Search Results - "Zhang, Ruijie K"

Enzymatic construction of highly strained carbocycles by Chen, Kai, Huang, Xiongyi, Kan, S B Jennifer, Zhang, Ruijie K, Arnold, Frances H

“…Small carbocycles are structurally rigid and possess high intrinsic energy due to their ring strain. These features lead to broad applications but also create…”
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Enantioselective Aminohydroxylation of Styrenyl Olefins Catalyzed by an Engineered Hemoprotein by Cho, Inha, Prier, Christopher K., Jia, Zhi‐Jun, Zhang, Ruijie K., Görbe, Tamás, Arnold, Frances H.

“…Chiral 1,2‐amino alcohols are widely represented in biologically active compounds from neurotransmitters to antivirals. While many synthetic methods have been…”
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Directed Evolution of a Bright Near-Infrared Fluorescent Rhodopsin Using a Synthetic Chromophore by Herwig, Lukas, Rice, Austin J, Bedbrook, Claire N, Zhang, Ruijie K, Lignell, Antti, Cahn, Jackson K B, Renata, Hans, Dodani, Sheel C, Cho, Inha, Cai, Long, Gradinaru, Viviana, Arnold, Frances H

“…By engineering a microbial rhodopsin, Archaerhodopsin-3 (Arch), to bind a synthetic chromophore, merocyanine retinal, in place of the natural chromophore…”
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Enantioselective Enzyme-Catalyzed Aziridination Enabled by Active-Site Evolution of a Cytochrome P450 by Farwell, Christopher C, Zhang, Ruijie K, McIntosh, John A, Hyster, Todd K, Arnold, Frances H

“…One of the greatest challenges in protein design is creating new enzymes, something evolution does all the time, starting from existing ones. Borrowing from…”
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Selective C H bond functionalization with engineered heme proteins: new tools to generate complexity by Zhang, Ruijie K, Huang, Xiongyi, Arnold, Frances H

“…C—H functionalization is an attractive strategy to construct and diversify molecules. Heme proteins, predominantly cytochromes P450, are responsible for an…”
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Enantiodivergent α‑Amino C–H Fluoroalkylation Catalyzed by Engineered Cytochrome P450s by Zhang, Juner, Huang, Xiongyi, Zhang, Ruijie K, Arnold, Frances H

“…The introduction of fluoroalkyl groups into organic compounds can significantly alter pharmacological characteristics. One enabling but underexplored approach…”
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Enantioselective, intermolecular benzylic C–H amination catalysed by an engineered iron-haem enzyme by Prier, Christopher K., Zhang, Ruijie K., Buller, Andrew R., Brinkmann-Chen, Sabine, Arnold, Frances H.

“…C–H bonds are ubiquitous structural units of organic molecules. Although these bonds are generally considered to be chemically inert, the recent emergence of…”
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Enantioselective Aminohydroxylation of Styrenyl Olefins Catalyzed by an Engineered Hemoprotein by Cho, Inha, Prier, Christopher K., Jia, Zhi‐Jun, Zhang, Ruijie K., Görbe, Tamás, Arnold, Frances H.

“…Chiral 1,2‐amino alcohols are widely represented in biologically active compounds from neurotransmitters to antivirals. While many synthetic methods have been…”
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Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp3 C–H functionalization by Zhang, Ruijie K., Chen, Kai, Huang, Xiongyi, Wohlschlager, Lena, Renata, Hans, Arnold, Frances H.

“…Although abundant in organic molecules, carbon–hydrogen (C–H) bonds are typically considered unreactive and unavailable for chemical manipulation. Recent…”
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Nitrene Transfer Catalyzed by a Non-Heme Iron Enzyme and Enhanced by Non-Native Small-Molecule Ligands by Goldberg, Nathaniel W, Knight, Anders M, Zhang, Ruijie K, Arnold, Frances H

“…Transition-metal catalysis is a powerful tool for the construction of chemical bonds. Here we show that Pseudomonas savastanoi ethylene-forming enzyme, a…”
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Selective CH bond functionalization with engineered heme proteins: new tools to generate complexity by Zhang, Ruijie K, Huang, Xiongyi, Arnold, Frances H

“…[Display omitted] •Interplay between synthetic chemistry and enzyme discovery/creation.•Cytochromes P450 for selective hydroxylation of complex…”
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Development of Scalable Processes with Underutilized Biocatalyst Classes by Phelan, Ryan M., Abrahamson, Michael J., Brown, Jesse T. C., Zhang, Ruijie K., Zwick, Christian R.

“…Over the past few decades, biocatalysis has become a significant contributor to the manufacture of complex active pharmaceutical ingredients (APIs),…”
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Enzymatic assembly of carbon–carbon bonds via iron-catalysed sp^sup 3^ C–H functionalization by Zhang, Ruijie K, Chen, Kai, Huang, Xiongyi, Wohlschlager, Lena, Renata, Hans, Arnold, Frances H

“…Although abundant in organic molecules, carbon-hydrogen (C-H) bonds are typically considered unreactive and unavailable for chemical manipulation. Recent…”
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Enzymatic assembly of carbon-carbon bonds via iron-catalysed sp.sup.3 C-H functionalization by Zhang, Ruijie K, Chen, Kai, Huang, Xiongyi, Wohlschlager, Lena, Renata, Hans, Arnold, Frances H

“…Although abundant in organic molecules, carbon-hydrogen (C-H) bonds are typically considered unreactive and unavailable for chemical manipulation. Recent…”
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Enantioselective, Intermolecular Benzylic C–H Amination Catalyzed by an Engineered Iron-Heme Enzyme by Prier, Christopher K., Zhang, Ruijie K., Buller, Andrew R., Brinkmann-Chen, Sabine, Arnold, Frances H.

“…C–H bonds are ubiquitous structural units of organic molecules; while these bonds are generally considered to be chemically inert, the recent emergence of…”
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Enzymatic assembly of carbon-carbon bonds via iron-catalysed sp 3 C-H functionalization by Zhang, Ruijie K, Chen, Kai, Huang, Xiongyi, Wohlschlager, Lena, Renata, Hans, Arnold, Frances H

“…Although abundant in organic molecules, carbon-hydrogen (C-H) bonds are typically considered unreactive and unavailable for chemical manipulation. Recent…”
Get full text