Search Results - "Zhang, Shenpeng R"

Human amnion epithelial cell therapy reduces hypertension-induced vascular stiffening and cognitive impairment by Dinh, Quynh Nhu, Lo, Cecilia, Zhang, David Wong, Tran, Vivian, Gibson-Hughes, Tayla, Sheriff, Ashleigh, Diep, Henry, Kim, Hyun Ah, Zhang, Shenpeng R., Barreto-Arce, Liz J., Jelinic, Maria, Vinh, Antony, Arumugam, Thiruma V., Chan, Siow Teng, Lim, Rebecca, Drummond, Grant R., Sobey, Christopher G., De Silva, T. Michael

“…Vascular inflammation and fibrosis are hallmarks of hypertension and contribute to the development of cardiovascular disease and cognitive impairment. However,…”
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MouseMove: an open source program for semi-automated analysis of movement and cognitive testing in rodents by Samson, Andre L., Ju, Lining, Ah Kim, Hyun, Zhang, Shenpeng R., Lee, Jessica A. A., Sturgeon, Sharelle A., Sobey, Christopher G., Jackson, Shaun P., Schoenwaelder, Simone M.

“…The Open Field (OF) test is one of the most commonly used assays for assessing exploratory behaviour and generalised locomotor activity in rodents…”
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Protection against brain injury after ischemic stroke by intravenous human amnion epithelial cells in combination with tissue plasminogen activator by Barreto-Arce, Liz J, Kim, Hyun Ah, Chan, Siow Teng, Lim, Rebecca, Drummond, Grant R, Ma, Henry, Phan, Thanh G, Sobey, Christopher G, Zhang, Shenpeng R

“…Thrombolytic agents such as tissue plasminogen activator (tPA) are the only drug class approved to treat ischemic stroke and are usually administered within…”
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Phase I trial outcome of amnion cell therapy in patients with ischemic stroke (I-ACT) by Phan, Thanh G, Lim, Rebecca, Chan, Siow T, McDonald, Hannah, Gan, Poh-Yi, Zhang, Shenpeng R, Barreto Arce, Liz J, Vuong, Jason, Thirugnanachandran, Tharani, Clissold, Benjamin, Ly, John, Singhal, Shaloo, Hervet, Marie Veronic, Kim, Hyun Ah, Drummond, Grant R, Wallace, Euan M, Ma, Henry, Sobey, Christopher G

“…We proposed a Phase I dose escalation trial to assess the safety of allogeneic human amniotic epithelial cells (hAECs) in stroke patients with a view to…”
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Hippocampal transcriptome profiling reveals common disease pathways in chronic hypoperfusion and aging by Baik, Sang-Ha, Selvaraji, Sharmelee, Fann, David Y, Poh, Luting, Jo, Dong-Gyu, Herr, Deron R, Zhang, Shenpeng R, Kim, Hyun Ah, Silva, Michael De, Lai, Mitchell K P, Chen, Christopher Li-Hsian, Drummond, Grant R, Lim, Kah-Leong, Sobey, Christopher G, Arumugam, Thiruma V

“…Vascular dementia (VaD) is a progressive cognitive impairment of vascular etiology. VaD is characterized by cerebral hypoperfusion, increased blood-brain…”
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Targeting the Immune System for Ischemic Stroke by Zhang, Shenpeng R., Phan, Thanh G., Sobey, Christopher G.

“…Stroke is responsible for almost 6 million deaths and more than 10% of all mortalities each year, and two-thirds of stroke survivors remain disabled. With…”
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Systemic treatment with human amnion epithelial cells after experimental traumatic brain injury by Ah Kim, Hyun, Semple, Bridgette D., Dill, Larissa K., Pham, Louise, Dworkin, Sebastian, Zhang, Shenpeng R., Lim, Rebecca, Sobey, Christopher G., McDonald, Stuart J.

“…Systemic administration of human amnion epithelial cells (hAECs) was recently shown to reduce neuropathology and improve functional recovery following ischemic…”
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Ischemic stroke and infection: A brief update on mechanisms and potential therapies by Ghelani, Drishti P., Kim, Hyun Ah, Zhang, Shenpeng R., Drummond, Grant R., Sobey, Christopher G., De Silva, T. Michael

“…[Display omitted] Ischemic stroke triggers a multifaceted inflammatory response in the brain that contributes to secondary brain injury and infarct expansion…”
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Treatment with an interleukin-1 receptor antagonist mitigates neuroinflammation and brain damage after polytrauma by Sun, Mujun, Brady, Rhys D., Wright, David K., Kim, Hyun Ah, Zhang, Shenpeng R., Sobey, Christopher G., Johnstone, Maddison R., O'Brien, Terence J., Semple, Bridgette D., McDonald, Stuart J., Shultz, Sandy R.

“…•IL-1ra treatment was assessed in a TBI+tibial fracture (polytrauma) mouse model.•IL-1ra treatment reduced neuroinflammatory markers after polytrauma.•IL-1ra…”
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Post-stroke cognitive impairment and brain hemorrhage are augmented in hypertensive mice by Wong Zhang, David E, Gibson Hughes, Tayla A, Figueiredo Galvao, Hericka B, Lo, Cecilia, Dinh, Quynh Nhu, Zhang, Shenpeng R, Kim, Hyun Ah, Selvaraji, Sharmalee, Clarkson, Andrew N, Arumugam, Thiruma V, Drummond, Grant, Sobey, Christopher G, De Silva, T Michael

“…Hypertension is a major risk factor for both stroke and cognitive impairment, but it is unclear whether it may specifically affect post-stroke cognitive…”
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Bim Deletion Reduces Functional Deficits Following Ischemic Stroke in Association with Modulation of Apoptosis and Inflammation by Glab, Jason A., Puthalakath, Hamsa, Zhang, Shenpeng R., Vinh, Antony, Drummond, Grant R., Sobey, Christopher G., De Silva, T. Michael, Kim, Hyun Ah

“…Cellular apoptosis is a key pathological mechanism contributing to neuronal death following ischemic stroke. The pro-apoptotic Bcl-2 family protein, Bim, is an…”
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IL-37 increases in patients after ischemic stroke and protects from inflammatory brain injury, motor impairment and lung infection in mice by Zhang, Shenpeng R., Nold, Marcel F., Tang, Sung-Chun, Bui, Christine B., Nold, Claudia A., Arumugam, Thiruma V., Drummond, Grant R., Sobey, Christopher G., Kim, Hyun Ah

“…Post-stroke inflammation may contribute to secondary brain injury and systemic immunosuppression. Interleukin(IL)-37 is an immunosuppressive cytokine belonging…”
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Large-Scale Multivariate Analysis to Interrogate an Animal Model of Stroke: Novel Insights Into Poststroke Pathology by Zhang, Shenpeng R., Kim, Hyun Ah, Chu, Hannah X., Lee, Seyoung, Evans, Megan A., Li, Xia, Ma, Henry, Drummond, Grant R., Sobey, Christopher G., Phan, Thanh G.

“…Preclinical stroke studies endeavor to model the pathophysiology of clinical stroke, assessing a range of parameters of injury and impairment. However,…”
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Corrigendum: Phase I trial outcome of amnion cell therapy in patients with ischemic stroke (I-ACT) by Phan, Thanh G., Lim, Rebecca, Krause, Mirja, Chan, Siow T., McDonald, Hannah, Gan, Poh-Yi, Zhang, Shenpeng R., Barreto Arce, Liz J., Vuong, Jason, Thirugnanachandran, Tharani, Clissold, Benjamin, Ly, John, Singhal, Shaloo, Hervet, Marie Veronic, Kim, Hyun Ah, Drummond, Grant R., Wallace, Euan M., Ma, Henry, Sobey, Christopher G.

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IL-33 modulates inflammatory brain injury but exacerbates systemic immunosuppression following ischemic stroke by Zhang, Shenpeng R, Piepke, Marius, Chu, Hannah X, Broughton, Brad Rs, Shim, Raymond, Wong, Connie Hy, Lee, Seyoung, Evans, Megan A, Vinh, Antony, Sakkal, Samy, Arumugam, Thiruma V, Magnus, Tim, Huber, Samuel, Gelderblom, Mathias, Drummond, Grant R, Sobey, Christopher G, Kim, Hyun Ah

“…Stroke triggers a complex inflammatory process in which the balance between pro- and antiinflammatory mediators is critical for the development of the brain…”
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Brain immune cell composition and functional outcome after cerebral ischemia: comparison of two mouse strains by Kim, Hyun Ah, Whittle, Stephanie C, Lee, Seyoung, Chu, Hannah X, Zhang, Shenpeng R, Wei, Zihui, Arumugam, Thiruma V, Vinh, Anthony, Drummond, Grant R, Sobey, Christopher G

“…Inflammatory cells may contribute to secondary brain injury following cerebral ischemia. The C57Bl/6 mouse strain is known to exhibit a T helper 1-prone,…”
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HUMAN AMNION EPITHELIAL CELLS REDUCE BLOOD PRESSURE AND PREVENT AORTIC INFLAMMATION AND COLLAGEN EXPRESSION DURING EXPERIMENTAL HYPERTENSION by Dinh, Quynh Nhu, De Silva, Cecilia, Diep, Henry, Zhang, Shenpeng R, Arce, Liz J Barreto, Lim, Rebecca, Drummond, Grant R, Sobey, Christopher G, Silva, T. Michael De

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Human amnion epithelial cells reduces hypertension induced vascular stiffening and cognitive impairment by Dinh, Quynh Nhu, De Silva, Cecilia, Zhang, David, Diep, Henry, Zhang, Shenpeng R, Barreto Arce, Liz J, Vinh, Antony, Arumugam, Thiruma V, Lim, Rebecca, Drummond, Grant R, Sobey, Christopher G, De Silva, T. Michael

“…Abstract only Introduction: Vascular stiffening and inflammation are hallmarks of hypertension and contribute to the development of cardiovascular disease and…”
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