Search Results - "Zhang, Youxi"

Physiologically Based Pharmacokinetic Modeling of Cefadroxil in Mouse, Rat, and Human to Predict Concentration-Time Profile at Infected Tissue by Tan, Zhongxia, Zhang, Youxi, Wang, Chao, Sun, Le

“…The aim of this study was to develop physiologically based pharmacokinetic (PBPK) models capable of simulating cefadroxil concentrations in plasma and tissues…”
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RVG-Peptide-Linked Trimethylated Chitosan for Delivery of siRNA to the Brain by Gao, Yikun, Wang, Zhan-You, Zhang, Jinghai, Zhang, Youxi, Huo, Hong, Wang, Tianyi, Jiang, Tongying, Wang, Siling

“…In this work, a peptide derived from the rabies virus glycoprotein (RVG) was linked to siRNA/trimethylated chitosan (TMC) complexes through bifunctional PEG…”
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Protective properties of mesocellular silica foams against aggregation and enzymatic hydrolysis of loaded proteins for oral protein delivery by He, Ye, Wang, Mengyang, Zhang, Haotian, Zhang, Youxi, Gao, Yikun, Wang, Siling

“…[Display omitted] Numerous types of mesoporous silica nanoparticles (MSNs) have been studied as carriers for small molecular drugs. However, few reports have…”
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Promoting the Application of Big Data in Construction through Stakeholder Collaboration Based on a Two-Mode Network by Wang, Yali, Zhang, Youxi, Wang, Hao, Meng, Qinglin, Zhai, Yuwei, Dong, Na

“…Presently, the application of big data in the construction industry encounters numerous obstacles and involves diverse stakeholders, with the intricate network…”
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Prodrug design targeting intestinal PepT1 for improved oral absorption: design and performance by Zhang, Youxi, Sun, Jin, Sun, Yongbing, Wang, Yongjun, He, Zhonggui

“…Oligopeptide transporter 1 (PepT1) plays an essential role in the oral absorption of di-and tripeptides from the digestion of ingested protein. PepT1 has…”
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Current prodrug strategies for improving oral absorption of nucleoside analogues by Zhang, Youxi, Gao, Yikun, Wen, Xiaojing, Ma, Haiying

“…Nucleoside analogues are first line chemotherapy in various severe diseases: AIDS (acquired immunodeficiency disease syndrome), cytomegalovirus infections,…”
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A Carrier-Mediated Prodrug Approach To Improve the Oral Absorption of Antileukemic Drug Decitabine by Zhang, Youxi, Sun, Jin, Gao, Yikun, Jin, Ling, Xu, Youjun, Lian, He, Sun, Yongbing, Sun, Yinghua, Liu, Jianyu, Fan, Rui, Zhang, Tianhong, He, Zhonggui

“…Decitabine (5-aza-2′-deoxycytidine, DAC) is a novel DNA methyltransferase (DNMT) inhibitor for the treatment of myelodysplastic syndrome, acute and chronic…”
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Development of a supercritical fluid chromatography-tandem mass spectrometry method for the determination of azacitidine in rat plasma and its application to a bioavailability study by Li, Dongpo, Zhang, Tianhong, Kou, Longfa, Zhang, Youxi, Sun, Jin, He, Zhonggui

“…Azacitidine is widely used for the treatment of myelodysplastic syndromes (MDS) and acute myelogenous leukaemia (AML). The analysis of azacitidine in…”
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Bifunctional Peptidomimetic Prodrugs of Didanosine for Improved Intestinal Permeability and Enhanced Acidic Stability: Synthesis, Transepithelial Transport, Chemical Stability and Pharmacokinetics by Yan, Zhongtian, Sun, Jin, Chang, Yannan, Liu, Yanhua, Fu, Qiang, Xu, Youjun, Sun, Yongbing, Pu, Xiaohui, Zhang, Youxi, Jing, Yongkui, Yin, Shiliang, Zhu, Meng, Wang, Yongjun, He, Zhonggui

“…Five peptidomimetic prodrugs of didanosine (DDI) were synthesized and designed to improve bioavailability of DDI following oral administration via targeting…”
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Enhanced paracellular and transcellular paclitaxel permeation by chitosan–vitamin E succinate–N-acetyl-l-cysteine copolymer on Caco-2 cell monolayer by Lian, He, Zhang, Tianhong, Sun, Jin, Pu, Xiaohui, Tang, Yilin, Zhang, Youxi, He, Zhonggui

“…The aim of this study was to evaluate the underlying mechanism of enhanced oral absorption of paclitaxel (PTX)-loaded chitosan–vitamin E succinate– N -acetyl-…”
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Zwitterion-functionalized mesoporous silica nanoparticles for enhancing oral delivery of protein drugs by overcoming multiple gastrointestinal barriers by Gao, Yikun, He, Ye, Zhang, Haotian, Zhang, Youxi, Gao, Tianbin, Wang, Jia-Hong, Wang, Siling

“…[Display omitted] Oral delivery of protein or peptide drugs confronts several barriers, the intestinal epithelium and the mucus barrier on the gastrointestinal…”
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Approaches and materials for endocytosis-independent intracellular delivery of proteins by Chen, Nanxi, He, Ye, Zang, Mingming, Zhang, Youxi, Lu, Hongyan, Zhao, Qinfu, Wang, Siling, Gao, Yikun

“…The intracellular delivery of proteins is of great significance. For diseases such as cancer, heart disease and neurodegenerative diseases, many important…”
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A physiologically based pharmacokinetic model for valacyclovir established based on absolute expression quantity of hPEPT1 and its application by Sun, Le, Wang, Chao, Zhang, Youxi

“…In this study, a physiologically based pharmacokinetic (PBPK) model was established for valacyclovir based on absolute expression quantity of hPEPT1 along the…”
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Carrier proteins boost expression of PR-39-derived peptide in Pichia pastoris by Liu, Minzhi, Xiao, Yao, Yang, Yan, Zhou, Sihan, Shen, Xin, Zhang, Youxi, Wang, Wei

“…Multidrug resistance presents difficulties in preventing and treating bacterial infections. Proline-rich antimicrobial peptides (PrAMPs) inhibit bacterial…”
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Managing the high capital cost of prefabricated construction through stakeholder collaboration: a two-mode network analysis by Zhang, Youxi, Liu, Yu, Yu, Rui, Zuo, Jian, Dong, Na

“…Purpose Prefabricated construction (PC) can benefit construction industry due to its high efficiency, energy saving, consumption reduction and safety. However,…”
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Glucose-responsive insulin microneedle patches for long-acting delivery and release visualization by He, Ye, Chen, Nanxi, Zang, Mingming, Zhang, Jinghai, Zhang, Youxi, Lu, Hongyan, Zhao, Qinfu, Mao, Yuling, Yuan, Yue, Wang, Siling, Gao, Yikun

“…Limited drug loading and incomplete drug release are two major obstacles that traditional polymeric microneedles (MNs) have to overcome. For smart…”
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Targeted delivery of atorvastatin via asialoglycoprotein receptor (ASGPR) by Zhang, Youxi, Zhang, Xinfu, Zeng, Chunxi, Li, Bin, Zhang, Chengxiang, Li, Wenqing, Hou, Xucheng, Dong, Yizhou

“…[Display omitted] Targeted drug delivery platforms can increase the concentration of drugs in specific cell populations, reduce adverse effects, and hence…”
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CRISPR-Cas12a Possesses Unconventional DNase Activity that Can Be Inactivated by Synthetic Oligonucleotides by Li, Bin, Yan, Jingyue, Zhang, Youxi, Li, Wenqing, Zeng, Chunxi, Zhao, Weiyu, Hou, Xucheng, Zhang, Chengxiang, Dong, Yizhou

“…CRISPR-Cas12a (CRISPR-Cpf1) was reported to have multiple types of cleavage activities. Without the assistance of CRISPR RNA (crRNA), we investigated DNase…”
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Enhanced Oral Delivery of Paclitaxel Using Acetylcysteine Functionalized Chitosan-Vitamin E Succinate Nanomicelles Based on a Mucus Bioadhesion and Penetration Mechanism by Lian, He, Zhang, Tianhong, Sun, Jin, Liu, Xiaohong, Ren, Guolian, Kou, Longfa, Zhang, Youxi, Han, Xiaopeng, Ding, Wenya, Ai, Xiaoyu, Wu, Chunnuan, Li, Lin, Wang, Yongjun, Sun, Yinghua, Wang, Siling, He, Zhonggui

“…In addition to being a physiological protective barrier, the gastrointestinal mucosal membrane is also a primary obstacle that hinders the oral absorption of…”
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An HPLC–MS/MS method for simultaneous determination of decitabine and its valyl prodrug valdecitabine in rat plasma by Zhang, Youxi, Sun, Jin, Gao, Yikun, Kong, Ying, Xu, Youjun, Jia, Weiru, Liao, Chuanrong, Zhang, Peng, Lian, He, Han, Xiaopeng, Li, Dongpo, Geng, Yajie, He, Zhonggui

“…► A C18 column (150mm×4.6mm, 3.5μm) was applied to obtain satisfactory separation. ► A cation exchange solid phase extraction provided high recovery and clean…”
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