Search Results - "Zhang, Mingjie"
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Determination of Film Cooling Effectiveness and Heat Transfer Coefficient Simultaneously on a Flat Plate
Published in Energies (Basel) (01-06-2022)“…In this paper, flat plate film cooling with two rows of compound angle cylindrical film cooling holes was investigated. A data processing method was evaluated…”
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Formation of biological condensates via phase separation: Characteristics, analytical methods, and physiological implications
Published in The Journal of biological chemistry (04-10-2019)“…Liquid–liquid phase separation (LLPS) facilitates the formation of condensed biological assemblies with well-delineated physical boundaries, but without lipid…”
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3
Structures and target recognition modes of PDZ domains: recurring themes and emerging pictures
Published in Biochemical journal (01-10-2013)“…PDZ domains are highly abundant protein-protein interaction modules and are often found in multidomain scaffold proteins. PDZ-domain-containing scaffold…”
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4
Reconstituted Postsynaptic Density as a Molecular Platform for Understanding Synapse Formation and Plasticity
Published in Cell (23-08-2018)“…Synapses are semi-membraneless, protein-dense, sub-micron chemical reaction compartments responsible for signal processing in each and every neuron. Proper…”
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5
Protein Complex Assemblies in Epithelial Cell Polarity and Asymmetric Cell Division
Published in Journal of molecular biology (28-09-2018)“…Asymmetric local concentration of protein complexes on distinct membrane regions is a fundamental property in numerous biological processes and is a hallmark…”
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Organization and dynamics of PDZ-domain-related supramodules in the postsynaptic density
Published in Nature reviews. Neuroscience (01-02-2009)“…Key Points The postsynaptic density (PSD) of excitatory synapses is a membrane-associated mega-organelle that is highly enriched in glutamate receptors and…”
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RIM and RIM-BP Form Presynaptic Active-Zone-like Condensates via Phase Separation
Published in Molecular cell (07-03-2019)“…Both the timing and kinetics of neurotransmitter release depend on the positioning of clustered Ca2+ channels in active zones to docked synaptic vesicles on…”
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The Par3/Par6/aPKC complex and epithelial cell polarity
Published in Experimental cell research (10-06-2013)“…Apical–basal polarity is the basic organizing principle of epithelial cells, and endows epithelial cells to function as defensive barriers and as mediators of…”
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Liquid–Liquid Phase Separation in Biology: Specific Stoichiometric Molecular Interactions vs Promiscuous Interactions Mediated by Disordered Sequences
Published in Biochemistry (Easton) (10-08-2021)“…Extensive studies in the past few years have shown that nonmembrane bound organelles are likely assembled via liquid–liquid phase separation (LLPS), a process…”
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Gephyrin-mediated formation of inhibitory postsynaptic density sheet via phase separation
Published in Cell research (01-03-2021)“…Inhibitory synapses are also known as symmetric synapses due to their lack of prominent postsynaptic densities (PSDs) under a conventional electron microscope…”
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Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity
Published in Cell (25-08-2016)“…Postsynaptic densities (PSDs) are membrane semi-enclosed, submicron protein-enriched cellular compartments beneath postsynaptic membranes, which constantly…”
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Vesicle Tethering on the Surface of Phase-Separated Active Zone Condensates
Published in Molecular cell (07-01-2021)“…Tethering of synaptic vesicles (SVs) to the active zone determines synaptic strength, although the molecular basis governing SV tethering is elusive. Here, we…”
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13
Par complex cluster formation mediated by phase separation
Published in Nature communications (08-05-2020)“…The evolutionarily conserved Par3/Par6/aPKC complex regulates the polarity establishment of diverse cell types and distinct polarity-driven functions. However,…”
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14
A review of simplified numerical approaches for fast urban airflow simulation
Published in Building and environment (15-04-2023)“…As the urban area under study continues to expand, the high computational cost of urban wind and thermal environments simulation is becoming a major challenge…”
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Rapid dispersion of SynGAP from synaptic spines triggers AMPA receptor insertion and spine enlargement during LTP
Published in Neuron (Cambridge, Mass.) (07-01-2015)“…SynGAP is a Ras-GTPase activating protein highly enriched at excitatory synapses in the brain. Previous studies have shown that CaMKII and the RAS-ERK pathway…”
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Therapeutic Applications of Nanomedicine: Recent Developments and Future Perspectives
Published in Molecules (Basel, Switzerland) (01-05-2024)“…The concept of nanomedicine has evolved significantly in recent decades, leveraging the unique phenomenon known as the enhanced permeability and retention…”
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Terahertz time-gated spectral imaging for content extraction through layered structures
Published in Nature communications (09-09-2016)“…Spatial resolution, spectral contrast and occlusion are three major bottlenecks for non-invasive inspection of complex samples with current imaging…”
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Liquid-Liquid Phase Separation in Physiology and Pathophysiology of the Nervous System
Published in The Journal of neuroscience (03-02-2021)“…Molecules within cells are segregated into functional domains to form various organelles. While some of those organelles are delimited by lipid membranes…”
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Therapeutic potential of plant-derived natural compounds in Alzheimer’s disease: Targeting microglia-mediated neuroinflammation
Published in Biomedicine & pharmacotherapy (01-09-2024)“…Microglia are resident immune cells of the central nervous system (CNS) with roles in sensing, housekeeping, and defense. Exploring the role of microglia in…”
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Mechanisms of MAGUK-mediated cellular junctional complex organization
Published in Current opinion in structural biology (01-02-2018)“…•The GK domain of MAGUKs has evolved from a nucleotide kinase into a versatile protein binding module.•MAGUK GKs can bind to both phosphorylated and…”
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