Search Results - "Zhao, Fangqing"
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Accurate quantification of circular RNAs identifies extensive circular isoform switching events
Published in Nature communications (03-01-2020)“…Detection and quantification of circular RNAs (circRNAs) face several significant challenges, including high false discovery rate, uneven rRNA depletion and…”
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CircAtlas: an integrated resource of one million highly accurate circular RNAs from 1070 vertebrate transcriptomes
Published in Genome Biology (28-04-2020)“…Existing circular RNA (circRNA) databases have become essential for transcriptomics. However, most are unsuitable for mining in-depth information for candidate…”
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Circular RNA identification based on multiple seed matching
Published in Briefings in bioinformatics (28-09-2018)“…Abstract Computational detection methods have been widely used in studies on the biogenesis and the function of circular RNAs (circRNAs). However, all of the…”
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CIRI: an efficient and unbiased algorithm for de novo circular RNA identification
Published in Genome Biology (13-01-2015)“…Recent studies reveal that circular RNAs (circRNAs) are a novel class of abundant, stable and ubiquitous noncoding RNA molecules in animals. Comprehensive…”
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Deterministic transition of enterotypes shapes the infant gut microbiome at an early age
Published in Genome Biology (24-08-2021)“…The succession of the gut microbiota during the first few years plays a vital role in human development. We elucidate the characteristics and alternations of…”
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Translocation of vaginal microbiota is involved in impairment and protection of uterine health
Published in Nature communications (07-07-2021)“…The vaginal and uterine microbiota play important roles in the health of the female reproductive system. However, the interactions among the microbes in these…”
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Comprehensive identification of internal structure and alternative splicing events in circular RNAs
Published in Nature communications (28-06-2016)“…Although previous studies demonstrated circular RNAs (circRNAs) does not exclusively comprise mRNA exons, no study has extensively explored their internal…”
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Changes to gut amino acid transporters and microbiome associated with increased E/I ratio in Chd8+/− mouse model of ASD-like behavior
Published in Nature communications (03-03-2022)“…Autism spectrum disorder (ASD), a group of neurodevelopmental disorders characterized by social communication deficits and stereotyped behaviors, may be…”
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Single-cell metagenomics: challenges and applications
Published in Protein & cell (01-05-2018)“…With the development of high throughput sequencing and single-cell genomics technologies, many uncultured bacterial communities have been dissected by…”
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Reconstruction of full-length circular RNAs enables isoform-level quantification
Published in Genome medicine (19-01-2019)“…Currently, circRNA studies are shifting from the identification of circular transcripts to understanding their biological functions. However, such endeavors…”
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Phage-bacteria interaction network in human oral microbiome
Published in Environmental microbiology (01-07-2016)“…Summary Although increasing knowledge suggests that bacteriophages play important roles in regulating microbial ecosystems, phage–bacteria interaction in human…”
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12
Exploring the cellular landscape of circular RNAs using full-length single-cell RNA sequencing
Published in Nature communications (10-06-2022)“…Previous studies have demonstrated the highly specific expression of circular RNAs (circRNAs) in different tissues and organisms, but the cellular architecture…”
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13
MetaSort untangles metagenome assembly by reducing microbial community complexity
Published in Nature communications (23-01-2017)“…Most current approaches to analyse metagenomic data rely on reference genomes. Novel microbial communities extend far beyond the coverage of reference…”
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14
Illuminating functions of evolutionarily conserved long non-coding RNAs
Published in Science China. Life sciences (01-09-2024)Get full text
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15
Convergent Evolution of Rumen Microbiomes in High-Altitude Mammals
Published in Current biology (25-07-2016)“…Studies of genetic adaptation, a central focus of evolutionary biology, most often focus on the host’s genome and only rarely on its co-evolved microbiome. The…”
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Genomic insights into the cellular specialization of predation in raptorial protists
Published in BMC biology (07-05-2024)“…Predation is a fundamental mechanism for organisms to acquire energy, and various species have evolved diverse tools to enhance their hunting abilities. Among…”
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Prioritization and functional assessment of noncoding variants associated with complex diseases
Published in Genome medicine (11-07-2018)“…Unraveling functional noncoding variants associated with complex diseases is still a great challenge. We present a novel algorithm, Prioritization And…”
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18
Expanded Expression Landscape and Prioritization of Circular RNAs in Mammals
Published in Cell reports (Cambridge) (19-03-2019)“…Circular RNAs (circRNAs) are emerging as essential regulators of various biological and disease processes. To comprehensively understand the diversity of…”
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Gut microbiota dysbiosis contributes to the development of hypertension
Published in Microbiome (01-02-2017)“…Recently, the potential role of gut microbiome in metabolic diseases has been revealed, especially in cardiovascular diseases. Hypertension is one of the most…”
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HTQC: a fast quality control toolkit for Illumina sequencing data
Published in BMC bioinformatics (31-01-2013)“…Illumina sequencing platform is widely used in genome research. Sequence reads quality assessment and control are needed for downstream analysis. However,…”
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