Search Results - "Zhao, Manzhi"

New insight into the role of macrophages in ovarian function and ovarian aging by Tang, Maoxing, Zhao, Manzhi, Shi, Yuhua

“…Macrophages (MΦs) are the most abundant leukocytes in mammalian ovaries that have heterogeneity and plasticity. A body of evidence has indicated that these…”
Get full text

Stratification of hospitalized COVID-19 patients into clinical severity progression groups by immuno-phenotyping and machine learning by Mueller, Yvonne M., Schrama, Thijs J., Ruijten, Rik, Schreurs, Marco W. J., Grashof, Dwin G. B., van de Werken, Harmen J. G., Lasinio, Giovanna Jona, Álvarez-Sierra, Daniel, Kiernan, Caoimhe H., Castro Eiro, Melisa D., van Meurs, Marjan, Brouwers-Haspels, Inge, Zhao, Manzhi, Li, Ling, de Wit, Harm, Ouzounis, Christos A., Wilmsen, Merel E. P., Alofs, Tessa M., Laport, Danique A., van Wees, Tamara, Kraker, Geoffrey, Jaimes, Maria C., Van Bockstael, Sebastiaan, Hernández-González, Manuel, Rokx, Casper, Rijnders, Bart J. A., Pujol-Borrell, Ricardo, Katsikis, Peter D.

“…Quantitative or qualitative differences in immunity may drive clinical severity in COVID-19. Although longitudinal studies to record the course of…”
Get full text

Rapid in vitro generation of bona fide exhausted CD8+ T cells is accompanied by Tcf7 promotor methylation by Zhao, Manzhi, Kiernan, Caoimhe H., Stairiker, Christopher J., Hope, Jennifer L., Leon, Leticia G., van Meurs, Marjan, Brouwers-Haspels, Inge, Boers, Ruben, Boers, Joachim, Gribnau, Joost, van IJcken, Wilfred F. J., Bindels, Eric M., Hoogenboezem, Remco M., Erkeland, Stefan J., Mueller, Yvonne M., Katsikis, Peter D.

“…Exhaustion is a dysfunctional state of cytotoxic CD8+ T cells (CTL) observed in chronic infection and cancer. Current in vivo models of CTL exhaustion using…”
Get full text

Overcoming immune checkpoint blockade resistance in solid tumors with intermittent ITK inhibition by Zhao, Manzhi, Li, Ling, Kiernan, Caoimhe H., Castro Eiro, Melisa D., Dammeijer, Floris, van Meurs, Marjan, Brouwers-Haspels, Inge, Wilmsen, Merel E. P., Grashof, Dwin G. B., van de Werken, Harmen J. G., Hendriks, Rudi W., Aerts, Joachim G., Mueller, Yvonne M., Katsikis, Peter D.

“…Cytotoxic CD8 + T cell (CTL) exhaustion is driven by chronic antigen stimulation. Reversing CTL exhaustion with immune checkpoint blockade (ICB) has provided…”
Get full text

Ibrutinib directly reduces CD8+T cell exhaustion independent of BTK by Li, Ling, Zhao, Manzhi, Kiernan, Caoimhe H., Castro Eiro, Melisa D., van Meurs, Marjan, Brouwers-Haspels, Inge, Wilmsen, Merel E. P., Grashof, Dwin G. B., van de Werken, Harmen J. G., Hendriks, Rudi W., Mueller, Yvonne M., Katsikis, Peter D.

“…IntroductionCytotoxic CD8+ T cell (CTL) exhaustion is a dysfunctional state of T cells triggered by persistent antigen stimulation, with the characteristics of…”
Get full text

The association between ambient temperature and antimicrobial resistance of Klebsiella pneumoniae in China: a difference-in-differences analysis by Zeng, Yingchao, Li, Weibin, Zhao, Manzhi, Li, Jia, Liu, Xu, Shi, Lin, Yang, Xinyi, Xia, Haohai, Yang, Shifang, Yang, Lianping

“…Antimicrobial resistance (AMR) of ( ) poses a significant global public health threat and is responsible for a high prevalence of infections and mortality…”
Get full text

Effects of pay-for-performance based antimicrobial stewardship on antimicrobial consumption and expenditure: An interrupted time series analysis by Xia, Haohai, Li, Jia, Yang, Xinyi, Zeng, Yingchao, Shi, Lin, Li, Weibin, Liu, Xu, Yang, Shifang, Zhao, Manzhi, Chen, Jie, Yang, Lianping

“…To evaluate the impact of pay-for-performance on antimicrobial consumption and antimicrobial expenditure in a large teaching hospital in Guangzhou, China. We…”
Get full text

Multiple impacts of the COVID-19 pandemic and antimicrobial stewardship on antimicrobial resistance in nosocomial infections: an interrupted time series analysis by Li, Weibin, Yang, Xinyi, Liu, Chaojie, Liu, Xu, Shi, Lin, Zeng, Yingchao, Xia, Haohai, Li, Jia, Zhao, Manzhi, Yang, Shifang, Li, Xiaojie, Hu, Bo, Yang, Lianping

“…The emergency response to the COVID-19 pandemic may disrupt hospital management activities of antimicrobial resistance (AMR). This study aimed to determine the…”
Get full text

Novel insights in preventing Gram-negative bacterial infection in cirrhotic patients: review on the effects of GM-CSF in maintaining homeostasis of the immune system by Xu, Dong, Zhao, Manzhi, Song, Yuhu, Song, Jianxin, Huang, Yuancheng, Wang, Junshuai

“…Cirrhotic patients with dysfunctional and/or low numbers of leukocytes are often infected with bacteria, especially Gram-negative bacteria, which is…”
Get full text

Multifunctional 3D-printed scaffolds eradiate orthotopic osteosarcoma and promote osteogenesis via microwave thermo-chemotherapy combined with immunotherapy by Ma, Limin, Zhou, Jielong, Wu, Qiong, Luo, Guowen, Zhao, Manzhi, Zhong, Guoqing, Zheng, Yufeng, Meng, Xianwei, Cheng, Shi, Zhang, Yu

“…Tumor recurrence and a lack of bone-tissue integration are two critical concerns in the surgical treatment of osteosarcoma. Thus, an advanced multifunctional…”
Get full text

T cell toxicity of HIV latency reversing agents by Zhao, Manzhi, De Crignis, Elisa, Rokx, Casper, Verbon, Annelies, van Gelder, Teun, Mahmoudi, Tokameh, Katsikis, Peter D., Mueller, Yvonne M.

“…[Display omitted] Combination antiretroviral therapy reduces morbidity and mortality in HIV infected patients. However, the cure of HIV infection is hindered…”
Get full text

ITK inhibition improves the response to immune checkpoint blockade in solid tumors by Li, Ling, Zhao, Manzhi, Kiernan, Caoimhe H, Castro Eiro, Melisa D, Dammeijer, Floris, van Meurs, Marjan, Brouwers-Haspels, Inge, Wilmsen, Merel, Grashof, Dwin G.B, van de Werken, Harmen J.G, Hendriks, Rudi W, Aerts, Joachim G, Mueller, Yvonne M, Katsikis, Peter D

“…Cytotoxic CD8+ T cell (CTL) exhaustion is driven by persistent T cell receptor (TCR) stimulation in chronic infections and tumors. The exhausted state of T…”
Get full text

Establishment And Application of An in Vitro Cd8+ T Cell Exhaustion System by Zhao, Manzhi, Kiernan, Caoimhe H., Leon, Leticia G., van Meurs, Marjan, Brouwers-Haspels, Inge, Mueller, Yvonne M, Katsikis, Peter D

“…Exhaustion is a dysfunctional state of cytotoxic CD8+ T cells (CTL). In vivo models of CTL exhaustion yield very few exhausted CTL, limiting the analysis can…”
Get full text

Hepatitis E Virus Infects Neurons and Brains by Zhou, Xinying, Huang, Fen, Xu, Lei, Lin, Zhanmin, de Vrij, Femke M. S., Ayo-Martin, Ane C., van der Kroeg, Mark, Zhao, Manzhi, Yin, Yuebang, Wang, Wenshi, Cao, Wanlu, Wang, Yijin, Kushner, Steven A., Peron, Jean Marie, Alric, Laurent, de Man, Robert A., Jacobs, Bart C., van Eijk, Jeroen J., Aronica, Eleonora M. A., Sprengers, Dave, Metselaar, Herold J., de Zeeuw, Chris I., Dalton, Harry R., Kamar, Nassim, Peppelenbosch, Maikel P., Pan, Qiuwei

“…Hepatitis E virus (HEV), as a hepatotropic virus, is supposed to exclusively infect the liver and only cause hepatitis. However, a broad range of extrahepatic…”
Get full text

A combination of TLR9 and STING agonists induces potent neopeptide-specific T cell immunity and improves ICB efficacy in tumor models by Hioki, Kou, Castro Eiro, Melisa D., Li, Ling, Wilmsen, Merel E.P., Kiernan, Caoimhe H., Brouwers-Haspels, Inge, van Meurs, Marjan, de Vos, Kevin, Wildemans, Marlous, Zhao, Manzhi, de Wit, Harm, Grashof, Dwin G.B., van de Werken, Harmen J.G., Mueller, Yvonne M., Schliehe, Christopher, Ishii, Ken J., Katsikis, Peter D.

“…Immunotherapies such as immune checkpoint blockade (ICB) therapies have been developed in the last years as a promising strategy for the treatment of cancer,…”
Get full text

TLR9 plus STING Agonist Adjuvant Combination Induces Potent Neopeptide T Cell Immunity and Improves Immune Checkpoint Blockade Efficacy in a Tumor Model by Castro Eiro, Melisa D, Hioki, Kou, Li, Ling, Wilmsen, Merel E P, Kiernan, Caoimhe H, Brouwers-Haspels, Inge, van Meurs, Marjan, Zhao, Manzhi, de Wit, Harm, Grashof, Dwin G B, van de Werken, Harmen J G, Mueller, Yvonne M, Schliehe, Christopher, Temizoz, Burcu, Kobiyama, Kouji, Ishii, Ken J, Katsikis, Peter D

“…Immune checkpoint blockade (ICB) immunotherapies have emerged as promising strategies for the treatment of cancer; however, there remains a need to improve…”
Get full text

Identification of a core miRNA signature unique to exhausted cytotoxic CD8+ T cells by Kiernan, Caoimhe H., Hope, Jennifer L, Leon, Leticia G., Zhao, Manzhi, van Meurs, Marjan, Brouwers-Haspels, Inge, van Strien, Paulette, Bindels, Erik, Hoogenboezem, Remco M., Li, Yunlei, Stubbs, Andrew P., Zehn, Dietmar, Mueller, Yvonne M, Erkeland, Stefan J., Katsikis, Peter D

“…Cytotoxic CD8+ T lymphocytes (CTLs) play a major role in protection against chronic viral infections and tumors. Chronic antigen stimulation in both conditions…”
Get full text

Myostatin is involved in skeletal muscle dysfunction in chronic obstructive pulmonary disease via Drp-1 mediated abnormal mitochondrial division by Tan, Zhidan, Zhao, Manzhi, Li, Jing, Li, Siqi, Zhu, Su, Yao, Xiaoxuan, Gao, Xinglin, Yang, Shifang

“…Skeletal muscle dysfunction (SMD) is one of the most prominent extrapulmonary effects of chronic obstructive pulmonary disease (COPD). Myostatin negatively…”
Get full text

MicroRNA-139 Expression Is Dispensable for the Generation of Influenza-Specific CD8 + T Cell Responses by Hope, Jennifer L, Zhao, Manzhi, Stairiker, Christopher J, Kiernan, Caoimhe H, Carey, Alison J, Mueller, Yvonne M, van Meurs, Marjan, Brouwers-Haspels, Inge, Otero, Dennis C, Bae, Eun-Ah, Faso, Hannah A, Maas, Alex, de Looper, Hans, Fortina, Paolo M, Rigoutsos, Isidore, Bradley, Linda M, Erkeland, Stefan J, Katsikis, Peter D

“…MicroRNAs (miRNAs/miRs) are small, endogenous noncoding RNAs that are important post-transcriptional regulators with clear roles in the development of the…”
Get full text

Diabetes mellitus and the neutrophil to lymphocyte ratio predict overall survival in non-viral hepatocellular carcinoma treated with transarterial chemoembolization by ZHANG, JIANGGUO, GONG, FENGYUN, LI, LING, ZHAO, MANZHI, SONG, JIANXIN

“…Diabetes mellitus (DM) and systemic inflammation are closely associated with the development of hepatocellular carcinoma (HCC). However, the prognostic…”
Get full text