Search Results - "Zhang, Wannian"

State-of-the-art strategies for targeting protein-protein interactions by small-molecule inhibitors by Sheng, Chunquan, Dong, Guoqiang, Miao, Zhenyuan, Zhang, Wannian, Wang, Wei

“…Targeting protein-protein interactions (PPIs) has emerged as a viable approach in modern drug discovery. However, the identification of small molecules…”
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Inhibitor of Apoptosis Protein (IAP) Antagonists in Anticancer Agent Discovery: Current Status and Perspectives by Cong, Hui, Xu, Lijuan, Wu, Yougen, Qu, Zhuo, Bian, Tengfei, Zhang, Wannian, Xing, Chengguo, Zhuang, Chunlin

“…Apoptosis, an important form of programmed cell death (PCD), is a tightly regulated cellular process to eliminate unwanted or damaged cells. Resistance of…”
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New lead structures in antifungal drug discovery by Sheng, C, Zhang, W

“…During the past two decades, the incidence of invasive fungal infections has been increasing dramatically. Clinical available antifungal agents have several…”
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Rapid Identification of Keap1–Nrf2 Small-Molecule Inhibitors through Structure-Based Virtual Screening and Hit-Based Substructure Search by Zhuang, Chunlin, Narayanapillai, Sreekanth, Zhang, Wannian, Sham, Yuk Yin, Xing, Chengguo

“…In this study, rapid structure-based virtual screening and hit-based substructure search were utilized to identify small molecules that disrupt the interaction…”
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New Tricks for an Old Natural Product: Discovery of Highly Potent Evodiamine Derivatives as Novel Antitumor Agents by Systemic Structure–Activity Relationship Analysis and Biological Evaluations by Dong, Guoqiang, Wang, Shengzheng, Miao, Zhenyuan, Yao, Jianzhong, Zhang, Yongqiang, Guo, Zizhao, Zhang, Wannian, Sheng, Chunquan

“…Evodiamine is a quinazolinocarboline alkaloid isolated from the fruits of traditional Chinese herb Evodiae fructus. Previously, we identified N13-substituted…”
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Mechanism and Improved Dissolution of Glycyrrhetinic Acid Solid Dispersion by Alkalizers by Dong, Luning, Mai, Yaping, Liu, Qiang, Zhang, Wannian, Yang, Jianhong

“…The purpose of this study was to increase the dissolution of glycyrrhetinic acid (GA) by preparing ternary solid dispersion (TSD) systems containing…”
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Ligand-based substituent-anchoring design of selective receptor-interacting protein kinase 1 necroptosis inhibitors for ulcerative colitis therapy by Zhu, Jing, Xin, Meng, Xu, Congcong, He, Yuan, Zhang, Wannian, Wang, Zhibin, Zhuang, Chunlin

“…Receptor-interacting protein (RIP) kinase 1 is involved in immune-mediated inflammatory diseases including ulcerative colitis (UC) by regulating necroptosis…”
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Structure-based optimizations of a necroptosis inhibitor (SZM594) as novel protective agents of acute lung injury by Xu, Lijuan, Tu, Ye, Li, Jiao, Zhang, Wannian, Wang, Zhibin, Zhuang, Chunlin, Xue, Lei

“…Targeting RIPK1 is a promising strategy for the treatment or alleviation of acute lung injury (ALI). SZM594, a benzothiazole compound previously developed by…”
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Pharmacokinetic, Tissue Distribution, Metabolite, and Toxicity Evaluation of the Matrine Derivative, (6aS, 10S, 11aR, 11bR, 11cS)-10-Methylaminododecahydro-3a, 7a-Diaza-benzo (de) Anthracene-8-thione by Li, Liuyan, Lu, Fangfang, Ding, Shuqin, Wang, Xiaoying, Wang, Weibiao, Zhang, Wannian, Xu, Weiheng, Zhuang, Chunlin, Miao, Zhenyuan, Ma, Xueqin

“…MASM, a structurally modified derivative of matrine, exhibits superior efficacy in reducing inflammation and liver injury in rats when compared to matrine…”
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Radiosensitization of human pancreatic cancer by piperlongumine analogues by Ma, Hao, Wu, Yuelin, Zhang, Wannian, Zhang, Huojun, Miao, Zhenyuan, Zhuang, Chunlin

“…A series of piperlongumine derivatives were synthesized. Compounds 9c and 9d enhanced the radiosensitivity of Panc-1 and SW1990 cells with high sensitivity…”
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Dual NAMPT/HDAC Inhibitors as a New Strategy for Multitargeting Antitumor Drug Discovery by Chen, Wei, Dong, Guoqiang, Wu, Ying, Zhang, Wannian, Miao, Chaoyu, Sheng, Chunquan

“…Novel dual nicotinamide phosphoribosyltransferase (NAMPT) and histone deacetylase (HDAC) inhibitors were designed by a pharmacophore fusion approach. The…”
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Preparation and characterization of wet-milled cyclovirobuxine D nanosuspensions by Han, Tianyan, Yong, Jinjiao, Liu, Qiang, Gu, Xiangshuai, Zhang, Wannian, Yang, Jianhong

“…This study aims to develop nanosuspensions for improving the dissolution of poorly water-soluble cyclovirobuxine D (CVB-D) containing a binary stabilizer…”
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Chlorin p6‑Based Water-Soluble Amino Acid Derivatives as Potent Photosensitizers for Photodynamic Therapy by Meng, Zhi, Yu, Bin, Han, Guiyan, Liu, Minghui, Shan, Bin, Dong, Guoqiang, Miao, Zhenyuan, Jia, Ningyang, Tan, Zou, Li, Buhong, Zhang, Wannian, Zhu, Haiying, Sheng, Chunquan, Yao, Jianzhong

“…The development of novel photosensitizer with high phototoxicity, low dark toxicity, and good water solubility is a challenging task for photodynamic therapy…”
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Novel fluorescent probes of 10-hydroxyevodiamine: autophagy and apoptosis-inducing anticancer mechanisms by Chen, Shuqiang, Dong, Guoqiang, Wu, Shanchao, Liu, Na, Zhang, Wannian, Sheng, Chunquan

“…Natural product evodiamine and its derivatives represent a promising class of multi-target antitumor agents. However, the clinical development of these…”
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Updated research and applications of small molecule inhibitors of Keap1-Nrf2 protein-protein interaction: a review by Zhuang, Chunlin, Miao, Zhenyuan, Sheng, Chunquan, Zhang, Wannian

“…The Keap1-Nrf2-ARE pathway is one of the most important regulators of cytoprotective responses to oxidative and/or electrophilic stresses, which is believed to…”
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JMJD4-demethylated RIG-I prevents hepatic steatosis and carcinogenesis by Li, Zhenyang, Zhou, Ye, Jia, Kaiwei, Yang, Yingyun, Zhang, Liyuan, Wang, Suyuan, Dong, Yue, Wang, Mu, Li, Yunhui, Lu, Shan, Zhang, Wannian, Zhang, Luxin, Fan, Yiwen, Zhang, Dingji, Li, Nan, Yu, Yizhi, Cao, Xuetao, Hou, Jin

“…Abstract Background Hepatocarcinogenesis is driven by necroinflammation or metabolic disorders, and the underlying mechanisms remain largely elusive. We…”
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New strategies in the discovery of novel non-camptothecin topoisomerase I inhibitors by Sheng, Chunquan, Miao, Zhenyuan, Zhang, Wannian

“…Topoisomerase I (Top1) represents an important target of active interest in developing novel anticancer agents. Camptothecin derivatives are the only class of…”
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A potent phosphodiester Keap1-Nrf2 protein-protein interaction inhibitor as the efficient treatment of Alzheimer's disease by Sun, Yi, Xu, Lijuan, Zheng, Dongpeng, Wang, Jue, Liu, Guodong, Mo, Zixin, Liu, Chao, Zhang, Wannian, Yu, Jianqiang, Xing, Chengguo, He, Ling, Zhuang, Chunlin

“…The Keap1-Nrf2 pathway has been established as a therapeutic target for Alzheimer's disease (AD). Directly inhibiting the protein-protein interaction (PPI)…”
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Design, synthesis and antifungal activity of novel triazole derivatives containing substituted 1,2,3-triazole-piperdine side chains by Jiang, Zhigan, Gu, Julin, Wang, Chen, Wang, Shengzheng, Liu, Na, Jiang, Yan, Dong, Guoqiang, Wang, Yan, Liu, Yang, Yao, Jianzhong, Miao, Zhenyuan, Zhang, Wannian, Sheng, Chunquan

“…Due to increasing incidence of invasive fungal infections and severe drug resistance to triazole antifungal agents, a series of novel antifungal triazoles with…”
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Discovery of simplified sampangine derivatives as novel fungal biofilm inhibitors by Liu, Na, Zhong, Hua, Tu, Jie, Jiang, Zhigan, Jiang, Yanjuan, Jiang, Yan, Jiang, Yuanying, Li, Jian, Zhang, Wannian, Wang, Yan, Sheng, Chunquan

“…Lack of novel antifungal agents and severe drug resistance have led to high incidence and associated mortality of invasive fungal infections. To tackle the…”
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