, Zhao, Yan G., Li, Di, Zhao, Hongyu, Huang, Jie, Miao, Guangyan, Feng, Du, Liu, Pingsheng, Li, Dong, Zhang, Hong

“…Very little is known about the spatiotemporal generation of lipid droplets (LDs) from the endoplasmic reticulum (ER) and the factors that mediate ER-LD…”
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Vmp1, Vps13D, and Marf/Mfn2 function in a conserved pathway to regulate mitochondria and ER contact in development and disease by Shen, James L., Fortier, Tina M., Zhao, Yan G., Wang, Ruoxi, Burmeister, Margit, Baehrecke, Eric H.

“…Mutations in Vps13D cause defects in autophagy, clearance of mitochondria, and human movement disorders. Here, we discover that Vps13D functions in a pathway…”
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A switch from canonical to noncanonical autophagy shapes B cell responses by Martinez-Martin, Nuria, Maldonado, Paula, Gasparrini, Francesca, Frederico, Bruno, Aggarwal, Shweta, Gaya, Mauro, Tsui, Carlson, Burbage, Marianne, Keppler, Selina Jessica, Montaner, Beatriz, Jefferies, Harold B. J., Nair, Usha, Zhao, Yan G., Domart, Marie-Charlotte, Collinson, Lucy, Bruckbauer, Andreas, Tooze, Sharon A., Batista, Facundo D.

“…Autophagy is important in a variety of cellular and pathophysiological situations; however, its role in immune responses remains elusive. Here, we show that…”
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A critical role of VMP1 in lipoprotein secretion by Morishita, Hideaki, Zhao, Yan G, Tamura, Norito, Nishimura, Taki, Kanda, Yuki, Sakamaki, Yuriko, Okazaki, Mitsuyo, Li, Dongfang, Mizushima, Noboru

“…Lipoproteins are lipid-protein complexes that are primarily generated and secreted from the intestine, liver, and visceral endoderm and delivered to peripheral…”
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The Incredible ULKs: Autophagy and Beyond by Zhao, Yan G., Zhang, Hong

“…Atg1 integrates nutrient status and autophagy. In this issue, Joo et al. (2016) reveal that the mammalian Atg1 homologs ULK1/2 are dispensable for neuronal…”
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Mice deficient in Epg5 exhibit selective neuronal vulnerability to degeneration by Zhao, Hongyu, Zhao, Yan G, Wang, Xingwei, Xu, Lanjun, Miao, Lin, Feng, Du, Chen, Quan, Kovács, Attila L, Fan, Dongsheng, Zhang, Hong

“…The molecular mechanism underlying the selective vulnerability of certain neuronal populations associated with neurodegenerative diseases remains poorly…”
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Endomembrane remodeling in SARS-CoV-2 infection by Chen, Di, Zhao, Yan G., Zhang, Hong

“…During severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, the viral proteins intimately interact with host factors to remodel the…”
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The p53-induced Gene Ei24 Is an Essential Component of the Basal Autophagy Pathway by Zhao, Yan G., Zhao, Hongyu, Miao, Lin, Wang, Li, Sun, Fei, Zhang, Hong

“…Ei24 is a DNA damage response gene involved in growth suppression and apoptosis. The physiological function of Ei24, however, is poorly understood. Here we…”
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Mice deficient in the Vici syndrome gene Epg5 exhibit features of retinitis pigmentosa by Miao, Guangyan, Zhao, Yan G, Zhao, Hongyu, Ji, Cuicui, Sun, Huayu, Chen, Yingyu, Zhang, Hong

“…Autophagy helps to maintain cellular homeostasis by removing misfolded proteins and damaged organelles, and generally acts as a cytoprotective mechanism for…”
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The Nobel Prize： an appetizer before the feast by Zhao, Yan G., Zhang, Hong

“…Autophagy, which means ＂self-eating＂, is a process in which a portion of the cytosol is enclosed in a double-membrane autophagosome and delivered to the…”
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Core autophagy genes and human diseases by Zhao, Yan G, Zhang, Hong

“…Autophagy involves the formation of double-membrane autophagosomes and their delivery to lysosomes for degradation. In response to various endogenous and…”
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The ER Contact Proteins VAPA/B Interact with Multiple Autophagy Proteins to Modulate Autophagosome Biogenesis by Zhao, Yan G., Liu, Nan, Miao, Guangyan, Chen, Yong, Zhao, Hongyu, Zhang, Hong

“…The endoplasmic reticulum (ER) is the site of biogenesis of the isolation membrane (IM, autophagosome precursor) and forms extensive contacts with IMs during…”
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β-propeller proteins WDR45 and WDR45B regulate autophagosome maturation into autolysosomes in neural cells by Ji, Cuicui, Zhao, Hongyu, Chen, Di, Zhang, Hong, Zhao, Yan G.

“…Mutations in WDR45 and WDR45B cause the human neurological diseases β-propeller protein-associated neurodegeneration (BPAN) and intellectual disability (ID),…”
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