Cyclodextrin solubilization of the antibacterial agents triclosan and triclocarban: Formation of aggregates and higher-order complexes

It is well known that water-soluble cyclodextrins form inclusion complexes with many lipophilic water-insoluble drugs and that such complexation frequently enhances the aqueous solubility of drugs. It is also well known that various excipients, such as water-soluble polymers, organic acids and bases...

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Bibliographic Details
Published in:	International journal of pharmaceutics Vol. 297; no. 1; pp. 213 - 222
Main Authors:	Duan, Matt S., Zhao, Nelson, Össurardóttir, Ína B., Thorsteinsson, Thorsteinn, Loftsson, Thorsteinn
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 13-06-2005 Elsevier
Subjects:	2-Hydroxypropyl-beta-cyclodextrin Anti-Infective Agents - administration & dosage Anti-Infective Agents - chemistry Antibacterial agents beta-Cyclodextrins - chemistry Biological and medical sciences Carbanilides - administration & dosage Carbanilides - chemistry Chemistry, Pharmaceutical Cyclodextrins Cyclodextrins - chemistry Dimethyl Sulfoxide General pharmacology Inclusion complexes Lysine - chemistry Magnesium Magnetic Resonance Spectroscopy Medical sciences Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Povidone Solubility Triclosan - administration & dosage Triclosan - chemistry Antibacterial agents Cyclodextrins Inclusion complexes Pharmaceutical technology Solubilization Triclocarban Cyclodextrin Chlorine Organic compounds Antiseptic Phenols Ureas Triclosan Aggregate Antibacterial agent Inclusion compound Disinfecting agent
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Summary:	It is well known that water-soluble cyclodextrins form inclusion complexes with many lipophilic water-insoluble drugs and that such complexation frequently enhances the aqueous solubility of drugs. It is also well known that various excipients, such as water-soluble polymers, organic acids and bases and metal ions can enhance the solubilizing effects of cyclodextrins. However, it is not clear how these excipients enhance the effects. The effects of cyclodextrins, 2-hydroxypropyl-β-cyclodextrin (HPβCD) and randomly methylated β-cyclodextrin (RMβCD) on the aqueous solubility of triclosan and triclocarban were investigated. The phase-solubility profiles were all of type A P indicating formation of higher-order complexes or complex aggregates. Addition of lysine and other excipients enhanced the RMβCD solubilization of triclocarban. NMR spectroscopic studies, including 2D ROESY and 1D gROESY techniques, indicated that HPβCD and RMβCD, as well as their complexes, form aggregates of two to three cyclodextrin molecules. The critical concentration for the aggregate formation was determined to be 5.4% (w/v). Lysine, polyvinylpyrrolidone and magnesium ions formed non-inclusion complexes resulting in formation of multiple-component cyclodextrin complexes in aqueous solutions with triclocarban.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0378-5173 1873-3476
DOI:	10.1016/j.ijpharm.2005.04.007