Search Results - "Zhao, Dianyuan"
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Neutrophils promote the development of reparative macrophages mediated by ROS to orchestrate liver repair
Published in Nature communications (06-03-2019)“…Phagocytes, including neutrophils and macrophages, have been suggested to function in a cooperative way in the initial phase of inflammatory responses, but…”
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2
ALK1 signaling is required for the homeostasis of Kupffer cells and prevention of bacterial infection
Published in The Journal of clinical investigation (01-02-2022)“…Macrophages are highly heterogeneous immune cells that fulfill tissue-specific functions. Tissue-derived signals play a critical role in determining macrophage…”
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3
GDF2 and BMP10 coordinate liver cellular crosstalk to maintain liver health
Published in eLife (25-10-2024)“…The liver is the largest solid organ in the body and is primarily composed of hepatocytes (HCs), endothelial cells (ECs), Kupffer cells (KCs), and hepatic…”
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4
C-type lectin receptor LSECtin-mediated apoptotic cell clearance by macrophages directs intestinal repair in experimental colitis
Published in Proceedings of the National Academy of Sciences - PNAS (23-10-2018)“…Epithelial barrier disruption is a major cause of inflammatory bowel disease (IBD); however, the cellular and molecular regulation of intestinal epithelial…”
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5
LSECtin on tumor-associated macrophages enhances breast cancer stemness via interaction with its receptor BTN3A3
Published in Cell research (01-05-2019)“…Macrophages have been suggested to contribute to constructing a cancer stem cell (CSC) niche. However, whether and how macrophages regulate the activity of…”
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6
The Myeloid LSECtin Is a DAP12-Coupled Receptor That Is Crucial for Inflammatory Response Induced by Ebola Virus Glycoprotein
Published in PLoS pathogens (01-03-2016)“…Fatal Ebola virus infection is characterized by a systemic inflammatory response similar to septic shock. Ebola glycoprotein (GP) is involved in this process…”
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Correction: The Myeloid LSECtin Is a DAP12-Coupled Receptor That Is Crucial for Inflammatory Response Induced by Ebola Virus Glycoprotein
Published in PLoS pathogens (01-03-2016)Get full text
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8
The Role of Kupffer Cells as Mediators of Adipose Tissue Lipolysis
Published in The Journal of immunology (1950) (15-11-2019)“…Kupffer cells (KCs) are the resident macrophages of the liver, and they respond to and counteract metabolic stresses, such as those imposed by high-fat diet…”
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Comprehensive Proteomics Analysis Reveals Metabolic Reprogramming of Tumor-Associated Macrophages Stimulated by the Tumor Microenvironment
Published in Journal of proteome research (06-01-2017)“…Tumor-associated macrophages (TAMs) are major components of the tumor microenvironment. Although a role for TAMs in promoting tumor progression has been…”
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10
Dysregulated Response of Follicular Helper T Cells to Hepatitis B Surface Antigen Promotes HBV Persistence in Mice and Associates With Outcomes of Patients
Published in Gastroenterology (New York, N.Y. 1943) (01-06-2018)“…Production of neutralizing antibodies against hepatitis B surface antigen (HBsAg) is dysregulated in patients with persistent hepatitis B virus (HBV)…”
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11
In-Depth Proteomic Analysis Reveals Phenotypic Diversity of Macrophages in Liver Fibrosis
Published in Journal of proteome research (01-11-2024)“…Macrophages make up a heterogeneous population of immune cells that exhibit diverse phenotypes and functions in health and disease. Although macrophage…”
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12
Comprehensive Proteomics Analysis Reveals Dynamic Phenotypes of Tumor-Associated Macrophages and Their Precursor Cells in Tumor Progression
Published in Journal of proteome research (02-02-2024)“…Tumor-associated macrophages (TAMs) are key regulators in tumor progression, but the precise role of bone marrow-derived monocytes (Mons) as TAM precursors and…”
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13
30-color full spectrum flow cytometry panel for deep immunophenotyping of T cell subsets in murine tumor tissue
Published in Journal of immunological methods (01-05-2023)“…This 30-color full spectrum flow cytometry panel was developed and optimized for in-depth analysis T cells immunophenotype in tumor microenvironment and…”
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14
GDF2 and BMP10 coordinate liver cellular crosstalk to maintain liver health
Published in eLife (25-10-2024)“…The liver is the largest solid organ in the body and is primarily composed of hepatocytes (HCs), endothelial cells (ECs), Kupffer cells (KCs), and hepatic…”
Get full text
Journal Article -
15
ALK1 signaling is required for the homeostasis of Kupffer cells and prevention of bacterial infection
Published in The Journal of clinical investigation (01-02-2022)“…Macrophages are highly heterogeneous immune cells that fulfill tissue-specific functions. Tissue-derived signals play a critical role in determining macrophage…”
Get full text
Journal Article -
16
Novel roles of liver sinusoidal endothelial cell lectin in colon carcinoma cell adhesion, migration and in-vivo metastasis to the liver
Published in Gut (01-08-2013)“…Adhesion molecules play an important role in tumour metastasis. The liver is a frequent target for the metastasis of several tumour types. However, virtually…”
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17
Liver Sinusoidal Endothelial Cell Lectin, LSECtin, Negatively Regulates Hepatic T-Cell Immune Response
Published in Gastroenterology (New York, N.Y. 1943) (01-10-2009)“…Background & Aims The liver is an organ with paradoxic immunologic properties and is known for its tolerant microenvironment, which holds important…”
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18
Involvement of LSECtin in the hepatic natural killer cell response
Published in Biochemical and biophysical research communications (15-07-2016)“…Accumulating evidence has indicated that natural killer cells (NK cells) play an important role in immune responses generated in the liver. However, the…”
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19
Liver sinusoidal endothelial cell lectin inhibits CTL-dependent virus clearance in mouse models of viral hepatitis
Published in The Journal of immunology (1950) (15-04-2013)“…Liver sinusoidal endothelial cell lectin (LSECtin) was recently reported to suppress intrahepatic T cell immunity and to limit immune-mediated liver injury…”
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20
Up-regulation of Cbl-b is associated with LSECtin-mediated inhibition of different CD4+ T-cell subsets
Published in Immunobiology (1979) (01-04-2013)“…Abstract Recently, LSECtin was identified as a co-inhibitory molecule involved in the control of T cell-mediated acute liver injury. However, it is not known…”
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