Search Results - "Zhao, Deyao"

Rolling microneedle electrode array (RoMEA) empowered nucleic acid delivery and cancer immunotherapy by Yang, Tongren, Huang, Dong, Li, Chunhui, Zhao, Deyao, Li, Junshi, Zhang, Mengjie, Chen, Yufeng, Wang, Qining, Liang, Zicai, Liang, Xing-Jie, Li, Zhihong, Huang, Yuanyu

“…[Display omitted] •siRNA therapy shows encouraging potential in disease treatment, but is hampered by insufficient delivery.•Combination of electroporation and…”
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A circulating miRNA signature as a diagnostic biomarker for non-invasive early detection of breast cancer by Zhang, Lei, Xu, Ye, Jin, Xingyu, Wang, Zengwu, Wu, Yidi, Zhao, Deyao, Chen, Gang, Li, Deyu, Wang, Xiaoxia, Cao, Huiqing, Xie, Yuntao, Liang, Zicai

“…Novel, non-invasive biomarkers to diagnose breast cancer with high sensitivity and specificity are greatly desired. Circulating microRNAs (miRNAs) show…”
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Efficient hepatic delivery and protein expression enabled by optimized mRNA and ionizable lipid nanoparticle by Yang, Tongren, Li, Chunhui, Wang, Xiaoxia, Zhao, Deyao, Zhang, Mengjie, Cao, Huiqing, Liang, Zicai, Xiao, Haihua, Liang, Xing-Jie, Weng, Yuhua, Huang, Yuanyu

“…mRNA is a novel class of therapeutic modality that holds great promise in vaccination, protein replacement therapy, cancer immunotherapy, immune cell…”
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Ionizable lipid-assisted efficient hepatic delivery of gene editing elements for oncotherapy by Li, Chunhui, Yang, Tongren, Weng, Yuhua, Zhang, Mengjie, Zhao, Deyao, Guo, Shuai, Hu, Bo, Shao, Wanxuan, Wang, Xiaoxia, Hussain, Abid, Liang, Xing-Jie, Huang, Yuanyu

“…CRISPR/Cas9-based gene editing has emerged as a powerful biotechnological tool, that relies on Cas9 protein and single guided RNA (sgRNA) to edit target DNA…”
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Cuproptosis, the novel type of oxidation-induced cell death in thoracic cancers: can it enhance the success of immunotherapy? by Zhao, Ruiwen, Sukocheva, Olga, Tse, Edmund, Neganova, Margarita, Aleksandrova, Yulia, Zheng, Yufei, Gu, Hao, Zhao, Deyao, Madhunapantula, SabbaRao V, Zhu, Xiaorong, Liu, Junqi, Fan, Ruitai

“…Copper is an important metal micronutrient, required for the balanced growth and normal physiological functions of human organism. Copper-related toxicity and…”
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Lipid-conjugated siRNA hitchhikes endogenous albumin for tumor immunotherapy by Hu, Bo, Kong, Sudong, Weng, Yuhua, Zhao, Deyao, Hussain, Abid, Jiao, Qingze, Zhan, Shijing, Qiu, Ling, Lin, Jianguo, Xie, Minhao, Li, Bo, Huang, Yuanyu

“…With the development of a small interfering RNA (siRNA) delivery strategy, increasing siRNA therapeutics for tumor treatment appeared in clinical trials and…”
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A Flow-Through Cell Electroporation Device for Rapidly and Efficiently Transfecting Massive Amounts of Cells in vitro and ex vivo by Zhao, Deyao, Huang, Dong, Li, Yang, Wu, Mengxi, Zhong, Wenfeng, Cheng, Qiang, Wang, Xiaoxia, Wu, Yidi, Zhou, Xiao, Wei, Zewen, Li, Zhihong, Liang, Zicai

“…Continuous cell electroporation is an appealing non-viral approach for genetically transfecting a large number of cells. Yet the traditional macro-scale…”
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AIFM2 promotes hepatocellular carcinoma metastasis by enhancing mitochondrial biogenesis through activation of SIRT1/PGC-1α signaling by Guo, Sanxing, Li, Fengying, Liang, Yixuan, Zheng, Yufei, Mo, Yingyi, Zhao, Deyao, Jiang, Zhixiong, Cui, Mengmeng, Qi, Lixia, Chen, Jiaxing, Wan, Lixin, Chen, Guoyong, Wei, Sidong, Yang, Qi, Liu, Junqi

“…AIFM2 is a crucial NADH oxidase involved in the regulation of cytosolic NAD + . However, the role of AIFM2 in the progression of human cancers remains largely…”
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Development of A Decahedral Nanoenzyme Capable of Overcoming Hypoxia to Facilitate the Iodine-125 Radiosensitization of Esophageal Cancer by Jiao, Dechao, Wu, Kunpeng, Xu, Kaihao, Liu, Yiming, Zhao, Deyao, Han, Xinwei, Fan, Ruitai

“…Radioisotopes have long been leveraged for internal radiotherapy-mediated cancer treatment. However, such therapeutic approaches are associated with serious…”
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CircATIC inhibits esophageal carcinoma progression and promotes radiosensitivity by elevating RHCG through sponging miR‐10‐3p by Zhang, Kai, Fan, Ruitai, Zhao, Deyao, Liu, Peipei, Yang, Zheng, Liu, Junqi, Zhang, Song, Rao, Shilei, Wang, Yang, Wan, Lixin

“…Background Circular RNAs (circRNAs) are implicated in the progression and radiosensitivity of human cancers, including esophageal carcinoma (ESCA). In this…”
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A Laminar Flow Electroporation System for Efficient DNA and siRNA Delivery by Wei, Zewen, Zhao, Deyao, Li, Xueming, Wu, Mengxi, Wang, Wei, Huang, Huang, Wang, Xiaoxia, Du, Quan, Liang, Zicai, Li, Zhihong

“…By introducing a hydrodynamic mechanism into a microfluidics-based electroporation system, we developed a novel laminar flow electroporation system with high…”
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Pharmacokinetic Behaviors of Intravenously Administered siRNA in Glandular Tissues by Huang, Yuanyu, Cheng, Qiang, Ji, Jia-Li, Zheng, Shuquan, Du, Lili, Meng, Lingwei, Wu, Yidi, Zhao, Deyao, Wang, Xiaoxia, Lai, Li, Cao, Huiqing, Xiao, Kai, Gao, Shan, Liang, Zicai

“…The pharmacokinetics of small interfering RNAs (siRNAs) is a pivotal issue for siRNA-based drug development. In this study, we comprehensively investigated the…”
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Dual effects of radiotherapy on tumor microenvironment and its contribution towards the development of resistance to immunotherapy in gastrointestinal and thoracic cancers by Zhao, Deyao, Mo, Yingyi, Neganova, Margarita E., Aleksandrova, Yulia, Tse, Edmund, Chubarev, Vladimir N., Fan, Ruitai, Sukocheva, Olga A., Liu, Junqi

“…Successful clinical methods for tumor elimination include a combination of surgical resection, radiotherapy, and chemotherapy. Radiotherapy is one of the…”
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An efficient and high-throughput electroporation microchip applicable for siRNA delivery by Huang, Huang, Wei, Zewen, Huang, Yuanyu, Zhao, Deyao, Zheng, Lianghong, Cai, Tianjing, Wu, Mengxi, Wang, Wei, Ding, Xianfeng, Zhou, Zhuan, Du, Quan, Li, Zhihong, Liang, Zicai

“…Here we report a novel electroporation microchip with great performance and compatibility with the standard multi-well plate used in biological research. The…”
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Profiling of mismatch discrimination in RNAi enabled rational design of allele-specific siRNAs by Huang, Huang, Qiao, Renping, Zhao, Deyao, Zhang, Tong, Li, Youxian, Yi, Fan, Lai, Fangfang, Hong, Junmei, Ding, Xianfeng, Yang, Zhenjun, Zhang, Lihe, Du, Quan, Liang, Zicai

“…Silencing specificity is a critical issue in the therapeutic applications of siRNA, particularly in the treatment of single nucleotide polymorphism (SNP)…”
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A photo-triggerable aptamer nanoswitch for spatiotemporal controllable siRNA delivery by Zhao, Deyao, Yang, Ge, Liu, Qing, Liu, Wenjing, Weng, Yuhua, Zhao, Yi, Qu, Feng, Li, Lele, Huang, Yuanyu

“…A photo-triggerable aptamer nanoswitch was proposed for spatiotemporal regulation of siRNA delivery. Recognition between AS1411 and nucleolin was effectively…”
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pH-Sensitive Nanomicelles for High-Efficiency siRNA Delivery in Vitro and in Vivo: An Insight into the Design of Polycations with Robust Cytosolic Release by Zhou, Junhui, Wu, Yidi, Wang, Changrong, Cheng, Qiang, Han, Shangcong, Wang, Xiaoxia, Zhang, Jianhua, Deng, Liandong, Zhao, Deyao, Du, Lili, Cao, Huiqing, Liang, Zicai, Huang, Yuanyu, Dong, Anjie

“…The extremely low efficient cytosolic release of the internalized siRNA has emerged recently as a central issue for siRNA delivery, while there is a lack of…”
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The study of relationships between pKa value and siRNA delivery efficiency based on tri-block copolymers by Du, Lili, Wang, Changrong, Meng, Lingwei, Cheng, Qiang, Zhou, Junhui, Wang, Xiaoxia, Zhao, Deyao, Zhang, Jianhua, Deng, Liandong, Liang, Zicai, Dong, Anjie, Cao, Huiqing

“…Tri-block copolymers have exhibited great potentials in small interfering RNA (siRNA) therapeutics. To reveal structure-activity relationships, we here…”
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Recent progresses of exosome–liposome fusions in drug delivery by Zheng, Lulu, Hu, Bo, Zhao, Deyao, Liu, Wenjing, Liu, Qing, Huang, Yuanyu, Ruan, Shaobo

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Electroporation on microchips: the harmful effects of pH changes and scaling down by Li, Yang, Wu, Mengxi, Zhao, Deyao, Wei, Zewen, Zhong, Wenfeng, Wang, Xiaoxia, Liang, Zicai, Li, Zhihong

“…Electroporation has been widely used in delivering foreign biomolecules into cells, but there is still much room for improvement, such as cell viability and…”
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