Search Results - "Zhang, ZhengKui"

The interactions between cGAS-STING pathway and pathogens by Cheng, Zhangliang, Dai, Tong, He, Xuelin, Zhang, Zhengkui, Xie, Feng, Wang, Shuai, Zhang, Long, Zhou, Fangfang

“…Cytosolic DNA is an indicator of pathogen invasion or DNA damage. The cytosolic DNA sensor cyclic guanosine monophosphate-adenosine monophosphate (cGAMP)…”
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ITGA1 Promotes Glioma Cell Proliferation and Affects Immune Cell Infiltration in Low‐Grade Glioma by Ren, Yanhong, Xu, Jianchang, Zhang, Zhengkui, Yu, Rutong

“…Background: Low‐grade glioma (LGG) is a commonly occurring type of central nervous system cancer. Integrin α1 (ITGA1), a family member of integrins, is implied…”
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OTUB2 Promotes Cancer Metastasis via Hippo-Independent Activation of YAP and TAZ by Zhang, Zhengkui, Du, Jinjin, Wang, Shuai, Shao, Li, Jin, Ke, Li, Fang, Wei, Bajin, Ding, Wei, Fu, Peifen, van Dam, Hans, Wang, Aijun, Jin, Jin, Ding, Chen, Yang, Bing, Zheng, Min, Feng, Xin-Hua, Guan, Kun-Liang, Zhang, Long

“…The transcriptional regulators YAP and TAZ play important roles in development, physiology, and tumorigenesis and are negatively controlled by the Hippo…”
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Methods and Technologies for Exosome Isolation and Characterization by Zhang, Mengdi, Jin, Ke, Gao, Liang, Zhang, Zhengkui, Li, Fang, Zhou, Fangfang, Zhang, Long

“…Exosomes, a specific subclass of the extracellular vesicles secreted by most cell types, play an important role in cell–cell communication by transporting…”
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Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7 by Zhang, Zhengkui, Fan, Yao, Xie, Feng, Zhou, Hang, Jin, Ke, Shao, Li, Shi, Wenhao, Fang, Pengfei, Yang, Bing, van Dam, Hans, ten Dijke, Peter, Zheng, Xiaofeng, Yan, Xiaohua, Jia, Junling, Zheng, Min, Jin, Jin, Ding, Chen, Ye, Sheng, Zhou, Fangfang, Zhang, Long

“…Metastasis is the main cause of death in cancer patients. TGF-β is pro-metastatic for malignant cancer cells. Here we report a loss-of-function screen in mice…”
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The Functional Deubiquitinating Enzymes in Control of Innate Antiviral Immunity by Zong, Zhi, Zhang, Zhengkui, Wu, Liming, Zhang, Long, Zhou, Fangfang

“…Innate antiviral immunity is the first line of host defense against invading viral pathogens. Immunity activation primarily relies on the recognition of…”
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Exosomal miR-485-3p derived from pancreatic ductal epithelial cells inhibits pancreatic cancer metastasis through targeting PAK1 by Li, Mingzhe, Zhou, Jiaxin, Zhang, Zhengkui, Li, Jisong, Wang, Feng, Ma, Ling, Tian, Xiaodong, Mao, Zebin, Yang, Yinmo

“…Cell competition is an important feature in pancreatic cancer (PC) progression, but the underlying mechanism remains elusive. This study aims to explore the…”
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The long noncoding RNA H19 promotes cell proliferation via E2F-1 in pancreatic ductal adenocarcinoma by Ma, Ling, Tian, Xiaodong, Wang, Feng, Zhang, Zhengkui, Du, Chong, Xie, Xuehai, Kornmann, Marko, Yang, Yinmo

“…H19 is a long noncoding RNA differentially expressed in many tumors and participates in tumorigenesis. This study aimed to investigate the expression and…”
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Shape Effects of Cylindrical versus Spherical Unimolecular Polymer Nanomaterials on in Vitro and in Vivo Behaviors by Zhang, Zhengkui, Liu, Changren, Li, Cheng, Wu, Wei, Jiang, Xiqun

“…To date, how the shape of nanomaterials influences their biological properties is poorly understood, due to the insufficient controllability of current…”
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USP4 inhibits SMAD4 monoubiquitination and promotes activin and BMP signaling by Zhou, Fangfang, Xie, Feng, Jin, Ke, Zhang, Zhengkui, Clerici, Marcello, Gao, Rui, van Dinther, Maarten, Sixma, Titia K, Huang, Huizhe, Zhang, Long, ten Dijke, Peter

“…SMAD4 is a common intracellular effector for TGF‐β family cytokines, but the mechanism by which its activity is dynamically regulated is unclear. We…”
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FAF1 Regulates Antiviral Immunity by Inhibiting MAVS but Is Antagonized by Phosphorylation upon Viral Infection by Dai, Tong, Wu, Liming, Wang, Shuai, Wang, Jing, Xie, Feng, Zhang, Zhengkui, Fang, Xiuwu, Li, Jingxian, Fang, Pengfei, Li, Fang, Jin, Ke, Dai, Jianfeng, Yang, Bing, Zhou, Fangfang, van Dam, Hans, Cai, Dachuan, Huang, Huizhe, Zhang, Long

“…Mitochondrial antiviral signaling protein (MAVS) is an adaptor of the innate immune receptor retinoic acid-inducible gene 1 (RIG-I) that links recognition of…”
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LncRNA H19-Derived miR-675-3p Promotes Epithelial-Mesenchymal Transition and Stemness in Human Pancreatic Cancer Cells by targeting the STAT3 Pathway by Wang, Feng, Rong, Long, Zhang, Zhengkui, Li, Mingzhe, Ma, Ling, Ma, Yongsu, Xie, Xuehai, Tian, Xiaodong, Yang, Yinmo

“…Objective: The functional role and mechanism of the long noncoding RNA (lncRNA) H19 in regulating human pancreatic cancer (PC) cell stemness and invasion have…”
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Regulation of TGF-β Superfamily Signaling by SMAD Mono-Ubiquitination by Xie, Feng, Zhang, Zhengkui, van Dam, Hans, Zhang, Long, Zhou, Fangfang

“…TGF-β(transforming growth factor-β) superfamily signaling mediators are important regulators of diverse physiological and pathological events. TGF-β signals…”
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YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through IKKɛ-mediated phosphorylation by Wang, Shuai, Xie, Feng, Chu, Feng, Zhang, Zhengkui, Yang, Bing, Dai, Tong, Gao, Liang, Wang, Lin, Ling, Li, Jia, Junling, van Dam, Hans, Jin, Jin, Zhang, Long, Zhou, Fangfang

“…Intracellular detection of viral invasion triggers activation of the transcription factor IRF3 and antiviral interferon production. Fangfang Zhou and…”
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Hedgehog Signaling Regulates Epithelial-Mesenchymal Transition in Pancreatic Cancer Stem-Like Cells by Wang, Feng, Ma, Ling, Zhang, Zhengkui, Liu, Xiaoran, Gao, Hongqiao, Zhuang, Yan, Yang, Pei, Kornmann, Marko, Tian, Xiaodong, Yang, Yinmo

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TRAF4 mediates activation of TGF-β signaling and is a biomarker for oncogenesis in breast cancer by Zhou, FangFang, Li, Fang, Xie, Feng, Zhang, ZhengKui, Huang, HuiZhe, Zhang, Long

“…The tumor-promoting arm of transforming growth factor beta (TGF-β) receptor signaling contributes to advanced cancer progression and is considered a master…”
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Harnessing epithelial-mesenchymal plasticity to boost cancer immunotherapy by Gu, Yuanzhuo, Zhang, Zhengkui, ten Dijke, Peter

“…Immune checkpoint blockade (ICB) therapy is a powerful option for cancer treatment. Despite demonstrable progress, most patients fail to respond or achieve…”
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Anti-tumor macrophages activated by ferumoxytol combined or surface-functionalized with the TLR3 agonist poly (I : C) promote melanoma regression by Zhao, Jiaojiao, Zhang, Zhengkui, Xue, Yaxian, Wang, Guoqun, Cheng, Yuan, Pan, Yuchen, Zhao, Shuli, Hou, Yayi

“…Macrophages orchestrate inflammation and control the promotion or inhibition of tumors and metastasis. Ferumoxytol (FMT), a clinically approved iron oxide…”
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Tumor-derived exosomes antagonize innate antiviral immunity by Gao, Liang, Wang, Lin, Dai, Tong, Jin, Ke, Zhang, Zhengkui, Wang, Shuai, Xie, Feng, Fang, Pengfei, Yang, Bing, Huang, Huizhe, van Dam, Hans, Zhou, Fangfang, Zhang, Long

“…Malignancies can compromise innate immunity, but the mechanisms of this are largely unknown. Here we found that, via tumor-derived exosomes (TEXs), cancers…”
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YAP antagonizes innate antiviral immunity and is targeted for lysosomal degradation through IKKε-mediated phosphorylation by Wang, Shuai, Xie, Feng, Chu, Feng, Zhang, Zhengkui, Yang, Bing, Dai, Tong, Gao, Liang, Wang, Lin, Ling, Li, Jia, Junling, Van Dam, Hans, Jin, Jin, Zhang, Long, Zhou, Fangfang

“…The transcription regulator YAP controls organ size by regulating cell growth, proliferation and apoptosis. However, whether YAP has a role in innate antiviral…”
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