Search Results - "Zhang, Regan"
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Nilotinib reduces muscle fibrosis in chronic muscle injury by promoting TNF-mediated apoptosis of fibro/adipogenic progenitors
Published in Nature medicine (01-07-2015)“…Tgf-β1 contributes to fibrosis during chronic injury by abrogating Tnf-directed apoptosis of fibro/adipogenic progenitor cells during muscle regeneration…”
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Tissue‐resident mesenchymal stem/progenitor cells in skeletal muscle: collaborators or saboteurs?
Published in The FEBS journal (01-09-2013)“…Although the regenerative potential of adult skeletal muscle is maintained by satellite cells, other stem/progenitor cell populations also reside in skeletal…”
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The role of microglia in human disease: therapeutic tool or target?
Published in Acta neuropathologica (01-09-2014)“…Microglia have long been the focus of much attention due to their strong proliferative response (microgliosis) to essentially any kind of damage to the CNS…”
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The murine caecal microRNA signature depends on the presence of the endogenous microbiota
Published in International journal of biological sciences (01-01-2012)“…The intestinal messenger RNA expression signature is affected by the presence and composition of the endogenous microbiota, with effects on host physiology…”
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The methyltransferase G9a regulates HoxA9-dependent transcription in AML
Published in Genes & development (15-02-2014)“…Chromatin modulators are emerging as attractive drug targets, given their widespread implication in human cancers and susceptibility to pharmacological…”
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Inhibition of Methyltransferase Setd7 Allows the In Vitro Expansion of Myogenic Stem Cells with Improved Therapeutic Potential
Published in Cell stem cell (01-02-2018)“…The development of cell therapy for repairing damaged or diseased skeletal muscle has been hindered by the inability to significantly expand immature,…”
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Nonmyogenic Cells in Skeletal Muscle Regeneration
Published in Current Topics in Developmental Biology (2011)“…Although classical dogma dictates that satellite cells are the primary cell type involved in skeletal muscle regeneration, alternative cell types such as a…”
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Book Chapter Journal Article -
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The lysine methyltransferase Ehmt2/G9a is dispensable for skeletal muscle development and regeneration
Published in Skeletal muscle (27-05-2016)“…Euchromatic histone-lysine N-methyltransferase 2 (G9a/Ehmt2) is the main enzyme responsible for the apposition of H3K9 di-methylation on histones. Due to its…”
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Role of stem/progenitor cells in reparative disorders
Published in Fibrogenesis & tissue repair (27-12-2012)“…Adult stem cells are activated to proliferate and differentiate during normal tissue homeostasis as well as in disease states and injury. This activation is a…”
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Journal Article