Search Results - "Zhao, Jie V"

Genetic proxies for antihypertensive drugs and mental disorders: Mendelian randomization study in European and East Asian populations by Fan, Bohan, Zhao, Jie V

“…Mental disorders are among the top causes of disease burden worldwide. Existing evidence regarding the repurposing of antihypertensives for mental disorders…”
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The role of testosterone in chronic kidney disease and kidney function in men and women: a bi-directional Mendelian randomization study in the UK Biobank by Zhao, Jie V, Schooling, C Mary

“…Chronic kidney disease (CKD) has an apparent sex disparity, with a more rapid progress in men than in women. Whether the well-established sex-specific…”
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Disentangling the common genetic architecture and causality of rheumatoid arthritis and systemic lupus erythematosus with COVID‐19 outcomes: Genome‐wide cross trait analysis and bidirectional Mendelian randomization study by Yao, Minhao, Huang, Xin, Guo, Yunshan, Zhao, Jie V., Liu, Zhonghua

“…Coronavirus Disease (COVID‐19) may cause a dysregulation of the immune system and has complex relationships with multiple autoimmune diseases, including…”
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Effect of linoleic acid on ischemic heart disease and its risk factors: a Mendelian randomization study by Zhao, Jie V, Schooling, C Mary

“…The role of n-6 polyunsaturated fatty acids (PUFAs) in ischemic heart disease (IHD) is controversial, and dietary guidelines vary. Observationally, lower…”
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Exploration of Metabolic Biomarkers Linking Red Meat Consumption to Ischemic Heart Disease Mortality in the UK Biobank by Fan, Bohan, Huang, Xin, Zhao, Jie V

“…Growing evidence suggests that red meat consumption is a risk factor for cardiovascular health, with potential sex disparity. The metabolic mechanisms have not…”
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Selection bias as an explanation for the observed protective association of childhood adiposity with breast cancer by Schooling, C Mary, Fei, Kezhen, Zhao, Jie V

“…Recalled childhood adiposity is inversely associated with breast cancer observationally, including in Mendelian randomization (MR) studies. Breast cancer…”
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Long-term exposure to ambient air pollution with sarcopenia among middle-aged and older adults in China by Shi, Wenming, Li, Yongzhen, Zhao, Jie V

“…Few studies have examined the role of outdoor air pollution exposure in sarcopenia in Asia. We aimed to investigate the association of outdoor air pollutants…”
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Using Mendelian randomization study to assess the renal effects of antihypertensive drugs by Zhao, Jie V, Schooling, C Mary

“…Angiotensin-converting enzyme (ACE) inhibitors and/or in combination with calcium channel blockers (CCBs) are generally recommended as the first-line…”
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L-carnitine, a friend or foe for cardiovascular disease? A Mendelian randomization study by Zhao, Jie V, Burgess, Stephen, Fan, Bohan, Schooling, C Mary

“…L-carnitine is emerging as an item of interest for cardiovascular disease (CVD) prevention and treatment, but controversy exists. To examine the effectiveness…”
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Sex-Specific Associations of Red Meat and Processed Meat Consumption with Serum Metabolites in the UK Biobank by Fan, Bohan, Zhao, Jie V

“…Red meat consumption has been found to closely related to cardiometabolic health, with sex disparity. However, the specific metabolic factors corresponding to…”
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Thyroid function and ischemic heart disease: a Mendelian randomization study by Zhao, Jie V., Schooling, C. Mary

“…To clarify the role of thyroid function in ischemic heart disease (IHD) we assessed IHD risk and risk factors according to genetically predicted thyroid…”
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Genetically predicted sex hormone binding globulin and ischemic heart disease in men and women: a univariable and multivariable Mendelian randomization study by Zhao, Jie V., Schooling, C. Mary

“…Men are more vulnerable to ischemic heart disease (IHD) than women, possibly due to testosterone. Correspondingly, sex hormone binding globulin (SHBG) which…”
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Evaluation of glycemic traits in susceptibility to COVID-19 risk: a Mendelian randomization study by Au Yeung, Shiu Lun, Zhao, Jie V, Schooling, C Mary

“…Observational studies suggest poorer glycemic traits and type 2 diabetes associated with coronavirus disease 2019 (COVID-19) risk although these findings could…”
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Effect of glutamate and aspartate on ischemic heart disease, blood pressure, and diabetes: a Mendelian randomization study by Zhao, Jie V, Kwok, M K, Schooling, C Mary

“…Evolutionary biology suggests reproduction trades off against longevity. Genetic selection in favor of fertility and ischemic heart disease (IHD) exists in…”
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Age and sex specific effects of APOE genotypes on ischemic heart disease and its risk factors in the UK Biobank by Li, Mengyu, Zhao, Jie V., Kwok, Man Ki, Schooling, C. Mary

“…APOE genotypes are associated with ischemic heart disease (IHD), several other cardiovascular diseases and dementia. Previous studies have not comprehensively…”
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The associations of plasma phospholipid arachidonic acid with cardiovascular diseases: A Mendelian randomization study by Zhang, Ting, Zhao, Jie V., Schooling, C. Mary

“…Arachidonic acid (AA), a major long-chain n-6 polyunsaturated fatty acid in animal foods, has been linked to inflammation, coagulation, and testosterone, which…”
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Iron status and non-alcoholic fatty liver disease: A Mendelian randomization study by Sun, Kexin, Zhao, Jie V, Nelson, Edmund Anthony Severn, Wong, Vincent Wai Sun, Lam, Hugh Simon Hung San, Hui, Lai Ling

“…The aim of this study was to assess the association of genetically determined iron status with the risk for non-alcoholic fatty liver disease (NAFLD) using…”
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Using genetics to understand the role of kidney function in COVID-19: a mendelian randomization study by Zhao, Jie V, Schooling, C. Mary

“…Abstract Background Kidney dysfunction occurs in severe COVID-19, and is a predictor of COVID-19 mortality. Whether kidney dysfunction causes severe COVID-19,…”
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Effect of Berberine on Cardiovascular Disease Risk Factors: A Mechanistic Randomized Controlled Trial by Zhao, Jie V, Yeung, Wai-Fung, Chan, Yap-Hang, Vackova, Dana, Leung, June Y. Y, Ip, Dennis K. M, Zhao, Jiaxi, Ho, Wai-Kwan, Tse, Hung-fat, Schooling, Catherine Mary

“…Cardiovascular disease (CVD) is a major contributor to the global burden of disease. Berberine, a long-standing, widely used, traditional Chinese medicine, is…”
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General and Sex-Specific Effects of Vitamin D Against Atrial Fibrillation and Young-Onset Ischemic Stroke: A Mendelian Randomization Series by Chan, Yap-Hang, Zhao, Jie V, Schooling, C. Mary, Yeung, Shiu-Lun Au, Wong, Yuen-Kwun, Au, Ka-Wing, Tang, Clara S, Cheung, Chloe YY, Xu, Aimin, Sham, Pak-Chung, Lam, Tai-Hing, Lam, Karen Siu-Ling, Tse, Hung-Fat

“…Background: Whether vitamin D deficiency causes atrial fibrillation and ischemic stroke of young onset <50 years was unknown.Methods: We derived a Genetic Risk…”
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