Search Results - "Zhang, Ying E"

Direct Regulation of Alternative Splicing by SMAD3 through PCBP1 Is Essential to the Tumor-Promoting Role of TGF-β by Tripathi, Veenu, Sixt, Katherine M., Gao, Shaojian, Xu, Xuan, Huang, Jing, Weigert, Roberto, Zhou, Ming, Zhang, Ying E.

“…In advanced stages of cancers, TGF-β promotes tumor progression in conjunction with inputs from receptor tyrosine kinase pathways. However, mechanisms that…”
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Phosphorylation of SMURF2 by ATM exerts a negative feedback control of DNA damage response by Tang, Liu-Ya, Thomas, Adam, Zhou, Ming, Zhang, Ying E.

“…Timely repair of DNA double-strand breaks (DSBs) is essential to maintaining genomic integrity and preventing illnesses induced by genetic abnormalities. We…”
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Transforming Growth Factor-β: An Agent of Change in the Tumor Microenvironment by Stuelten, Christina H., Zhang, Ying E.

“…Transforming Growth Factor-β (TGF-β) is a key regulator of embryonic development, adult tissue homeostasis, and lesion repair. In tumors, TGF-β is a potent…”
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Non-Smad Signaling Pathways of the TGF-β Family by Zhang, Ying E

“…Transforming growth factor β (TGF-β) and structurally related factors use several intracellular signaling pathways in addition to Smad signaling to regulate a…”
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Opposing functions of circadian protein DBP and atypical E2F family E2F8 in anti-tumor Th9 cell differentiation by Park, Sang-A, Lim, Yun-Ji, Ku, Wai Lim, Zhang, Dunfang, Cui, Kairong, Tang, Liu-Ya, Chia, Cheryl, Zanvit, Peter, Chen, Zuojia, Jin, Wenwen, Wang, Dandan, Xu, Junji, Liu, Ousheng, Wang, Fu, Cain, Alexander, Guo, Nancy, Nakatsukasa, Hiroko, Wu, Chuan, Zhang, Ying E., Zhao, Keji, Chen, WanJun

“…Interleukin-9 (IL-9)-producing CD4 + T helper cells (Th9) have been implicated in allergy/asthma and anti-tumor immunity, yet molecular insights on their…”
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Oxy210, a Semi-Synthetic Oxysterol, Exerts Anti-Inflammatory Effects in Macrophages via Inhibition of Toll-like Receptor (TLR) 4 and TLR2 Signaling and Modulation of Macrophage Polarization by Wang, Feng, Stappenbeck, Frank, Tang, Liu-Ya, Zhang, Ying E, Hui, Simon T, Lusis, Aldons J, Parhami, Farhad

“…Inflammatory responses by the innate and adaptive immune systems protect against infections and are essential to health and survival. Many diseases including…”
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Non-proteolytic ubiquitin modification of PPARγ by Smurf1 protects the liver from steatosis by Zhu, Kun, Tang, Yi, Xu, Xuan, Dang, Hien, Tang, Liu-Ya, Wang, Xiang, Wang, Xin Wei, Zhang, Ying E

“…Nonalcoholic fatty liver disease (NAFLD) is characterized by abnormal accumulation of triglycerides (TG) in the liver and other metabolic syndrome symptoms,…”
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MicroRNA-19b exacerbates systemic sclerosis through promoting Th9 cells by Lim, Yun-Ji, Park, Sang-A, Wang, Dandan, Jin, Wenwen, Ku, Wai Lim, Zhang, Dunfang, Xu, Junji, Patiño, Liliana C., Liu, Na, Chen, Weiwei, Kazmi, Rida, Zhao, Keji, Zhang, Ying E., Sun, Lingyun, Chen, WanJun

“…Systemic sclerosis (SSc) is a chronic autoimmune disease characterized by fibrosis of the skin and multiple vital organs, but the immunological pathogenesis of…”
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Non-Smad pathways in TGF-β signaling by Zhang, Ying E

“…Transforming growth factor-β utilizes a multitude of intracellular signaling pathways in addition to Smads to regulate a wide array of cellular functions…”
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Mechanistic insight into contextual TGF-β signaling by Zhang, Ying E

“…Transforming growth factor-β (TGF-β) controls a wide range of cellular functions by activating both SMADs and non-SMAD pathways. In different tissue or…”
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SIRT7 Deacetylates STRAP to Regulate p53 Activity and Stability by Yu, Miao, Shi, Xiaoyan, Ren, Mengmeng, Liu, Lu, Qi, Hao, Zhang, Chi, Zou, Junhua, Qiu, Xiaoyan, Zhu, Wei-Guo, Zhang, Ying E, Wang, Wengong, Luo, Jianyuan

“…Serine-threonine kinase receptor-associated protein (STRAP) functions as a regulator of both TGF-β and p53 signaling that participates in the regulation of…”
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Tumor Necrosis Factor Promotes Runx2 Degradation through Up-regulation of Smurf1 and Smurf2 in Osteoblasts by Kaneki, Hiroyuki, Guo, Ruolin, Chen, Di, Yao, Zhenqiang, Schwarz, Edward M., Zhang, Ying E., Boyce, Brendan F., Xing, Lianping

“…Tumor necrosis factor (TNF) plays an important role in the pathogenesis of inflammatory bone loss through stimulation of osteoclastic bone resorption and…”
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Requirement of Smurf-mediated endocytosis of Patched1 in sonic hedgehog signal reception by Yue, Shen, Tang, Liu-Ya, Tang, Ying, Tang, Yi, Shen, Qiu-Hong, Ding, Jie, Chen, Yan, Zhang, Zengdi, Yu, Ting-Ting, Zhang, Ying E, Cheng, Steven Y

“…Cell surface reception of Sonic hedgehog (Shh) must ensure that the graded morphogenic signal is interpreted accordingly in neighboring cells to specify tissue…”
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Essential role of chromatin remodeling protein Bptf in early mouse embryos and embryonic stem cells by Landry, Joseph, Sharov, Alexei A, Piao, Yulan, Sharova, Lioudmila V, Xiao, Hua, Southon, Eileen, Matta, Jennifer, Tessarollo, Lino, Zhang, Ying E, Ko, Minoru S H, Kuehn, Michael R, Yamaguchi, Terry P, Wu, Carl

“…We have characterized the biological functions of the chromatin remodeling protein Bptf (Bromodomain PHD-finger Transcription Factor), the largest subunit of…”
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Ubiquitin Ligase Smurf1 Controls Osteoblast Activity and Bone Homeostasis by Targeting MEKK2 for Degradation by Yamashita, Motozo, Ying, Sai-Xia, Zhang, Gen-mu, Li, Cuiling, Cheng, Steven Y., Deng, Chu-xia, Zhang, Ying E.

“…Bone is constantly resorbed and formed throughout life by coordinated actions of osteoclasts and osteoblasts. Here we show that Smurf1, a HECT domain ubiquitin…”
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Smad3 reduces susceptibility to hepatocarcinoma by sensitizing hepatocytes to apoptosis through downregulation of Bcl-2 by Yang, Yu-An, Zhang, Gen-Mu, Feigenbaum, Lionel, Zhang, Ying E.

“…In the liver, derangement of TGF-β signaling is associated with an increased incidence of hepatocellular carcinoma (HCC), but the mechanism is not clear. We…”
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Ubiquitin Ligase Smurf1 Mediates Tumor Necrosis Factor-induced Systemic Bone Loss by Promoting Proteasomal Degradation of Bone Morphogenetic Signaling Proteins by Guo, Ruolin, Yamashita, Motozo, Zhang, Qian, Zhou, Quan, Chen, Di, Reynolds, David G., Awad, Hani A., Yanoso, Laura, Zhao, Lan, Schwarz, Edward M., Zhang, Ying E., Boyce, Brendan F., Xing, Lianping

“…Chronic inflammatory disorders, such as rheumatoid arthritis, are often accompanied by systemic bone loss, which is thought to occur through inflammatory…”
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Oxysterol derivatives Oxy186 and Oxy210 inhibit WNT signaling in non-small cell lung cancer by Tang, Liu-Ya, Spezia, Marie, Chen, Ting, Shin, Jee-Hye, Wang, Feng, Stappenbeck, Frank, Lebensohn, Andres M, Parhami, Farhad, Zhang, Ying E

“…Developmental signaling pathways such as those of Hedgehog (HH) and WNT play critical roles in cancer stem cell self-renewal, migration, and differentiation…”
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Smad Ubiquitination Regulatory Factor 2 Promotes Metastasis of Breast Cancer Cells by Enhancing Migration and Invasiveness by CHAOYANG JIN, YANG, Yu-An, ANVER, Miriam R, MORRIS, Nicole, XIANGCHUN WANG, ZHANG, Ying E

“…Controlled protein degradation mediated by ubiquitin/proteasome system (UPS) plays a crucial role in modulating a broad range of cellular responses…”
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Image-based genome-wide siRNA screen identifies selective autophagy factors by ORVEDAHL, Anthony, SUMPTER, Rhea, FORST, Christian V, WRANA, Jeffrey L, ZHANG, Ying E, LUBY-PHELPS, Katherine, XAVIER, RamnikJ, YANG XIE, LEVINE, Beth, GUANGHUA XIAO, AYLWIN NG, ZHONGJU ZOU, YI TANG, NARIMATSU, Masahiro, GILPIN, Christopher, QIHUA SUN, ROTH, Michael

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