Search Results - "Zhang, Peiyi"

Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity by He, Yonghan, Zhang, Xuan, Chang, Jianhui, Kim, Ha-Neui, Zhang, Peiyi, Wang, Yingying, Khan, Sajid, Liu, Xingui, Zhang, Xin, Lv, Dongwen, Song, Lin, Li, Wen, Thummuri, Dinesh, Yuan, Yaxia, Wiegand, Janet S., Ortiz, Yuma T., Budamagunta, Vivekananda, Elisseeff, Jennifer H., Campisi, Judith, Almeida, Maria, Zheng, Guangrong, Zhou, Daohong

“…Small molecules that selectively kill senescent cells (SCs), termed senolytics, have the potential to prevent and treat various age-related diseases and extend…”
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Development of a BCL-xL and BCL-2 dual degrader with improved anti-leukemic activity by Lv, Dongwen, Pal, Pratik, Liu, Xingui, Jia, Yannan, Thummuri, Dinesh, Zhang, Peiyi, Hu, Wanyi, Pei, Jing, Zhang, Qi, Zhou, Shuo, Khan, Sajid, Zhang, Xuan, Hua, Nan, Yang, Qingping, Arango, Sebastian, Zhang, Weizhou, Nayak, Digant, Olsen, Shaun K., Weintraub, Susan T., Hromas, Robert, Konopleva, Marina, Yuan, Yaxia, Zheng, Guangrong, Zhou, Daohong

“…PROteolysis-TArgeting Chimeras (PROTACs) have emerged as an innovative drug development platform. However, most PROTACs have been generated empirically because…”
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Optimization of X-axis servo drive performance using PSO fuzzy control technique for double-axis dicing saw by Cao, Weifeng, Zhang, Peiyi, Mi, Qingtao, Sun, Yahui, Shi, Jun, Liang, Wanyong

“…The dicing saw is a critical piece of equipment in IC processing, primarily used to cut wafers. Due to the high spindle speed, even small errors in the cutting…”
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Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL by Nayak, Digant, Lv, Dongwen, Yuan, Yaxia, Zhang, Peiyi, Hu, Wanyi, Nayak, Anindita, Ruben, Eliza A., Lv, Zongyang, Sung, Patrick, Hromas, Robert, Zheng, Guangrong, Zhou, Daohong, Olsen, Shaun K.

“…Overexpression of BCL-xL and BCL-2 play key roles in tumorigenesis and cancer drug resistance. Advances in PROTAC technology facilitated recent development of…”
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Proteolysis-targeting chimera against BCL-XL destroys tumor-infiltrating regulatory T cells by Kolb, Ryan, De, Umasankar, Khan, Sajid, Luo, Yuewan, Kim, Myung-Chul, Yu, Haijun, Wu, Chaoyan, Mo, Jiao, Zhang, Xin, Zhang, Peiyi, Zhang, Xuan, Borcherding, Nicholas, Koppel, Daniel, Fu, Yang-Xin, Zheng, Song Guo, Avram, Dorina, Zheng, Guangrong, Zhou, Daohong, Zhang, Weizhou

“…Regulatory T cells (Tregs) play an important role in maintaining immune homeostasis and, within tumors, their upregulation is common and promotes an…”
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DT2216-a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas by He, Yonghan, Koch, Raphael, Budamagunta, Vivekananda, Zhang, Peiyi, Zhang, Xuan, Khan, Sajid, Thummuri, Dinesh, Ortiz, Yuma T, Zhang, Xin, Lv, Dongwen, Wiegand, Janet S, Li, Wen, Palmer, Adam C, Zheng, Guangrong, Weinstock, David M, Zhou, Daohong

“…Patients with advanced T cell lymphomas (TCLs) have limited therapeutic options and poor outcomes in part because their TCLs evade apoptosis through…”
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Molecular Mechanisms of Hepatocarcinogenesis Following Sustained Virological Response in Patients with Chronic Hepatitis C Virus Infection by Hayes, C Nelson, Zhang, Peiyi, Zhang, Yizhou, Chayama, Kazuaki

“…Despite the success of direct-acting antiviral (DAA) agents in treating chronic hepatitis C virus (HCV) infection, the number of cases of HCV-related…”
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Co-targeting BCL-XL and BCL-2 by PROTAC 753B eliminates leukemia cells and enhances efficacy of chemotherapy by targeting senescent cells by Jia, Yannan, Han, Lina, Ramage, Cassandra L, Wang, Zhe, Weng, Connie C, Yang, Lei, Colla, Simona, Ma, Helen, Zhang, Weiguo, Andreeff, Michael, Daver, Naval, Jain, Nitin, Pemmaraju, Naveen, Bhalla, Kapil, Mustjoki, Satu, Zhang, Peiyi, Zheng, Guangrong, Zhou, Daohong, Zhang, Qi, Konopleva, Marina

“…BCL-XL and BCL-2 are key anti-apoptotic proteins and validated cancer targets. 753B is a novel BCL-XL/BCL-2 proteolysis targeting chimera (PROTAC) that targets…”
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TNF Receptor: Fc Fusion Protein Downregulates RANKL/OPG Ratio by Inhibiting CXCL16/CXCR6 in Active Ankylosing Spondylitis by Zhang, Peiyi, Zhou, Shufen, Chen, Zhe, Tian, Ye, Wang, Qianqian, Li, Hui, Zhang, Tiantian, Guo, Qin, Wang, Meiying, Guo, Chengshan

“…Clinical studies indicate that recombinant tumor necrosis factor receptor:Fc fusion protein (rhTNFR:Fc) quickly alleviates symptoms and physical signs of…”
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PROTAC-Mediated Dual Degradation of BCL-xL and BCL-2 Is a Highly Effective Therapeutic Strategy in Small-Cell Lung Cancer by Khan, Sajid, Cao, Lin, Wiegand, Janet, Zhang, Peiyi, Zajac-Kaye, Maria, Kaye, Frederic J, Zheng, Guangrong, Zhou, Daohong

“…BCL-xL and BCL-2 are validated therapeutic targets in small-cell lung cancer (SCLC). Targeting these proteins with navitoclax (formerly ABT263, a dual BCL-xL/2…”
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The burden of Hepatitis B virus infection in Kenya: A systematic review and meta-analysis by Makokha, Grace Naswa, Zhang, Peiyi, Hayes, C Nelson, Songok, Elijah, Chayama, Kazuaki

“…Chronic Hepatitis B virus (HBV) infection causes liver cirrhosis and cancer and is a major public health concern in Kenya. However, so far no systematic review…”
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Formulation development of anti-rheumatoid gel of Saraca asoca (Roxb.) De Wilde hydroalcoholic extract containing eucalyptus oil and peppermint oil as penetration enhancer by Li, Yi, Zhang, Peiyi, Yang, Zhaowen, Ma, Fang, Savina, Dhiman, Anju, Li, Faxin

“…Abstract In the present research investigation, various concentrations of hydro-alcoholic extract of Saraca asoca (Roxb.) De Wilde (family: Caesalpinaceae)…”
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The psychological impact of the COVID-19 outbreak among the fever patients in the lockdown zone by Chen, Yuewei, Ma, Qian, Xie, Xiaoshuai, Cao, Kekui, Hou, Zhencai, Zhang, Peiyi

“…COVID-19 pandemic is still ongoing, which not only impact physical health but psychological health. This research aims to analyze the psychological impact of…”
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Axial plane single-molecule super-resolution microscopy of whole cells by An, Sha, Ziegler, Karl Ferdinand, Zhang, Peiyi, Wang, Yu, Kwok, Tim, Xu, Fan, Bi, Cheng, Matosevic, Sandro, Yin, Peng, Li, Tongcang, Huang, Fang

“…Fluorescence nanoscopy has become an indispensable tool for studying organelle structures, protein dynamics, and interactions in biological sciences…”
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AhR agonist tapinarof ameliorates lupus autoimmunity by suppressing Tfh cell differentiation via regulation of the JAK2‐STAT3 signaling pathway by Zhang, Ying, Pan, Yanyan, Zhang, Peiyi, Wang, Fang, Han, Ying, Li, Kailin, Jiang, Wen, Wang, Jue, Luan, Yun, Xin, Qian

“…Background The aryl hydrocarbon receptor (AhR) is a critical regulator of the pathogenesis of autoimmune disorders. We aimed to investigate the therapeutic…”
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PROTACs are effective in addressing the platelet toxicity associated with BCL-XL inhibitors by Zhang, Peiyi, Zhang, Xuan, Liu, Xingui, Khan, Sajid, Zhou, Daohong, Zheng, Guangrong

“…BCL-XL is an anti-apoptotic protein that plays an important role in tumorigenesis, metastasis, and intrinsic or therapy-induced cancer drug resistance. More…”
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Concise Synthesis of (S)‑δ-CEHC, a Metabolite of Vitamin E by Burke, Matthew, Pal, Pratik, Zhang, Peiyi, Zhang, Xuan, Zheng, Guangrong

“…Carboxyethyl hydroxychromans (CEHCs) are natural metabolites of vitamin E (VE). Their urinary levels can serve as useful biomarkers for the nutritional…”
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Co-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibit small-cell lung cancer growth without causing on-target toxicities in mice by Khan, Sajid, Kellish, Patrick, Connis, Nick, Thummuri, Dinesh, Wiegand, Janet, Zhang, Peiyi, Zhang, Xuan, Budamagunta, Vivekananda, Hua, Nan, Yang, Yang, De, Umasankar, Jin, Lingtao, Zhang, Weizhou, Zheng, Guangrong, Hromas, Robert, Hann, Christine, Zajac-Kaye, Maria, Kaye, Frederic J., Zhou, Daohong

“…Small-cell lung cancer (SCLC) is an aggressive malignancy with limited therapeutic options. The dismal prognosis in SCLC is in part associated with an…”
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BCL-XL PROTAC degrader DT2216 synergizes with sotorasib in preclinical models of KRASG12C-mutated cancers by Khan, Sajid, Wiegand, Janet, Zhang, Peiyi, Hu, Wanyi, Thummuri, Dinesh, Budamagunta, Vivekananda, Hua, Nan, Jin, Lingtao, Allegra, Carmen J, Kopetz, Scott E, Zajac-Kaye, Maria, Kaye, Frederic J, Zheng, Guangrong, Zhou, Daohong

“…Abstract KRAS mutations are the most common oncogenic drivers. Sotorasib (AMG510), a covalent inhibitor of KRAS G12C , was recently approved for the treatment…”
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In Situ Synthetic ZIF-8/Carbon Aerogel Composites as Solid-Phase Microextraction Coating for the Detection of Phthalic Acid Esters in Water Samples by Dong, Zong-Mu, Zhang, Peiyi, Sun, Tong, Xia, Qian, Wu, Jian-Feng, Zhao, Guang-Chao

“…In this study, a hybrid composite featuring zeolitic imidazolate framework-8/carbon aerogel (ZIF-8/CA) was synthesized via in situ nucleation and growth of…”
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