Search Results - "Zhang, Rosemary F"

Discovery of potent and efficacious pyrrolopyridazines as dual JAK1/3 inhibitors by Hynes, John, Wu, Hong, Kempson, James, Duan, James J.-W., Lu, Zhonghui, Jiang, Bin, Stachura, Sylwia, Tokarski, John S., Sack, John S., Khan, Javed A., Lippy, Jonathan S., Zhang, Rosemary F., Pitt, Sidney, Shen, Guoxiang, Gillooly, Kate, McIntyre, Kim, Carter, Percy H., Barrish, Joel C., Nadler, Steven G., Salter-Cid, Luisa M., Fura, Aberra, Schieven, Gary L., Pitts, William J., Wrobleski, Stephen T.

“…[Display omitted] A series of potent dual JAK1/3 inhibitors have been developed from a moderately selective JAK3 inhibitor. Substitution at the C6 position of…”
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Discovery of 4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (BMS-582949), a Clinical p38α MAP Kinase Inhibitor for the Treatment of Inflammatory Diseases by Liu, Chunjian, Lin, James, Wrobleski, Stephen T, Lin, Shuqun, Hynes, John, Wu, Hong, Dyckman, Alaric J, Li, Tianle, Wityak, John, Gillooly, Kathleen M, Pitt, Sidney, Shen, Ding Ren, Zhang, Rosemary F, McIntyre, Kim W, Salter-Cid, Luisa, Shuster, David J, Zhang, Hongjian, Marathe, Punit H, Doweyko, Arthur M, Sack, John S, Kiefer, Susan E, Kish, Kevin F, Newitt, John A, McKinnon, Murray, Dodd, John H, Barrish, Joel C, Schieven, Gary L, Leftheris, Katerina

“…The discovery and characterization of 7k (BMS-582949), a highly selective p38α MAP kinase inhibitor that is currently in phase II clinical trials for the…”
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Discovery of a JAK1/3 Inhibitor and Use of a Prodrug To Demonstrate Efficacy in a Model of Rheumatoid Arthritis by Spergel, Steven H, Mertzman, Michael E, Kempson, James, Guo, Junqing, Stachura, Sylwia, Haque, Lauren, Lippy, Jonathan S, Zhang, Rosemary F, Galella, Michael, Pitt, Sidney, Shen, Guoxiang, Fura, Aberra, Gillooly, Kathleen, McIntyre, Kim W, Tang, Vicky, Tokarski, John, Sack, John S, Khan, Javed, Carter, Percy H, Barrish, Joel C, Nadler, Steven G, Salter-Cid, Luisa M, Schieven, Gary L, Wrobleski, Stephen T, Pitts, William J

“…The four members of the Janus family of nonreceptor tyrosine kinases play a significant role in immune function. The JAK family kinase inhibitor, tofacitinib…”
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Discovery of pyrrolo[1,2-b]pyridazine-3-carboxamides as Janus kinase (JAK) inhibitors by Duan, James J-W, Lu, Zhonghui, Jiang, Bin, Yang, Bingwei V, Doweyko, Lidia M, Nirschl, David S, Haque, Lauren E, Lin, Shuqun, Brown, Gregory, Hynes, Jr, John, Tokarski, John S, Sack, John S, Khan, Javed, Lippy, Jonathan S, Zhang, Rosemary F, Pitt, Sidney, Shen, Guoxiang, Pitts, William J, Carter, Percy H, Barrish, Joel C, Nadler, Steven G, Salter-Cid, Luisa M, McKinnon, Murray, Fura, Aberra, Schieven, Gary L, Wrobleski, Stephen T

“…A new class of Janus kinase (JAK) inhibitors was discovered using a rationally designed pyrrolo[1,2-b]pyridazine-3-carboxamide scaffold. Preliminary studies…”
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Benzothiazole based inhibitors of p38α MAP kinase by Liu, Chunjian, Lin, James, Pitt, Sidney, Zhang, Rosemary F., Sack, John S., Kiefer, Susan E., Kish, Kevin, Doweyko, Arthur M., Zhang, Hongjian, Marathe, Punit H., Trzaskos, James, Mckinnon, Murray, Dodd, John H., Barrish, Joel C., Schieven, Gary L., Leftheris, Katerina

“…The rational design, synthesis, and SAR studies of a novel class of benzothiazole based inhibitors of p38α MAP kinase are described. Rational design,…”
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5-Cyanopyrimidine Derivatives as a Novel Class of Potent, Selective, and Orally Active Inhibitors of p38α MAP Kinase by Liu, Chunjian, Wrobleski, Stephen T, Lin, James, Ahmed, Gulzar, Metzger, Axel, Wityak, John, Gillooly, Kathleen M, Shuster, David J, McIntyre, Kim W, Pitt, Sidney, Shen, Ding Ren, Zhang, Rosemary F, Zhang, Hongjian, Doweyko, Arthur M, Diller, David, Henderson, Ian, Barrish, Joel C, Dodd, John H, Schieven, Gary L, Leftheris, Katerina

“…A novel class of 5-cyanopyrimidine-based inhibitors of p38α MAP kinase has been investigated. Analogues optimized through SAR iterations display low nanomolar…”
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Discovery of 4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (BMS-582949), a Clinical p38[alpha] MAP Kinase Inhibitor for the Treatment of Inflammatory Diseases by Liu, Chunjian, Lin, James, Wrobleski, Stephen T., Lin, Shuqun, Hynes, Jr., John, Wu, Hong, Dyckman, Alaric J., Li, Tianle, Wityak, John, Gillooly, Kathleen M., Pitt, Sidney, Shen, Ding Ren, Zhang, Rosemary F., McIntyre, Kim W., Salter-Cid, Luisa, Shuster, David J., Zhang, Hongjian, Marathe, Punit H., Doweyko, Arthur M., Sack, John S., Kiefer, Susan E., Kish, Kevin F., Newitt, John A., McKinnon, Murray, Dodd, John H., Barrish, Joel C., Schieven, Gary L., Leftheris, Katerina

“…The discovery and characterization of 7k (BMS-582949), a highly selective p38{alpha} MAP kinase inhibitor that is currently in phase II clinical trials for the…”
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5-Cyanopyrimidine derivatives as a novel class of potent, selective, and orally active inhibitors of p38alpha MAP kinase by Liu, Chunjian, Wrobleski, Stephen T, Lin, James, Ahmed, Gulzar, Metzger, Axel, Wityak, John, Gillooly, Kathleen M, Shuster, David J, McIntyre, Kim W, Pitt, Sidney, Shen, Ding Ren, Zhang, Rosemary F, Zhang, Hongjian, Doweyko, Arthur M, Diller, David, Henderson, Ian, Barrish, Joel C, Dodd, John H, Schieven, Gary L, Leftheris, Katerina

“…A novel class of 5-cyanopyrimidine-based inhibitors of p38alpha MAP kinase has been investigated. Analogues optimized through SAR iterations display low…”
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Benzothiazole based inhibitors of p38alpha MAP kinase by Liu, Chunjian, Lin, James, Pitt, Sidney, Zhang, Rosemary F, Sack, John S, Kiefer, Susan E, Kish, Kevin, Doweyko, Arthur M, Zhang, Hongjian, Marathe, Punit H, Trzaskos, James, Mckinnon, Murray, Dodd, John H, Barrish, Joel C, Schieven, Gary L, Leftheris, Katerina

“…Rational design, synthesis, and SAR studies of a novel class of benzothiazole based inhibitors of p38alpha MAP kinase are described. The issue of metabolic…”
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