Search Results - "Zhang, Yuexiu"

RING-Domain E3 Ligase-Mediated Host-Virus Interactions: Orchestrating Immune Responses by the Host and Antagonizing Immune Defense by Viruses by Zhang, Yuexiu, Li, Lian-Feng, Munir, Muhammad, Qiu, Hua-Ji

“…The RING-domain E3 ligases (RING E3s), a group of E3 ligases containing one or two RING finger domains, are involved in various cellular processes such as cell…”
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Three SARS-CoV-2 spike protein variants delivered intranasally by measles and mumps vaccines are broadly protective by Zhang, Yuexiu, Chamblee, Michelle, Xu, Jiayu, Qu, Panke, Shamseldin, Mohamed M., Yoo, Sung J., Misny, Jack, Thongpan, Ilada, KC, Mahesh, Hall, Jesse M., Gupta, Yash A., Evans, John P., Lu, Mijia, Ye, Chengjin, Hsu, Cheng Chih, Liang, Xueya, Martinez-Sobrido, Luis, Yount, Jacob S., Boyaka, Prosper N., Liu, Shan-Lu, Dubey, Purnima, Peeples, Mark E., Li, Jianrong

“…As the new SARS-CoV-2 Omicron variants and subvariants emerge, there is an urgency to develop intranasal, broadly protective vaccines. Here, we developed…”
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Viral RNA N6-methyladenosine modification modulates both innate and adaptive immune responses of human respiratory syncytial virus by Xue, Miaoge, Zhang, Yuexiu, Wang, Haitao, Kairis, Elizabeth L, Lu, Mijia, Ahmad, Sadeem, Attia, Zayed, Harder, Olivia, Zhang, Zijie, Wei, Jiangbo, Chen, Phylip, Gao, Youling, Peeples, Mark E, Sharma, Amit, Boyaka, Prosper, He, Chuan, Hur, Sun, Niewiesk, Stefan, Li, Jianrong

“…Human respiratory syncytial virus (RSV) is the leading cause of respiratory tract infections in humans. A well-known challenge in the development of a live…”
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MERTK is a host factor that promotes classical swine fever virus entry and antagonizes innate immune response in PK-15 cells by Zheng, Guanglai, Li, Lian-Feng, Zhang, Yuexiu, Qu, Liang, Wang, Wenjing, Li, Miao, Yu, Shaoxiong, Zhou, Mo, Luo, Yuzi, Sun, Yuan, Munir, Muhammad, Li, Su, Qiu, Hua-Ji

“…Classical swine fever virus (CSFV) is a member of the genus Pestivirus in the Flaviviridae family. To date, the host factors required for CSFV entry remain…”
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Rationally Designed ACE2-Derived Peptides Inhibit SARS-CoV‑2 by Larue, Ross C, Xing, Enming, Kenney, Adam D, Zhang, Yuexiu, Tuazon, Jasmine A, Li, Jianrong, Yount, Jacob S, Li, Pui-Kai, Sharma, Amit

“…Severe acute respiratory syndrome coronavirus (SARS-CoV)-2 is a novel and highly pathogenic coronavirus and is the causative agent of the coronavirus disease…”
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Abstract 2659: 5-methylcytosine (m5C) RNA modification controls the innate immune response to virus infection by regulating type I interferons by Zhang, Yuexiu, Zhang, Li-Sheng, Qing, Dai, Xu, Jiayu, Chen, Phylip, Peeples, Mark, Sharma, Amit, He, Chuan, Li, Jianrong

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Nonsegmented Negative-Sense RNA Viruses Utilize N 6 -Methyladenosine (m 6 A) as a Common Strategy To Evade Host Innate Immunity by Lu, Mijia, Xue, Miaoge, Wang, Hai-Tao, Kairis, Elizabeth L, Ahmad, Sadeem, Wei, Jiangbo, Zhang, Zijie, Liu, Qinzhe, Zhang, Yuexiu, Gao, Youling, Garcin, Dominique, Peeples, Mark E, Sharma, Amit, Hur, Sun, He, Chuan, Li, Jianrong

“…-Methyladenosine (m A) is the most abundant internal RNA modification catalyzed by host RNA methyltransferases. As obligate intracellular parasites, many…”
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Human Hemoglobin Subunit Beta Functions as a Pleiotropic Regulator of RIG-I/MDA5-Mediated Antiviral Innate Immune Responses by Yang, Qian, Bai, Si-Yu, Li, Lian-Feng, Li, Su, Zhang, Yuexiu, Munir, Muhammad, Qiu, Hua-Ji

“…Hemoglobin is an important oxygen-carrying protein and plays crucial roles in establishing host resistance against pathogens and in regulating innate immune…”
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SARS-CoV-2 prefusion spike protein stabilized by six rather than two prolines is more potent for inducing antibodies that neutralize viral variants of concern by Lu, Mijia, Chamblee, Michelle, Zhang, Yuexiu, Ye, Chengjin, Dravid, Piyush, Park, Jun-Gyu, Mahesh, K C, Trivedi, Sheetal, Murthy, Satyapramod, Sharma, Himanshu, Cassady, Cole, Chaiwatpongsakorn, Supranee, Liang, Xueya, Yount, Jacob S, Boyaka, Prosper N, Peeples, Mark E, Martinez-Sobrido, Luis, Kapoor, Amit, Li, Jianrong

“…The spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the main target for neutralizing antibodies (NAbs). The S protein…”
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A safe and highly efficacious measles virus-based vaccine expressing SARS-CoV-2 stabilized prefusion spike by Lu, Mijia, Dravid, Piyush, Zhang, Yuexiu, Trivedi, Sheetal, Li, Anzhong, Harder, Olivia, KC, Mahesh, Chaiwatpongsakorn, Supranee, Zani, Ashley, Kenney, Adam, Zeng, Cong, Cai, Chuanxi, Ye, Chengjin, Liang, Xueya, Shimamura, Masako, Liu, Shan-Lu, Mejias, Asuncion, Ramilo, Octavio, Boyaka, Prosper N., Qiu, Jianming, Martinez-Sobrido, Luis, Yount, Jacob S., Peeples, Mark E., Kapoor, Amit, Niewiesk, Stefan, Li, Jianrong

“…The current pandemic of COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) highlights an urgent need to develop a safe,…”
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KARR-seq reveals cellular higher-order RNA structures and RNA-RNA interactions by Wu, Tong, Cheng, Anthony Youzhi, Zhang, Yuexiu, Xu, Jiayu, Wu, Jinjun, Wen, Li, Li, Xiao, Liu, Bei, Dou, Xiaoyang, Wang, Pingluan, Zhang, Linda, Fei, Jingyi, Li, Jianrong, Ouyang, Zhengqing, He, Chuan

“…RNA fate and function are affected by their structures and interactomes. However, how RNA and RNA-binding proteins (RBPs) assemble into higher-order structures…”
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5-methylcytosine (m 5 C) RNA modification controls the innate immune response to virus infection by regulating type I interferons by Zhang, Yuexiu, Zhang, Li-Sheng, Dai, Qing, Chen, Phylip, Lu, Mijia, Kairis, Elizabeth L, Murugaiah, Valarmathy, Xu, Jiayu, Shukla, Rajni Kant, Liang, Xueya, Zou, Zhongyu, Cormet-Boyaka, Estelle, Qiu, Jianming, Peeples, Mark E, Sharma, Amit, He, Chuan, Li, Jianrong

“…5-methylcytosine (m C) is one of the most prevalent modifications of RNA, playing important roles in RNA metabolism, nuclear export, and translation. However,…”
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Porcine RING Finger Protein 114 Inhibits Classical Swine Fever Virus Replication via K27-Linked Polyubiquitination of Viral NS4B by Zhang, Yuexiu, Zhang, Huawei, Zheng, Guang-Lai, Yang, Qian, Yu, Shaoxiong, Wang, Jinghan, Li, Su, Li, Lian-Feng, Qiu, Hua-Ji

“…In the host, many RING domain E3 ligases have been reported to inhibit viral replication through various mechanisms. In a previous screen, we found that…”
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Heparanase Blockade as a Novel Dual-Targeting Therapy for COVID-19 by Xiang, Jingyu, Lu, Mijia, Shi, Min, Cheng, Xiaogang, Kwakwa, Kristin A, Davis, Jennifer L, Su, Xinming, Bakewell, Suzanne J, Zhang, Yuexiu, Fontana, Francesca, Xu, Yalin, Veis, Deborah J, DiPersio, John F, Ratner, Lee, Sanderson, Ralph D, Noseda, Alessandro, Mollah, Shamim, Li, Jianrong, Weilbaecher, Katherine N

“…The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused over 5 million deaths…”
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Interferon-Inducible Oligoadenylate Synthetase-Like Protein Acts as an Antiviral Effector against Classical Swine Fever Virus via the MDA5-Mediated Type I Interferon-Signaling Pathway by Li, Lian-Feng, Yu, Jiahui, Zhang, Yuexiu, Yang, Qian, Li, Yongfeng, Zhang, Lingkai, Wang, Jinghan, Li, Su, Luo, Yuzi, Sun, Yuan, Qiu, Hua-Ji

“…Classical swine fever virus (CSFV) is the causative agent of classical swine fever (CSF), which poses a serious threat to the global pig industry. Interferons…”
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Recombinant measles virus expressing prefusion spike protein stabilized by six rather than two prolines is more efficacious against SARS‐CoV‐2 infection by Zhang, Yuexiu, Lu, Mijia, Thongpan, Ilada, Xu, Jiayu, KC, Mahesh, Dravid, Piyush, Trivedi, Sheetal, Sharma, Himanshu, Liang, Xueya, Kapoor, Amit, Peeples, Mark E., Li, Jianrong

“…Measles virus (MeV) has been an excellent vector platform for delivering vaccines against many pathogens because of its high safety and efficacy, and induction…”
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A Methyltransferase-Defective Vesicular Stomatitis Virus-Based SARS-CoV-2 Vaccine Candidate Provides Complete Protection against SARS-CoV-2 Infection in Hamsters by Lu, Mijia, Zhang, Yuexiu, Dravid, Piyush, Li, Anzhong, Zeng, Cong, KC, Mahesh, Trivedi, Sheetal, Sharma, Himanshu, Chaiwatpongsakorn, Supranee, Zani, Ashley, Kenney, Adam, Cai, Chuanxi, Ye, Chengjin, Liang, Xueya, Qiu, Jianming, Martinez-Sobrido, Luis, Yount, Jacob S, Boyaka, Prosper N, Liu, Shan-Lu, Peeples, Mark E, Kapoor, Amit, Li, Jianrong

“…The current pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to dramatic economic…”
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A highly efficacious live attenuated mumps virus-based SARS-CoV-2 vaccine candidate expressing a six-proline stabilized prefusion spike by Zhang, Yuexiu, Lu, Mijia, Mahesh, K C, Kim, Eunsoo, Shamseldin, Mohamed M, Ye, Chengjin, Dravid, Piyush, Chamblee, Michelle, Park, Jun-Gyu, Hall, Jesse M, Trivedi, Sheetal, Chaiwatpongsakorn, Supranee, Kenny, Adam D, Murthy, Satyapramod Srinivasa, Sharma, Himanshu, Liang, Xueya, Yount, Jacob S, Kapoor, Amit, Martinez-Sobrido, Luis, Dubey, Purnima, Boyaka, Prosper N, Peeples, Mark E, Li, Jianrong

“…With the rapid increase in SARS-CoV-2 cases in children, a safe and effective vaccine for this population is urgently needed. The MMR (measles/mumps/rubella)…”
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Viral RNA N 6-methyladenosine modification modulates both innate and adaptive immune responses of human respiratory syncytial virus by Xue, Miaoge, Zhang, Yuexiu, Wang, Haitao, Kairis, Elizabeth L, Mijia Lu, Sadeem Ahmad, Zayed Attia, Olivia Harder, Zhang, Zijie, Wei, Jiangbo, Chen, Phylip, Gao, Youling, Mark E. Peeples, Sharma, Amit, Boyaka, Prosper, He, Chuan, Sun Hur, Stefan Niewiesk, Jianrong Li

“…Human respiratory syncytial virus (RSV) is the leading cause of respiratory tract infections in humans. A well-known challenge in the development of a live…”
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Viral RNA N.sup.6-methyladenosine modification modulates both innate and adaptive immune responses of human respiratory syncytial virus by Xue, Miaoge, Zhang, Yuexiu, Wang, Haitao, Kairis, Elizabeth L, Lu, Mijia, Ahmad, Sadeem, Attia, Zayed, Harder, Olivia, Zhang, Zijie, Wei, Jiangbo, Chen, Phylip, Gao, Youling, Peeples, Mark E, Sharma, Amit, Boyaka, Prosper, He, Chuan, Hur, Sun, Niewiesk, Stefan, Li, Jianrong

“…Human respiratory syncytial virus (RSV) is the leading cause of respiratory tract infections in humans. A well-known challenge in the development of a live…”
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