Search Results - "Zhao, Sihai D"

Comprehensive Genomic Characterization of Long Non-coding RNAs across Human Cancers by Yan, Xiaohui, Hu, Zhongyi, Feng, Yi, Hu, Xiaowen, Yuan, Jiao, Zhao, Sihai D., Zhang, Youyou, Yang, Lu, Shan, Weiwei, He, Qun, Fan, Lingling, Kandalaft, Lana E., Tanyi, Janos L., Li, Chunsheng, Yuan, Chao-Xing, Zhang, Dongmei, Yuan, Huiqing, Hua, Keqin, Lu, Yiling, Katsaros, Dionyssios, Huang, Qihong, Montone, Kathleen, Fan, Yi, Coukos, George, Boyd, Jeff, Sood, Anil K., Rebbeck, Timothy, Mills, Gordon B., Dang, Chi V., Zhang, Lin

“…The discovery of long non-coding RNA (lncRNA) has dramatically altered our understanding of cancer. Here, we describe a comprehensive analysis of lncRNA…”
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A Functional Genomic Approach Identifies FAL1 as an Oncogenic Long Noncoding RNA that Associates with BMI1 and Represses p21 Expression in Cancer by Hu, Xiaowen, Feng, Yi, Zhang, Dongmei, Zhao, Sihai D., Hu, Zhongyi, Greshock, Joel, Zhang, Youyou, Yang, Lu, Zhong, Xiaomin, Wang, Li-Ping, Jean, Stephanie, Li, Chunsheng, Huang, Qihong, Katsaros, Dionyssios, Montone, Kathleen T., Tanyi, Janos L., Lu, Yiling, Boyd, Jeff, Nathanson, Katherine L., Li, Hongzhe, Mills, Gordon B., Zhang, Lin

“…In a genome-wide survey on somatic copy-number alterations (SCNAs) of long noncoding RNA (lncRNA) in 2,394 tumor specimens from 12 cancer types, we found that…”
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Integrated Analysis of Genetic Ancestry and Genomic Alterations across Cancers by Yuan, Jiao, Hu, Zhongyi, Mahal, Brandon A., Zhao, Sihai D., Kensler, Kevin H., Pi, Jingjiang, Hu, Xiaowen, Zhang, Youyou, Wang, Yueying, Jiang, Junjie, Li, Chunsheng, Zhong, Xiaomin, Montone, Kathleen T., Guan, Guoqiang, Tanyi, Janos L., Fan, Yi, Xu, Xiaowei, Morgan, Mark A., Long, Meixiao, Zhang, Yuzhen, Zhang, Rugang, Sood, Anil K., Rebbeck, Timothy R., Dang, Chi V., Zhang, Lin

“…Disparities in cancer care have been a long-standing challenge. We estimated the genetic ancestry of The Cancer Genome Atlas patients, and performed a…”
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Deep evolutionary conservation of autism-related genes by Shpigler, Hagai Y., Saul, Michael C., Corona, Frida, Block, Lindsey, Ahmed, Amy Cash, Zhao, Sihai D., Robinson, Gene E.

“…E. O. Wilson proposed in Sociobiology that similarities between human and animal societies reflect common mechanistic and evolutionary roots. When introduced…”
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Bayesian Machine Learning Enables Identification of Transcriptional Network Disruptions Associated with Drug-Resistant Prostate Cancer by Blatti, Charles, de la Fuente, Jesús, Gao, Huanyao, Marín-Goñi, Irene, Chen, Zikun, Zhao, Sihai D, Tan, Winston, Weinshilboum, Richard, Kalari, Krishna R, Wang, Liewei, Hernaez, Mikel

“…Survival rates of patients with metastatic castration-resistant prostate cancer (mCRPC) are low due to lack of response or acquired resistance to available…”
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Power of testing for exposure effects under incomplete mediation by Zhou, Ruixuan R, Zucker, David M, Zhao, Sihai D

“…Mediation analysis studies situations where an exposure may affect an outcome both directly and indirectly through intervening variables called mediators. It…”
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High-dimensional classification via nonparametric empirical Bayes and maximum likelihood inference by DICKER, LEE H., ZHAO, SIHAI D.

“…We propose new nonparametric empirical Bayes methods for high-dimensional classification. Our classifiers are designed to approximate the Bayes classifier in a…”
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More powerful genetic association testing via a new statistical framework for integrative genomics by Zhao, Sihai D, Cai, T. Tony, Li, Hongzhe

“…Integrative genomics offers a promising approach to more powerful genetic association studies. The hope is that combining outcome and genotype data with other…”
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Cross‐species systems analysis of evolutionary toolkits of neurogenomic response to social challenge by Saul, Michael C., Blatti, Charles, Yang, Wei, Bukhari, Syed A., Shpigler, Hagai Y., Troy, Joseph M., Seward, Christopher H., Sloofman, Laura, Chandrasekaran, Sriram, Bell, Alison M., Stubbs, Lisa, Robinson, Gene E., Zhao, Sihai D., Sinha, Saurabh

“…Social challenges like territorial intrusions evoke behavioral responses in widely diverging species. Recent work has showed that evolutionary “toolkits”—genes…”
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Genetic Reduction in Left Ventricular Protein Kinase C-α and Adverse Ventricular Remodeling in Human Subjects by Hu, Ray, Morley, Michael P, Brandimarto, Jeffrey, Tucker, Nathan R, Parsons, Victoria A, Zhao, Sihai D, Meder, Benjamin, Katus, Hugo A, Rühle, Frank, Stoll, Monika, Villard, Eric, Cambien, François, Lin, Honghuang, Smith, Nicholas L, Felix, Janine F, Vasan, Ramachandran S, van der Harst, Pim, Newton-Cheh, Christopher, Li, Jin, Kim, Cecilia E, Hakonarson, Hakon, Hannenhalli, Sridhar, Ashley, Euan A, Moravec, Christine S, Tang, W H Wilson, Maillet, Marjorie, Molkentin, Jeffery D, Ellinor, Patrick T, Margulies, Kenneth B, Cappola, Thomas P

“…Inhibition of PKC-α (protein kinase C-α) enhances contractility and cardioprotection in animal models, but effects in humans are unknown. Genotypes at…”
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Neck Dissection After Chemoradiotherapy: Timing and Complications by Goguen, Laura A, Chapuy, Claudia I, Li, Yi, Zhao, Sihai D, Annino, Donald J

“…OBJECTIVES To determine the incidence of postchemoradiotherapy (post-CRT) neck dissection (ND) complications; to ascertain whether timing (<12 vs ≥12 weeks)…”
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Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases by Li, Yun R, Li, Jin, Zhao, Sihai D, Bradfield, Jonathan P, Mentch, Frank D, Maggadottir, S Melkorka, Hou, Cuiping, Abrams, Debra J, Chang, Diana, Gao, Feng, Guo, Yiran, Wei, Zhi, Connolly, John J, Cardinale, Christopher J, Bakay, Marina, Glessner, Joseph T, Li, Dong, Kao, Charlly, Thomas, Kelly A, Qiu, Haijun, Chiavacci, Rosetta M, Kim, Cecilia E, Wang, Fengxiang, Snyder, James, Richie, Marylyn D, Flatø, Berit, Førre, Øystein, Denson, Lee A, Thompson, Susan D, Becker, Mara L, Guthery, Stephen L, Latiano, Anna, Perez, Elena, Resnick, Elena, Russell, Richard K, Wilson, David C, Silverberg, Mark S, Annese, Vito, Lie, Benedicte A, Punaro, Marilynn, Dubinsky, Marla C, Monos, Dimitri S, Strisciuglio, Caterina, Staiano, Annamaria, Miele, Erasmo, Kugathasan, Subra, Ellis, Justine A, Munro, Jane E, Sullivan, Kathleen E, Wise, Carol A, Chapel, Helen, Cunningham-Rundles, Charlotte, Grant, Struan F A, Orange, Jordan S, Sleiman, Patrick M A, Behrens, Edward M, Griffiths, Anne M, Satsangi, Jack, Finkel, Terri H, Keinan, Alon, Prak, Eline T Luning, Polychronakos, Constantin, Baldassano, Robert N, Li, Hongzhe, Keating, Brendan J, Hakonarson, Hakon

“…A meta-analysis across ten pediatric autoimmune diseases reveals shared genetic architecture and novel susceptibility loci. Genome-wide association studies…”
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Genetic sharing and heritability of paediatric age of onset autoimmune diseases by Li, Yun R., Zhao, Sihai D., Li, Jin, Bradfield, Jonathan P., Mohebnasab, Maede, Steel, Laura, Kobie, Julie, Abrams, Debra J., Mentch, Frank D., Glessner, Joseph T., Guo, Yiran, Wei, Zhi, Connolly, John J., Cardinale, Christopher J., Bakay, Marina, Li, Dong, Maggadottir, S. Melkorka, Thomas, Kelly A., Qui, Haijun, Chiavacci, Rosetta M., Kim, Cecilia E., Wang, Fengxiang, Snyder, James, Flatø, Berit, Førre, Øystein, Denson, Lee A., Thompson, Susan D., Becker, Mara L., Guthery, Stephen L., Latiano, Anna, Perez, Elena, Resnick, Elena, Strisciuglio, Caterina, Staiano, Annamaria, Miele, Erasmo, Silverberg, Mark S., Lie, Benedicte A., Punaro, Marilynn, Russell, Richard K., Wilson, David C., Dubinsky, Marla C., Monos, Dimitri S., Annese, Vito, Munro, Jane E., Wise, Carol, Chapel, Helen, Cunningham-Rundles, Charlotte, Orange, Jordan S., Behrens, Edward M., Sullivan, Kathleen E., Kugathasan, Subra, Griffiths, Anne M., Satsangi, Jack, Grant, Struan F. A., Sleiman, Patrick M. A., Finkel, Terri H., Polychronakos, Constantin, Baldassano, Robert N., Luning Prak, Eline T., Ellis, Justine A., Li, Hongzhe, Keating, Brendan J., Hakonarson, Hakon

“…Autoimmune diseases (AIDs) are polygenic diseases affecting 7–10% of the population in the Western Hemisphere with few effective therapies. Here, we quantify…”
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A Functional genomic approach identifies FAL1 as an oncogenic long noncoding RNA that associates with BMI1 and represses p21 expression in human cancer by Hu, Xiaowen, Feng, Yi, Zhang, Dongmei, Zhao, Sihai D, Hu, Zhongyi, Greshock, Joel, Zhang, Youyou, Yang, Lu, Zhong, Xiaomin, Wang, Li-Ping, Jean, Stephanie, Li, Chunsheng, Huang, Qihong, Katsaros, Dionyssios, Montone, Kathleen T., Tanyi, Janos L., Lu, Yiling, Boyd, Jeff, Nathanson, Katherine L., Li, Hongzhe, Mills, Gordon B., Zhang, Lin

“…In a genome-wide survey on somatic copy number alterations (SCNAs) of long non-coding RNA (lncRNA) in 2,394 tumor specimens from 12 cancer types, we found that…”
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Capturing patterns of variation unique to a specific dataset by Tu, Robin, Foss, Alexander H, Zhao, Sihai D

“…Capturing patterns of variation present in a dataset is important in exploratory data analysis and unsupervised learning. Contrastive dimension reduction…”
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Nonparametric empirical Bayes and maximum likelihood estimation for high-dimensional data analysis by Dicker, Lee H, Zhao, Sihai D

“…Nonparametric empirical Bayes methods provide a flexible and attractive approach to high-dimensional data analysis. One particularly elegant empirical Bayes…”
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Sure screening for estimating equations in ultra-high dimensions by Zhao, Sihai D, Li, Yi

“…As the number of possible predictors generated by high-throughput experiments continues to increase, methods are needed to quickly screen out unimportant…”
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Mechanisms and efficacy of metformin-mediated suppression of established experimental abdominal aortic aneurysms by Xu, Baohui, Li, Gang, Li, Yankui, Deng, Hongping, Cabot, Anna, Guo, Jia, Samura, Makoto, Zheng, Xiaoya, Chen, Tiffany, Zhao, Sihai, Fujimura, Naoki, Dalman, Ronald L.

“…Metformin treatment attenuates experimental abdominal aortic aneurysm (AAA) formation, as well as reduces clinical AAA diameter enlargement in patients with…”
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