Search Results - "Zhang, Yan J."

Recommendations for Validation of LC-MS/MS Bioanalytical Methods for Protein Biotherapeutics by Jenkins, Rand, Duggan, Jeffrey X., Aubry, Anne-Françoise, Zeng, Jianing, Lee, Jean W., Cojocaru, Laura, Dufield, Dawn, Garofolo, Fabio, Kaur, Surinder, Schultz, Gary A., Xu, Keyang, Yang, Ziping, Yu, John, Zhang, Yan J., Vazvaei, Faye

“…ABSTRACT This paper represents the consensus views of a cross-section of companies and organizations from the USA and Canada regarding the validation and…”
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Eliminating Preparation of Multisample External Calibration Curves and Dilution of Study Samples Using the Multiple Isotopologue Reaction Monitoring (MIRM) Technique in Quantitative LC-MS/MS Bioanalysis by Gu, Huidong, Zhao, Yue, DeMichele, Marissa, Zheng, Naiyu, Zhang, Yan J, Pillutla, Renuka, Zeng, Jianing

“…Preparation of multisample external calibration curves and dilution of study samples are critical steps in bioanalytical sample processing for quantitative…”
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In-Sample Calibration Curve Using Multiple Isotopologue Reaction Monitoring of a Stable Isotopically Labeled Analyte for Instant LC-MS/MS Bioanalysis and Quantitative Proteomics by Gu, Huidong, Zhao, Yue, DeMichele, Marissa, Zheng, Naiyu, Zhang, Yan J, Pillutla, Renuka, Zeng, Jianing

“…A novel methodology of in-sample calibration curves (ISCC) using multiple isotopologue reaction monitoring (MIRM) of multiple naturally occurring isotopologue…”
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Antipeptide Immunocapture with In-Sample Calibration Curve Strategy for Sensitive and Robust LC-MS/MS Bioanalysis of Clinical Protein Biomarkers in Formalin-Fixed Paraffin-Embedded Tumor Tissues by Zheng, Naiyu, Taylor, Kristin, Gu, Huidong, Santockyte, Rasa, Wang, Xi-Tao, McCarty, Jean, Adelakun, Olufemi, Zhang, Yan J, Pillutla, Renuka, Zeng, Jianing

“…Despite huge promises, bioanalysis of protein biomarkers in formalin-fixed paraffin-embedded (FFPE) tissues by liquid chromatography-tandem mass spectrometry…”
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Fit-for-purpose protein biomarker assay validation strategies using hybrid immunocapture-liquid chromatography-tandem-mass spectrometry platform: Quantitative analysis of total soluble cluster of differentiation 73 by Zhao, Yue, Gu, Huidong, Postelnek, Jennifer, DeMichele, Marissa, Yuan, Long, Zhang, Yan J., Zeng, Jianing

“…In recent years, biomarkers have played more extensive roles as indicators of disease progression, safety, and drug efficacy. Targeted quantitative analysis of…”
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Technologies and strategies for bioanalysis of biopharmaceuticals by Zhang, Yan J, An, Hyun Joo

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Identification of Dynein Heavy Chain 7 as an Inner Arm Component of Human Cilia That Is Synthesized but Not Assembled in a Case of Primary Ciliary Dyskinesia by Zhang, Yan J., O'Neal, Wanda K., Randell, Scott H., Blackburn, Kevin, Moyer, Mary B., Boucher, Richard C., Ostrowski, Lawrence E.

“…Although the basic structure of the axoneme has been highly conserved throughout evolution, the varied functions of specialized axonemes require differences in…”
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Determination of Real Time in Vivo Drug Receptor Occupancy for a Covalent Binding Drug as a Clinical Pharmacodynamic Biomarker by Immunocapture-LC-MS/MS by Zheng, Naiyu, Catlett, Ian M, Taylor, Kristin, Gu, Huidong, Pattoli, Mark A, Neely, Robert J, Li, Wenying, Allentoff, Alban, Yuan, Xiling, Ciccimaro, Eugene, Yao, Ming, Warrack, Bethanne M, Burke, James R, Zhang, Yan J, Pillutla, Renuka, Zeng, Jianing

“…We report a novel immunocapture (IC)-LC-MS/MS methodology to directly measure real time in vivo receptor occupancy (RO) for a covalent binding drug in blood…”
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A multiplexed immunocapture liquid chromatography tandem mass spectrometry assay for the simultaneous measurement of myostatin and GDF-11 in rat serum using an automated sample preparation platform by Zhao, Yue, Liu, Guowen, Zambito, Frank C., Zhang, Yan J., DeSilva, Binodh S., Kozhich, Alexander T., Shen, Jim X.

“…Myostatin, also known as growth differentiation factor 8 (GDF-8), is a protein acting as a negative regulator in skeletal muscle growth. Inhibition of…”
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Characterization of labeled reagents in ligand-binding assays by a surface plasmon resonance biosensor by Duo, Jia, Bruno, JoAnne, Piccoli, Steven, DeSilva, Binodh, Zhang, Yan J

“…Ligand-binding assay (LBA) reagent labeling may change the binding characteristics of the reagent to its target and degrade its performance in LBAs. A surface…”
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Surface plasmon resonance as a tool for ligand-binding assay reagent characterization in bioanalysis of biotherapeutics by Duo, Jia, Bruno, JoAnne, Kozhich, Alexander, David-brown, Donata, Luo, Linlin, Kwok, Suk, Santockyte, Rasa, Haulenbeek, Jonathan, Liu, Rong, Hamuro, Lora, Peterson, Jon E, Piccoli, Steven, DeSilva, Binodh, Pillutla, Renuka, Zhang, Yan J

“…Ligand-binding assay (LBA) performance depends on quality reagents. Strategic reagent screening and characterization is critical to LBA development,…”
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The integration of ligand binding and LC-MS-based assays into bioanalytical strategies for protein analysis by Zhang, Yan J, Olah, Timothy V, Zeng, Jianing

“…Both LBAs and LC-MS-based assays are reviewed and summarized for applications in quantitative protein analysis. A strategy for platform selection is proposed…”
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Overview on biotherapeutic proteins: impact on bioanalysis by Zhang, Yan J, Luo, Linlin, Desai, Dharmesh D

“…This article provides an overview of the information and factors relevant to designing bioanalytical strategies in support of in vivo nonclinical and clinical…”
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LC-MS/MS bioanalysis of plasma 1, 14-tetradecanedioic acid and 1, 16-hexadecanedioic acid as candidate biomarkers for organic anion-transporting polypeptide mediated drug-drug interactions by Santockyte, Rasa, Kandoussi, Hamza, Chen, Weiqi, Zheng, Naiyu, Venkatarangan, Lata, Gan, Jinping, Shen, Hong, Bonacorsi, Samuel J, Easter, John, Burrell, Richard, Zhang, Yan J, Zeng, Jianing

“…A robust LC-MS/MS assay was developed to quantify endogenous 1, 14-tetradecanedioic acid (TDA) and 1, 16-hexadecanedioic acid (HDA) in human plasma as…”
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Activation of Toll-like receptor 2 on human tracheobronchial epithelial cells induces the antimicrobial peptide human beta defensin-2 by Hertz, Cheryl J, Wu, Qi, Porter, Edith Martin, Zhang, Yan J, Weismüller, Karl-Heinz, Godowski, Paul J, Ganz, Tomas, Randell, Scott H, Modlin, Robert L

“…As pattern recognition receptors capable of eliciting responses to a diverse array of microbial products, Toll-like receptors (TLRs) participate in the…”
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Quantitation of a PEGylated protein in monkey serum by UHPLC-HRMS using a surrogate disulfide-containing peptide: A new approach to bioanalysis and in vivo stability evaluation of disulfide-rich protein therapeutics by Zheng, Naiyu, Zeng, Jianing, Manney, Amy, Williams, Lakenya, Aubry, Anne-Françoise, Voronin, Kimberly, Buzescu, Adela, Zhang, Yan J., Allentoff, Alban, Xu, Carrie, Shen, Hongwu, Warner, William, Arnold, Mark E.

“…To quantify a therapeutic PEGylated protein in monkey serum as well as to monitor its potential in vivo instability and methionine oxidation, a novel ultra…”
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Rapid development of multiple 'fit-for-purpose' assays on an automatic microfluidic system using a streamlined process in support of early biotherapeutics discovery programs by Liu, Rong, Pillutla, Renuka, DeSilva, Binodh, Zhang, Yan J

“…With a rapid increase in the number of novel biotherapeutic programs in the pipelines, efficient development of ligand-binding assays for PK and PD studies in…”
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A generic template for automated bioanalytical ligand-binding assays using modular robotic scripts in support of discovery biotherapeutic programs by Duo, Jia, Dong, Huijin, DeSilva, Binodh, Zhang, Yan J

“…Sample dilution and reagent pipetting are time-consuming steps in ligand-binding assays (LBAs). Traditional automation-assisted LBAs use assay-specific scripts…”
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Electrochemiluminescence in bioanalysis by Rhyne, Paul W, Wong, Oi T, Zhang, Yan J, Weiner, Russell S

“…The discovery of electrochemiluminescence (ECL) and its development as a means of detection is truly a success story. Although studies describing ECL were…”
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Immunoassay-based measurement of clinical biomarkers for monitoring changes in nasal cavity by Zhang, Yan J., Luroe, Sherri, Schieber, Frank, Kelsey, Joan, Nabbie, Fizal, Rizzi, Giovanni, Richards, Penny, Weiner, Russell, Rhyne, Paul W.

“…Many drugs for treatment of allergies, migraine headaches, inflammation, and other indications are administered into the nasal cavity providing access to the…”
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