Search Results - "Zhao, Chuanmeng"

Real-Time Monitoring of Multistep Batch and Flow Synthesis Processes of a Key Intermediate of Lifitegrast by a Combined Spectrometer System with Both Near-Infrared and Raman Spectroscopies Coupled to Partial Least-Squares by Liu, Quan, Wu, Chuanjun, Liu, Huiting, Wang, Mengfei, Zhao, Chuanmeng, Zhang, Fuli

“…Process analytical technology (PAT) has been successfully applied in numerous chemical synthesis cases and is an important tool in pharmaceutical process…”
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Syntheses, Antifeedant Activity, and QSAR Analysis of New Oxa(thia)diazolyl 3(2H)-Pyridazinones by Cao, Song, Wei, Na, Zhao, Chuanmeng, Li, Lina, Huang, Qingchun, Qian, Xuhong

“…Twenty-eight new oxa(thia)diazolyl 3(2H)-pyridazinone derivatives were synthesized. Some compounds showed good chronic growth activities against the armyworm,…”
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Practical Process for synthesizing R‑TetrahydropapaverineA Key Intermediate of Cisatracurium Besylate (Nimbex) by Peng, Peng, Zheng, Zhibo, Yu, Jun, Gao, Xuezhi, Yang, Jiangtao, Zhao, Chuanmeng, Zhang, Fuli

“…In this paper, a practical process to synthesize the key intermediate R-tetrahydropapaverine of cisatracurium besylate was proposed. First,…”
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Development of an Improved Synthetic Process of Clonazepam by Preventing the Formation of a Trimeric Compound in the Presence of HCl by Gao, Xuezhi, Xu, Jiajian, Liu, Chunfeng, Peng, Peng, Zhao, Chuanmeng, Chen, Mengke, Qiu, Pengcheng, Zhang, Fuli

“…An improved synthesis process of clonazepam was developed with the key parameters determined. The trimer intermediate (9) of clonazepam prepared by using the…”
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Synthesis and Crystallization Research of Voclosporin by Jiang, Bibo, Liu, Jiajia, Li, Ying, Mai, Zidan, Lin, Liya, Xu, Shengjun, He, Yongfu, Chen, Fei, Shao, Jianfen, Zhao, Chuanmeng, Zhang, Fuli

“…In this study, an enhanced methodology for the synthesis and crystallization of Voclosporin was devised. Isopropyl acetate was selected as the solvent for the…”
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Development of a Novel Chemoenzymatic Process for 3‑(Methylsulfonyl)‑l‑phenylalanine Phenylmethyl EsterA Key Intermediate of Lifitegrast (Xiidra) by Wu, Chuanjun, Guo, Heng, Tang, Jiawei, Xia, Lintao, Shao, Jianfen, He, Yongfu, Chen, Fei, Peng, Peng, Han, Yuewen, Zhao, Chuanmeng, Zhang, Fuli, Chen, Shaoxin

“…In the present study, a practical chemoenzymatic method was developed for the synthesis of chiral phenylalanine derivative 1, which is the key intermediate of…”
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Synthesis, Isolation, Characterization and Suppression of Impurities during Optimization of Empagliflozin (Jardiance) by Peng, Peng, Zhao, Chuanmeng, Yang, Jiangtao, Liu, Xiao, Yu, Jun, Zhang, Fuli

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Improved Synthesis and Impurity Identification of (R)‑Lacosamide by Yang, Anjiang, Hu, Feifei, Li, Zhong, Chen, Mengdi, Cai, Jianguang, Wang, Linghui, Zhang, Tao, Zhao, Chuanmeng, Zhang, Fuli

“…An improved synthesis of Lacosamide 1 with high purity has been developed. Critical parameters of each step were identified as well as the impurities…”
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Practical Synthesis of 5,7-Dichlorotetrahydroisoquinoline-6-carboxylic AcidKey Intermediate of Lifitegrast (Xiidra) by Liu, Xu, Guo, Heng, Peng, Peng, Li, Yaping, Yang, Jiangtao, Wu, Chuanjun, Xu, Shengjun, Zhao, Chuanmeng, Zhang, Fuli

“…In the present study, a practical method for synthesizing the key intermediate 5,7-dichlorotetrahydroisoquinoline-6-carboxylic acid (1) of Lifitegrast was…”
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Synthesis of thiohydantoins under one-pot three-component solvent-free conditions by Cao, Song, Zhu, Longjie, Zhao, Chuanmeng, Tang, Xiuhong, Sun, Huajun, Feng, Xin, Qian, Xuhong

“…A direct and efficient one-pot three-component synthesis protocol was developed for the synthesis of thiohydantoins from readily and widely available…”
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