Search Results - "Zhang, Rugang"

NAD+ metabolism governs the proinflammatory senescence-associated secretome by Nacarelli, Timothy, Lau, Lena, Fukumoto, Takeshi, Zundell, Joseph, Fatkhutdinov, Nail, Wu, Shuai, Aird, Katherine M., Iwasaki, Osamu, Kossenkov, Andrew V., Schultz, David, Noma, Ken-ichi, Baur, Joseph A., Schug, Zachary, Tang, Hsin-Yao, Speicher, David W., David, Gregory, Zhang, Rugang

“…Cellular senescence is a stable growth arrest that is implicated in tissue ageing and cancer. Senescent cells are characterized by an upregulation of…”
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Combining PARP with ATR inhibition overcomes PARP inhibitor and platinum resistance in ovarian cancer models by Kim, Hyoung, Xu, Haineng, George, Erin, Hallberg, Dorothy, Kumar, Sushil, Jagannathan, Veena, Medvedev, Sergey, Kinose, Yasuto, Devins, Kyle, Verma, Priyanka, Ly, Kevin, Wang, Yifan, Greenberg, Roger A., Schwartz, Lauren, Johnson, Neil, Scharpf, Robert B., Mills, Gordon B., Zhang, Rugang, Velculescu, Victor E., Brown, Eric J., Simpkins, Fiona

“…Ovarian cancer (OVCA) inevitably acquires resistance to platinum chemotherapy and PARP inhibitors (PARPi). We show that acquisition of PARPi-resistance is…”
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Selective targeting of different populations of myeloid-derived suppressor cells by histone deacetylase inhibitors by Hashimoto, Ayumi, Fukumoto, Takeshi, Zhang, Rugang, Gabrilovich, Dmitry

“…Myeloid-derived suppressor cells (MDSCs) are widely implicated in negative regulation of immune responses in cancer. Inhibition of class I histone deacetylases…”
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Targeting the ATR/CHK1 Axis with PARP Inhibition Results in Tumor Regression in BRCA -Mutant Ovarian Cancer Models by Kim, Hyoung, George, Erin, Ragland, Ryan, Rafail, Stavros, Zhang, Rugang, Krepler, Clemens, Morgan, Mark, Herlyn, Meenhard, Brown, Eric, Simpkins, Fiona

“…PARP inhibition (PARPi) has modest clinical activity in recurrent -mutant ( ) high-grade serous ovarian cancers (HGSOC). We hypothesized that PARPi increases…”
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Topoisomerase 1 cleavage complex enables pattern recognition and inflammation during senescence by Zhao, Bo, Liu, Pingyu, Fukumoto, Takeshi, Nacarelli, Timothy, Fatkhutdinov, Nail, Wu, Shuai, Lin, Jianhuang, Aird, Katherine M., Tang, Hsin-Yao, Liu, Qin, Speicher, David W., Zhang, Rugang

“…Cyclic cGMP-AMP synthase (cGAS) is a pattern recognition cytosolic DNA sensor that is essential for cellular senescence. cGAS promotes inflammatory…”
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Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers by Bitler, Benjamin G, Aird, Katherine M, Garipov, Azat, Li, Hua, Amatangelo, Michael, Kossenkov, Andrew V, Schultz, David C, Liu, Qin, Shih, Ie-Ming, Conejo-Garcia, Jose R, Speicher, David W, Zhang, Rugang

“…Ovarian tumors with common mutations in the epigenetic regulator ARID1A are shown to be sensitive to inhibition of EZH2, another epigenetic regulator, showing…”
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Detection of senescence-associated heterochromatin foci (SAHF) by Aird, Katherine M, Zhang, Rugang

“…One of the most prominent features of cellular senescence, a stress response that prevents the propagation of cells that have accumulated potentially oncogenic…”
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Targeting cellular senescence to combat cancer and ageing by Wang, Chen, Hao, Xue, Zhang, Rugang

“…Senescence is a complex cellular process that is implicated in various physiological and pathological processes. It is characterized by a stable state of cell…”
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Targeting the IRE1α/XBP1s pathway suppresses CARM1-expressing ovarian cancer by Lin, Jianhuang, Liu, Heng, Fukumoto, Takeshi, Zundell, Joseph, Yan, Qingqing, Tang, Chih-Hang Anthony, Wu, Shuai, Zhou, Wei, Guo, Dajiang, Karakashev, Sergey, Hu, Chih-Chi Andrew, Sarma, Kavitha, Kossenkov, Andrew V., Zhang, Rugang

“…CARM1 is often overexpressed in human cancers including in ovarian cancer. However, therapeutic approaches based on CARM1 expression remain to be an unmet…”
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Molecular Dissection of Formation of Senescence-Associated Heterochromatin Foci by Zhang, Rugang, Chen, Wei, Adams, Peter D.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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EZH2 Inhibition Sensitizes CARM1-High, Homologous Recombination Proficient Ovarian Cancers to PARP Inhibition by Karakashev, Sergey, Fukumoto, Takeshi, Zhao, Bo, Lin, Jianhuang, Wu, Shuai, Fatkhutdinov, Nail, Park, Pyoung-Hwa, Semenova, Galina, Jean, Stephanie, Cadungog, Mark G., Borowsky, Mark E., Kossenkov, Andrew V., Liu, Qin, Zhang, Rugang

“…In response to DNA double-strand breaks, MAD2L2-containing shieldin complex plays a critical role in the choice between homologous recombination (HR) and…”
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BET Bromodomain Inhibition Promotes Anti-tumor Immunity by Suppressing PD-L1 Expression by Zhu, Hengrui, Bengsch, Fee, Svoronos, Nikolaos, Rutkowski, Melanie R., Bitler, Benjamin G., Allegrezza, Michael J., Yokoyama, Yuhki, Kossenkov, Andrew V., Bradner, James E., Conejo-Garcia, Jose R., Zhang, Rugang

“…Restoration of anti-tumor immunity by blocking PD-L1 signaling through the use of antibodies has proven to be beneficial in cancer therapy. Here, we show…”
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Integrated Analysis of Genetic Ancestry and Genomic Alterations across Cancers by Yuan, Jiao, Hu, Zhongyi, Mahal, Brandon A., Zhao, Sihai D., Kensler, Kevin H., Pi, Jingjiang, Hu, Xiaowen, Zhang, Youyou, Wang, Yueying, Jiang, Junjie, Li, Chunsheng, Zhong, Xiaomin, Montone, Kathleen T., Guan, Guoqiang, Tanyi, Janos L., Fan, Yi, Xu, Xiaowei, Morgan, Mark A., Long, Meixiao, Zhang, Yuzhen, Zhang, Rugang, Sood, Anil K., Rebbeck, Timothy R., Dang, Chi V., Zhang, Lin

“…Disparities in cancer care have been a long-standing challenge. We estimated the genetic ancestry of The Cancer Genome Atlas patients, and performed a…”
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BET Bromodomain Inhibition Synergizes with PARP Inhibitor in Epithelial Ovarian Cancer by Karakashev, Sergey, Zhu, Hengrui, Yokoyama, Yuhki, Zhao, Bo, Fatkhutdinov, Nail, Kossenkov, Andrew V., Wilson, Andrew J., Simpkins, Fiona, Speicher, David, Khabele, Dineo, Bitler, Benjamin G., Zhang, Rugang

“…PARP inhibition is known to be an effective clinical strategy in BRCA mutant cancers, but PARP inhibition has not been applied to BRCA-proficient tumors. Here,…”
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ARID1A-mutated ovarian cancers depend on HDAC6 activity by Bitler, Benjamin G., Wu, Shuai, Park, Pyoung Hwa, Hai, Yang, Aird, Katherine M., Wang, Yemin, Zhai, Yali, Kossenkov, Andrew V., Vara-Ailor, Ana, Rauscher III, Frank J., Zou, Weiping, Speicher, David W., Huntsman, David G., Conejo-Garcia, Jose R., Cho, Kathleen R., Christianson, David W., Zhang, Rugang

“…ARID1A , encoding a subunit of the SWI/SNF chromatin-remodelling complex, is the most frequently mutated epigenetic regulator across all human cancers. ARID1A…”
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HMGB2 orchestrates the chromatin landscape of senescence-associated secretory phenotype gene loci by Aird, Katherine M, Iwasaki, Osamu, Kossenkov, Andrew V, Tanizawa, Hideki, Fatkhutdinov, Nail, Bitler, Benjamin G, Le, Linh, Alicea, Gretchen, Yang, Ting-Lin, Johnson, F Brad, Noma, Ken-Ichi, Zhang, Rugang

“…Cellular senescence is a stable cell growth arrest that is characterized by the silencing of proliferation-promoting genes through compaction of chromosomes…”
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Integrative comparison of the genomic and transcriptomic landscape between prostate cancer patients of predominantly African or European genetic ancestry by Yuan, Jiao, Kensler, Kevin H, Hu, Zhongyi, Zhang, Youyou, Zhang, Tianli, Jiang, Junjie, Xu, Mu, Pan, Yutian, Long, Meixiao, Montone, Kathleen T, Tanyi, Janos L, Fan, Yi, Zhang, Rugang, Hu, Xiaowen, Rebbeck, Timothy R, Zhang, Lin

“…Men of predominantly African Ancestry (AA) have higher prostate cancer (CaP) incidence and worse survival than men of predominantly European Ancestry (EA)…”
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PI3K therapy reprograms mitochondrial trafficking to fuel tumor cell invasion by Caino, M. Cecilia, Jagadish C. Ghosh, Young Chan Chae, Valentina Vaira, Dayana B. Rivadeneira, Alice Faversani, Paolo Rampini, Andrew V. Kossenkov, Katherine M. Aird, Rugang Zhang, Marie R. Webster, Ashani T. Weeraratna, Silvano Bosari, Lucia R. Languino, Dario C. Altieri

“…Molecular therapies are hallmarks of “personalized” medicine, but how tumors adapt to these agents is not well-understood. Here we show that small-molecule…”
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Tumor Cell-Independent Estrogen Signaling Drives Disease Progression through Mobilization of Myeloid-Derived Suppressor Cells by Svoronos, Nikolaos, Perales-Puchalt, Alfredo, Allegrezza, Michael J, Rutkowski, Melanie R, Payne, Kyle K, Tesone, Amelia J, Nguyen, Jenny M, Curiel, Tyler J, Cadungog, Mark G, Singhal, Sunil, Eruslanov, Evgeniy B, Zhang, Paul, Tchou, Julia, Zhang, Rugang, Conejo-Garcia, Jose R

“…The role of estrogens in antitumor immunity remains poorly understood. Here, we show that estrogen signaling accelerates the progression of different…”
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Epigenetic Basis of Cellular Senescence and Its Implications in Aging by Nacarelli, Timothy, Liu, Pingyu, Zhang, Rugang

“…Cellular senescence is a tumor suppressive response that has become recognized as a major contributor of tissue aging. Senescent cells undergo a stable…”
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